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Aliases for PDS5B Gene

Aliases for PDS5B Gene

  • PDS5 Cohesin Associated Factor B 2 3 5
  • Androgen-Induced Proliferation Inhibitor 2 3 4
  • Androgen-Induced Prostate Proliferative Shutoff-Associated Protein AS3 3 4
  • APRIN 3 4
  • AS3 3 4
  • PDS5, Regulator Of Cohesion Maintenance, Homolog B (S. Cerevisiae) 2
  • Sister Chromatid Cohesion Protein PDS5 Homolog B 3
  • Androgen Induced Inhibitor Of Proliferation 3
  • Androgen-Induced Shutoff 3 3
  • KIAA0979 4
  • CG008 3

External Ids for PDS5B Gene

Previous HGNC Symbols for PDS5B Gene

  • APRIN

Previous GeneCards Identifiers for PDS5B Gene

  • GC13P032059
  • GC13P033160
  • GC13P013971

Summaries for PDS5B Gene

Entrez Gene Summary for PDS5B Gene

  • This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015]

GeneCards Summary for PDS5B Gene

PDS5B (PDS5 Cohesin Associated Factor B) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Mitotic Metaphase and Anaphase. GO annotations related to this gene include binding. An important paralog of this gene is PDS5A.

UniProtKB/Swiss-Prot for PDS5B Gene

  • Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.

Gene Wiki entry for PDS5B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDS5B Gene

Genomics for PDS5B Gene

Regulatory Elements for PDS5B Gene

Enhancers for PDS5B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G032425 1.3 ENCODE dbSUPER 10.3 -158.4 -158356 4.9 HDGF HNRNPUL1 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ENSG00000212293 N4BP2L2 PDS5B N4BP2L1 GC13M032421
GH13G032837 1.3 FANTOM5 Ensembl ENCODE 9.3 +252.6 252624 2.5 CTCF FOXA2 NFIB ASH2L RBBP5 RAD21 ETV6 RELB IKZF2 CHD2 KL PDS5B ENSG00000277151 LINC00423
GH13G032471 1.1 Ensembl ENCODE 10.3 -114.5 -114464 1.8 PKNOX1 PTBP1 TCF12 GATA2 EGR1 EGR2 CREB3 NFIC SMARCA4 KLF16 N4BP2L2 N4BP2L1 ENSG00000212293 PDS5B ATP8A2P2 ENSG00000270008
GH13G033032 0.9 Ensembl ENCODE 9.9 +447.0 446974 1.2 ZBTB40 GABPA FOXA1 ZNF579 RAD51 POLR2A NBN ETV6 EZH2 PDS5B KL STARD13-IT1
GH13G032639 0.7 ENCODE 12.5 +53.3 53272 0.2 CTCF ZNF654 ZNF680 BHLHE40 HLF TRIM22 REST RAD21 PRDM6 ZNF143 PDS5B GC13M032668
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PDS5B on UCSC Golden Path with GeneCards custom track

Promoters for PDS5B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000060913 873 3001 PKNOX1 ARID4B SIN3A ZNF2 ZNF48 YY1 ELK1 CBX5 ZNF143 ZNF207

Genomic Location for PDS5B Gene

Chromosome:
13
Start:
32,586,427 bp from pter
End:
32,778,020 bp from pter
Size:
191,594 bases
Orientation:
Plus strand

Genomic View for PDS5B Gene

Genes around PDS5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDS5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDS5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDS5B Gene

Proteins for PDS5B Gene

  • Protein details for PDS5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTI5-PDS5B_HUMAN
    Recommended name:
    Sister chromatid cohesion protein PDS5 homolog B
    Protein Accession:
    Q9NTI5
    Secondary Accessions:
    • Q5R3S3
    • Q5W0K8
    • Q6NSC3
    • Q8IXT6
    • Q9H5N8
    • Q9Y2I5
    • Q9Y451

    Protein attributes for PDS5B Gene

    Size:
    1447 amino acids
    Molecular mass:
    164667 Da
    Quaternary structure:
    • Interacts with the cohesin complex. Interacts with RAD21; the interaction is direct. Interacts with WAPL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive (Probable).
    SequenceCaution:
    • Sequence=BAA76823.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PDS5B Gene

    Alternative splice isoforms for PDS5B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDS5B Gene

Post-translational modifications for PDS5B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for PDS5B

No data available for DME Specific Peptides for PDS5B Gene

Domains & Families for PDS5B Gene

Protein Domains for PDS5B Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NTI5

UniProtKB/Swiss-Prot:

PDS5B_HUMAN :
  • Belongs to the PDS5 family.
Family:
  • Belongs to the PDS5 family.
genes like me logo Genes that share domains with PDS5B: view

No data available for Gene Families for PDS5B Gene

Function for PDS5B Gene

Molecular function for PDS5B Gene

UniProtKB/Swiss-Prot Function:
Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.
UniProtKB/Swiss-Prot Induction:
By the synthetic androgen R1881 in prostate carcinoma cells undergoing proliferative arrest. Maximum levels occur 18-20 hours after androgen exposure.

Gene Ontology (GO) - Molecular Function for PDS5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 19412548
GO:0005515 protein binding IPI 15837422
GO:0005524 ATP binding TAS 10215036
genes like me logo Genes that share ontologies with PDS5B: view
genes like me logo Genes that share phenotypes with PDS5B: view

Animal Models for PDS5B Gene

MGI Knock Outs for PDS5B:

Animal Model Products

CRISPR Products

miRNA for PDS5B Gene

miRTarBase miRNAs that target PDS5B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDS5B Gene

Localization for PDS5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDS5B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDS5B gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for PDS5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region TAS --
GO:0000785 chromatin IDA 16682347
GO:0005634 nucleus ISS,TAS --
GO:0005654 nucleoplasm TAS,IDA --
GO:0005694 chromosome TAS --
genes like me logo Genes that share ontologies with PDS5B: view

Pathways & Interactions for PDS5B Gene

genes like me logo Genes that share pathways with PDS5B: view

Pathways by source for PDS5B Gene

Gene Ontology (GO) - Biological Process for PDS5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IBA --
GO:0007049 cell cycle IEA --
GO:0007062 sister chromatid cohesion TAS --
GO:0007064 mitotic sister chromatid cohesion IMP 15855230
GO:0007067 mitotic nuclear division IEA --
genes like me logo Genes that share ontologies with PDS5B: view

No data available for SIGNOR curated interactions for PDS5B Gene

Transcripts for PDS5B Gene

Unigene Clusters for PDS5B Gene

PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDS5B Gene

No ASD Table

Relevant External Links for PDS5B Gene

GeneLoc Exon Structure for
PDS5B
ECgene alternative splicing isoforms for
PDS5B

Expression for PDS5B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PDS5B Gene

Protein differential expression in normal tissues from HIPED for PDS5B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.6), Lymph node (8.5), and Fetal ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PDS5B Gene



Protein tissue co-expression partners for PDS5B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PDS5B Gene:

PDS5B

SOURCE GeneReport for Unigene cluster for PDS5B Gene:

Hs.744901

mRNA Expression by UniProt/SwissProt for PDS5B Gene:

Q9NTI5-PDS5B_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for PDS5B Gene

  • Blood(4.5)
  • Liver(4.4)
  • Nervous system(2.7)
  • Kidney(2.6)
  • Lung(2.6)
  • Adrenal gland(2.1)
  • Lymph node(2.1)
  • Pancreas(2.1)
  • Skin(2.1)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with PDS5B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDS5B Gene

Orthologs for PDS5B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PDS5B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDS5B 34 35
  • 99.86 (n)
dog
(Canis familiaris)
Mammalia PDS5B 34 35
  • 95.53 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PDS5B 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PDS5B 34 35
  • 93.9 (n)
oppossum
(Monodelphis domestica)
Mammalia PDS5B 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pds5b 34 16 35
  • 89.78 (n)
rat
(Rattus norvegicus)
Mammalia Pds5b 34
  • 86.44 (n)
chicken
(Gallus gallus)
Aves PDS5B 34 35
  • 84.14 (n)
lizard
(Anolis carolinensis)
Reptilia PDS5B 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pds5b 34
  • 77.58 (n)
Str.20129 34
zebrafish
(Danio rerio)
Actinopterygii pds5b 34 35
  • 72.14 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9260 34
fruit fly
(Drosophila melanogaster)
Insecta pds5 34 35
  • 48.16 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010643 34
  • 46.91 (n)
worm
(Caenorhabditis elegans)
Secernentea evl-14 34 35
  • 41.93 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F25806g 34
  • 41.39 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PDS5 34 35
  • 41.09 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL076W 34
  • 40.23 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pds5 34
  • 42.62 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00424 34
  • 40.46 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
OneToMany
Species where no ortholog for PDS5B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDS5B Gene

ENSEMBL:
Gene Tree for PDS5B (if available)
TreeFam:
Gene Tree for PDS5B (if available)

Paralogs for PDS5B Gene

Paralogs for PDS5B Gene

(1) SIMAP similar genes for PDS5B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PDS5B: view

Variants for PDS5B Gene

Sequence variations from dbSNP and Humsavar for PDS5B Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000056137 -- 32,647,692(+) TTAGT(C/G)TTTAT intron-variant
rs1000059050 -- 32,740,889(+) GGCGC(C/T)AGTGA intron-variant
rs1000059464 -- 32,616,754(+) AACTG(C/T)AAAAT intron-variant
rs1000062325 -- 32,712,470(+) TGATT(G/T)TGAGG intron-variant
rs1000066330 -- 32,757,807(+) TCATC(C/T)TTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDS5B Gene

Variant ID Type Subtype PubMed ID
dgv1626n100 CNV loss 25217958
esv2448396 CNV deletion 19546169
esv2609555 CNV deletion 19546169
esv3305636 CNV mobile element insertion 20981092
esv3355380 CNV insertion 20981092
esv3631725 CNV loss 21293372
esv3631726 CNV loss 21293372
nsv1143587 CNV deletion 24896259
nsv507688 OTHER sequence alteration 20534489
nsv832577 CNV gain 17160897

Variation tolerance for PDS5B Gene

Residual Variation Intolerance Score: 1.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 33.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDS5B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PDS5B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDS5B Gene

Disorders for PDS5B Gene

Relevant External Links for PDS5B

Genetic Association Database (GAD)
PDS5B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDS5B

No disorders were found for PDS5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDS5B Gene

Publications for PDS5B Gene

  1. Early gene expression during androgen-induced inhibition of proliferation of prostate cancer cells: a new suppressor candidate on chromosome 13, in the BRCA2-Rb1 locus. (PMID: 10215036) Geck P. … Soto A.M. (J. Steroid Biochem. Mol. Biol. 1999) 2 3 4 22 64
  2. Androgen-induced proliferative quiescence in prostate cancer cells: the role of AS3 as its mediator. (PMID: 10963680) Geck P. … Soto A.M. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 22 64
  3. Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres. (PMID: 24141881) Carretero M. … Losada A. (EMBO J. 2013) 2 3 64
  4. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney S.J. … . (Mol. Psychiatry 2011) 3 46 64
  5. Sororin mediates sister chromatid cohesion by antagonizing wapl. (PMID: 21111234) Nishiyama T. … Peters J.M. (Cell 2010) 3 4 64

Products for PDS5B Gene

Sources for PDS5B Gene

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