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Aliases for ATF6 Gene

Aliases for ATF6 Gene

  • Activating Transcription Factor 6 2 3
  • CAMP-Dependent Transcription Factor ATF-6 Alpha 3 4
  • Activating Transcription Factor 6 Alpha 2 4
  • Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha 3
  • ATF6-Alpha 4
  • ATF6A 3

External Ids for ATF6 Gene

Previous GeneCards Identifiers for ATF6 Gene

  • GC01P159370
  • GC01P157386
  • GC01P158432
  • GC01P158923
  • GC01P158467
  • GC01P160002
  • GC01P161736
  • GC01P132981

Summaries for ATF6 Gene

Entrez Gene Summary for ATF6 Gene

  • This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]

GeneCards Summary for ATF6 Gene

ATF6 (Activating Transcription Factor 6) is a Protein Coding gene. Diseases associated with ATF6 include wolfram syndrome and cystic fibrosis. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is ATF6B.

UniProtKB/Swiss-Prot for ATF6 Gene

  • Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5-CCAC[GA]-3half of the ER stress response element (ERSE) (5-CCAAT-N(9)-CCAC[GA]-3) and of ERSE II (5-ATTGG-N-CCACG-3). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor.

Gene Wiki entry for ATF6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATF6 Gene

Genomics for ATF6 Gene

Regulatory Elements for ATF6 Gene

Genomic Location for ATF6 Gene

Start:
161,766,244 bp from pter
End:
161,964,070 bp from pter
Size:
197,827 bases
Orientation:
Plus strand

Genomic View for ATF6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATF6 Gene

Proteins for ATF6 Gene

  • Protein details for ATF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18850-ATF6A_HUMAN
    Recommended name:
    Cyclic AMP-dependent transcription factor ATF-6 alpha
    Protein Accession:
    P18850
    Secondary Accessions:
    • O15139
    • Q5VW62
    • Q6IPB5
    • Q9UEC9

    Protein attributes for ATF6 Gene

    Size:
    670 amino acids
    Molecular mass:
    74585 Da
    Quaternary structure:
    • Homodimer and heterodimer with ATF6-beta. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC). Interacts also with the transcription factors GTF2I, YY1 and SRF. Interacts (via lumenal domain) with THBS1 (By similarity). Interacts with THBS4 (via EGF-like 3; calcium-binding domain) which facilitates its processing, activation and nuclear translocation (PubMed:22682248). Interacts with XBP1 isoform 2; the interaction occurs in a ER stress-dependent manner (PubMed:17765680).

neXtProt entry for ATF6 Gene

Proteomics data for ATF6 Gene at MOPED

Post-translational modifications for ATF6 Gene

  • During unfolded protein response an approximative 50 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases.
  • N-glycosylated. The glycosylation status may serve as a sensor for ER homeostasis, resulting in ATF6 activation to trigger the unfolded protein response (UPR).
  • Phosphorylated in vitro by MAPK14/P38MAPK
  • Ubiquitination at Lys424 and Lys436
  • Glycosylation at Asn472, Asn584, and Asn643
  • Modification sites at PhosphoSitePlus

Other Protein References for ATF6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ATF6 Gene

Domains for ATF6 Gene

Gene Families for ATF6 Gene

HGNC:
  • bZIP :basic leucine zipper proteins

Protein Domains for ATF6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ATF6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18850

UniProtKB/Swiss-Prot:

ATF6A_HUMAN :
  • P18850
Domain:
  • The basic domain functions as a nuclear localization signal
  • The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. ATF subfamily.
genes like me logo Genes that share domains with ATF6: view

Function for ATF6 Gene

Molecular function for ATF6 Gene

UniProtKB/Swiss-Prot Function: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5-CCAC[GA]-3half of the ER stress response element (ERSE) (5-CCAAT-N(9)-CCAC[GA]-3) and of ERSE II (5-ATTGG-N-CCACG-3). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor.

Gene Ontology (GO) - Molecular Function for ATF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 11779464
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 11163209
GO:0003713 transcription coactivator activity TAS 10866666
GO:0005515 protein binding IPI 16469704
GO:0035497 cAMP response element binding IEA --
genes like me logo Genes that share ontologies with ATF6: view
genes like me logo Genes that share phenotypes with ATF6: view

Animal Models for ATF6 Gene

MGI Knock Outs for ATF6:

Animal Model Products

CRISPR Products

miRNA for ATF6 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATF6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ATF6 Gene

Localization for ATF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATF6 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Processed cyclic AMP-dependent transcription factor ATF-6 alpha: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. THBS4 promotes its nuclear shuttling.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATF6 Gene COMPARTMENTS Subcellular localization image for ATF6 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
golgi apparatus 4
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ATF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005634 nucleus TAS 22013210
GO:0005635 nuclear envelope TAS 10866666
GO:0005654 nucleoplasm TAS --
GO:0005783 endoplasmic reticulum IDA 11256944
genes like me logo Genes that share ontologies with ATF6: view

Pathways for ATF6 Gene

genes like me logo Genes that share pathways with ATF6: view

PCR Array Products

Gene Ontology (GO) - Biological Process for ATF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 10564271
GO:0006457 protein folding TAS 10564271
GO:0006950 response to stress TAS 10866666
genes like me logo Genes that share ontologies with ATF6: view

Compounds for ATF6 Gene

(8) Novoseek inferred chemical compound relationships for ATF6 Gene

Compound -log(P) Hits PubMed IDs
tunicamycin 76.4 8
thapsigargin 68 12
sterol 41.5 4
leucine 32.8 6
dithiothreitol 31.4 1
genes like me logo Genes that share compounds with ATF6: view

Transcripts for ATF6 Gene

Unigene Clusters for ATF6 Gene

Activating transcription factor 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATF6

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ATF6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATF6 Gene

No ASD Table

Relevant External Links for ATF6 Gene

GeneLoc Exon Structure for
ATF6
ECgene alternative splicing isoforms for
ATF6

Expression for ATF6 Gene

mRNA expression in normal human tissues for ATF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATF6 Gene

This gene is overexpressed in Whole Blood (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATF6 Gene

SOURCE GeneReport for Unigene cluster for ATF6 Gene Hs.492740

mRNA Expression by UniProt/SwissProt for ATF6 Gene

P18850-ATF6A_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with ATF6: view

In Situ Assay Products

Orthologs for ATF6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATF6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATF6 35
  • 99.4 (n)
  • 99.4 (a)
ATF6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATF6 35
  • 91.07 (n)
  • 92.85 (a)
ATF6 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATF6 35
  • 89.46 (n)
  • 91.34 (a)
ATF6 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atf6 35
  • 84.91 (n)
  • 86.13 (a)
Atf6 16
Atf6 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATF6 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATF6 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atf6 35
  • 84.81 (n)
  • 87.5 (a)
chicken
(Gallus gallus)
Aves ATF6 35
  • 68.08 (n)
  • 64.58 (a)
ATF6 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATF6 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atf6 35
  • 62.06 (n)
  • 57.39 (a)
zebrafish
(Danio rerio)
Actinopterygii atf6 35
  • 54.69 (n)
  • 47.42 (a)
atf6 36
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Atf6 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for ATF6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATF6 Gene

ENSEMBL:
Gene Tree for ATF6 (if available)
TreeFam:
Gene Tree for ATF6 (if available)

Paralogs for ATF6 Gene

Paralogs for ATF6 Gene

Selected SIMAP similar genes for ATF6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ATF6: view

Variants for ATF6 Gene

Sequence variations from dbSNP and Humsavar for ATF6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9482 -- 161,958,537(+) TCGTC(A/G)GTTCC reference, synonymous-codon
rs13401 -- 161,958,778(+) AGGAG(A/G)AAAGA utr-variant-3-prime
rs905594 -- 161,771,484(+) aggtg(C/T)ctcca intron-variant
rs905596 -- 161,845,414(+) AGTGC(A/G)AACAC intron-variant
rs924777 -- 161,879,114(+) gtaga(A/G)gcaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATF6 Gene

Variant ID Type Subtype PubMed ID
nsv428257 CNV Loss 18775914
esv33393 CNV Gain+Loss 17666407
nsv464184 CNV Gain 19166990
nsv464206 CNV Gain 19166990
nsv470744 CNV Gain 18288195
nsv3276 CNV Insertion 18451855
esv269148 CNV Insertion 20981092
nsv831747 CNV Loss 17160897

Relevant External Links for ATF6 Gene

HapMap Linkage Disequilibrium report
ATF6
Human Gene Mutation Database (HGMD)
ATF6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATF6 Gene

Disorders for ATF6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for ATF6 Gene including...

Search for ATF6 Gene in MalaCards »

(2) Novoseek inferred disease relationships for ATF6 Gene

Disease -log(P) Hits PubMed IDs
ischemia 0 3
hepatocellular carcinoma 0 2

Relevant External Links for ATF6

Genetic Association Database (GAD)
ATF6
Human Genome Epidemiology (HuGE) Navigator
ATF6
genes like me logo Genes that share disorders with ATF6: view

No data available for UniProtKB/Swiss-Prot for ATF6 Gene

Publications for ATF6 Gene

  1. Interaction of ATF6 and serum response factor. (PMID: 9271374) Zhu C. … Prywes R. (Mol. Cell. Biol. 1997) 2 3 4 23
  2. Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins; involvement of basic-leucine zipper transcription factors. (PMID: 9837962) Yoshida H. … Mori K. (J. Biol. Chem. 1998) 2 3 4 23
  3. Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response. (PMID: 11158310) Yoshida H. … Mori K. (Mol. Cell. Biol. 2001) 3 4 23
  4. Identification of the G13 (cAMP-response-element-binding protein- related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response. (PMID: 11256944) Haze K. … Mori K. (Biochem. J. 2001) 2 3 23
  5. Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response. (PMID: 14699159) Hong M. … Lee A.S. (J. Biol. Chem. 2004) 3 4 23

Products for ATF6 Gene

  • Addgene plasmids for ATF6

Sources for ATF6 Gene

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