Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MYH15 Gene

Aliases for MYH15 Gene

  • Myosin, Heavy Chain 15 2 3 5
  • Myosin, Heavy Polypeptide 15 2
  • Myosin Heavy Chain 15 4
  • KIAA1000 4

External Ids for MYH15 Gene

Previous GeneCards Identifiers for MYH15 Gene

  • GC03M109581
  • GC03M108108
  • GC03M105472

Summaries for MYH15 Gene

GeneCards Summary for MYH15 Gene

MYH15 (Myosin, Heavy Chain 15) is a Protein Coding gene. Among its related pathways are Integrin Pathway and ERK Signaling. GO annotations related to this gene include actin binding and motor activity. An important paralog of this gene is MYH4.

UniProtKB/Swiss-Prot for MYH15 Gene

  • Muscle contraction.

Tocris Summary for MYH15 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells, almost all eukaryotic cells are known to contain myosins.

Gene Wiki entry for MYH15 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYH15 Gene

Genomics for MYH15 Gene

Regulatory Elements for MYH15 Gene

Genomic Location for MYH15 Gene

108,380,368 bp from pter
108,549,465 bp from pter
169,098 bases
Minus strand

Genomic View for MYH15 Gene

Genes around MYH15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYH15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYH15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYH15 Gene

Proteins for MYH15 Gene

  • Protein details for MYH15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for MYH15 Gene

    1946 amino acids
    Molecular mass:
    224619 Da
    Quaternary structure:
    • Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
    • Sequence=BAA76844.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for MYH15 Gene

Proteomics data for MYH15 Gene at MOPED

Post-translational modifications for MYH15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYH15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYH15 Gene

Domains & Families for MYH15 Gene

Gene Families for MYH15 Gene

Suggested Antigen Peptide Sequences for MYH15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
  • The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
  • Contains 1 IQ domain.
  • Contains 1 myosin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYH15: view

Function for MYH15 Gene

Molecular function for MYH15 Gene

UniProtKB/Swiss-Prot Function:
Muscle contraction.

Gene Ontology (GO) - Molecular Function for MYH15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MYH15: view

Phenotypes for MYH15 Gene

genes like me logo Genes that share phenotypes with MYH15: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYH15 Gene

Localization for MYH15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYH15 Gene

Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.

Subcellular locations from

Jensen Localization Image for MYH15 Gene COMPARTMENTS Subcellular localization image for MYH15 gene
Compartment Confidence
cytoskeleton 4
nucleus 3
cytosol 2
mitochondrion 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for MYH15 Gene

Pathways & Interactions for MYH15 Gene

genes like me logo Genes that share pathways with MYH15: view

Interacting Proteins for MYH15 Gene

Gene Ontology (GO) - Biological Process for MYH15 Gene


No data available for SIGNOR curated interactions for MYH15 Gene

Drugs & Compounds for MYH15 Gene

(5) Additional Compounds for MYH15 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ML 9 hydrochloride
W-7 hydrochloride

(5) Tocris Compounds for MYH15 Gene

Compound Action Cas Number
(+-)-Blebbistatin Selective inhibitor of myosin II ATPase activity 674289-55-5
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) 1177356-70-5
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760) 856925-71-8
ML 9 hydrochloride Myosin light chain kinase inhibitor 105637-50-1
W-7 hydrochloride Calmodulin antagonist. Inhibits myosin light chain kinase 61714-27-0
genes like me logo Genes that share compounds with MYH15: view

Transcripts for MYH15 Gene

mRNA/cDNA for MYH15 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYH15 Gene

Myosin, heavy chain 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYH15 Gene

No ASD Table

Relevant External Links for MYH15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MYH15 Gene

mRNA expression in normal human tissues for MYH15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYH15 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.4).

Protein differential expression in normal tissues from HIPED for MYH15 Gene

This gene is overexpressed in Nasal epithelium (37.7) and Heart (16.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYH15 Gene

SOURCE GeneReport for Unigene cluster for MYH15 Gene Hs.731060

genes like me logo Genes that share expression patterns with MYH15: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MYH15 Gene

Orthologs for MYH15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYH15 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MYH15 35
  • 86.04 (n)
  • 80.42 (a)
MYH15 36
  • 79 (a)
(Canis familiaris)
Mammalia MYH15 35
  • 87.45 (n)
  • 83.44 (a)
MYH15 36
  • 83 (a)
(Mus musculus)
Mammalia Myh15 35
  • 82.1 (n)
  • 75.69 (a)
Myh15 16
Myh15 36
  • 76 (a)
(Pan troglodytes)
Mammalia MYH15 35
  • 99.43 (n)
  • 99.02 (a)
MYH15 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Myh15 35
  • 81.03 (n)
  • 74.72 (a)
(Monodelphis domestica)
Mammalia MYH15 36
  • 58 (a)
(Gallus gallus)
Aves MYH15 36
  • 71 (a)
(Anolis carolinensis)
Reptilia MYH15 36
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mhc 36
  • 47 (a)
(Caenorhabditis elegans)
Secernentea myo-1 36
  • 41 (a)
myo-2 36
  • 41 (a)
myo-3 36
  • 42 (a)
myo-5 36
  • 43 (a)
myo-6 36
  • 41 (a)
unc-54 36
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MYO1 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
-- 36
  • 58 (a)
-- 36
  • 45 (a)
-- 36
  • 58 (a)
-- 36
  • 58 (a)
-- 36
  • 59 (a)
-- 36
  • 58 (a)
Species with no ortholog for MYH15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MYH15 Gene

Gene Tree for MYH15 (if available)
Gene Tree for MYH15 (if available)

Paralogs for MYH15 Gene

Paralogs for MYH15 Gene

(20) SIMAP similar genes for MYH15 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MYH15: view

Variants for MYH15 Gene

Sequence variations from dbSNP and Humsavar for MYH15 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs4299484 - 108,470,780(+) TGATC(C/T)GTGCC reference, missense
rs9868484 - 108,470,146(+) CATGT(A/G)CCAAT reference, missense
rs12638212 - 108,441,130(+) TGGCA(A/G)TCAGC reference, missense
rs3900940 - 108,428,881(+) TTGAG(C/T)CTGTA reference, missense
rs1078456 - 108,410,739(-) TTGCC(A/G)ACTGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MYH15 Gene

Variant ID Type Subtype PubMed ID
nsv829656 CNV Loss 17160897
nsv829657 CNV Gain 17160897
nsv526190 CNV Gain 19592680
nsv3937 CNV Loss 18451855
esv268776 CNV Insertion 20981092
nsv829658 CNV Gain 17160897
dgv5229n71 CNV Loss 21882294

Variation tolerance for MYH15 Gene

Residual Variation Intolerance Score: 62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.51; 92.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYH15 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYH15 Gene

Disorders for MYH15 Gene

Relevant External Links for MYH15

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MYH15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYH15 Gene

Publications for MYH15 Gene

  1. Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project. (PMID: 22443383) Oudot-Mellakh T. … Morange P.E. (Br. J. Haematol. 2012) 3 48 67
  2. Evolution of sarcomeric myosin heavy chain genes: evidence from fish. (PMID: 15014174) McGuigan K. … Postlethwait J.H. (Mol. Biol. Evol. 2004) 2 3
  3. Myosin gene mutation correlates with anatomical changes in the human lineage. (PMID: 15042088) Stedman H.H. … Mitchell M.A. (Nature 2004) 2 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PMID: 22360420) Martins-de-Souza D. … Bahn S. (J. Proteome Res. 2012) 3

Products for MYH15 Gene

Sources for MYH15 Gene

Back to Top