Aliases for LMTK2 Gene
External Ids for LMTK2 Gene
The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]
GeneCards Summary for LMTK2 Gene
LMTK2 (Lemur Tyrosine Kinase 2) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Akt Signaling. GO annotations related to this gene include protein serine/threonine kinase activity and protein phosphatase inhibitor activity. An important paralog of this gene is AATK.
UniProtKB/Swiss-Prot for LMTK2 Gene
Phosphorylates PPP1C, phosphorylase b and CFTR