Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LMTK2 Gene

Aliases for LMTK2 Gene

  • Lemur Tyrosine Kinase 2 2 3 4 5
  • Apoptosis-Associated Tyrosine Kinase 2 3 4
  • Serine/Threonine-Protein Kinase KPI-2 3 4
  • Kinase/Phosphatase/Inhibitor 2 3 4
  • CDK5/P35-Regulated Kinase 3 4
  • Brain-Enriched Kinase 3 4
  • EC 2.7.11.1 4 63
  • AATYK2 3 4
  • HBREK 3 4
  • Cprk 3 4
  • BREK 3 4
  • KPI2 3 4
  • LMR2 3 4
  • Cyclin-Dependent Kinase 5/P35-Regulated Kinase 3
  • Protein Phosphatase 1, Regulatory Subunit 100 3
  • Kinase Phosphatase Inhibitor 2 3
  • Regulatory Subunit 100 2
  • Protein Phosphatase 1 2
  • EC 2.7.11 63
  • PPP1R100 3
  • KIAA1079 4
  • KPI-2 3

External Ids for LMTK2 Gene

Previous GeneCards Identifiers for LMTK2 Gene

  • GC07P097347
  • GC07P097380
  • GC07P097574
  • GC07P097736
  • GC07P092337

Summaries for LMTK2 Gene

Entrez Gene Summary for LMTK2 Gene

  • The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]

GeneCards Summary for LMTK2 Gene

LMTK2 (Lemur Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with LMTK2 include Prostate Cancer Susceptibility. Among its related pathways are ERK Signaling and GPCR Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AATK.

UniProtKB/Swiss-Prot for LMTK2 Gene

  • Phosphorylates PPP1C, phosphorylase b and CFTR.

Gene Wiki entry for LMTK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMTK2 Gene

Genomics for LMTK2 Gene

Regulatory Elements for LMTK2 Gene

Enhancers for LMTK2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LMTK2 on UCSC Golden Path with GeneCards custom track

Promoters for LMTK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LMTK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for LMTK2 Gene

Chromosome:
7
Start:
98,106,875 bp from pter
End:
98,209,636 bp from pter
Size:
102,762 bases
Orientation:
Plus strand

Genomic View for LMTK2 Gene

Genes around LMTK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMTK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMTK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMTK2 Gene

Proteins for LMTK2 Gene

  • Protein details for LMTK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWU2-LMTK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase LMTK2
    Protein Accession:
    Q8IWU2
    Secondary Accessions:
    • A4D272
    • Q75MG7
    • Q9UPS3

    Protein attributes for LMTK2 Gene

    Size:
    1503 amino acids
    Molecular mass:
    164900 Da
    Quaternary structure:
    • Interacts with PPP1C and inhibitor-2.
    SequenceCaution:
    • Sequence=BAA83031.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LMTK2 Gene

Proteomics data for LMTK2 Gene at MOPED

Selected DME Specific Peptides for LMTK2 Gene

Post-translational modifications for LMTK2 Gene

Other Protein References for LMTK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for KPI2

Domains & Families for LMTK2 Gene

Suggested Antigen Peptide Sequences for LMTK2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IWU2

UniProtKB/Swiss-Prot:

LMTK2_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
genes like me logo Genes that share domains with LMTK2: view

Function for LMTK2 Gene

Molecular function for LMTK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Phosphorylates PPP1C, phosphorylase b and CFTR.

Enzyme Numbers (IUBMB) for LMTK2 Gene

Gene Ontology (GO) - Molecular Function for LMTK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IDA 12393858
GO:0004864 protein phosphatase inhibitor activity IDA 12393858
genes like me logo Genes that share ontologies with LMTK2: view
genes like me logo Genes that share phenotypes with LMTK2: view

Animal Models for LMTK2 Gene

MGI Knock Outs for LMTK2:

Animal Model Products

  • Taconic Biosciences Mouse Models for LMTK2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LMTK2 Gene

Localization for LMTK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LMTK2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LMTK2 Gene COMPARTMENTS Subcellular localization image for LMTK2 gene
Compartment Confidence
endosome 5
golgi apparatus 5
nucleus 3
plasma membrane 3
cytoskeleton 2
cytosol 2
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for LMTK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IMP 18429820
genes like me logo Genes that share ontologies with LMTK2: view

Pathways & Interactions for LMTK2 Gene

genes like me logo Genes that share pathways with LMTK2: view

SIGNOR curated interactions for LMTK2 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for LMTK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018105 peptidyl-serine phosphorylation IDA 16887929
GO:0018107 peptidyl-threonine phosphorylation IDA 16887929
GO:0043086 negative regulation of catalytic activity IDA 12393858
GO:0046777 protein autophosphorylation IDA 12393858
genes like me logo Genes that share ontologies with LMTK2: view

Drugs & Compounds for LMTK2 Gene

(1) Drugs for LMTK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for LMTK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with LMTK2: view

Transcripts for LMTK2 Gene

mRNA/cDNA for LMTK2 Gene

Unigene Clusters for LMTK2 Gene

Lemur tyrosine kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LMTK2 Gene

No ASD Table

Relevant External Links for LMTK2 Gene

GeneLoc Exon Structure for
LMTK2
ECgene alternative splicing isoforms for
LMTK2

Expression for LMTK2 Gene

mRNA expression in normal human tissues for LMTK2 Gene

Protein differential expression in normal tissues from HIPED for LMTK2 Gene

This gene is overexpressed in Adrenal (42.7) and Heart (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LMTK2 Gene



SOURCE GeneReport for Unigene cluster for LMTK2 Gene Hs.444179

mRNA Expression by UniProt/SwissProt for LMTK2 Gene

Q8IWU2-LMTK2_HUMAN
Tissue specificity: Mainly expressed in skeletal muscle, and weakly in brain and pancreas.
genes like me logo Genes that share expression patterns with LMTK2: view

Protein tissue co-expression partners for LMTK2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LMTK2 Gene

Orthologs for LMTK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LMTK2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LMTK2 35
  • 79.09 (n)
  • 76.93 (a)
LMTK2 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LMTK2 35
  • 83.79 (n)
  • 83.88 (a)
LMTK2 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lmtk2 35
  • 78.99 (n)
  • 77.91 (a)
Lmtk2 16
Lmtk2 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LMTK2 35
  • 99.36 (n)
  • 99.33 (a)
LMTK2 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lmtk2 35
  • 77.7 (n)
  • 74.21 (a)
oppossum
(Monodelphis domestica)
Mammalia LMTK2 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
chicken
(Gallus gallus)
Aves LMTK2 35
  • 63.08 (n)
  • 59.26 (a)
LMTK2 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LMTK2 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lmtk2 35
  • 61.15 (n)
  • 57.62 (a)
zebrafish
(Danio rerio)
Actinopterygii lmtk2 36
  • 42 (a)
OneToOne
Species with no ortholog for LMTK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LMTK2 Gene

ENSEMBL:
Gene Tree for LMTK2 (if available)
TreeFam:
Gene Tree for LMTK2 (if available)

Paralogs for LMTK2 Gene

Paralogs for LMTK2 Gene

(3) SIMAP similar genes for LMTK2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LMTK2: view

Variants for LMTK2 Gene

Sequence variations from dbSNP and Humsavar for LMTK2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs3735252 - 98,107,265(+) CACTT(C/G)CGCAA reference, missense
rs11765552 - 98,192,803(+) CAGGC(A/G/T)TGTCT reference, missense
rs3801295 - 98,193,646(+) CGGGC(A/G)ATGGC reference, missense
VAR_041727 A lung large cell carcinoma sample
rs34461195 - 98,192,248(+) GGAGC(A/G)TTGAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for LMTK2 Gene

Variant ID Type Subtype PubMed ID
nsv831066 CNV Loss 17160897
esv2734865 CNV Deletion 23290073
esv1940302 CNV Deletion 18987734
esv2734866 CNV Deletion 23290073
esv275549 CNV Complex 21479260
nsv5859 CNV Insertion 18451855
nsv888760 CNV Loss 21882294
dgv7395n71 CNV Loss 21882294
nsv888762 CNV Loss 21882294
nsv888763 CNV Loss 21882294
nsv888765 CNV Gain 21882294

Variation tolerance for LMTK2 Gene

Residual Variation Intolerance Score: 40.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.01; 92.07% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LMTK2 Gene

Disorders for LMTK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LMTK2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
prostate cancer susceptibility
- elite association - COSMIC cancer census association via MalaCards
Search LMTK2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LMTK2

Genetic Association Database (GAD)
LMTK2
Human Genome Epidemiology (HuGE) Navigator
LMTK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LMTK2
genes like me logo Genes that share disorders with LMTK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LMTK2 Gene

Publications for LMTK2 Gene

  1. Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling. (PMID: 15005709) Kawa S. … Yamamoto T. (Genes Cells 2004) 2 3 4 67
  2. A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2. (PMID: 12393858) Wang H. … Brautigan D.L. (J. Biol. Chem. 2002) 3 23
  3. Lemur Tyrosine Kinase 2, a novel target in prostate cancer therapy. (PMID: 26008968) Shah K. … Bradbury N.A. (Oncotarget 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for LMTK2 Gene

Sources for LMTK2 Gene

Content