Aliases for XRN2 Gene
External Ids for XRN2 Gene
Previous GeneCards Identifiers for XRN2 Gene
This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
GeneCards Summary for XRN2 Gene
XRN2 (5'-3' Exoribonuclease 2) is a Protein Coding gene. Diseases associated with XRN2 include amyotrophic lateral sclerosis type 4 and setx. Among its related pathways are Ribosome biogenesis in eukaryotes and Deadenylation-dependent mRNA decay. GO annotations related to this gene include nucleic acid binding and nuclease activity.
UniProtKB/Swiss-Prot for XRN2 Gene
Possesses 5->3 exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5 fragment which is subsequently processed to form the mature mRNA and a 3 fragment which remains attached to the elongating polymerase. The processive degradation of this 3 fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224).