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Aliases for UBOX5 Gene

Aliases for UBOX5 Gene

  • U-Box Domain Containing 5 2 3
  • Ubiquitin-Conjugating Enzyme 7-Interacting Protein 5 3 4
  • U-Box Domain-Containing Protein 5 3 4
  • UbcM4-Interacting Protein 5 3 4
  • UBCE7IP5 3 4
  • RNF37 3 4
  • HUIP5 3 4
  • UIP5 3 4
  • Ubiquitin Conjugating Enzyme 7 Interacting Protein 5 3
  • RING Finger Protein 37 3
  • EC 6.3.2.- 4
  • KIAA0860 4

External Ids for UBOX5 Gene

Previous GeneCards Identifiers for UBOX5 Gene

  • GC20M003039
  • GC20M003040
  • GC20M003041
  • GC20M003042
  • GC20M003043
  • GC20M003044
  • GC20M003045
  • GC20M003046
  • GC20M003047
  • GC20M003048
  • GC20M003049

Summaries for UBOX5 Gene

Entrez Gene Summary for UBOX5 Gene

  • This gene encodes a U-box domain containing protein. The encoded protein interacts with E2 enzymes and may play a role in the ubiquitination pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

GeneCards Summary for UBOX5 Gene

UBOX5 (U-Box Domain Containing 5) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-ubiquitin ligase activity.

UniProtKB/Swiss-Prot for UBOX5 Gene

  • May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates.

Gene Wiki entry for UBOX5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBOX5 Gene

Genomics for UBOX5 Gene

Regulatory Elements for UBOX5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UBOX5 Gene

3,107,573 bp from pter
3,160,196 bp from pter
52,624 bases
Minus strand

Genomic View for UBOX5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBOX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBOX5 Gene

Proteins for UBOX5 Gene

  • Protein details for UBOX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 37
    Protein Accession:
    Secondary Accessions:
    • Q6IAR5
    • Q86X87
    • Q9H4J2

    Protein attributes for UBOX5 Gene

    541 amino acids
    Molecular mass:
    58966 Da
    Quaternary structure:
    • Interacts with UBE2L3. Interacts with VCP.
    • Sequence=BAA74883.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for UBOX5 Gene


neXtProt entry for UBOX5 Gene

Proteomics data for UBOX5 Gene at MOPED

Post-translational modifications for UBOX5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBOX5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for UBOX5 Gene

Domains for UBOX5 Gene

Gene Families for UBOX5 Gene

  • RNF :RING-type (C3HC4) zinc fingers
  • UBOX :U-box domain containing

Protein Domains for UBOX5 Gene

Graphical View of Domain Structure for InterPro Entry



  • O94941
  • The U-box domain mediates interaction with E2 ubiquitin ligases and is required for the ubiquitin-protein ligase activity.
  • Contains 1 U-box domain.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with UBOX5: view

Function for UBOX5 Gene

Molecular function for UBOX5 Gene

UniProtKB/Swiss-Prot Function: May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates.

Enzyme Numbers (IUBMB) for UBOX5 Gene

Gene Ontology (GO) - Molecular Function for UBOX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0031625 ubiquitin protein ligase binding IPI 11274149
genes like me logo Genes that share ontologies with UBOX5: view

Phenotypes for UBOX5 Gene

GenomeRNAi human phenotypes for UBOX5:
genes like me logo Genes that share phenotypes with UBOX5: view

Animal Model Products

CRISPR Products

miRNA for UBOX5 Gene

miRTarBase miRNAs that target UBOX5

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for UBOX5 Gene

Localization for UBOX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBOX5 Gene

Nucleus. Note=Enriched in nuclear bodies. {ECO:0000269 PubMed:11274149}.

Subcellular locations from

Jensen Localization Image for UBOX5 Gene COMPARTMENTS Subcellular localization image for UBOX5 gene
Compartment Confidence
nucleus 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for UBOX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0016604 nuclear body IDA 11274149
genes like me logo Genes that share ontologies with UBOX5: view

Pathways for UBOX5 Gene

genes like me logo Genes that share pathways with UBOX5: view

UniProtKB/Swiss-Prot O94941-RNF37_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBOX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination ISS --
GO:0016567 protein ubiquitination --
genes like me logo Genes that share ontologies with UBOX5: view

Transcripts for UBOX5 Gene

Unigene Clusters for UBOX5 Gene

U-box domain containing 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBOX5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBOX5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: -
SP6: - -

Relevant External Links for UBOX5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBOX5 Gene

mRNA expression in normal human tissues for UBOX5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBOX5 Gene

SOURCE GeneReport for Unigene cluster for UBOX5 Gene Hs.654646

mRNA Expression by UniProt/SwissProt for UBOX5 Gene

Tissue specificity: Expressed in liver, heart, brain, kidney and testis.
genes like me logo Genes that share expressions with UBOX5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UBOX5 Gene

Orthologs for UBOX5 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBOX5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UBOX5 35
  • 99.38 (n)
  • 99.45 (a)
UBOX5 36
  • 99 (a)
(Bos Taurus)
Mammalia UBOX5 35
  • 88.87 (n)
  • 88.21 (a)
UBOX5 36
  • 88 (a)
(Canis familiaris)
Mammalia UBOX5 36
  • 90 (a)
(Mus musculus)
Mammalia Ubox5 35
  • 83.61 (n)
  • 79.59 (a)
Ubox5 16
Ubox5 36
  • 80 (a)
(Monodelphis domestica)
Mammalia UBOX5 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia UBOX5 36
  • 67 (a)
(Rattus norvegicus)
Mammalia Ubox5 35
  • 82.96 (n)
  • 79.55 (a)
(Gallus gallus)
Aves UBOX5 35
  • 68.42 (n)
  • 64.1 (a)
UBOX5 36
  • 63 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10221 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9098 35
ubox5 35
  • 61.02 (n)
  • 57.82 (a)
(Danio rerio)
Actinopterygii ubox5 35
  • 49.23 (n)
  • 43.96 (a)
ubox5 36
  • 39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2218 35
  • 44.04 (n)
  • 30.34 (a)
CG2218 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for UBOX5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBOX5 Gene

Gene Tree for UBOX5 (if available)
Gene Tree for UBOX5 (if available)

Paralogs for UBOX5 Gene

No data available for Paralogs for UBOX5 Gene

Variants for UBOX5 Gene

Sequence variations from dbSNP and Humsavar for UBOX5 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
VAR_046402 -
VAR_046403 -

Structural Variations from Database of Genomic Variants (DGV) for UBOX5 Gene

Variant ID Type Subtype PubMed ID
nsv833897 CNV Loss 17160897
nsv521437 CNV Loss 19592680
nsv526273 CNV Loss 19592680
nsv180149 CNV Loss 16902084
nsv524482 CNV Gain 19592680
nsv833898 CNV Gain+Loss 17160897
nsv912604 CNV Loss 21882294
nsv912605 CNV Loss 21882294
nsv912606 CNV Loss 21882294
dgv4518n71 CNV Loss 21882294

Relevant External Links for UBOX5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBOX5 Gene

Disorders for UBOX5 Gene

(1) University of Copenhagen DISEASES for UBOX5 Gene

genes like me logo Genes that share disorders with UBOX5: view

No data available for UniProtKB/Swiss-Prot for UBOX5 Gene

Publications for UBOX5 Gene

  1. Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes. (PMID: 11274149) Pringa E. … Harbers K. (J. Biol. Chem. 2001) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  4. A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4. (PMID: 10431818) Martinez-Noel G. … Harbers K. (FEBS Lett. 1999) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for UBOX5 Gene

Sources for UBOX5 Gene

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