Aliases for FOXJ1 Gene
External Ids for FOXJ1 Gene
Previous HGNC Symbols for FOXJ1 Gene
Previous GeneCards Identifiers for FOXJ1 Gene
This gene encodes a member of the forkhead family of transcription factors. Similar genes in zebrafish and mouse have been shown to regulate the transcription of genes that control the production of motile cilia. The mouse ortholog also functions in the determination of left-right asymmetry. Polymorphisms in this gene are associated with systemic lupus erythematosus and allergic rhinitis.[provided by RefSeq, Sep 2009]
GeneCards Summary for FOXJ1 Gene
FOXJ1 (Forkhead Box J1) is a Protein Coding gene. Diseases associated with FOXJ1 include Rhinitis and Allergic Rhinitis. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXK2.
UniProtKB/Swiss-Prot for FOXJ1 Gene
Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5-HWDTGTTTGTTTA-3 or 5-KTTTGTTGTTKTW-3 (where H is not G, W is A or T, D is not C, and K is G or T).