Aliases for XRN2 Gene
External Ids for XRN2 Gene
Previous GeneCards Identifiers for XRN2 Gene
This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript variants encoding different isoforms have been noted for this gene; however, their full-length nature is not known. [provided by RefSeq, Jul 2008]
GeneCards Summary for XRN2 Gene
XRN2 (5'-3' Exoribonuclease 2) is a Protein Coding gene. Diseases associated with XRN2 include amyotrophic lateral sclerosis type 4. Among its related pathways are Transport to the Golgi and subsequent modification and Translational Control. GO annotations related to this gene include nucleic acid binding and nuclease activity.
UniProtKB/Swiss-Prot for XRN2 Gene
Possesses 5->3 exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5 fragment which is subsequently processed to form the mature mRNA and a 3 fragment which remains attached to the elongating polymerase. The processive degradation of this 3 fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224).