Aliases for PALLD Gene
External Ids for PALLD Gene
Previous GeneCards Identifiers for PALLD Gene
This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and contraction. Polymorphisms in this gene are associated with a susceptibility to pancreatic cancer type 1, and also with a risk for myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
GeneCards Summary for PALLD Gene
PALLD (Palladin, Cytoskeletal Associated Protein) is a Protein Coding gene. Diseases associated with PALLD include Pancreatic Cancer 1 and Pancreatic Cancer Susceptibility 1. Among its related pathways are Cytoskeletal Signaling. GO annotations related to this gene include actin binding and muscle alpha-actinin binding. An important paralog of this gene is MYPN.
UniProtKB/Swiss-Prot for PALLD Gene
Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci.