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Aliases for MAPRE3 Gene

Aliases for MAPRE3 Gene

  • Microtubule Associated Protein RP/EB Family Member 3 2 3 5
  • EB1 Protein Family Member 3 3 4
  • End-Binding Protein 3 3 4
  • EBF3 3 4
  • RP3 3 4
  • EB3 3 4
  • Microtubule-Associated Protein RP/EB Family Member 3 3
  • APC Binding Protein 3
  • EBF3-S 3

External Ids for MAPRE3 Gene

Previous GeneCards Identifiers for MAPRE3 Gene

  • GC02P027114
  • GC02P027286
  • GC02P027168
  • GC02P027105
  • GC02P027193

Summaries for MAPRE3 Gene

Entrez Gene Summary for MAPRE3 Gene

  • The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAPRE3 Gene

MAPRE3 (Microtubule Associated Protein RP/EB Family Member 3) is a Protein Coding gene. Diseases associated with MAPRE3 include Adenomatous Polyposis Coli and Mature B-Cell Neoplasm. Among its related pathways are Remodeling of Adherens Junctions and PAK Pathway. GO annotations related to this gene include microtubule binding. An important paralog of this gene is MAPRE1.

UniProtKB/Swiss-Prot for MAPRE3 Gene

  • Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).

Gene Wiki entry for MAPRE3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPRE3 Gene

Genomics for MAPRE3 Gene

Regulatory Elements for MAPRE3 Gene

Enhancers for MAPRE3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G026717 2.2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 9.4 -248.1 -248117 10.1 HDGF FOXA2 MLX CREB3L1 SIN3A DMAP1 YY1 ZNF766 FOS ZNF263 CENPA GPN1 CAD LOC105374363 ZNF512 NRBP1 GTF3C2-AS1 KCNK3 SLC35F6 ENSG00000235267
GH02G026766 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.3 -200.4 -200363 6.8 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 ENSG00000272148 KHK AGBL5-IT1 DPYSL5 MAPRE3 SNX17 ADGRF3 CENPA CDKN2AIPNLP2
GH02G027090 1.6 Ensembl ENCODE dbSUPER 10 +123.5 123545 6.6 HNRNPUL1 FOXA2 MLX CREB3L1 ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF766 KHK ZNF513 CGREF1 ABHD1 ATRAID SLC5A6 CAD PRR30 TCF23 PREB
GH02G026911 1.3 ENCODE dbSUPER 11.1 -57.1 -57061 3.0 HDGF ATF1 ARNT SIN3A ARID4B DMAP1 ZNF48 YY1 ZNF766 ZNF143 KHK DPYSL5 MAPRE3 PREB PIR42524
GH02G027085 1.4 ENCODE dbSUPER 9.6 +117.1 117116 4.8 HDGF MLX ARNT CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 KHK SLC5A6 ATRAID ABHD1 CGREF1 PREB TRIM54 UCN MPV17 LOC100129724
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAPRE3 on UCSC Golden Path with GeneCards custom track

Promoters for MAPRE3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000114348 529 1401 HDGF PKNOX1 ARID4B SIN3A ZNF48 ZNF143 ZNF207 ZNF263 NCOA1 REST

Genomic Location for MAPRE3 Gene

Chromosome:
2
Start:
26,970,371 bp from pter
End:
27,027,219 bp from pter
Size:
56,849 bases
Orientation:
Plus strand

Genomic View for MAPRE3 Gene

Genes around MAPRE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPRE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPRE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPRE3 Gene

Proteins for MAPRE3 Gene

  • Protein details for MAPRE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPY8-MARE3_HUMAN
    Recommended name:
    Microtubule-associated protein RP/EB family member 3
    Protein Accession:
    Q9UPY8
    Secondary Accessions:
    • B7WPK5
    • O00265
    • Q6FHB0
    • Q6FI15
    • Q9BZP7
    • Q9BZP8

    Protein attributes for MAPRE3 Gene

    Size:
    281 amino acids
    Molecular mass:
    31982 Da
    Quaternary structure:
    • Interacts with APC2 (By similarity). Homodimer. Heterodimer with MAPRE1. Interacts with DCTN1 and SRCIN1. Binds to the C-terminal domain of APC. Binds monomeric and polymerized tubulin. Interacts (via C-terminus) with CLIP1. Interacts with SLAIN2.
    SequenceCaution:
    • Sequence=AAK07556.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK07557.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA72060.1; Type=Frameshift; Positions=199; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAPRE3 Gene

    Alternative splice isoforms for MAPRE3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPRE3 Gene

Post-translational modifications for MAPRE3 Gene

  • Ubiquitination at posLast=229229
  • Modification sites at PhosphoSitePlus

Other Protein References for MAPRE3 Gene

Antibody Products

  • Abcam antibodies for MAPRE3

No data available for DME Specific Peptides for MAPRE3 Gene

Domains & Families for MAPRE3 Gene

Protein Domains for MAPRE3 Gene

Suggested Antigen Peptide Sequences for MAPRE3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UPY8

UniProtKB/Swiss-Prot:

MARE3_HUMAN :
  • Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.
  • Belongs to the MAPRE family.
Domain:
  • Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.
Family:
  • Belongs to the MAPRE family.
genes like me logo Genes that share domains with MAPRE3: view

No data available for Gene Families for MAPRE3 Gene

Function for MAPRE3 Gene

Molecular function for MAPRE3 Gene

UniProtKB/Swiss-Prot Function:
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).

Gene Ontology (GO) - Molecular Function for MAPRE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10644998
GO:0008017 microtubule binding ISS 17310996
GO:0042802 identical protein binding IPI 27107012
genes like me logo Genes that share ontologies with MAPRE3: view
genes like me logo Genes that share phenotypes with MAPRE3: view

Animal Models for MAPRE3 Gene

MGI Knock Outs for MAPRE3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPRE3 Gene

Localization for MAPRE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPRE3 Gene

Cytoplasm, cytoskeleton. Note=Associated with the microtubule network. Detected at the plus end of microtubules.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPRE3 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
plasma membrane 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MAPRE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS 17310996
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0015630 microtubule cytoskeleton IEA --
GO:0030496 midbody ISS 17310996
genes like me logo Genes that share ontologies with MAPRE3: view

Pathways & Interactions for MAPRE3 Gene

genes like me logo Genes that share pathways with MAPRE3: view

Pathways by source for MAPRE3 Gene

SIGNOR curated interactions for MAPRE3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MAPRE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity ISS 17310996
GO:0045893 positive regulation of transcription, DNA-templated ISS 17310996
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with MAPRE3: view

Transcripts for MAPRE3 Gene

Unigene Clusters for MAPRE3 Gene

Microtubule-associated protein, RP/EB family, member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPRE3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - -
SP6:
SP7: - - -

Relevant External Links for MAPRE3 Gene

GeneLoc Exon Structure for
MAPRE3
ECgene alternative splicing isoforms for
MAPRE3

Expression for MAPRE3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAPRE3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAPRE3 Gene

This gene is overexpressed in Frontal cortex (19.4), Brain (13.8), Fetal Brain (11.9), and Retina (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAPRE3 Gene



Protein tissue co-expression partners for MAPRE3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAPRE3 Gene:

MAPRE3

SOURCE GeneReport for Unigene cluster for MAPRE3 Gene:

Hs.515860

mRNA Expression by UniProt/SwissProt for MAPRE3 Gene:

Q9UPY8-MARE3_HUMAN
Tissue specificity: Predominantly expressed in brain and muscle.

Evidence on tissue expression from TISSUES for MAPRE3 Gene

  • Nervous system(4.9)
  • Kidney(4.2)
  • Pancreas(3.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with MAPRE3: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPRE3 Gene

Orthologs for MAPRE3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAPRE3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPRE3 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPRE3 35 34
  • 94.9 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MAPRE3 34 35
  • 94.49 (n)
rat
(Rattus norvegicus)
Mammalia Mapre3 34
  • 92.88 (n)
mouse
(Mus musculus)
Mammalia Mapre3 16 35 34
  • 91.81 (n)
oppossum
(Monodelphis domestica)
Mammalia MAPRE3 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPRE3 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857732 34
  • 79.37 (n)
MAPRE3 35
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPRE3 35
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68667 34
zebrafish
(Danio rerio)
Actinopterygii mapre3a 35
  • 83 (a)
OneToMany
mapre3b 35 35
  • 81 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Eb1 36 35
  • 53 (a)
CG18190 36
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea Y59A8B.7 36
  • 51 (a)
ebp-1 35
  • 40 (a)
ManyToMany
VW02B12L.3 36
  • 34 (a)
ebp-2 35
  • 31 (a)
ManyToMany
ebp-3 35
  • 28 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BIM1 35
  • 27 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons EB1A 34
  • 49.42 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4467 34
Species where no ortholog for MAPRE3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MAPRE3 Gene

ENSEMBL:
Gene Tree for MAPRE3 (if available)
TreeFam:
Gene Tree for MAPRE3 (if available)

Paralogs for MAPRE3 Gene

Paralogs for MAPRE3 Gene

(2) SIMAP similar genes for MAPRE3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MAPRE3: view

Variants for MAPRE3 Gene

Sequence variations from dbSNP and Humsavar for MAPRE3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000052599 -- 26,973,337(+) CACAC(A/G)TTGTG intron-variant
rs1000072175 -- 26,991,802(+) AAATT(A/G)GGCCA intron-variant
rs1000085694 -- 26,985,023(+) GCTAA(A/G)CTTAC intron-variant
rs1000172226 -- 26,972,986(+) AGGGA(C/G)ATGAT intron-variant
rs1000210276 -- 27,014,599(+) CGTCT(A/C)TGCAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAPRE3 Gene

Variant ID Type Subtype PubMed ID
dgv6744n54 CNV loss 21841781
esv3590131 CNV loss 21293372
nsv455974 CNV loss 19166990

Variation tolerance for MAPRE3 Gene

Residual Variation Intolerance Score: 21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.01; 0.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAPRE3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPRE3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPRE3 Gene

Disorders for MAPRE3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAPRE3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
adenomatous polyposis coli
  • brain tumor-polyposis syndrome 2
mature b-cell neoplasm
  • mature b-cell lymphocytic neoplasm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAPRE3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAPRE3
genes like me logo Genes that share disorders with MAPRE3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAPRE3 Gene

Publications for MAPRE3 Gene

  1. Mammalian end binding proteins control persistent microtubule growth. (PMID: 19255245) Komarova Y. … Akhmanova A. (J. Cell Biol. 2009) 3 4 22 64
  2. Characterization of human MAPRE genes and their proteins. (PMID: 11161807) Su L.-K. … Qi Y. (Genomics 2001) 3 4 22 64
  3. RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells. (PMID: 9233623) Renner C. … Pfreundschuh M. (J. Immunol. 1997) 2 3 4 64
  4. Molecular insights into mammalian end-binding protein heterodimerization. (PMID: 20008324) De Groot C.O. … Steinmetz M.O. (J. Biol. Chem. 2010) 3 22 64
  5. Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity. (PMID: 19146815) Jaworski J. … Hoogenraad C.C. (Neuron 2009) 3 4 64

Products for MAPRE3 Gene

Sources for MAPRE3 Gene

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