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Aliases for FOXD4 Gene

Aliases for FOXD4 Gene

  • Forkhead Box D4 2 3 5
  • Forkhead-Related Transcription Factor 5 3 4
  • Forkhead-Related Protein FKHL9 3 4
  • Myeloid Factor-Alpha 3 4
  • FREAC-5 3 4
  • FOXD4A 3 4
  • FREAC5 3 4
  • FKHL9 3 4
  • Forkhead, Drosophila, Homolog-Like 9 3
  • Forkhead-Related Activator 5 3

External Ids for FOXD4 Gene

Previous HGNC Symbols for FOXD4 Gene

  • FKHL9

Previous GeneCards Identifiers for FOXD4 Gene

  • GC09M000084
  • GC09M000106
  • GC09M000058

Summaries for FOXD4 Gene

Entrez Gene Summary for FOXD4 Gene

  • This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. Mutations in this gene are associated with a complex phenotype consisting of dilated cardiomyopathy, obsessive-compulsive disorders, and suicidality. [provided by RefSeq, Mar 2012]

GeneCards Summary for FOXD4 Gene

FOXD4 (Forkhead Box D4) is a Protein Coding gene. Diseases associated with FOXD4 include cerebral palsy and obsessive-compulsive disorder. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXE3.

Gene Wiki entry for FOXD4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXD4 Gene

Genomics for FOXD4 Gene

Regulatory Elements for FOXD4 Gene

Genomic Location for FOXD4 Gene

Chromosome:
9
Start:
116,231 bp from pter
End:
118,417 bp from pter
Size:
2,187 bases
Orientation:
Minus strand

Genomic View for FOXD4 Gene

Genes around FOXD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXD4 Gene

Proteins for FOXD4 Gene

  • Protein details for FOXD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12950-FOXD4_HUMAN
    Recommended name:
    Forkhead box protein D4
    Protein Accession:
    Q12950
    Secondary Accessions:
    • B2RN05
    • B9EGL7
    • Q5VVK1
    • Q8WXT6

    Protein attributes for FOXD4 Gene

    Size:
    439 amino acids
    Molecular mass:
    47309 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXD4 Gene

Proteomics data for FOXD4 Gene at MOPED

Post-translational modifications for FOXD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FOXD4 Gene

Domains & Families for FOXD4 Gene

Gene Families for FOXD4 Gene

Protein Domains for FOXD4 Gene

Suggested Antigen Peptide Sequences for FOXD4 Gene

Graphical View of Domain Structure for InterPro Entry

Q12950

UniProtKB/Swiss-Prot:

FOXD4_HUMAN :
  • Contains 1 fork-head DNA-binding domain.
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXD4: view

Function for FOXD4 Gene

Molecular function for FOXD4 Gene

GENATLAS Biochemistry:
transcription factor-like 9,with a Drosophila homeo forkhead DNA binding domain homolog

Gene Ontology (GO) - Molecular Function for FOXD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0008301 DNA binding, bending ISS 7957066
genes like me logo Genes that share ontologies with FOXD4: view

Phenotypes for FOXD4 Gene

GenomeRNAi human phenotypes for FOXD4:
genes like me logo Genes that share phenotypes with FOXD4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FOXD4

miRNA for FOXD4 Gene

miRTarBase miRNAs that target FOXD4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FOXD4 Gene

Localization for FOXD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXD4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXD4 Gene COMPARTMENTS Subcellular localization image for FOXD4 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for FOXD4 Gene

Pathways & Interactions for FOXD4 Gene

SuperPathways for FOXD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with FOXD4: view

No data available for Pathways by source and SIGNOR curated interactions for FOXD4 Gene

Drugs & Compounds for FOXD4 Gene

No Compound Related Data Available

Transcripts for FOXD4 Gene

mRNA/cDNA for FOXD4 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXD4 Gene

Forkhead box D4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXD4 Gene

No ASD Table

Relevant External Links for FOXD4 Gene

GeneLoc Exon Structure for
FOXD4
ECgene alternative splicing isoforms for
FOXD4

Expression for FOXD4 Gene

mRNA expression in normal human tissues for FOXD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXD4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.1).

SOURCE GeneReport for Unigene cluster for FOXD4 Gene Hs.584759

genes like me logo Genes that share expression patterns with FOXD4: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FOXD4 Gene

Orthologs for FOXD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXD4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOXD4L1 35
  • 80.6 (n)
  • 74.92 (a)
mouse
(Mus musculus)
Mammalia Foxd4 35
  • 68.27 (n)
  • 55.88 (a)
Foxd4 16
chimpanzee
(Pan troglodytes)
Mammalia FOXD4L6 35
  • 86.25 (n)
  • 82.24 (a)
-- 36
  • 96 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Foxd4 35
  • 75.14 (n)
  • 65.64 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii foxd5 36
  • 37 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta fd59A 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-130 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
ManyToMany
CSA.2032 36
  • 23 (a)
ManyToMany
Species with no ortholog for FOXD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FOXD4 Gene

ENSEMBL:
Gene Tree for FOXD4 (if available)
TreeFam:
Gene Tree for FOXD4 (if available)

Paralogs for FOXD4 Gene

(11) SIMAP similar genes for FOXD4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FOXD4: view

Variants for FOXD4 Gene

Sequence variations from dbSNP and Humsavar for FOXD4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10959293 - 117,720(+) ACTAA(A/T)GAAGG reference, missense
rs2492216 - 117,713(+) AGCGG(C/T)CACTA reference, missense
rs7031810 - 117,666(+) GCGGA(C/T)GCTGT reference, missense
rs1665333 -- 116,318(+) GTCAG(A/G)CACAC utr-variant-3-prime
rs1665334 -- 116,719(+) CCAGC(A/G)GGATT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FOXD4 Gene

Variant ID Type Subtype PubMed ID
nsv891939 CNV Loss 21882294
dgv2266e1 CNV Complex 17122850
esv735 CNV CNV 17122850
dgv253e55 CNV Gain 17911159
dgv254e55 CNV Gain 17911159
nsv891940 CNV Gain 21882294
nsv515505 CNV Gain+Loss 19592680
esv27644 CNV Gain 19812545
nsv8403 CNV Gain+Loss 18304495
dgv7989n71 CNV Loss 21882294
nsv891942 CNV Gain 21882294
nsv891943 CNV Gain 21882294

Variation tolerance for FOXD4 Gene

Residual Variation Intolerance Score: 92.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.90; 89.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXD4 Gene

HapMap Linkage Disequilibrium report
FOXD4
Human Gene Mutation Database (HGMD)
FOXD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXD4 Gene

Disorders for FOXD4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FOXD4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cerebral palsy
  • mixed cerebral palsy
obsessive-compulsive disorder
  • obsessive-compulsive disorder, protection against
- elite association - COSMIC cancer census association via MalaCards
Search FOXD4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FOXD4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXD4
genes like me logo Genes that share disorders with FOXD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOXD4 Gene

Publications for FOXD4 Gene

  1. FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines. (PMID: 12234674) Freyaldenhoven B.S. … Wielckens K. (Gene 2002) 2 3 4 67
  2. Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12). (PMID: 8825632) Larsson C. … Carlsson P. (Genomics 1995) 2 3
  3. Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. (PMID: 7957066) Pierrou S. … Carlsson P. (EMBO J. 1994) 2 3
  4. Pure distal 9p deletion in a female infant with cerebral palsy. (PMID: 22876580) Chen C.P. … Wang W. (Genet. Couns. 2012) 3
  5. Inv dup del(9p): prenatal diagnosis and molecular cytogenetic characterization by fluorescence in situ hybridization and array comparative genomic hybridization. (PMID: 21482378) Chen C.P. … Wang W. (Taiwan J Obstet Gynecol 2011) 3

Products for FOXD4 Gene

Sources for FOXD4 Gene

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