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Aliases for COPG1 Gene

Aliases for COPG1 Gene

  • Coatomer Protein Complex Subunit Gamma 1 2 3 5
  • Coatomer Protein Complex, Subunit Gamma 1 2 3
  • Coat Protein Gamma-Cop 2 3
  • Gamma-1-Coat Protein 3 4
  • Gamma-1-COP 3 4
  • COPG 3 4
  • Coatomer Protein Complex, Subunit Gamma 2
  • Coatomer Subunit Gamma 3
  • Gamma-Coat Protein 3
  • Gamma-COP 3

External Ids for COPG1 Gene

Previous HGNC Symbols for COPG1 Gene

  • COPG

Previous GeneCards Identifiers for COPG1 Gene

  • GC03P128969
  • GC03P128970
  • GC03P129056

Summaries for COPG1 Gene

GeneCards Summary for COPG1 Gene

COPG1 (Coatomer Protein Complex Subunit Gamma 1) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF). GO annotations related to this gene include binding and structural molecule activity. An important paralog of this gene is COPG2.

UniProtKB/Swiss-Prot for COPG1 Gene

  • The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity).

Gene Wiki entry for COPG1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPG1 Gene

Genomics for COPG1 Gene

Regulatory Elements for COPG1 Gene

Promoters for COPG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COPG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for COPG1 Gene

Chromosome:
3
Start:
129,249,575 bp from pter
End:
129,277,773 bp from pter
Size:
28,199 bases
Orientation:
Plus strand

Genomic View for COPG1 Gene

Genes around COPG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COPG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COPG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPG1 Gene

Proteins for COPG1 Gene

  • Protein details for COPG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y678-COPG1_HUMAN
    Recommended name:
    Coatomer subunit gamma-1
    Protein Accession:
    Q9Y678
    Secondary Accessions:
    • A8K6M8
    • B3KMF6
    • Q54AC4

    Protein attributes for COPG1 Gene

    Size:
    874 amino acids
    Molecular mass:
    97718 Da
    Quaternary structure:
    • Oligomeric complex that consists of at least the alpha, beta, beta, gamma, delta, epsilon and zeta subunits. Interacts with ZNF289/ARFGAP2 through its C-terminal appendage domain. Interacts with EGFR upon EGF treatment; interaction is essential for regulation of EGF-dependent nuclear transport of EGFR by retrograde trafficking from the Golgi to the ER. Interacts with COPB1. Interacts with TMED10 (via C-terminus). Interacts with TMED2, TMED3, TMED7 and TMED9.

    Three dimensional structures from OCA and Proteopedia for COPG1 Gene

neXtProt entry for COPG1 Gene

Proteomics data for COPG1 Gene at MOPED

Post-translational modifications for COPG1 Gene

  • Ubiquitination at Lys 514, Lys 540, and Lys 572
  • Modification sites at PhosphoSitePlus

Other Protein References for COPG1 Gene

No data available for DME Specific Peptides for COPG1 Gene

Domains & Families for COPG1 Gene

Suggested Antigen Peptide Sequences for COPG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y678

UniProtKB/Swiss-Prot:

COPG1_HUMAN :
  • Belongs to the COPG family.
  • Contains 4 HEAT repeats.
Family:
  • Belongs to the COPG family.
Similarity:
  • Contains 4 HEAT repeats.
genes like me logo Genes that share domains with COPG1: view

No data available for Gene Families for COPG1 Gene

Function for COPG1 Gene

Molecular function for COPG1 Gene

UniProtKB/Swiss-Prot Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity).
genes like me logo Genes that share phenotypes with COPG1: view

Animal Models for COPG1 Gene

MGI Knock Outs for COPG1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for COPG1 Gene

Localization for COPG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPG1 Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Predominantly located in the cis-Golgi apparatus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COPG1 Gene COMPARTMENTS Subcellular localization image for COPG1 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for COPG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with COPG1: view

Pathways & Interactions for COPG1 Gene

genes like me logo Genes that share pathways with COPG1: view

Gene Ontology (GO) - Biological Process for COPG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048205 COPI coating of Golgi vesicle TAS --
genes like me logo Genes that share ontologies with COPG1: view

No data available for SIGNOR curated interactions for COPG1 Gene

Drugs & Compounds for COPG1 Gene

(2) Drugs for COPG1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-(Dimethylarsenic)Cysteine Experimental Pharma Target 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with COPG1: view

Transcripts for COPG1 Gene

Unigene Clusters for COPG1 Gene

Coatomer protein complex, subunit gamma 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COPG1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - - -
SP2:
SP3:
SP4:
SP5: -
SP6:

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for COPG1 Gene

GeneLoc Exon Structure for
COPG1
ECgene alternative splicing isoforms for
COPG1

Expression for COPG1 Gene

mRNA expression in normal human tissues for COPG1 Gene

Protein differential expression in normal tissues from HIPED for COPG1 Gene

This gene is overexpressed in Salivary gland (7.8) and Breast (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COPG1 Gene



SOURCE GeneReport for Unigene cluster for COPG1 Gene Hs.518250

genes like me logo Genes that share expression patterns with COPG1: view

Protein tissue co-expression partners for COPG1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COPG1 Gene

Orthologs for COPG1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COPG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COPG1 35
  • 99.54 (n)
  • 99.77 (a)
COPG1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COPG1 36
  • 97 (a)
OneToOne
COPG1 35
  • 88.63 (n)
  • 97.25 (a)
dog
(Canis familiaris)
Mammalia COPG1 35
  • 92.6 (n)
  • 98.63 (a)
COPG1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Copg1 16
Copg1 35
  • 89.17 (n)
  • 97.25 (a)
Copg1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COPG1 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COPG1 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Copg1 35
  • 89.32 (n)
  • 97.14 (a)
chicken
(Gallus gallus)
Aves COPG 36
  • 93 (a)
OneToOne
COPG 35
  • 82.07 (n)
  • 93.36 (a)
lizard
(Anolis carolinensis)
Reptilia COPG1 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68533 35
tropical clawed frog
(Silurana tropicalis)
Amphibia copg1 35
  • 77.73 (n)
  • 89.13 (a)
MGC76032 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13885 35
zebrafish
(Danio rerio)
Actinopterygii copg2 35
fruit fly
(Drosophila melanogaster)
Insecta gammaCop 36
  • 59 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T14G10.5 36
  • 52 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC21 36
  • 29 (a)
OneToMany
SEC21 38
rice
(Oryza sativa)
Liliopsida Os.7984 35
wheat
(Triticum aestivum)
Liliopsida Ta.14195 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4468 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
ManyToMany
CSA.452 36
  • 72 (a)
ManyToMany
Species with no ortholog for COPG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for COPG1 Gene

ENSEMBL:
Gene Tree for COPG1 (if available)
TreeFam:
Gene Tree for COPG1 (if available)

Paralogs for COPG1 Gene

Paralogs for COPG1 Gene

(3) SIMAP similar genes for COPG1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with COPG1: view

Variants for COPG1 Gene

Sequence variations from dbSNP and Humsavar for COPG1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_054039 -
rs6439159 -- 129,253,315(+) TAAGC(A/G)ATTCA intron-variant
rs6439160 -- 129,261,836(+) actct(C/T)gttac intron-variant
rs6762578 -- 129,273,204(+) ttttt(A/G)gtaga intron-variant
rs4927907 -- 129,260,221(-) GCTGA(C/T)ACCCC intron-variant

Variation tolerance for COPG1 Gene

Residual Variation Intolerance Score: 14.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.10; 69.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COPG1 Gene

HapMap Linkage Disequilibrium report
COPG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for COPG1 Gene

Disorders for COPG1 Gene

Relevant External Links for COPG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COPG1

No disorders were found for COPG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COPG1 Gene

Publications for COPG1 Gene

  1. Identification and characterization of novel isoforms of COP I subunits. (PMID: 11056392) Futatsumori M. … Nakayama K. (J. Biochem. 2000) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for COPG1 Gene

Sources for COPG1 Gene

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