Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MAPRE3 Gene

Aliases for MAPRE3 Gene

  • Microtubule-Associated Protein, RP/EB Family, Member 3 2 3
  • EBF3 3 4 6
  • RP3 3 4 6
  • EB3 3 4 6
  • EB1 Protein Family Member 3 3 4
  • End-Binding Protein 3 3 4
  • Microtubule-Associated Protein RP/EB Family Member 3 3
  • APC Binding Protein 3
  • EBF3-S 3

External Ids for MAPRE3 Gene

Summaries for MAPRE3 Gene

Entrez Gene Summary for MAPRE3 Gene

  • The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAPRE3 Gene

MAPRE3 (Microtubule-Associated Protein, RP/EB Family, Member 3) is a Protein Coding gene. Diseases associated with MAPRE3 include adenomatous polyposis coli. Among its related pathways are PAK Pathway and Remodeling of Adherens Junctions. GO annotations related to this gene include microtubule binding. An important paralog of this gene is MAPRE2.

UniProtKB/Swiss-Prot for MAPRE3 Gene

  • Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).

Gene Wiki entry for MAPRE3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPRE3 Gene

Genomics for MAPRE3 Gene

Genomic Location for MAPRE3 Gene

Start:
26,970,612 bp from pter
End:
27,027,219 bp from pter
Size:
56,608 bases
Orientation:
Plus strand

Genomic View for MAPRE3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAPRE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPRE3 Gene

Regulatory Elements for MAPRE3 Gene

Proteins for MAPRE3 Gene

  • Protein details for MAPRE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPY8-MARE3_HUMAN
    Recommended name:
    Microtubule-associated protein RP/EB family member 3
    Protein Accession:
    Q9UPY8
    Secondary Accessions:
    • B7WPK5
    • O00265
    • Q6FHB0
    • Q6FI15
    • Q9BZP7
    • Q9BZP8

    Protein attributes for MAPRE3 Gene

    Size:
    281 amino acids
    Molecular mass:
    31982 Da
    Quaternary structure:
    • Interacts with APC2 (By similarity). Homodimer. Heterodimer with MAPRE1. Interacts with DCTN1 and SRCIN1. Binds to the C-terminal domain of APC. Binds monomeric and polymerized tubulin. Interacts (via C-terminus) with CLIP1. Interacts with SLAIN2.
    SequenceCaution:
    • Sequence=AAK07556.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK07557.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA72060.1; Type=Frameshift; Positions=199; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAPRE3 Gene

    Alternative splice isoforms for MAPRE3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPRE3 Gene

Proteomics data for MAPRE3 Gene at MOPED

Post-translational modifications for MAPRE3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys113 and Lys229

Other Protein References for MAPRE3 Gene

No data available for DME Specific Peptides for MAPRE3 Gene

Domains for MAPRE3 Gene

Protein Domains for MAPRE3 Gene

UniProtKB/Swiss-Prot:

MARE3_HUMAN
Domain:
  • Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1:
    • Q9UPY8
  • Contains 1 CH (calponin-homology) domain.:
    • Q9UPY8
  • Contains 1 EB1 C-terminal domain.:
    • Q9UPY8
Family:
  • Belongs to the MAPRE family.:
    • Q9UPY8
genes like me logo Genes that share domains with MAPRE3: view

No data available for Gene Families for MAPRE3 Gene

Function for MAPRE3 Gene

Molecular function for MAPRE3 Gene

UniProtKB/Swiss-Prot Function: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).

Gene Ontology (GO) - Molecular Function for MAPRE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10644998
GO:0008017 microtubule binding ISS 17310996
genes like me logo Genes that share ontologies with MAPRE3: view

Phenotypes for MAPRE3 Gene

genes like me logo Genes that share phenotypes with MAPRE3: view

miRNA for MAPRE3 Gene

miRTarBase miRNAs that target MAPRE3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MAPRE3 Gene

Localization for MAPRE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPRE3 Gene

Cytoplasm, cytoskeleton. Note=Associated with the microtubule network. Detected at the plus end of microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPRE3 Gene COMPARTMENTS Subcellular localization image for MAPRE3 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for MAPRE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS 17310996
GO:0005874 microtubule --
GO:0005881 colocalizes_with cytoplasmic microtubule IDA 10644998
GO:0015630 microtubule cytoskeleton IDA 10644998
GO:0030496 midbody ISS 17310996
genes like me logo Genes that share ontologies with MAPRE3: view

Pathways for MAPRE3 Gene

genes like me logo Genes that share pathways with MAPRE3: view

Pathways by source for MAPRE3 Gene

Gene Ontology (GO) - Biological Process for MAPRE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity ISS 17310996
GO:0045893 positive regulation of transcription, DNA-templated ISS 17310996
GO:0051301 cell division IEA --
GO:1903033 positive regulation of microtubule plus-end binding IEA --
genes like me logo Genes that share ontologies with MAPRE3: view

Transcripts for MAPRE3 Gene

Unigene Clusters for MAPRE3 Gene

Microtubule-associated protein, RP/EB family, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAPRE3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - -
SP6:
SP7: - - -

Relevant External Links for MAPRE3 Gene

GeneLoc Exon Structure for
MAPRE3
ECgene alternative splicing isoforms for
MAPRE3

Expression for MAPRE3 Gene

mRNA expression in normal human tissues for MAPRE3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAPRE3 Gene

SOURCE GeneReport for Unigene cluster for MAPRE3 Gene Hs.515860

mRNA Expression by UniProt/SwissProt for MAPRE3 Gene

Q9UPY8-MARE3_HUMAN
Tissue specificity: Predominantly expressed in brain and muscle.
genes like me logo Genes that share expressions with MAPRE3: view

Orthologs for MAPRE3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAPRE3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPRE3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAPRE3 36
  • 94.49 (n)
  • 99.62 (a)
MAPRE3 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPRE3 36
  • 94.9 (n)
  • 99.64 (a)
MAPRE3 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapre3 36
  • 91.81 (n)
  • 99.29 (a)
Mapre3 16
Mapre3 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAPRE3 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPRE3 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapre3 36
  • 92.88 (n)
  • 99.29 (a)
chicken
(Gallus gallus)
Aves LOC100857732 36
  • 79.37 (n)
  • 85.64 (a)
MAPRE3 37
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPRE3 37
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68667 36
zebrafish
(Danio rerio)
Actinopterygii mapre3a 37
  • 83 (a)
OneToMany
mapre3b 37
  • 81 (a)
OneToMany
mapre3b 37
  • 81 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Eb1 37
  • 52 (a)
OneToMany
CG18190 38
  • 34 (a)
Eb1 38
  • 53 (a)
worm
(Caenorhabditis elegans)
Secernentea ebp-1 37
  • 40 (a)
ManyToMany
ebp-2 37
  • 31 (a)
ManyToMany
ebp-3 37
  • 28 (a)
ManyToMany
VW02B12L.3 38
  • 34 (a)
Y59A8B.7 38
  • 51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BIM1 37
  • 27 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons EB1A 36
  • 49.42 (n)
  • 43.04 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4467 36
Species with no ortholog for MAPRE3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MAPRE3 Gene

ENSEMBL:
Gene Tree for MAPRE3 (if available)
TreeFam:
Gene Tree for MAPRE3 (if available)

Paralogs for MAPRE3 Gene

Paralogs for MAPRE3 Gene

Selected SIMAP similar genes for MAPRE3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MAPRE3: view

Variants for MAPRE3 Gene

Sequence variations from dbSNP and Humsavar for MAPRE3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs10224 -- 27,025,895(-) TGTCA(A/G)CTTCA reference, synonymous-codon
rs12328 -- 27,026,573(+) ACCCA(C/T)CCTAT utr-variant-3-prime
rs14628 -- 27,025,901(-) ATCCA(A/C)TGTCA reference, missense
rs714513 -- 26,983,606(-) TAAAG(A/G)TAAAG intron-variant
rs722911 -- 26,988,344(-) CTTGA(C/T)GCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAPRE3 Gene

Variant ID Type Subtype PubMed ID
nsv455974 CNV Loss 19166990

Relevant External Links for MAPRE3 Gene

HapMap Linkage Disequilibrium report
MAPRE3

Disorders for MAPRE3 Gene

genes like me logo Genes that share disorders with MAPRE3: view

No data available for UniProtKB/Swiss-Prot for MAPRE3 Gene

Publications for MAPRE3 Gene

  1. Characterization of human MAPRE genes and their proteins. (PMID: 11161807) Su L.-K. … Qi Y. (Genomics 2001) 3 4 23
  2. RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells. (PMID: 9233623) Renner C. … Pfreundschuh M. (J. Immunol. 1997) 2 3 4
  3. Mammalian end binding proteins control persistent microtubule growth. (PMID: 19255245) Komarova Y. … Akhmanova A. (J. Cell Biol. 2009) 3 4 23
  4. Mitotic regulation of the stability of microtubule plus-end tracking protein EB3 by ubiquitin ligase SIAH-1 and Aurora mitotic kinases. (PMID: 19696028) Ban R. … Urano T. (J. Biol. Chem. 2009) 3 23
  5. Molecular insights into mammalian end-binding protein heterodimerization. (PMID: 20008324) De Groot C.O. … Steinmetz M.O. (J. Biol. Chem. 2010) 3 23

Products for MAPRE3 Gene

  • antibodies-online proteins for MAPRE3
  • antibodies-online antibodies for MAPRE3
  • antibodies-online kits for MAPRE3

Sources for MAPRE3 Gene

Back to Top

Content