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Aliases for MORC2 Gene

Aliases for MORC2 Gene

  • MORC Family CW-Type Zinc Finger 2 2 3 5
  • Zinc Finger CW-Type Coiled-Coil Domain Protein 1 3 4
  • ZCWCC1 3 4
  • Zinc Finger, CW-Type With Coiled-Coil Domain 1 2
  • Zinc Finger, CW Type With Coiled-Coil Domain 1 2
  • MORC Family CW-Type Zinc Finger Protein 2 3
  • KIAA0852 4
  • CMT2Z 3
  • ZCW3 3

External Ids for MORC2 Gene

Previous HGNC Symbols for MORC2 Gene

  • ZCWCC1

Previous GeneCards Identifiers for MORC2 Gene

  • GC22M029651
  • GC22M031322
  • GC22M014286

Summaries for MORC2 Gene

Entrez Gene Summary for MORC2 Gene

  • This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is known to regulate the condensation of heterochromatin in response to DNA damage and play a role in repressing transcription. The protein has been found to regulate the activity of ATP citrate lyase via specific interaction with this enzyme in the cytosol of lipogenic breast cancer cells. The protein also plays a role in lipogenesis and adipocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

GeneCards Summary for MORC2 Gene

MORC2 (MORC Family CW-Type Zinc Finger 2) is a Protein Coding gene. Diseases associated with MORC2 include Charcot-Marie-Tooth Disease 2Z and Autosomal Dominant Charcot-Marie-Tooth Disease Type 2Z. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is MORC1.

UniProtKB/Swiss-Prot for MORC2 Gene

  • Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). May act as a transcriptional repressor (PubMed:20225202). Down-regulates CA9 expression (PubMed:20110259).

Gene Wiki entry for MORC2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MORC2 Gene

Genomics for MORC2 Gene

Regulatory Elements for MORC2 Gene

Enhancers for MORC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G031097 1.6 Ensembl ENCODE dbSUPER 30.9 -134.6 -134555 10.5 HDGF FOXA2 PKNOX1 CREB3L1 MLX ARNT AGO1 ARID4B SIN3A DMAP1 MORC2 TUG1 SELENOM PLA2G3 ENSG00000214125 RNF185 SFI1 INPP5J ENSG00000273387
GH22G031234 1.9 FANTOM5 Ensembl ENCODE dbSUPER 14.5 -266.9 -266885 1.6 ATF1 PKNOX1 ARID4B SIN3A DMAP1 ZNF121 GLIS2 ELK1 GATA2 FOS LIMK2 MORC2 TUG1 RNF185 PRR14L INPP5J SELENOM PATZ1 LINC01521 SFI1
GH22G030572 1.4 ENCODE dbSUPER 15.4 +393.9 393915 4.5 HDGF PKNOX1 CREB3L1 MLX AGO1 ARID4B SIN3A DMAP1 YY1 SLC30A9 TUG1 MORC2 SLC35E4 PES1 GAL3ST1 SEC14L6
GH22G030828 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +137.4 137378 4.4 ATF1 ARNT SIN3A BRCA1 TCF12 GATA2 ELK1 FOS NCOA1 REST MORC2-AS1 MORC2 SLC35E4 DUSP18 OSBP2 LOC105372994 MIR3200
GH22G030234 2 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +721.8 721767 24.6 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B ZNF416 ZNF143 TUG1 LIF HORMAD2-AS1 MGC20647 MORC2 SEC14L4 DUSP18 THOC5 ENSG00000181123 ASCC2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MORC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MORC2 Gene

Chromosome:
22
Start:
30,925,130 bp from pter
End:
30,968,497 bp from pter
Size:
43,368 bases
Orientation:
Minus strand

Genomic View for MORC2 Gene

Genes around MORC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MORC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MORC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MORC2 Gene

Proteins for MORC2 Gene

  • Protein details for MORC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6X9-MORC2_HUMAN
    Recommended name:
    MORC family CW-type zinc finger protein 2
    Protein Accession:
    Q9Y6X9
    Secondary Accessions:
    • B2RNB1
    • Q9UF28
    • Q9Y6V2

    Protein attributes for MORC2 Gene

    Size:
    1032 amino acids
    Molecular mass:
    117823 Da
    Quaternary structure:
    • Interacts with HDAC4 (PubMed:20110259). Interacts with ACLY (PubMed:24286864).
    SequenceCaution:
    • Sequence=AAC12954.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA74875.2; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for MORC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MORC2 Gene

Post-translational modifications for MORC2 Gene

  • Ubiquitination at posLast=932932
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MORC2 Gene

Domains & Families for MORC2 Gene

Gene Families for MORC2 Gene

Protein Domains for MORC2 Gene

Suggested Antigen Peptide Sequences for MORC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MORC2: view

No data available for UniProtKB/Swiss-Prot for MORC2 Gene

Function for MORC2 Gene

Molecular function for MORC2 Gene

UniProtKB/Swiss-Prot Function:
Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). May act as a transcriptional repressor (PubMed:20225202). Down-regulates CA9 expression (PubMed:20110259).

Gene Ontology (GO) - Molecular Function for MORC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MORC2: view

Phenotypes for MORC2 Gene

genes like me logo Genes that share phenotypes with MORC2: view

Human Phenotype Ontology for MORC2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MORC2 Gene

Localization for MORC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MORC2 Gene

Nucleus. Cytoplasm, cytosol. Note=Mainly located in the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MORC2 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MORC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with MORC2: view

Pathways & Interactions for MORC2 Gene

SuperPathways for MORC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MORC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
genes like me logo Genes that share ontologies with MORC2: view

No data available for Pathways by source and SIGNOR curated interactions for MORC2 Gene

Transcripts for MORC2 Gene

Unigene Clusters for MORC2 Gene

MORC family CW-type zinc finger 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MORC2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1:
SP2: - -
SP3:

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27a · 27b
SP1:
SP2:
SP3: -

Relevant External Links for MORC2 Gene

GeneLoc Exon Structure for
MORC2
ECgene alternative splicing isoforms for
MORC2

Expression for MORC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MORC2 Gene

Protein differential expression in normal tissues from HIPED for MORC2 Gene

This gene is overexpressed in Kidney (21.0), Liver (13.3), and Adrenal (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MORC2 Gene



NURSA nuclear receptor signaling pathways regulating expression of MORC2 Gene:

MORC2

SOURCE GeneReport for Unigene cluster for MORC2 Gene:

Hs.555918

mRNA Expression by UniProt/SwissProt for MORC2 Gene:

Q9Y6X9-MORC2_HUMAN
Tissue specificity: Highly expressed in smooth muscle, pancreas and testis.

Evidence on tissue expression from TISSUES for MORC2 Gene

  • Nervous system(4.3)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with MORC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MORC2 Gene

Orthologs for MORC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MORC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MORC2 34 35
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia MORC2 34 35
  • 90.96 (n)
cow
(Bos Taurus)
Mammalia MORC2 34 35
  • 89.31 (n)
rat
(Rattus norvegicus)
Mammalia Morc2 34
  • 86.76 (n)
mouse
(Mus musculus)
Mammalia Morc2a 34 16 35
  • 86.64 (n)
Morc2b 35
  • 69 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MORC2 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MORC2 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves MORC2 34 35
  • 74.28 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 72 (a)
OneToMany
-- 35
  • 71 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia morc2 34
  • 66.55 (n)
Str.10569 34
zebrafish
(Danio rerio)
Actinopterygii morc2 34 35
  • 63.48 (n)
worm
(Caenorhabditis elegans)
Secernentea morc-1 35
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 59 (a)
OneToOne
Species where no ortholog for MORC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MORC2 Gene

ENSEMBL:
Gene Tree for MORC2 (if available)
TreeFam:
Gene Tree for MORC2 (if available)

Paralogs for MORC2 Gene

Paralogs for MORC2 Gene

(1) SIMAP similar genes for MORC2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MORC2: view

Variants for MORC2 Gene

Sequence variations from dbSNP and Humsavar for MORC2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs749060708 Charcot-Marie-Tooth disease 2Z (CMT2Z) [MIM:616688] 30,949,783(+) AATCT(C/G)AGTAG reference, missense
rs864309503 Pathogenic, Charcot-Marie-Tooth disease 2Z (CMT2Z) [MIM:616688] 30,941,503(-) ATCCC(C/T)GGATG reference, missense
rs864309504 Pathogenic, Charcot-Marie-Tooth disease 2Z (CMT2Z) [MIM:616688] 30,949,809(-) GAAGT(C/T)GGCCA reference, missense
VAR_076456 Charcot-Marie-Tooth disease 2Z (CMT2Z) [MIM:616688]
VAR_076460 Charcot-Marie-Tooth disease 2Z (CMT2Z) [MIM:616688]

Structural Variations from Database of Genomic Variants (DGV) for MORC2 Gene

Variant ID Type Subtype PubMed ID
nsv1110864 OTHER inversion 24896259

Variation tolerance for MORC2 Gene

Residual Variation Intolerance Score: 2.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MORC2 Gene

Human Gene Mutation Database (HGMD)
MORC2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MORC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MORC2 Gene

Disorders for MORC2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MORC2 Gene - From: ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
charcot-marie-tooth disease 2z
  • charcot-marie-tooth disease, axonal, autosomal dominant, type 2z
autosomal dominant charcot-marie-tooth disease type 2z
  • autosomal dominant charcot-marie-tooth disease type 2 due to morc2 mutation
charcot-marie-tooth disease, type 2e
  • charcot-marie-tooth disease, axonal, type 2e
charcot-marie-tooth disease
  • charcot marie tooth muscular atrophy
tooth disease
  • dental disorder
- elite association - COSMIC cancer census association via MalaCards
Search MORC2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MORC2_HUMAN
  • Charcot-Marie-Tooth disease 2Z (CMT2Z) [MIM:616688]: An autosomal dominant, axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. {ECO:0000269 PubMed:26497905, ECO:0000269 PubMed:26659848}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MORC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MORC2
genes like me logo Genes that share disorders with MORC2: view

No data available for Genatlas for MORC2 Gene

Publications for MORC2 Gene

  1. MORC2 mutations cause axonal Charcot-Marie-Tooth disease with pyramidal signs. (PMID: 26659848) Albulym O.M. … Nicholson G.A. (Ann. Neurol. 2016) 3 4 64
  2. Mutations in the MORC2 gene cause axonal Charcot-Marie-Tooth disease. (PMID: 26497905) Sevilla T. … EspinA^s C. (Brain 2015) 3 4 64
  3. Cytosolic functions of MORC2 in lipogenesis and adipogenesis. (PMID: 24286864) SA!nchez-Solana B. … Kumar R. (Biochim. Biophys. Acta 2014) 3 4 64
  4. Involvement of histone deacetylation in MORC2-mediated down- regulation of carbonic anhydrase IX. (PMID: 20110259) Shao Y. … Li F. (Nucleic Acids Res. 2010) 3 4 64
  5. Identification and expression analysis of a novel CW-type zinc finger protein MORC2 in cancer cells. (PMID: 20225202) Wang G.L. … Li F. (Anat. Rec. 2010) 3 4 64

Products for MORC2 Gene

Sources for MORC2 Gene

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