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Aliases for LMTK2 Gene

Aliases for LMTK2 Gene

  • Lemur Tyrosine Kinase 2 2 3 4
  • Apoptosis-Associated Tyrosine Kinase 2 3 4
  • Serine/Threonine-Protein Kinase KPI-2 3 4
  • Kinase/Phosphatase/Inhibitor 2 3 4
  • CDK5/P35-Regulated Kinase 3 4
  • Brain-Enriched Kinase 3 4
  • EC 4 63
  • AATYK2 3 4
  • HBREK 3 4
  • Cprk 3 4
  • BREK 3 4
  • KPI2 3 4
  • LMR2 3 4
  • Cyclin-Dependent Kinase 5/P35-Regulated Kinase 3
  • Protein Phosphatase 1, Regulatory Subunit 100 3
  • Kinase Phosphatase Inhibitor 2 3
  • Regulatory Subunit 100 2
  • Protein Phosphatase 1 2
  • EC 2.7.11 63
  • PPP1R100 3
  • KIAA1079 4
  • KPI-2 3

External Ids for LMTK2 Gene

Previous GeneCards Identifiers for LMTK2 Gene

  • GC07P097347
  • GC07P097380
  • GC07P097574
  • GC07P097736
  • GC07P092337

Summaries for LMTK2 Gene

Entrez Gene Summary for LMTK2 Gene

  • The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]

GeneCards Summary for LMTK2 Gene

LMTK2 (Lemur Tyrosine Kinase 2) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Akt Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AATK.

UniProtKB/Swiss-Prot for LMTK2 Gene

  • Phosphorylates PPP1C, phosphorylase b and CFTR

Gene Wiki entry for LMTK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMTK2 Gene

Genomics for LMTK2 Gene

Regulatory Elements for LMTK2 Gene

Genomic Location for LMTK2 Gene

98,106,875 bp from pter
98,209,636 bp from pter
102,762 bases
Plus strand

Genomic View for LMTK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LMTK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMTK2 Gene

Proteins for LMTK2 Gene

  • Protein details for LMTK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase LMTK2
    Protein Accession:
    Secondary Accessions:
    • A4D272
    • Q75MG7
    • Q9UPS3

    Protein attributes for LMTK2 Gene

    1503 amino acids
    Molecular mass:
    164900 Da
    Quaternary structure:
    • Interacts with PPP1C and inhibitor-2.
    • Sequence=BAA83031.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LMTK2 Gene

Proteomics data for LMTK2 Gene at MOPED

Selected DME Specific Peptides for LMTK2 Gene

Post-translational modifications for LMTK2 Gene

Other Protein References for LMTK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for LMTK2 Gene

Suggested Antigen Peptide Sequences for LMTK2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
genes like me logo Genes that share domains with LMTK2: view

Function for LMTK2 Gene

Molecular function for LMTK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function:
Phosphorylates PPP1C, phosphorylase b and CFTR

Enzyme Numbers (IUBMB) for LMTK2 Gene

Gene Ontology (GO) - Molecular Function for LMTK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 12393858
GO:0004864 protein phosphatase inhibitor activity IDA 12393858
GO:0005515 protein binding IPI 12393858
GO:0005524 ATP binding NAS 12393858
genes like me logo Genes that share ontologies with LMTK2: view
genes like me logo Genes that share phenotypes with LMTK2: view

Animal Models for LMTK2 Gene

MGI Knock Outs for LMTK2:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LMTK2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for LMTK2 Gene

Localization for LMTK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LMTK2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for LMTK2 Gene COMPARTMENTS Subcellular localization image for LMTK2 gene
Compartment Confidence
endosome 5
golgi apparatus 5
nucleus 3
cytoskeleton 2
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for LMTK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IDA 18029400
GO:0005794 Golgi apparatus IDA 12832520
GO:0016021 integral component of membrane IDA 12393858
GO:0048471 perinuclear region of cytoplasm IDA 12832520
GO:0055037 recycling endosome IDA 18029400
genes like me logo Genes that share ontologies with LMTK2: view

Pathways & Interactions for LMTK2 Gene

genes like me logo Genes that share pathways with LMTK2: view

Pathways by source for LMTK2 Gene

SIGNOR curated interactions for LMTK2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for LMTK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001881 receptor recycling IMP 18029400
GO:0006468 protein phosphorylation IDA 12393858
GO:0018105 peptidyl-serine phosphorylation IDA 16887929
GO:0018107 peptidyl-threonine phosphorylation IDA 16887929
GO:0032456 endocytic recycling IMP 18029400
genes like me logo Genes that share ontologies with LMTK2: view

Drugs & Compounds for LMTK2 Gene

(1) Drugs for LMTK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for LMTK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with LMTK2: view

Transcripts for LMTK2 Gene

mRNA/cDNA for LMTK2 Gene

Unigene Clusters for LMTK2 Gene

Lemur tyrosine kinase 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LMTK2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LMTK2 Gene

No ASD Table

Relevant External Links for LMTK2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LMTK2 Gene

mRNA expression in normal human tissues for LMTK2 Gene

Protein differential expression in normal tissues from HIPED for LMTK2 Gene

This gene is overexpressed in Adrenal (42.7) and Heart (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LMTK2 Gene

SOURCE GeneReport for Unigene cluster for LMTK2 Gene Hs.444179

mRNA Expression by UniProt/SwissProt for LMTK2 Gene

Tissue specificity: Mainly expressed in skeletal muscle, and weakly in brain and pancreas.
genes like me logo Genes that share expression patterns with LMTK2: view

Protein tissue co-expression partners for LMTK2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LMTK2 Gene

Orthologs for LMTK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LMTK2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LMTK2 35
  • 79.09 (n)
  • 76.93 (a)
LMTK2 36
  • 74 (a)
(Canis familiaris)
Mammalia LMTK2 35
  • 83.79 (n)
  • 83.88 (a)
LMTK2 36
  • 80 (a)
(Mus musculus)
Mammalia Lmtk2 35
  • 78.99 (n)
  • 77.91 (a)
Lmtk2 16
Lmtk2 36
  • 74 (a)
(Pan troglodytes)
Mammalia LMTK2 35
  • 99.36 (n)
  • 99.33 (a)
LMTK2 36
  • 93 (a)
(Rattus norvegicus)
Mammalia Lmtk2 35
  • 77.7 (n)
  • 74.21 (a)
(Monodelphis domestica)
Mammalia LMTK2 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
-- 36
  • 83 (a)
(Gallus gallus)
Aves LMTK2 35
  • 63.08 (n)
  • 59.26 (a)
LMTK2 36
  • 55 (a)
(Anolis carolinensis)
Reptilia LMTK2 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lmtk2 35
  • 61.15 (n)
  • 57.62 (a)
(Danio rerio)
Actinopterygii lmtk2 36
  • 42 (a)
Species with no ortholog for LMTK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LMTK2 Gene

Gene Tree for LMTK2 (if available)
Gene Tree for LMTK2 (if available)

Paralogs for LMTK2 Gene

Paralogs for LMTK2 Gene

(3) SIMAP similar genes for LMTK2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LMTK2: view

Variants for LMTK2 Gene

Sequence variations from dbSNP and Humsavar for LMTK2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs884896 -- 98,168,654(+) GCTAT(A/G)TAAAG intron-variant
rs884897 -- 98,168,805(+) ATCTA(A/G)TGTCC intron-variant
rs903593 -- 98,203,211(-) ggcac(C/T)gccct intron-variant
rs951987 -- 98,133,083(+) AAATG(A/G)AAACT intron-variant
rs951988 -- 98,133,162(+) CCAGA(C/G)CTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LMTK2 Gene

Variant ID Type Subtype PubMed ID
nsv831066 CNV Loss 17160897
esv2734865 CNV Deletion 23290073
esv1940302 CNV Deletion 18987734
esv2734866 CNV Deletion 23290073
esv275549 CNV Complex 21479260
nsv5859 CNV Insertion 18451855
nsv888760 CNV Loss 21882294
dgv7395n71 CNV Loss 21882294
nsv888762 CNV Loss 21882294
nsv888763 CNV Loss 21882294
nsv888765 CNV Gain 21882294

Variation tolerance for LMTK2 Gene

Residual Variation Intolerance Score: 40.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.01; 92.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LMTK2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMTK2 Gene

Disorders for LMTK2 Gene

Relevant External Links for LMTK2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LMTK2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LMTK2 Gene

Publications for LMTK2 Gene

  1. Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling. (PMID: 15005709) Kawa S. … Yamamoto T. (Genes Cells 2004) 2 67
  2. A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2. (PMID: 12393858) Wang H. … Brautigan D.L. (J. Biol. Chem. 2002) 23 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  5. LMTK2-mediated phosphorylation regulates CFTR endocytosis in human airway epithelial cells. (PMID: 24727471) Luz S. … Swiatecka-Urban A. (J. Biol. Chem. 2014) 67

Products for LMTK2 Gene

Sources for LMTK2 Gene

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