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Aliases for SIRT2 Gene

Aliases for SIRT2 Gene

  • Sirtuin 2 2 3 5
  • Regulatory Protein SIR2 Homolog 2 3 4
  • SIR2-Like Protein 2 3 4
  • SIR2L2 3 4
  • SIR2L 3 4
  • Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 2 (S. Cerevisiae) 2
  • Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 2 2
  • NAD-Dependent Protein Deacetylase Sirtuin-2 3
  • NAD-Dependent Deacetylase Sirtuin-2 3
  • Silent Information Regulator 2 3
  • Sir2-Related Protein Type 2 3
  • Sirtuin Type 2 3
  • EC 3.5.1.- 4
  • SIR2 3

External Ids for SIRT2 Gene

Previous HGNC Symbols for SIRT2 Gene

  • SIR2L

Previous GeneCards Identifiers for SIRT2 Gene

  • GC19M039981
  • GC19M039760
  • GC19M044045
  • GC19M044061
  • GC19M039369
  • GC19M035815

Summaries for SIRT2 Gene

Entrez Gene Summary for SIRT2 Gene

  • This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for SIRT2 Gene

SIRT2 (Sirtuin 2) is a Protein Coding gene. Diseases associated with SIRT2 include Wallerian Degeneration. Among its related pathways are Signaling events mediated by HDAC Class III and 4-1BB Pathway. GO annotations related to this gene include chromatin binding and histone deacetylase binding. An important paralog of this gene is SIRT3.

UniProtKB/Swiss-Prot for SIRT2 Gene

  • NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtubule stress agents, and hence allowing proper inheritance of chromosomes. Positively regulates the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex activity by deacetylating CDC20 and FZR1, then allowing progression through mitosis. Associates both with chromatin at transcriptional start sites (TSSs) and enhancers of active genes. Plays a role in cell cycle and chromatin compaction through epigenetic modulation of the regulation of histone H4 Lys-20 methylation (H4K20me1) during early mitosis. Specifically deacetylates histone H4 at Lys-16 (H4K16ac) between the G2/M transition and metaphase enabling H4K20me1 deposition by KMT5A leading to ulterior levels of H4K20me2 and H4K20me3 deposition throughout cell cycle, and mitotic S-phase progression. Deacetylates KMT5A modulating KMT5A chromatin localization during the mitotic stress response. Deacetylates also histone H3 at Lys-57 (H3K56ac) during the mitotic G2/M transition. Upon bacterium Listeria monocytogenes infection, deacetylates Lys-18 of histone H3 in a receptor tyrosine kinase MET- and PI3K/Akt-dependent manner, thereby inhibiting transcriptional activity and promoting late stages of listeria infection. During oocyte meiosis progression, may deacetylate histone H4 at Lys-16 (H4K16ac) and alpha-tubulin, regulating spindle assembly and chromosome alignment by influencing microtubule dynamics and kinetochore function. Deacetylates alpha-tubulin at Lys-40 and hence controls neuronal motility, oligodendroglial cell arbor projection processes and proliferation of non-neuronal cells. Phosphorylation at Ser-368 by a G1/S-specific cyclin E-CDK2 complex inactivates SIRT2-mediated alpha-tubulin deacetylation, negatively regulating cell adhesion, cell migration and neurite outgrowth during neuronal differentiation. Deacetylates PARD3 and participates in the regulation of Schwann cell peripheral myelination formation during early postnatal development and during postinjury remyelination. Involved in several cellular metabolic pathways. Plays a role in the regulation of blood glucose homeostasis by deacetylating and stabilizing phosphoenolpyruvate carboxykinase PCK1 activity in response to low nutrient availability. Acts as a key regulator in the pentose phosphate pathway (PPP) by deacetylating and activating the glucose-6-phosphate G6PD enzyme, and therefore, stimulates the production of cytosolic NADPH to counteract oxidative damage. Maintains energy homeostasis in response to nutrient deprivation as well as energy expenditure by inhibiting adipogenesis and promoting lipolysis. Attenuates adipocyte differentiation by deacetylating and promoting FOXO1 interaction to PPARG and subsequent repression of PPARG-dependent transcriptional activity. Plays a role in the regulation of lysosome-mediated degradation of protein aggregates by autophagy in neuronal cells. Deacetylates FOXO1 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagy. Deacetylates a broad range of transcription factors and co-regulators regulating target gene expression. Deacetylates transcriptional factor FOXO3 stimulating the ubiquitin ligase SCF(SKP2)-mediated FOXO3 ubiquitination and degradation. Deacetylates HIF1A and therefore promotes HIF1A degradation and inhibition of HIF1A transcriptional activity in tumor cells in response to hypoxia. Deacetylates RELA in the cytoplasm inhibiting NF-kappaB-dependent transcription activation upon TNF-alpha stimulation. Inhibits transcriptional activation by deacetylating p53/TP53 and EP300. Deacetylates also EIF5A. Functions as a negative regulator on oxidative stress-tolerance in response to anoxia-reoxygenation conditions. Plays a role as tumor suppressor.

  • Isoform 1: Deacetylates EP300, alpha-tubulin and histone H3 and H4.

  • Isoform 2: Deacetylates EP300, alpha-tubulin and histone H3 and H4.

  • Isoform 5: Lacks deacetylation activity.

Tocris Summary for SIRT2 Gene

  • Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or nucleus of the cell and are ubiquitously expressed.

Gene Wiki entry for SIRT2 Gene

Additional gene information for SIRT2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIRT2 Gene

Genomics for SIRT2 Gene

Regulatory Elements for SIRT2 Gene

Enhancers for SIRT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H039052 0.9 ENCODE 10.8 -153.6 -153631 2 MLX ZNF493 ZNF2 ZNF121 ZNF143 SP3 SP5 YY2 REST ZNF623 FBXO27 ENSG00000266963 ENSG00000269172 ENSG00000267375 ENSG00000269792 LOC105372399 ENSG00000269445 LGALS14 CATSPERG LOC100129935
GH19H039061 0.8 ENCODE dbSUPER 10.8 -161.7 -161694 0 ZNF280D RBAK EED ZSCAN4 ZNF133 ETV6 ZEB1 FBXO27 PAK4 NFKBIB SIRT2 FBXO17 GC19M039038 GC19P039085
GH19H038934 0.7 ENCODE 12.2 -34.6 -34556 0 PAF1 SOX5 GATAD2A KLF11 FOXA2 SAP130 FOXA3 ARID4B ZNF644 ZNF7 FBXO17 SARS2 SIRT2 NFKBIB ERVK9-11 PIR45188
GH19H038884 1 ENCODE dbSUPER 7.2 +13.7 13743 2 BCOR CTCF ZMYM3 ZNF384 ZNF121 CTBP1 ZNF316 ZNF600 ZNF280C EGR2 PAF1 SUPT5H SAMD4B SIRT2 ERVK9-11 GC19M038871 NFKBIB
GH19H038887 1 ENCODE dbSUPER 7.2 +12.2 12227 0 HDGF CTCF SAP130 RB1 ARID4B SIN3A ZNF2 RAD21 ZFHX2 CTBP1 SIRT2 GC19M038871 NFKBIB
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SIRT2 on UCSC Golden Path with GeneCards custom track

Promoters for SIRT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109346 -38 1801 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC ZNF610

Genomic Location for SIRT2 Gene

Chromosome:
19
Start:
38,878,555 bp from pter
End:
38,899,862 bp from pter
Size:
21,308 bases
Orientation:
Minus strand

Genomic View for SIRT2 Gene

Genes around SIRT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIRT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIRT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRT2 Gene

Proteins for SIRT2 Gene

  • Protein details for SIRT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXJ6-SIR2_HUMAN
    Recommended name:
    NAD-dependent protein deacetylase sirtuin-2
    Protein Accession:
    Q8IXJ6
    Secondary Accessions:
    • A8K3V1
    • B2RB45
    • O95889
    • Q924Y7
    • Q9P0G8
    • Q9UNT0
    • Q9Y6E9
    • U5TP13

    Protein attributes for SIRT2 Gene

    Size:
    389 amino acids
    Molecular mass:
    43182 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with CDC20, FOXO3 and FZR1. Associates with microtubule in primary cortical mature neurons (By similarity). Homotrimer. Isoform 1 and isoform 2 interact (via both phosphorylated, unphosphorylated, active or inactive forms) with HDAC6; the interaction is necessary for the complex to interact with alpha-tubulin, suggesting that these proteins belong to a large complex that deacetylates the cytoskeleton. Interacts with FOXO1; the interaction is disrupted upon serum-starvation or oxidative stress, leading to increased level of acetylated FOXO1 and induction of autophagy. Interacts with RELA; the interaction occurs in the cytoplasm and is increased in a TNF-alpha-dependent manner. Interacts with HOXA10; the interaction is direct. Interacts with YWHAB and YWHAG; the interactions occur in a AKT-dependent manner and increase SIRT2-dependent TP53 deacetylation. Interacts with MAPK1/ERK2 and MAPK3/ERK1; the interactions increase SIRT2 stability and deacetylation activity. Interacts (phosphorylated form) with KMT5A isoform 2; the interaction is direct, stimulates KMT5A-mediated methyltransferase activity on histone at Lys-20 (H4K20me1) and is increased in a H(2)O(2)-induced oxidative stress-dependent manner. Interacts with G6PD; the interaction is enhanced by H(2)O(2) treatment. Interacts with a G1/S-specific cyclin E-CDK2 complex. Interacts with AURKA, CDK5R1 (p35 form) and CDK5 and HIF1A. Isoform 1, isoform 2 and isoform 5 interact (via C-terminus region) with EP300.
    SequenceCaution:
    • Sequence=AAD45971.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAF67015.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SIRT2 Gene

    Alternative splice isoforms for SIRT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIRT2 Gene

Post-translational modifications for SIRT2 Gene

  • Acetylated by EP300; acetylation leads both to the decreased of SIRT2-mediated alpha-tubulin deacetylase activity and SIRT2-mediated down-regulation of TP53 transcriptional activity.
  • Phosphorylated at phosphoserine and phosphothreonine. Phosphorylated at Ser-368 by a mitotic kinase CDK1/cyclin B at the G2/M transition; phosphorylation regulates the delay in cell-cycle progression. Phosphorylated at Ser-368 by a mitotic kinase G1/S-specific cyclin E/Cdk2 complex; phosphorylation inactivates SIRT2-mediated alpha-tubulin deacetylation and thereby negatively regulates cell adhesion, cell migration and neurite outgrowth during neuronal differentiation. Phosphorylated by cyclin A/Cdk2 and p35-Cdk5 complexes and to a lesser extent by the cyclin D3/Cdk4 and cyclin B/Cdk1, in vitro. Dephosphorylated at Ser-368 by CDC14A and CDC14B around early anaphase.
  • Ubiquitinated.
  • Ubiquitination at Lys55
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for SIRT2 (Sirtuin 2/SIRT2)
  • Cell Signaling Technology (CST) Antibodies for SIRT2 (SIRT2)
  • Abcam antibodies for SIRT2

Assay Products

  • Cloud-Clone Corp. Assay Kits for SIRT2

No data available for DME Specific Peptides for SIRT2 Gene

Domains & Families for SIRT2 Gene

Gene Families for SIRT2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SIRT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IXJ6

UniProtKB/Swiss-Prot:

SIR2_HUMAN :
  • Belongs to the sirtuin family. Class I subfamily.
Family:
  • Belongs to the sirtuin family. Class I subfamily.
genes like me logo Genes that share domains with SIRT2: view

Function for SIRT2 Gene

Molecular function for SIRT2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by Sirtinol, A3 and M15 small molecules. Inhibited by nicotinamide. Inhibited by a macrocyclic peptide inhibitor S2iL5. Inhibited by EP300-induced acetylation.
UniProtKB/Swiss-Prot Function:
NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtubule stress agents, and hence allowing proper inheritance of chromosomes. Positively regulates the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex activity by deacetylating CDC20 and FZR1, then allowing progression through mitosis. Associates both with chromatin at transcriptional start sites (TSSs) and enhancers of active genes. Plays a role in cell cycle and chromatin compaction through epigenetic modulation of the regulation of histone H4 Lys-20 methylation (H4K20me1) during early mitosis. Specifically deacetylates histone H4 at Lys-16 (H4K16ac) between the G2/M transition and metaphase enabling H4K20me1 deposition by KMT5A leading to ulterior levels of H4K20me2 and H4K20me3 deposition throughout cell cycle, and mitotic S-phase progression. Deacetylates KMT5A modulating KMT5A chromatin localization during the mitotic stress response. Deacetylates also histone H3 at Lys-57 (H3K56ac) during the mitotic G2/M transition. Upon bacterium Listeria monocytogenes infection, deacetylates Lys-18 of histone H3 in a receptor tyrosine kinase MET- and PI3K/Akt-dependent manner, thereby inhibiting transcriptional activity and promoting late stages of listeria infection. During oocyte meiosis progression, may deacetylate histone H4 at Lys-16 (H4K16ac) and alpha-tubulin, regulating spindle assembly and chromosome alignment by influencing microtubule dynamics and kinetochore function. Deacetylates alpha-tubulin at Lys-40 and hence controls neuronal motility, oligodendroglial cell arbor projection processes and proliferation of non-neuronal cells. Phosphorylation at Ser-368 by a G1/S-specific cyclin E-CDK2 complex inactivates SIRT2-mediated alpha-tubulin deacetylation, negatively regulating cell adhesion, cell migration and neurite outgrowth during neuronal differentiation. Deacetylates PARD3 and participates in the regulation of Schwann cell peripheral myelination formation during early postnatal development and during postinjury remyelination. Involved in several cellular metabolic pathways. Plays a role in the regulation of blood glucose homeostasis by deacetylating and stabilizing phosphoenolpyruvate carboxykinase PCK1 activity in response to low nutrient availability. Acts as a key regulator in the pentose phosphate pathway (PPP) by deacetylating and activating the glucose-6-phosphate G6PD enzyme, and therefore, stimulates the production of cytosolic NADPH to counteract oxidative damage. Maintains energy homeostasis in response to nutrient deprivation as well as energy expenditure by inhibiting adipogenesis and promoting lipolysis. Attenuates adipocyte differentiation by deacetylating and promoting FOXO1 interaction to PPARG and subsequent repression of PPARG-dependent transcriptional activity. Plays a role in the regulation of lysosome-mediated degradation of protein aggregates by autophagy in neuronal cells. Deacetylates FOXO1 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagy. Deacetylates a broad range of transcription factors and co-regulators regulating target gene expression. Deacetylates transcriptional factor FOXO3 stimulating the ubiquitin ligase SCF(SKP2)-mediated FOXO3 ubiquitination and degradation. Deacetylates HIF1A and therefore promotes HIF1A degradation and inhibition of HIF1A transcriptional activity in tumor cells in response to hypoxia. Deacetylates RELA in the cytoplasm inhibiting NF-kappaB-dependent transcription activation upon TNF-alpha stimulation. Inhibits transcriptional activation by deacetylating p53/TP53 and EP300. Deacetylates also EIF5A. Functions as a negative regulator on oxidative stress-tolerance in response to anoxia-reoxygenation conditions. Plays a role as tumor suppressor.
UniProtKB/Swiss-Prot Function:
Isoform 1: Deacetylates EP300, alpha-tubulin and histone H3 and H4.
UniProtKB/Swiss-Prot Function:
Isoform 2: Deacetylates EP300, alpha-tubulin and histone H3 and H4.
UniProtKB/Swiss-Prot Function:
Isoform 5: Lacks deacetylation activity.
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to low levels of glucose and anoxia-reoxygenation stress. Up-regulated by trichostatin A. Down-regulated in response to high levels of glucose. Down-regulated by histone deacetylation in several tumors.

Enzyme Numbers (IUBMB) for SIRT2 Gene

Gene Ontology (GO) - Molecular Function for SIRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 23908241
GO:0003950 NOT NAD+ ADP-ribosyltransferase activity TAS 17456799
GO:0004407 histone deacetylase activity IDA 17488717
GO:0005515 protein binding IPI 12697818
GO:0008134 transcription factor binding IPI 12887892
genes like me logo Genes that share ontologies with SIRT2: view
genes like me logo Genes that share phenotypes with SIRT2: view

Animal Models for SIRT2 Gene

MGI Knock Outs for SIRT2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SIRT2

CRISPR Products

miRNA for SIRT2 Gene

miRTarBase miRNAs that target SIRT2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SIRT2
  • Applied Biological Materials Clones for SIRT2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIRT2 Gene

Localization for SIRT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRT2 Gene

Nucleus. Cytoplasm, perinuclear region. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle. Midbody. Chromosome. Perikaryon. Cell projection. Cell projection, growth cone. Myelin membrane. Note=Deacetylates FOXO3 in the cytoplasm. Colocalizes with PLP1 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat. Colocalizes with CDK5R1 in the perikaryon, neurites and growth cone of hippocampal neurons. Colocalizes with alpha-tubulin in neuronal growth cone. Localizes in the cytoplasm and nucleus of germinal vesicle (GV) stage oocytes. Colocalizes with alpha-tubulin on the meiotic spindle as the oocytes enter into metaphase, and also during meiotic anaphase and telophase, especially with the midbody. Colocalizes with PARD3 in internodal region of axons. Colocalizes with acetylated alpha-tubulin in cell projection processes during primary oligodendrocyte precursor (OLP) differentiation (By similarity). Localizes in the cytoplasm during most of the cell cycle except in the G2/M transition and during mitosis, where it is localized in association with chromatin and induces deacetylation of histone at Lys-16 (H4K16ac). Colocalizes with KMT5A at mitotic foci. Colocalizes with CDK1 at centrosome during prophase and splindle fibers during metaphase. Colocalizes with Aurora kinase AURKA at centrosome during early prophase and in the centrioles and growing mitotic spindle throughout metaphase. Colocalizes with Aurora kinase AURKB during cytokinesis with the midbody. Colocalizes with microtubules. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins. Shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Colocalizes with EP300 in the nucleus. Translocates to the nucleus and chromatin upon bacterium Listeria monocytogenes infection in interphase cells. {ECO:0000250}.
Isoform 1: Cytoplasm. Nucleus. Note=Predominantly localized in the cytoplasmic.
Isoform 2: Cytoplasm. Nucleus. Note=Predominantly localized in the cytoplasmic.
Isoform 5: Cytoplasm. Nucleus. Note=Predominantly localized in the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIRT2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5
mitochondrion 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SIRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region IEA --
GO:0005634 nucleus IDA,IEA 15213244
GO:0005677 chromatin silencing complex NAS 12697818
GO:0005694 chromosome IDA,IEA 16648462
GO:0005720 nuclear heterochromatin ISS --
genes like me logo Genes that share ontologies with SIRT2: view

Pathways & Interactions for SIRT2 Gene

genes like me logo Genes that share pathways with SIRT2: view

Pathways by source for SIRT2 Gene

1 Sino Biological pathway for SIRT2 Gene
1 Cell Signaling Technology pathway for SIRT2 Gene
2 GeneGo (Thomson Reuters) pathways for SIRT2 Gene
2 Qiagen pathways for SIRT2 Gene

SIGNOR curated interactions for SIRT2 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SIRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 23908241
GO:0000183 chromatin silencing at rDNA NAS 11427894
GO:0002376 immune system process IEA --
GO:0006342 chromatin silencing NAS 12697818
GO:0006348 chromatin silencing at telomere NAS 11427894
genes like me logo Genes that share ontologies with SIRT2: view

Drugs & Compounds for SIRT2 Gene

(16) Drugs for SIRT2 Gene - From: ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Panobinostat Approved, Investigational Pharma Inhibition, inhibitor Histone deacetylase (HDAC)inhibitors 136
Nicotinamide Approved Nutra 937,941
Resveratrol Experimental, Investigational Pharma Cyclooxygenase inhibitor 123
AGK 2 Pharma Selective SIRT2 inhibitor 0
Salermide Pharma SIRT1 and SIRT2 inhibitor 0

(4) Additional Compounds for SIRT2 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
O-acetyl-ADP-ribose
EX 527
49843-98-3
SirReal 2
709002-46-0

(5) Tocris Compounds for SIRT2 Gene

Compound Action Cas Number
AGK 2 Selective SIRT2 inhibitor 304896-28-4
EX 527 Selective SIRT1 inhibitor 49843-98-3
Salermide SIRT1 and SIRT2 inhibitor 1105698-15-4
SirReal 2 Selective inhibitor of SIRT2 709002-46-0
Sirtinol Selective sirtuin family deacetylase inhibitor 410536-97-9

(13) ApexBio Compounds for SIRT2 Gene

Compound Action Cas Number
AGK 2 304896-28-4
AK-7 420831-40-9
EX-527 R-enantiomer 848193-69-1
EX-527 S-enantiomer 848193-68-0
Inauhzin SIRT1 inhibitor 309271-94-1
Resveratrol 501-36-0
Salermide 1105698-15-4
Sirtinol SIRT inhibitor 410536-97-9
Splitomicin 5690-03-9
SRT2104 (GSK2245840) 1093403-33-8
Tenovin-1 SIRT2 inhibitor, activates p53 380315-80-0
Tenovin-6 SIRT inhibitor and p53 activator 1011557-82-6
Triacetyl Resveratrol Cell-permeable resveratrol prodrug 42206-94-0
genes like me logo Genes that share compounds with SIRT2: view

Drug Products

Transcripts for SIRT2 Gene

Unigene Clusters for SIRT2 Gene

Sirtuin 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SIRT2
  • Applied Biological Materials Clones for SIRT2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SIRT2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i · 1j · 1k ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ·
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - - -
SP5: - - - -
SP6: - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - -
SP9: - - - - - - -
SP10: - - - - -
SP11: - - - - - - - - - - - -
SP12: - - - - - -
SP13: - - - - -
SP14: - -
SP15:

ExUns: 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: - - - - - -
SP6: -
SP7: -
SP8: -
SP9:
SP10:
SP11: - - - - - - - - -
SP12:
SP13:
SP14:
SP15:

Relevant External Links for SIRT2 Gene

GeneLoc Exon Structure for
SIRT2
ECgene alternative splicing isoforms for
SIRT2

Expression for SIRT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SIRT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIRT2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.6).

Protein differential expression in normal tissues from HIPED for SIRT2 Gene

This gene is overexpressed in Spinal cord (30.3), Frontal cortex (17.9), and Brain (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SIRT2 Gene



Protein tissue co-expression partners for SIRT2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SIRT2 Gene:

SIRT2

SOURCE GeneReport for Unigene cluster for SIRT2 Gene:

Hs.466693

mRNA Expression by UniProt/SwissProt for SIRT2 Gene:

Q8IXJ6-SIR2_HUMAN
Tissue specificity: Isoform 1 is expressed in heart, liver and skeletal muscle, weakly expressed in the cortex. Isoform 2 is strongly expressed in the cortex, weakly expressed in heart and liver. Weakly expressed in several malignancies including breast, liver, brain, kidney and prostate cancers compared to normal tissues. Weakly expressed in glioma cell lines compared to normal brain tissues (at protein level). Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network.

Evidence on tissue expression from TISSUES for SIRT2 Gene

  • Nervous system(5)
  • Lung(4.6)
  • Liver(4.5)
  • Adrenal gland(4.3)
  • Muscle(3.7)
  • Heart(3.1)
  • Intestine(2.4)
  • Skin(2.4)
  • Kidney(2.3)
  • Blood(2.1)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with SIRT2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SIRT2 Gene

Orthologs for SIRT2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SIRT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIRT2 33 34
  • 99.4 (n)
cow
(Bos Taurus)
Mammalia SIRT2 33 34
  • 88.17 (n)
dog
(Canis familiaris)
Mammalia SIRT2 33 34
  • 86.42 (n)
mouse
(Mus musculus)
Mammalia Sirt2 33 16 34
  • 85.86 (n)
rat
(Rattus norvegicus)
Mammalia Sirt2 33
  • 85.67 (n)
oppossum
(Monodelphis domestica)
Mammalia SIRT2 34
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves SIRT2 33 34
  • 73.29 (n)
lizard
(Anolis carolinensis)
Reptilia SIRT2 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489469 33
  • 64.77 (n)
zebrafish
(Danio rerio)
Actinopterygii sirt2 33 34
  • 63.97 (n)
wufb57d05 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002943 33
  • 57.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sirt2 33 34
  • 55.85 (n)
CG5085 35
  • 49 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL018C 33
  • 54.53 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11033g 33
  • 50.19 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HST2 33 34
  • 49.88 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00523 33
  • 55.81 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1012 34
  • 55 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hst2 33
  • 48.98 (n)
Species where no ortholog for SIRT2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIRT2 Gene

ENSEMBL:
Gene Tree for SIRT2 (if available)
TreeFam:
Gene Tree for SIRT2 (if available)

Paralogs for SIRT2 Gene

Paralogs for SIRT2 Gene

genes like me logo Genes that share paralogs with SIRT2: view

Variants for SIRT2 Gene

Sequence variations from dbSNP and Humsavar for SIRT2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000180561 -- 38,893,736(+) GAGTT(-/GAG)GAGGT intron-variant
rs1000255777 -- 38,893,992(+) GTGGT(A/G)GAGAG intron-variant, nc-transcript-variant
rs1000538826 -- 38,882,844(+) GACAC(A/C)TAATG intron-variant
rs1000582023 -- 38,879,506(+) CTGCG(A/G)TGCAG intron-variant, upstream-variant-2KB
rs1000611679 -- 38,885,656(+) CGCAA(C/T)CTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIRT2 Gene

Variant ID Type Subtype PubMed ID
nsv1160616 CNV duplication 26073780

Variation tolerance for SIRT2 Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.82; 47.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIRT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIRT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIRT2 Gene

Disorders for SIRT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SIRT2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
wallerian degeneration
  • wallerian degeneration of the pyramidal tract
- elite association - COSMIC cancer census association via MalaCards
Search SIRT2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SIRT2

Human Genome Epidemiology (HuGE) Navigator
SIRT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIRT2
genes like me logo Genes that share disorders with SIRT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIRT2 Gene

Publications for SIRT2 Gene

  1. Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2. (PMID: 10393250) Afshar G … Murnane JP (Gene 1999) 2 3 4 22 60
  2. The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility. (PMID: 18332217) Pandithage R … Lüscher B (The Journal of cell biology 2008) 3 4 22 60
  3. Mutations in SIRT2 deacetylase which regulate enzymatic activity but not its interaction with HDAC6 and tubulin. (PMID: 17516032) Nahhas F … Tainsky MA (Molecular and cellular biochemistry 2007) 3 4 22 60
  4. Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation. (PMID: 17488717) North BJ … Verdin E (The Journal of biological chemistry 2007) 3 4 22 60
  5. The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. (PMID: 12620231) North BJ … Verdin E (Molecular cell 2003) 3 4 22 60

Products for SIRT2 Gene

  • Addgene plasmids for SIRT2

Sources for SIRT2 Gene

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