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Aliases for PALLD Gene

Aliases for PALLD Gene

  • Palladin, Cytoskeletal Associated Protein 2 3
  • Sarcoma Antigen NY-SAR-77 3 4
  • KIAA0992 4 6
  • SIH002 3 4
  • PNCA1 3 6
  • Myoneurin 3
  • Palladin 3
  • CGI-151 3
  • CGI151 3
  • MYN 3

External Ids for PALLD Gene

Previous GeneCards Identifiers for PALLD Gene

  • GC04P169793
  • GC04P169654
  • GC04P169418
  • GC04P165170

Summaries for PALLD Gene

Entrez Gene Summary for PALLD Gene

  • This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and contraction. Polymorphisms in this gene are associated with a susceptibility to pancreatic cancer type 1, and also with a risk for myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for PALLD Gene

PALLD (Palladin, Cytoskeletal Associated Protein) is a Protein Coding gene. Diseases associated with PALLD include pancreatic cancer 1 and pancreatic cancer susceptibility 1. GO annotations related to this gene include actin binding and muscle alpha-actinin binding. An important paralog of this gene is MYPN.

UniProtKB/Swiss-Prot for PALLD Gene

  • Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci.

Gene Wiki entry for PALLD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PALLD Gene

Genomics for PALLD Gene

Regulatory Elements for PALLD Gene

Genomic Location for PALLD Gene

Start:
168,497,066 bp from pter
End:
168,928,457 bp from pter
Size:
431,392 bases
Orientation:
Plus strand

Genomic View for PALLD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PALLD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PALLD Gene

Proteins for PALLD Gene

  • Protein details for PALLD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WX93-PALLD_HUMAN
    Recommended name:
    Palladin
    Protein Accession:
    Q8WX93
    Secondary Accessions:
    • B3KTG2
    • B5MD56
    • B7ZMM5
    • Q7L3E0
    • Q7Z3W0
    • Q86WE8
    • Q8N1M2
    • Q9UGA0
    • Q9UQF5
    • Q9Y2J6
    • Q9Y3E9

    Protein attributes for PALLD Gene

    Size:
    1383 amino acids
    Molecular mass:
    150564 Da
    Quaternary structure:
    • Interacts with EPS8, LASP1 and VASP (By similarity). Interacts with ACTN, ARGBP2, LPP, PFN1, SPIN90, SRC and EZR.
    SequenceCaution:
    • Sequence=AAD34146.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAO65174.1; Type=Frameshift; Positions=1150, 1154; Evidence={ECO:0000305}; Sequence=BAA76836.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC04796.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PALLD Gene

    Alternative splice isoforms for PALLD Gene

neXtProt entry for PALLD Gene

Proteomics data for PALLD Gene at MOPED

Post-translational modifications for PALLD Gene

  • Phosphorylated predominantly on serines and, to a lesser extent, on tyrosines (By similarity). Phosphorylation at Ser-1118 by PKB/AKT1 modulates cytoskeletal organization and cell motility.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PALLD Gene

Domains for PALLD Gene

Gene Families for PALLD Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing

Graphical View of Domain Structure for InterPro Entry

Q8WX93

UniProtKB/Swiss-Prot:

PALLD_HUMAN :
  • Q8WX93
Domain:
  • Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the myotilin/palladin family.
genes like me logo Genes that share domains with PALLD: view

Function for PALLD Gene

Molecular function for PALLD Gene

UniProtKB/Swiss-Prot Function: Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci.
UniProtKB/Swiss-Prot Induction: Isoform 3 is expressed de novo. Isoform 4 is up-regulated by TGFB1 during myofibroblast differentiation.

Gene Ontology (GO) - Molecular Function for PALLD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 11598191
GO:0051371 muscle alpha-actinin binding TAS 16125169
genes like me logo Genes that share ontologies with PALLD: view
genes like me logo Genes that share phenotypes with PALLD: view

Animal Models for PALLD Gene

MGI Knock Outs for PALLD:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PALLD Gene

Localization for PALLD Gene

Subcellular locations from UniProtKB/Swiss-Prot for PALLD Gene

Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell projection, ruffle. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere, Z line. Note=Localizes to stress fibers and Z lines.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PALLD Gene COMPARTMENTS Subcellular localization image for PALLD gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for PALLD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005634 nucleus IDA 11598191
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005884 actin filament IDA 11598191
genes like me logo Genes that share ontologies with PALLD: view

Pathways for PALLD Gene

SuperPathways for PALLD Gene

No Data Available

Gene Ontology (GO) - Biological Process for PALLD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization NAS 11598191
genes like me logo Genes that share ontologies with PALLD: view

No data available for Pathways by source for PALLD Gene

Transcripts for PALLD Gene

Unigene Clusters for PALLD Gene

Palladin, cytoskeletal associated protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PALLD Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^
SP1: - - -
SP2:
SP3: -
SP4: - - - - -
SP5:
SP6: - - -
SP7:
SP8: -
SP9:
SP10:

ExUns: 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24a · 24b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PALLD Gene

GeneLoc Exon Structure for
PALLD
ECgene alternative splicing isoforms for
PALLD

Expression for PALLD Gene

mRNA expression in normal human tissues for PALLD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PALLD Gene

This gene is overexpressed in Esophagus - Muscularis (5.4) and Esophagus - Gastroesophageal Junction (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PALLD Gene

SOURCE GeneReport for Unigene cluster for PALLD Gene Hs.151220

mRNA Expression by UniProt/SwissProt for PALLD Gene

Q8WX93-PALLD_HUMAN
Tissue specificity: Detected in both muscle and non-muscle tissues. High expression in prostate, ovary, colon, and kidney. Not detected in spleen, skeletal muscle, lung and peripheral blood lymphocytes (at protein level). Protein is overexpressed in FA6, HPAF, IMIM-PC2, SUIT-2 and PancTu-II sporadic pancreatic cancer cell lines.
genes like me logo Genes that share expressions with PALLD: view

Orthologs for PALLD Gene

This gene was present in the common ancestor of chordates.

Orthologs for PALLD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PALLD 35
  • 98.17 (n)
  • 98.23 (a)
PALLD 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PALLD 35
  • 75.73 (n)
  • 78.86 (a)
PALLD 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC477351 35
  • 90.58 (n)
  • 91 (a)
PALLD 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Palld 35
  • 85.02 (n)
  • 88.07 (a)
Palld 16
Palld 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PALLD 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100360205 35
  • 83.95 (n)
  • 86.54 (a)
chicken
(Gallus gallus)
Aves PALLD 35
  • 73.01 (n)
  • 70.82 (a)
PALLD 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.1924 35
tropical clawed frog
(Silurana tropicalis)
Amphibia palld 35
  • 68.19 (n)
  • 68.89 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14105 35
zebrafish
(Danio rerio)
Actinopterygii palld 35
  • 62.35 (n)
  • 63.41 (a)
palld 36
  • 46 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.17 36
  • 42 (a)
OneToMany
Species with no ortholog for PALLD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PALLD Gene

ENSEMBL:
Gene Tree for PALLD (if available)
TreeFam:
Gene Tree for PALLD (if available)

Paralogs for PALLD Gene

Paralogs for PALLD Gene

genes like me logo Genes that share paralogs with PALLD: view

Variants for PALLD Gene

Sequence variations from dbSNP and Humsavar for PALLD Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs4161 -- 168,498,497(+) TAAAT(A/C)TGACA intron-variant
rs867632 -- 168,860,102(-) GTGTT(C/T)ACCCG intron-variant
rs867901 -- 168,841,303(-) TGATG(C/T)ACATT intron-variant
rs869396 -- 168,766,849(+) actgc(A/C)agcta intron-variant
rs869397 -- 168,766,917(+) gcagc(A/T)catca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PALLD Gene

Variant ID Type Subtype PubMed ID
nsv881379 CNV Gain 21882294
nsv528045 CNV Gain 19592680
esv2728714 CNV Deletion 23290073
nsv880897 CNV Gain 21882294
nsv461834 CNV Gain 19166990
nsv830147 CNV Gain 17160897
nsv509944 CNV Loss 20534489
esv1342986 CNV Insertion 17803354
esv2728715 CNV Deletion 23290073
esv4297 CNV Deletion 18987735
esv2666909 CNV Deletion 23128226
esv2728716 CNV Deletion 23290073
esv2728717 CNV Deletion 23290073
esv2666829 CNV Deletion 23128226
esv22309 CNV Gain 19812545
nsv524640 CNV Gain 19592680
nsv291025 CNV Loss 16902084
esv1134701 CNV Insertion 17803354
esv2673045 CNV Deletion 23128226
nsv881010 CNV Gain 21882294
nsv437949 CNV Loss 16468122
nsv290017 CNV Loss 16902084
esv2658080 CNV Deletion 23128226
nsv525234 CNV Gain 19592680
nsv527077 CNV Gain 19592680
esv271337 CNV Insertion 20981092
esv34043 CNV Loss 18971310

Relevant External Links for PALLD Gene

HapMap Linkage Disequilibrium report
PALLD
Human Gene Mutation Database (HGMD)
PALLD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PALLD Gene

Disorders for PALLD Gene

(1) OMIM Diseases for PALLD Gene (608092)

UniProtKB/Swiss-Prot

PALLD_HUMAN
  • Pancreatic cancer 1 (PNCA1) [MIM:606856]: A malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue. {ECO:0000269 PubMed:17194196, ECO:0000269 PubMed:17415588}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Note=Genetic variations in PALLD may be associated with myocardial infarction.

(2) University of Copenhagen DISEASES for PALLD Gene

Relevant External Links for PALLD

Genetic Association Database (GAD)
PALLD
Human Genome Epidemiology (HuGE) Navigator
PALLD
genes like me logo Genes that share disorders with PALLD: view

Publications for PALLD Gene

  1. Identification of four gene variants associated with myocardial infarction. (PMID: 16175505) Shiffman D. … Kane J.P. (Am. J. Hum. Genet. 2005) 3 4 23
  2. Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism. (PMID: 17194196) Pogue-Geile K.L. … Brentnall T.A. (PLoS Med. 2006) 3 4 23
  3. Absence of deleterious palladin mutations in patients with familial pancreatic cancer. (PMID: 19336541) Klein A.P. … Goggins M. (Cancer Epidemiol. Biomarkers Prev. 2009) 3 23 48
  4. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  5. The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer. (PMID: 17415588) Zogopoulous G. … Gallinger S. (Hum. Genet. 2007) 3 4 48

Products for PALLD Gene

Sources for PALLD Gene

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