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Aliases for NID2 Gene

Aliases for NID2 Gene

  • Nidogen 2 2 3 5
  • Osteonidogen 2 3 4
  • NID-2 3 4
  • Nidogen 2 (Osteonidogen) 3

External Ids for NID2 Gene

Previous GeneCards Identifiers for NID2 Gene

  • GC14M049794
  • GC14M046267
  • GC14M050461
  • GC14M051541
  • GC14M052471
  • GC14M032632

Summaries for NID2 Gene

Entrez Gene Summary for NID2 Gene

  • This gene encodes a member of the nidogen family of basement membrane proteins. This protein is a cell-adhesion protein that binds collagens I and IV and laminin and may be involved in maintaining the structure of the basement membrane.[provided by RefSeq, Jun 2010]

GeneCards Summary for NID2 Gene

NID2 (Nidogen 2) is a Protein Coding gene. Diseases associated with NID2 include urinary bladder cancer. Among its related pathways are Degradation of the extracellular matrix and Non-integrin membrane-ECM interactions. GO annotations related to this gene include calcium ion binding and collagen binding. An important paralog of this gene is NID1.

UniProtKB/Swiss-Prot for NID2 Gene

  • Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions.

Gene Wiki entry for NID2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NID2 Gene

Genomics for NID2 Gene

Regulatory Elements for NID2 Gene

Enhancers for NID2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NID2 on UCSC Golden Path with GeneCards custom track

Promoters for NID2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NID2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NID2 Gene

Chromosome:
14
Start:
52,004,802 bp from pter
End:
52,069,231 bp from pter
Size:
64,430 bases
Orientation:
Minus strand

Genomic View for NID2 Gene

Genes around NID2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NID2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NID2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NID2 Gene

Proteins for NID2 Gene

  • Protein details for NID2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14112-NID2_HUMAN
    Recommended name:
    Nidogen-2
    Protein Accession:
    Q14112
    Secondary Accessions:
    • A8K6I7
    • B4DU19
    • O43710

    Protein attributes for NID2 Gene

    Size:
    1375 amino acids
    Molecular mass:
    151254 Da
    Quaternary structure:
    • Interacts with LAMA2 (By similarity). Interacts with COL13A1.
    SequenceCaution:
    • Sequence=BAA13087.1; Type=Frameshift; Positions=54, 68, 150, 172; Evidence={ECO:0000305}; Sequence=BAA24112.1; Type=Frameshift; Positions=54, 68, 150, 172; Evidence={ECO:0000305};

    Alternative splice isoforms for NID2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NID2 Gene

Proteomics data for NID2 Gene at MOPED

Post-translational modifications for NID2 Gene

Other Protein References for NID2 Gene

Antibody Products

No data available for DME Specific Peptides for NID2 Gene

Domains & Families for NID2 Gene

Suggested Antigen Peptide Sequences for NID2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14112

UniProtKB/Swiss-Prot:

NID2_HUMAN :
  • Contains 5 EGF-like domains.
  • Contains 5 LDL-receptor class B repeats.
Domain:
  • Contains 5 EGF-like domains.
  • Contains 1 NIDO domain.
  • Contains 1 nidogen G2 beta-barrel domain.
  • Contains 2 thyroglobulin type-1 domains.
Similarity:
  • Contains 5 LDL-receptor class B repeats.
genes like me logo Genes that share domains with NID2: view

No data available for Gene Families for NID2 Gene

Function for NID2 Gene

Molecular function for NID2 Gene

UniProtKB/Swiss-Prot Function:
Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions.

Phenotypes for NID2 Gene

MGI mutant phenotypes for NID2:
inferred from 1 alleles
GenomeRNAi human phenotypes for NID2:
genes like me logo Genes that share phenotypes with NID2: view

Animal Model Products

miRNA for NID2 Gene

miRTarBase miRNAs that target NID2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NID2 Gene

Localization for NID2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NID2 Gene

Secreted, extracellular space, extracellular matrix, basement membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NID2 Gene COMPARTMENTS Subcellular localization image for NID2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for NID2 Gene

Pathways & Interactions for NID2 Gene

genes like me logo Genes that share pathways with NID2: view

Pathways by source for NID2 Gene

2 Reactome pathways for NID2 Gene

Gene Ontology (GO) - Biological Process for NID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007160 cell-matrix adhesion IEA --
genes like me logo Genes that share ontologies with NID2: view

No data available for SIGNOR curated interactions for NID2 Gene

Drugs & Compounds for NID2 Gene

No Compound Related Data Available

Transcripts for NID2 Gene

Unigene Clusters for NID2 Gene

Nidogen 2 (osteonidogen):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NID2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18 ^
SP1: - - - -
SP2:
SP3: - -
SP4:
SP5:
SP6:
SP7:

ExUns: 19a · 19b · 19c ^ 20a · 20b ^ 21a · 21b ^ 22
SP1: - -
SP2:
SP3:
SP4: - -
SP5: -
SP6:
SP7:

Relevant External Links for NID2 Gene

GeneLoc Exon Structure for
NID2
ECgene alternative splicing isoforms for
NID2

Expression for NID2 Gene

mRNA expression in normal human tissues for NID2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NID2 Gene

This gene is overexpressed in Adipocyte (21.0) and Urinary Bladder (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NID2 Gene



SOURCE GeneReport for Unigene cluster for NID2 Gene Hs.369840

mRNA Expression by UniProt/SwissProt for NID2 Gene

Q14112-NID2_HUMAN
Tissue specificity: Heart, placenta and bone. Less in pancreas, kidney and skeletal muscle.
genes like me logo Genes that share expression patterns with NID2: view

Protein tissue co-expression partners for NID2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NID2 Gene

Orthologs for NID2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NID2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia NID2 35
  • 86.81 (n)
  • 84.16 (a)
NID2 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nid2 35
  • 82.76 (n)
  • 82.07 (a)
Nid2 16
Nid2 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NID2 35
  • 99.35 (n)
  • 99.1 (a)
NID2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nid2 35
  • 81.9 (n)
  • 80.63 (a)
cow
(Bos Taurus)
Mammalia NID2 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NID2 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NID2 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves NID2 35
  • 67.29 (n)
  • 67.08 (a)
NID2 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NID2 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nid2 35
  • 58.46 (n)
  • 53.94 (a)
Str.6011 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8084 35
zebrafish
(Danio rerio)
Actinopterygii nid2 35
nid2a 35
  • 58.06 (n)
  • 54.79 (a)
nid2a 36
  • 44 (a)
OneToMany
nid2b 36
  • 44 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ndg 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nid-1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3675 36
  • 35 (a)
OneToMany
Species with no ortholog for NID2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NID2 Gene

ENSEMBL:
Gene Tree for NID2 (if available)
TreeFam:
Gene Tree for NID2 (if available)

Paralogs for NID2 Gene

Paralogs for NID2 Gene

(8) SIMAP similar genes for NID2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NID2: view

Variants for NID2 Gene

Sequence variations from dbSNP and Humsavar for NID2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_035836 A breast cancer sample
rs17124969 - 52,054,151(+) AATTG(C/T)CCTCA reference, missense
rs35657569 - 52,054,028(-) AAAGC(A/C)TTTAG reference, missense
rs17831525 - 52,042,345(+) GTGAG(A/G)TGCCC reference, missense
rs35147930 - 52,038,828(-) TGAAC(A/G/T)TGGAC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NID2 Gene

Variant ID Type Subtype PubMed ID
nsv901947 CNV Gain 21882294
nsv85620 CNV Insertion 16902084
nsv901948 CNV Gain 21882294

Variation tolerance for NID2 Gene

Residual Variation Intolerance Score: 99.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.98; 79.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NID2 Gene

HapMap Linkage Disequilibrium report
NID2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NID2 Gene

Disorders for NID2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NID2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
urinary bladder cancer
  • bladder cancer
- elite association - COSMIC cancer census association via MalaCards
Search NID2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NID2

Genetic Association Database (GAD)
NID2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NID2
genes like me logo Genes that share disorders with NID2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NID2 Gene

Publications for NID2 Gene

  1. Nidogen-2: a new basement membrane protein with diverse binding properties. (PMID: 9733643) Kohfeldt E. … Timpl R. (J. Mol. Biol. 1998) 2 3 4 67
  2. Nidogen 1 and 2 gene promoters are aberrantly methylated in human gastrointestinal cancer. (PMID: 17328794) Ulazzi L. … Negrini M. (Mol. Cancer 2007) 3 23
  3. Epithelial basement membrane proteins perlecan and nidogen-2 are up-regulated in stromal cells after epithelial injury in human corneas. (PMID: 25797478) Torricelli A.A. … Wilson S.E. (Exp. Eye Res. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A genome-wide gene-environment interaction analysis for tobacco smoke and lung cancer susceptibility. (PMID: 24658283) Zhang R. … Chen F. (Carcinogenesis 2014) 3

Products for NID2 Gene

Sources for NID2 Gene

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