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Aliases for FOXJ1 Gene

Aliases for FOXJ1 Gene

  • Forkhead Box J1 2 3
  • FKHL13 3 4 6
  • HFH4 3 4 6
  • Hepatocyte Nuclear Factor 3 Forkhead Homolog 4 3 4
  • Forkhead-Related Protein FKHL13 3 4
  • HFH-4 3 4
  • Forkhead Transcription Factor HFH-4 3
  • Forkhead Box Protein J1 3
  • Fork Head Homologue 4 3
  • Forkhead-Like 13 3

External Ids for FOXJ1 Gene

Previous HGNC Symbols for FOXJ1 Gene

  • FKHL13

Previous GeneCards Identifiers for FOXJ1 Gene

  • GC17M073990
  • GC17M077124
  • GC17M074596
  • GC17M074729
  • GC17M071644
  • GC17M074132
  • GC17M069561

Summaries for FOXJ1 Gene

Entrez Gene Summary for FOXJ1 Gene

  • This gene encodes a member of the forkhead family of transcription factors. Similar genes in zebrafish and mouse have been shown to regulate the transcription of genes that control the production of motile cilia. The mouse ortholog also functions in the determination of left-right asymmetry. Polymorphisms in this gene are associated with systemic lupus erythematosus and allergic rhinitis.[provided by RefSeq, Sep 2009]

GeneCards Summary for FOXJ1 Gene

FOXJ1 (Forkhead Box J1) is a Protein Coding gene. Diseases associated with FOXJ1 include allergic rhinitis and rhinitis. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and double-stranded DNA binding. An important paralog of this gene is FOXK2.

UniProtKB/Swiss-Prot for FOXJ1 Gene

  • Transcription factor required for motile ciliogenesis.

Gene Wiki entry for FOXJ1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXJ1 Gene

Genomics for FOXJ1 Gene

Regulatory Elements for FOXJ1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FOXJ1 Gene

76,136,333 bp from pter
76,141,299 bp from pter
4,967 bases
Minus strand

Genomic View for FOXJ1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXJ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXJ1 Gene

Proteins for FOXJ1 Gene

  • Protein details for FOXJ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Forkhead box protein J1
    Protein Accession:
    Secondary Accessions:
    • O00630

    Protein attributes for FOXJ1 Gene

    421 amino acids
    Molecular mass:
    45247 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXJ1 Gene

Proteomics data for FOXJ1 Gene at MOPED

Post-translational modifications for FOXJ1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXJ1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FOXJ1 Gene

Domains for FOXJ1 Gene

Gene Families for FOXJ1 Gene

Protein Domains for FOXJ1 Gene

Suggested Antigen Peptide Sequences for FOXJ1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 fork-head DNA-binding domain.
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXJ1: view

Function for FOXJ1 Gene

Molecular function for FOXJ1 Gene

GENATLAS Biochemistry:
transcription factor-like 13,with a Drosophila homeo forkhead DNA binding domain,mouse hepatocyte nuclear factor 3 homolog,expression confined to cilia/flagella producing cells
UniProtKB/Swiss-Prot Function:
Transcription factor required for motile ciliogenesis.

Gene Ontology (GO) - Molecular Function for FOXJ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 9096351
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003677 DNA binding NAS 9073514
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 9073514
GO:0043565 sequence-specific DNA binding --
genes like me logo Genes that share ontologies with FOXJ1: view
genes like me logo Genes that share phenotypes with FOXJ1: view

Animal Models for FOXJ1 Gene

MGI Knock Outs for FOXJ1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for FOXJ1 Gene

Localization for FOXJ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXJ1 Gene

Subcellular locations from

Jensen Localization Image for FOXJ1 Gene COMPARTMENTS Subcellular localization image for FOXJ1 gene
Compartment Confidence
nucleus 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for FOXJ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17008636
genes like me logo Genes that share ontologies with FOXJ1: view

Pathways for FOXJ1 Gene

SuperPathways for FOXJ1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXJ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0002508 central tolerance induction ISS --
GO:0002635 negative regulation of germinal center formation ISS --
GO:0002897 positive regulation of central B cell tolerance induction ISS --
GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin ISS --
genes like me logo Genes that share ontologies with FOXJ1: view

No data available for Pathways by source for FOXJ1 Gene

Transcripts for FOXJ1 Gene

mRNA/cDNA for FOXJ1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(68) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXJ1 Gene

Forkhead box J1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXJ1 Gene

No ASD Table

Relevant External Links for FOXJ1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FOXJ1 Gene

mRNA expression in normal human tissues for FOXJ1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXJ1 Gene

This gene is overexpressed in Fallopian Tube (9.2), Testis (7.5), Cervix - Endocervix (6.7), Brain - Caudate (basal ganglia) (4.1), and Brain - Hypothalamus (4.0).

SOURCE GeneReport for Unigene cluster for FOXJ1 Gene Hs.651204

mRNA Expression by UniProt/SwissProt for FOXJ1 Gene

Tissue specificity: Testis, oviduct, lung and brain cortex
genes like me logo Genes that share expressions with FOXJ1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for FOXJ1 Gene

Orthologs for FOXJ1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXJ1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FOXJ1 35
  • 93.27 (n)
  • 95.72 (a)
FOXJ1 36
  • 96 (a)
(Canis familiaris)
Mammalia FOXJ1 35
  • 91.69 (n)
  • 93.59 (a)
FOXJ1 36
  • 93 (a)
(Mus musculus)
Mammalia Foxj1 35
  • 88.04 (n)
  • 92.64 (a)
Foxj1 16
Foxj1 36
  • 93 (a)
(Pan troglodytes)
Mammalia FOXJ1 35
  • 99.52 (n)
  • 99.76 (a)
FOXJ1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Foxj1 35
  • 87.97 (n)
  • 92.16 (a)
(Monodelphis domestica)
Mammalia FOXJ1 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia FOXJ1 36
  • 86 (a)
(Gallus gallus)
Aves FOXJ1 35
  • 71.06 (n)
  • 68.05 (a)
(Anolis carolinensis)
Reptilia FOXJ1 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia foxj1 35
  • 66.26 (n)
  • 65.37 (a)
Str.533 35
African clawed frog
(Xenopus laevis)
Amphibia foxJ1 35
(Danio rerio)
Actinopterygii foxj1a 35
  • 63.07 (n)
  • 62.78 (a)
foxj1a 36
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FKH1 36
  • 13 (a)
FKH2 36
  • 11 (a)
FKH2 38
Species with no ortholog for FOXJ1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXJ1 Gene

Gene Tree for FOXJ1 (if available)
Gene Tree for FOXJ1 (if available)

Paralogs for FOXJ1 Gene

genes like me logo Genes that share paralogs with FOXJ1: view

Variants for FOXJ1 Gene

Sequence variations from dbSNP and Humsavar for FOXJ1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs567486701 -- 76,138,486(+) ACCAC(C/G)GTCTC intron-variant
rs568485567 -- 76,136,027(+) CTGGG(G/T)CTGGG downstream-variant-500B
rs569060949 -- 76,137,518(+) CTGTC(A/G)GCAGC reference, synonymous-codon
rs569101247 -- 76,136,965(+) CCTGG(A/G)GAAGC utr-variant-3-prime
rs569659484 -- 76,138,157(+) AACCG(C/T)TAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXJ1 Gene

Variant ID Type Subtype PubMed ID
nsv908824 CNV Loss 21882294
nsv833546 CNV Loss 17160897
dgv3270n71 CNV Loss 21882294

Relevant External Links for FOXJ1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXJ1 Gene

Disorders for FOXJ1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for FOXJ1 Gene in MalaCards »

(3) Diseases for FOXJ1 Gene


  • Allergic rhinitis (ALRH) [MIM:607154]: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for FOXJ1 Gene

Relevant External Links for FOXJ1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FOXJ1: view

No data available for OMIM , Novoseek inferred disease relationships and Genatlas for FOXJ1 Gene

Publications for FOXJ1 Gene

  1. The human hepatocyte nuclear factor 3/fork head gene FKHL13: genomic structure and pattern of expression. (PMID: 9073514) Murphy D.B. … Thies U. (Genomics 1997) 2 3 4 23
  2. Identification of single nucleotide polymorphisms in FOXJ1 and their association with allergic rhinitis. (PMID: 16518568) Li C.-S. … Chung H.-T. (J. Hum. Genet. 2006) 2 3 4 48
  3. A human forkhead/winged-helix transcription factor expressed in developing pulmonary and renal epithelium. (PMID: 9530170) Pelletier G.J. … Hackett B.P. (Am. J. Physiol. 1998) 3 4 23
  4. The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo. (PMID: 9096351) Lim L. … Costa R.H. (Proc. Natl. Acad. Sci. U.S.A. 1997) 3 23
  5. No deleterious mutations in the FOXJ1 (alias HFH-4) gene in patients with primary ciliary dyskinesia (PCD). (PMID: 11060460) Maiti A.K. … Antonarakis S.E. (Cytogenet. Cell Genet. 2000) 3 23

Products for FOXJ1 Gene

Sources for FOXJ1 Gene

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