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Aliases for EXOSC7 Gene

Aliases for EXOSC7 Gene

  • Exosome Component 7 2 3 4
  • RRP42 3 4 6
  • Ribosomal RNA-Processing Protein 42 3 4
  • P8 3 4
  • Exosome Complex Exonuclease RRP42 3
  • Exosome Complex Component RRP42 3
  • KIAA0116 4
  • HRrp42p 3
  • Rrp42p 3
  • EAP1 3

External Ids for EXOSC7 Gene

Summaries for EXOSC7 Gene

GeneCards Summary for EXOSC7 Gene

EXOSC7 (Exosome Component 7) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Unfolded Protein Response. GO annotations related to this gene include RNA binding and exoribonuclease activity. An important paralog of this gene is EXOSC9.

UniProtKB/Swiss-Prot for EXOSC7 Gene

  • Non-catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes

Gene Wiki entry for EXOSC7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOSC7 Gene

Genomics for EXOSC7 Gene

Genomic Location for EXOSC7 Gene

Start:
44,975,241 bp from pter
End:
45,036,066 bp from pter
Size:
60,826 bases
Orientation:
Plus strand

Genomic View for EXOSC7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EXOSC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOSC7 Gene

Regulatory Elements for EXOSC7 Gene

Proteins for EXOSC7 Gene

  • Protein details for EXOSC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15024-EXOS7_HUMAN
    Recommended name:
    Exosome complex component RRP42
    Protein Accession:
    Q15024
    Secondary Accessions:
    • Q96E72

    Protein attributes for EXOSC7 Gene

    Size:
    291 amino acids
    Molecular mass:
    31821 Da
    Quaternary structure:
    • Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure. Interacts with EXOSC1. Interacts with ZC3HAV1.

    Three dimensional structures from OCA and Proteopedia for EXOSC7 Gene

neXtProt entry for EXOSC7 Gene

Proteomics data for EXOSC7 Gene at MOPED

Post-translational modifications for EXOSC7 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys205, Lys244, and Lys260

Other Protein References for EXOSC7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for EXOSC7 Gene

Domains for EXOSC7 Gene

Protein Domains for EXOSC7 Gene

UniProtKB/Swiss-Prot:

EXOS7_HUMAN
Family:
  • Belongs to the RNase PH family.:
    • Q15024
genes like me logo Genes that share domains with EXOSC7: view

No data available for Gene Families for EXOSC7 Gene

Function for EXOSC7 Gene

Molecular function for EXOSC7 Gene

UniProtKB/Swiss-Prot Function: Non-catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes

Gene Ontology (GO) - Molecular Function for EXOSC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3-5-exoribonuclease activity TAS 11849973
GO:0003723 RNA binding TAS 11849973
GO:0004532 NOT exoribonuclease activity IDA 17174896
GO:0005515 protein binding IPI 11719186
genes like me logo Genes that share ontologies with EXOSC7: view

Phenotypes for EXOSC7 Gene

GenomeRNAi human phenotypes for EXOSC7:
genes like me logo Genes that share phenotypes with EXOSC7: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for EXOSC7 Gene

Localization for EXOSC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOSC7 Gene

Nucleus, nucleolus. Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EXOSC7 Gene COMPARTMENTS Subcellular localization image for EXOSC7 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for EXOSC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000178 exosome (RNase complex) TAS 11849973
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with EXOSC7: view

Pathways for EXOSC7 Gene

genes like me logo Genes that share pathways with EXOSC7: view

Pathways by source for EXOSC7 Gene

1 KEGG pathway for EXOSC7 Gene

Gene Ontology (GO) - Biological Process for EXOSC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0006364 rRNA processing TAS 11849973
GO:0006401 RNA catabolic process NAS 11719186
GO:0010467 gene expression TAS --
GO:0016070 RNA metabolic process --
genes like me logo Genes that share ontologies with EXOSC7: view

Transcripts for EXOSC7 Gene

Unigene Clusters for EXOSC7 Gene

Exosome component 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EXOSC7 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c
SP1: -
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: - - -
SP6:

Relevant External Links for EXOSC7 Gene

GeneLoc Exon Structure for
EXOSC7
ECgene alternative splicing isoforms for
EXOSC7

Expression for EXOSC7 Gene

mRNA expression in normal human tissues for EXOSC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EXOSC7 Gene

SOURCE GeneReport for Unigene cluster for EXOSC7 Gene Hs.719958

genes like me logo Genes that share expressions with EXOSC7: view

Orthologs for EXOSC7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EXOSC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EXOSC7 36
  • 98.85 (n)
  • 98.97 (a)
EXOSC7 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EXOSC7 36
  • 89.69 (n)
  • 96.91 (a)
EXOSC7 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EXOSC7 36
  • 92.1 (n)
  • 96.91 (a)
EXOSC7 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Exosc7 36
  • 89.81 (n)
  • 95.53 (a)
Exosc7 16
Exosc7 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EXOSC7 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EXOSC7 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Exosc7 36
  • 88.55 (n)
  • 95.53 (a)
chicken
(Gallus gallus)
Aves EXOSC7 36
  • 78.24 (n)
  • 87.29 (a)
EXOSC7 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 85 (a)
OneToMany
-- 37
  • 76 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia exosc7 36
  • 71.95 (n)
  • 80.34 (a)
zebrafish
(Danio rerio)
Actinopterygii exosc7 36
  • 69.87 (n)
  • 74.91 (a)
exosc7 37
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010483 36
  • 56.63 (n)
  • 54.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rrp42 36
  • 54.83 (n)
  • 49.31 (a)
Rrp42 37
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea exos-7 37
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRP42 39
RRP45 37
  • 19 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G07750 36
  • 48.71 (n)
  • 40.96 (a)
rice
(Oryza sativa)
Liliopsida Os12g0403800 36
  • 49.94 (n)
  • 41.51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 54 (a)
OneToOne
Species with no ortholog for EXOSC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOSC7 Gene

ENSEMBL:
Gene Tree for EXOSC7 (if available)
TreeFam:
Gene Tree for EXOSC7 (if available)

Paralogs for EXOSC7 Gene

Paralogs for EXOSC7 Gene

Selected SIMAP similar genes for EXOSC7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with EXOSC7: view

Variants for EXOSC7 Gene

Sequence variations from dbSNP and Humsavar for EXOSC7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs6794 - 45,011,283(+) GTGTT(C/G)TGCAC missense, reference, nc-transcript-variant
rs871085 -- 44,983,641(+) TCTCC(C/T)CTGCT intron-variant
rs939308 -- 44,982,719(-) AGGGC(C/T)GGCTC intron-variant
rs1879241 -- 45,011,698(+) GAATC(A/T)CAAAG intron-variant, downstream-variant-500B
rs2056322 -- 44,987,495(-) acctg(C/T)gttca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EXOSC7 Gene

Variant ID Type Subtype PubMed ID
nsv834676 CNV Gain+Loss 17160897
esv2675874 CNV Deletion 23128226
nsv508914 CNV Insertion 20534489

Relevant External Links for EXOSC7 Gene

HapMap Linkage Disequilibrium report
EXOSC7

Disorders for EXOSC7 Gene

No disorders were found for EXOSC7 Gene.

No data available for UniProtKB/Swiss-Prot for EXOSC7 Gene

Publications for EXOSC7 Gene

  1. Protein-protein interactions of hCsl4p with other human exosome subunits. (PMID: 11812149) Raijmakers R. … Pruijn G.J.M. (J. Mol. Biol. 2002) 2 3 4 23
  2. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. (PMID: 11719186) Chen C.-Y. … Karin M. (Cell 2001) 2 3 4
  3. Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. (PMID: 12419256) Raijmakers R. … Pruijn G.J.M. (J. Mol. Biol. 2002) 3 4
  4. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T. … Nomura N. (DNA Res. 1995) 3 4
  5. Reconstitution, activities, and structure of the eukaryotic RNA exosome. (PMID: 17174896) Liu Q. … Lima C.D. (Cell 2006) 3 4

Products for EXOSC7 Gene

Sources for EXOSC7 Gene

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