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Aliases for RRAS2 Gene

Aliases for RRAS2 Gene

  • Related RAS Viral (R-Ras) Oncogene Homolog 2 2 3
  • TC21 3 4 6
  • Teratocarcinoma Oncogene 3 4
  • Ras-Like Protein TC21 3 4
  • Ras-Related Protein R-Ras2 3

External Ids for RRAS2 Gene

Summaries for RRAS2 Gene

Entrez Gene Summary for RRAS2 Gene

  • This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

GeneCards Summary for RRAS2 Gene

RRAS2 (Related RAS Viral (R-Ras) Oncogene Homolog 2) is a Protein Coding gene. Diseases associated with RRAS2 include teratocarcinoma and ovarian cancer, somatic. Among its related pathways are MAPK signaling pathway and GPCR Pathway. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is HRAS.

UniProtKB/Swiss-Prot for RRAS2 Gene

  • It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion

Gene Wiki entry for RRAS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRAS2 Gene

Genomics for RRAS2 Gene

Genomic Location for RRAS2 Gene

Start:
14,277,920 bp from pter
End:
14,364,506 bp from pter
Size:
86,587 bases
Orientation:
Minus strand

Genomic View for RRAS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RRAS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRAS2 Gene

Regulatory Elements for RRAS2 Gene

Proteins for RRAS2 Gene

  • Protein details for RRAS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62070-RRAS2_HUMAN
    Recommended name:
    Ras-related protein R-Ras2
    Protein Accession:
    P62070
    Secondary Accessions:
    • B2R9Z3
    • B7Z5Z2
    • B7Z6C4
    • B7Z7H6
    • P17082

    Protein attributes for RRAS2 Gene

    Size:
    204 amino acids
    Molecular mass:
    23400 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA36545.1; Type=Frameshift; Positions=4, 8, 12; Evidence={ECO:0000305}; Sequence=AAM12638.1; Type=Frameshift; Positions=4, 8, 12; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RRAS2 Gene

    Alternative splice isoforms for RRAS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RRAS2 Gene

Proteomics data for RRAS2 Gene at MOPED

Post-translational modifications for RRAS2 Gene

  • May be post-translationally modified by both palmitoylation and polyisoprenylation
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RRAS2 Gene

Domains for RRAS2 Gene

UniProtKB/Swiss-Prot:

RRAS2_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Ras family.:
    • P62070
genes like me logo Genes that share domains with RRAS2: view

No data available for Gene Families for RRAS2 Gene

Function for RRAS2 Gene

Molecular function for RRAS2 Gene

UniProtKB/Swiss-Prot Function: It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion

Gene Ontology (GO) - Molecular Function for RRAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 10777492
GO:0005515 protein binding IPI 12620389
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RRAS2: view
genes like me logo Genes that share phenotypes with RRAS2: view

Animal Models for RRAS2 Gene

MGI Knock Outs for RRAS2:

miRNA for RRAS2 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RRAS2 Gene

Localization for RRAS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRAS2 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RRAS2 Gene COMPARTMENTS Subcellular localization image for RRAS2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RRAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005783 endoplasmic reticulum NAS 10777492
GO:0005886 plasma membrane IEA --
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane IDA 16210410
genes like me logo Genes that share ontologies with RRAS2: view

Pathways for RRAS2 Gene

genes like me logo Genes that share pathways with RRAS2: view

Pathways by source for RRAS2 Gene

Gene Ontology (GO) - Biological Process for RRAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IDA 16210410
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RRAS2: view

Compounds for RRAS2 Gene

(1) HMDB Compounds for RRAS2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(7) Novoseek inferred chemical compound relationships for RRAS2 Gene

Compound -log(P) Hits PubMed IDs
gdp 58.5 2
tetrapeptide 52.3 1
gtp 46.9 4
agar 31.8 1
threonine 22.1 1
genes like me logo Genes that share compounds with RRAS2: view

Transcripts for RRAS2 Gene

Unigene Clusters for RRAS2 Gene

Related RAS viral (r-ras) oncogene homolog 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RRAS2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: - -
SP2: -
SP3: -

Relevant External Links for RRAS2 Gene

GeneLoc Exon Structure for
RRAS2
ECgene alternative splicing isoforms for
RRAS2

Expression for RRAS2 Gene

mRNA expression in normal human tissues for RRAS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RRAS2 Gene

SOURCE GeneReport for Unigene cluster for RRAS2 Gene Hs.502004

mRNA Expression by UniProt/SwissProt for RRAS2 Gene

P62070-RRAS2_HUMAN
Tissue specificity: Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas.
genes like me logo Genes that share expressions with RRAS2: view

Orthologs for RRAS2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RRAS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RRAS2 36
  • 98.86 (n)
  • 99.51 (a)
RRAS2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RRAS2 36
  • 95.42 (n)
  • 100 (a)
RRAS2 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RRAS2 36
  • 95.66 (n)
  • 99.41 (a)
RRAS2 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rras2 36
  • 92.97 (n)
  • 100 (a)
Rras2 16
Rras2 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RRAS2 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RRAS2 37
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rras2 36
  • 92.48 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RRAS2 36
  • 86.14 (n)
  • 97.52 (a)
RRAS2 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RRAS2 37
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11640 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9521 36
zebrafish
(Danio rerio)
Actinopterygii rras2 36
  • 79.77 (n)
  • 96.02 (a)
rras2 37
  • 96 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002812 36
  • 63.58 (n)
  • 75.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ras64B 36
  • 62.92 (n)
  • 71.12 (a)
Ras64B 37
  • 69 (a)
OneToMany
Ras64B 38
  • 71 (a)
worm
(Caenorhabditis elegans)
Secernentea ras-1 36
  • 61.08 (n)
  • 63.01 (a)
ras-1 37
  • 56 (a)
OneToMany
C08F8.7 38
  • 45 (a)
ras-1 38
  • 62 (a)
ras-2 38
  • 57 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL262W 36
  • 58.69 (n)
  • 63.8 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAS1 36
  • 63.56 (n)
  • 64.67 (a)
RAS1 37
  • 37 (a)
ManyToMany
RAS1 39
RAS2 37
  • 32 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C13387g 36
  • 63.6 (n)
  • 66.87 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08823 36
  • 61.59 (n)
  • 67.07 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ras1 36
  • 59.17 (n)
  • 63.31 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2254 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 67 (a)
OneToMany
Species with no ortholog for RRAS2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRAS2 Gene

ENSEMBL:
Gene Tree for RRAS2 (if available)
TreeFam:
Gene Tree for RRAS2 (if available)

Paralogs for RRAS2 Gene

Paralogs for RRAS2 Gene

Pseudogenes.org Pseudogenes for RRAS2 Gene

genes like me logo Genes that share paralogs with RRAS2: view

Variants for RRAS2 Gene

Sequence variations from dbSNP and Humsavar for RRAS2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs8570 -- 14,279,213(-) TAGAC(C/G)AAGAA utr-variant-3-prime
rs930160 -- 14,364,576(+) CACGC(C/T)CAAGC upstream-variant-2KB
rs963212 -- 14,303,186(-) ACTTA(C/T)TACTA intron-variant
rs1431374 -- 14,282,429(-) CATCA(A/G)TCAGC intron-variant
rs1431375 -- 14,329,900(+) CTTCA(C/T)CTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RRAS2 Gene

Variant ID Type Subtype PubMed ID
esv990130 CNV Insertion 20482838
esv4848 CNV Deletion 18987735
esv2744128 CNV Deletion 23290073
nsv38548 CNV Loss 16902084
esv990812 CNV Deletion 20482838
esv1753534 CNV Deletion 17803354
esv6194 CNV Loss 19470904
esv25684 CNV Loss 19812545

Relevant External Links for RRAS2 Gene

HapMap Linkage Disequilibrium report
RRAS2

Disorders for RRAS2 Gene

UniProtKB/Swiss-Prot

RRAS2_HUMAN
  • Ovarian cancer (OC) [MIM:167000]: The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. {ECO:0000269 PubMed:8052619}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(2) Novoseek inferred disease relationships for RRAS2 Gene

Disease -log(P) Hits PubMed IDs
tumors 23.4 8
breast cancer 14.6 2

Relevant External Links for RRAS2

Genetic Association Database (GAD)
RRAS2
Human Genome Epidemiology (HuGE) Navigator
RRAS2
genes like me logo Genes that share disorders with RRAS2: view

Publications for RRAS2 Gene

  1. Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line. (PMID: 2108320) Drivas G.T. … D'Eustachio P. (Mol. Cell. Biol. 1990) 2 3 4
  2. A human oncogene of the RAS superfamily unmasked by expression cDNA cloning. (PMID: 8052619) Chan A.M.-L. … Aaronson S.A. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4
  3. A polymorphism in the TC21 promoter associates with an unfavorable tamoxifen treatment outcome in breast cancer. (PMID: 19047159) Rokavec M. … Brauch H. (Cancer Res. 2008) 3 23 49
  4. Essential function for the GTPase TC21 in homeostatic antigen receptor signaling. (PMID: 19561613) Delgado P. … AlarcA^n B. (Nat. Immunol. 2009) 3 23
  5. Structural and spatial determinants regulating TC21 activation by RasGRF family nucleotide exchange factors. (PMID: 19692568) Calvo F. … Crespo P. (Mol. Biol. Cell 2009) 3 23

Products for RRAS2 Gene

Sources for RRAS2 Gene

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