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Aliases for MYH15 Gene

Aliases for MYH15 Gene

  • Myosin Heavy Chain 15 2 3 4 5
  • Myosin, Heavy Polypeptide 15 2 3
  • Myosin-15 3
  • KIAA1000 4

External Ids for MYH15 Gene

Previous GeneCards Identifiers for MYH15 Gene

  • GC03M109581
  • GC03M108108
  • GC03M105472

Summaries for MYH15 Gene

GeneCards Summary for MYH15 Gene

MYH15 (Myosin Heavy Chain 15) is a Protein Coding gene. Diseases associated with MYH15 include Autosomal Recessive Nonsyndromic Deafness 3. Among its related pathways are Immune response CCR3 signaling in eosinophils and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. GO annotations related to this gene include actin binding and motor activity. An important paralog of this gene is MYH6.

UniProtKB/Swiss-Prot for MYH15 Gene

  • Muscle contraction.

Tocris Summary for MYH15 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells, almost all eukaryotic cells are known to contain myosins.

Gene Wiki entry for MYH15 Gene

No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYH15 Gene

Genomics for MYH15 Gene

Regulatory Elements for MYH15 Gene

Enhancers for MYH15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G108406 0.9 ENCODE 19.1 +142.7 142687 0.2 PKNOX1 FOXA2 ARNT ARID4B FEZF1 YY1 TCF12 GATA2 ZNF143 MXD4 MYH15 HHLA2 GC03M108377 GC03M108465
GH03G108129 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5 +417.0 417040 5.0 PKNOX1 ZSCAN4 FEZF1 GATA2 ZNF366 ETV6 FOS IKZF2 JUNB MBD2 CD47 IFT57 MYH15 GC03M108125
GH03G108477 0.7 Ensembl 9.9 +71.8 71765 0.6 CTCF ZNF654 STAT1 TRIM22 REST RAD21 FOXA1 GATA3 SMC3 ZNF143 MYH15 GC03M108465 GC03M108377
GH03G108470 1 Ensembl ENCODE 5.8 +77.1 77125 3.6 HNRNPUL1 SOX13 FOXA2 JUN TEAD4 ZNF48 FOSL1 GATA2 RCOR1 PCBP1 DZIP3 MYH15 KIAA1524 RPL13P8 GC03M108465 GC03M108377
GH03G108821 1 Ensembl ENCODE dbSUPER 5.3 -274.7 -274685 5.0 NFIC CTBP1 ZNF146 FEZF1 DZIP3 RETNLB MYH15 TRAT1 GC03P108894
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYH15 on UCSC Golden Path with GeneCards custom track

Genomic Location for MYH15 Gene

Chromosome:
3
Start:
108,380,368 bp from pter
End:
108,549,465 bp from pter
Size:
169,098 bases
Orientation:
Minus strand

Genomic View for MYH15 Gene

Genes around MYH15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYH15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYH15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYH15 Gene

Proteins for MYH15 Gene

  • Protein details for MYH15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2K3-MYH15_HUMAN
    Recommended name:
    Myosin-15
    Protein Accession:
    Q9Y2K3

    Protein attributes for MYH15 Gene

    Size:
    1946 amino acids
    Molecular mass:
    224619 Da
    Quaternary structure:
    • Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
    SequenceCaution:
    • Sequence=BAA76844.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for MYH15 Gene

Post-translational modifications for MYH15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYH15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYH15 Gene

Domains & Families for MYH15 Gene

Gene Families for MYH15 Gene

Suggested Antigen Peptide Sequences for MYH15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2K3

UniProtKB/Swiss-Prot:

MYH15_HUMAN :
  • The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Domain:
  • The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYH15: view

Function for MYH15 Gene

Molecular function for MYH15 Gene

UniProtKB/Swiss-Prot Function:
Muscle contraction.

Gene Ontology (GO) - Molecular Function for MYH15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0005516 calmodulin binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MYH15: view

Phenotypes for MYH15 Gene

genes like me logo Genes that share phenotypes with MYH15: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYH15 Gene

Localization for MYH15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYH15 Gene

Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYH15 gene
Compartment Confidence
cytoskeleton 4
nucleus 3
mitochondrion 2
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MYH15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016459 myosin complex IEA --
GO:0030016 myofibril IEA --
GO:0032982 myosin filament IEA --
genes like me logo Genes that share ontologies with MYH15: view

Pathways & Interactions for MYH15 Gene

genes like me logo Genes that share pathways with MYH15: view

Gene Ontology (GO) - Biological Process for MYH15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002074 extraocular skeletal muscle development IEA --
genes like me logo Genes that share ontologies with MYH15: view

No data available for SIGNOR curated interactions for MYH15 Gene

Drugs & Compounds for MYH15 Gene

(2) Drugs for MYH15 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(R)-(+)-Blebbistatin Pharma non-muscle myosin II ATPases inhibitor, cell-permeable, Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) 0
BTS Pharma Selective inhibitor of skeletal muscle myosin II ATPase activity 0

(2) Additional Compounds for MYH15 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-Blebbistatin
674289-55-5
(S)-(-)-Blebbistatin
856925-71-8

(4) Tocris Compounds for MYH15 Gene

Compound Action Cas Number
(+-)-Blebbistatin Selective inhibitor of myosin II ATPase activity 674289-55-5
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) 1177356-70-5
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760) 856925-71-8
BTS Selective inhibitor of skeletal muscle myosin II ATPase activity 1576-37-0
genes like me logo Genes that share compounds with MYH15: view

Transcripts for MYH15 Gene

mRNA/cDNA for MYH15 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYH15 Gene

Myosin, heavy chain 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYH15 Gene

No ASD Table

Relevant External Links for MYH15 Gene

GeneLoc Exon Structure for
MYH15
ECgene alternative splicing isoforms for
MYH15

Expression for MYH15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYH15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYH15 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.4).

Protein differential expression in normal tissues from HIPED for MYH15 Gene

This gene is overexpressed in Nasal epithelium (37.7) and Heart (16.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYH15 Gene



NURSA nuclear receptor signaling pathways regulating expression of MYH15 Gene:

MYH15

SOURCE GeneReport for Unigene cluster for MYH15 Gene:

Hs.731060

Evidence on tissue expression from TISSUES for MYH15 Gene

  • Nervous system(4.6)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with MYH15: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYH15 Gene

Orthologs for MYH15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYH15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYH15 34 35
  • 99.43 (n)
dog
(Canis familiaris)
Mammalia MYH15 34 35
  • 87.45 (n)
cow
(Bos Taurus)
Mammalia MYH15 34 35
  • 86.04 (n)
mouse
(Mus musculus)
Mammalia Myh15 34 16 35
  • 82.1 (n)
rat
(Rattus norvegicus)
Mammalia Myh15 34
  • 81.03 (n)
oppossum
(Monodelphis domestica)
Mammalia MYH15 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYH15 35
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYH15 35
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mhc 35
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea myo-5 35
  • 43 (a)
ManyToMany
unc-54 35
  • 43 (a)
ManyToMany
myo-3 35
  • 42 (a)
ManyToMany
myo-1 35
  • 41 (a)
ManyToMany
myo-2 35
  • 41 (a)
ManyToMany
myo-6 35
  • 41 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MYO1 35
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 59 (a)
ManyToMany
-- 35
  • 58 (a)
ManyToMany
-- 35
  • 58 (a)
ManyToMany
-- 35
  • 58 (a)
ManyToMany
-- 35
  • 58 (a)
ManyToMany
-- 35
  • 58 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
Species where no ortholog for MYH15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MYH15 Gene

ENSEMBL:
Gene Tree for MYH15 (if available)
TreeFam:
Gene Tree for MYH15 (if available)

Paralogs for MYH15 Gene

Paralogs for MYH15 Gene

(20) SIMAP similar genes for MYH15 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MYH15: view

Variants for MYH15 Gene

Sequence variations from dbSNP and Humsavar for MYH15 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000004530 -- 108,542,761(+) TGTTA(C/T)AATTC intron-variant
rs1000020229 -- 108,397,581(+) TATGG(A/T)GGGGG intron-variant
rs1000043817 -- 108,510,674(+) AGACT(A/G)AAGAG intron-variant
rs1000114856 -- 108,534,024(+) GACTT(A/C)TACAT intron-variant
rs1000141067 -- 108,468,029(+) GGTGC(A/G)ATCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYH15 Gene

Variant ID Type Subtype PubMed ID
esv3304498 CNV mobile element insertion 20981092
esv3347514 CNV insertion 20981092
esv3398084 CNV insertion 20981092
nsv1006774 CNV loss 25217958
nsv1011158 CNV gain 25217958
nsv3937 CNV deletion 18451855
nsv478652 CNV novel sequence insertion 20440878
nsv526190 CNV gain 19592680
nsv829656 CNV loss 17160897
nsv829657 CNV gain 17160897
nsv829658 CNV gain 17160897

Variation tolerance for MYH15 Gene

Residual Variation Intolerance Score: 62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.51; 92.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYH15 Gene

Human Gene Mutation Database (HGMD)
MYH15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYH15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYH15 Gene

Disorders for MYH15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYH15 Gene - From: DISEASES

Disorder Aliases PubMed IDs
autosomal recessive nonsyndromic deafness 3
  • autosomal recessive deafness 3, neurosensory nonsyndromic recessive deafness 3
- elite association - COSMIC cancer census association via MalaCards
Search MYH15 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYH15

Genetic Association Database (GAD)
MYH15
Human Genome Epidemiology (HuGE) Navigator
MYH15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYH15
genes like me logo Genes that share disorders with MYH15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYH15 Gene

Publications for MYH15 Gene

  1. Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project. (PMID: 22443383) Oudot-Mellakh T. … Morange P.E. (Br. J. Haematol. 2012) 3 46 64
  2. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke M.M. … Psaty B.M. (Stroke 2009) 3 46 64
  3. Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry. (PMID: 19752551) Luke M.M. … Mannhalter C. (Cerebrovasc. Dis. 2009) 3 46 64
  4. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D. … Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 46 64
  5. Five common gene variants identify elevated genetic risk for coronary heart disease. (PMID: 18073581) Bare L.A. … Boerwinkle E. (Genet. Med. 2007) 3 46 64

Products for MYH15 Gene

Sources for MYH15 Gene

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