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Aliases for FIGF Gene

Aliases for FIGF Gene

  • C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) 2 3 5
  • VEGF-D 3 4
  • VEGFD 3 4
  • C-Fos-Induced Growth Factor 4

External Ids for FIGF Gene

Previous HGNC Symbols for FIGF Gene

  • VEGFD

Previous GeneCards Identifiers for FIGF Gene

  • GC0XM014808
  • GC0XM014189
  • GC0XM014565
  • GC0XM014725
  • GC0XM015123
  • GC0XM015273
  • GC0XM013122

Summaries for FIGF Gene

Entrez Gene Summary for FIGF Gene

  • The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011]

GeneCards Summary for FIGF Gene

FIGF (C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D)) is a Protein Coding gene. Diseases associated with FIGF include breast cancer and lymphangioleiomyomatosis. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include protein homodimerization activity and chemoattractant activity. An important paralog of this gene is VEGFC.

UniProtKB/Swiss-Prot for FIGF Gene

  • Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.

Gene Wiki entry for FIGF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FIGF Gene

Genomics for FIGF Gene

Regulatory Elements for FIGF Gene

Genomic Location for FIGF Gene

Chromosome:
X
Start:
15,345,591 bp from pter
End:
15,384,413 bp from pter
Size:
38,823 bases
Orientation:
Minus strand

Genomic View for FIGF Gene

Genes around FIGF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FIGF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FIGF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FIGF Gene

Proteins for FIGF Gene

  • Protein details for FIGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43915-VEGFD_HUMAN
    Recommended name:
    Vascular endothelial growth factor D
    Protein Accession:
    O43915
    Secondary Accessions:
    • B2R7Z3

    Protein attributes for FIGF Gene

    Size:
    354 amino acids
    Molecular mass:
    40444 Da
    Quaternary structure:
    • Homodimer; non-covalent and antiparallel.

    Three dimensional structures from OCA and Proteopedia for FIGF Gene

neXtProt entry for FIGF Gene

Proteomics data for FIGF Gene at MOPED

Post-translational modifications for FIGF Gene

  • Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.
  • Glycosylation at Asn 155, Asn 185, and Asn 287
  • Modification sites at PhosphoSitePlus

Other Protein References for FIGF Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FIGF Gene

Domains & Families for FIGF Gene

Suggested Antigen Peptide Sequences for FIGF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43915

UniProtKB/Swiss-Prot:

VEGFD_HUMAN :
  • Belongs to the PDGF/VEGF growth factor family.
Family:
  • Belongs to the PDGF/VEGF growth factor family.
genes like me logo Genes that share domains with FIGF: view

No data available for Gene Families for FIGF Gene

Function for FIGF Gene

Molecular function for FIGF Gene

GENATLAS Biochemistry:
c-fos induced growth factor
UniProtKB/Swiss-Prot Function:
Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.

LifeMap Function Summary for FIGF Gene

FIGF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for FIGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005172 vascular endothelial growth factor receptor binding IEA,IPI 9435229
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with FIGF: view
genes like me logo Genes that share phenotypes with FIGF: view

Animal Models for FIGF Gene

MGI Knock Outs for FIGF:

Animal Model Products

miRNA for FIGF Gene

miRTarBase miRNAs that target FIGF

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FIGF Gene

Localization for FIGF Gene

Subcellular locations from UniProtKB/Swiss-Prot for FIGF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FIGF Gene COMPARTMENTS Subcellular localization image for FIGF gene
Compartment Confidence
extracellular 5
cytoskeleton 1
cytosol 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for FIGF Gene

Pathways & Interactions for FIGF Gene

genes like me logo Genes that share pathways with FIGF: view

SIGNOR curated interactions for FIGF Gene

Activates:

Gene Ontology (GO) - Biological Process for FIGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001666 response to hypoxia IEA --
GO:0002576 platelet degranulation TAS --
GO:0007596 blood coagulation TAS --
GO:0008283 cell proliferation IEA --
genes like me logo Genes that share ontologies with FIGF: view

Drugs & Compounds for FIGF Gene

(5) Drugs for FIGF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for FIGF Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FIGF: view

Transcripts for FIGF Gene

mRNA/cDNA for FIGF Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FIGF Gene

C-fos induced growth factor (vascular endothelial growth factor D):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FIGF Gene

No ASD Table

Relevant External Links for FIGF Gene

GeneLoc Exon Structure for
FIGF
ECgene alternative splicing isoforms for
FIGF

Expression for FIGF Gene

mRNA expression in normal human tissues for FIGF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FIGF Gene

This gene is overexpressed in Lung (x7.3), Muscle - Skeletal (x4.5), and Cervix - Ectocervix (x4.4).

Protein differential expression in normal tissues from HIPED for FIGF Gene

This gene is overexpressed in Cerebrospinal fluid (63.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FIGF Gene



SOURCE GeneReport for Unigene cluster for FIGF Gene Hs.11392

mRNA Expression by UniProt/SwissProt for FIGF Gene

O43915-VEGFD_HUMAN
Tissue specificity: Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas.
genes like me logo Genes that share expression patterns with FIGF: view

Protein tissue co-expression partners for FIGF Gene

Primer Products

In Situ Assay Products

Orthologs for FIGF Gene

This gene was present in the common ancestor of chordates.

Orthologs for FIGF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FIGF 35
  • 87.66 (n)
  • 86.16 (a)
FIGF 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FIGF 35
  • 87.38 (n)
  • 87.57 (a)
FIGF 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Figf 35
  • 86.21 (n)
  • 85.27 (a)
Figf 16
Figf 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FIGF 35
  • 99.44 (n)
  • 99.44 (a)
FIGF 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Figf 35
  • 85.47 (n)
  • 86.54 (a)
oppossum
(Monodelphis domestica)
Mammalia FIGF 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FIGF 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves FIGF 35
  • 73.06 (n)
  • 73.06 (a)
FIGF 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FIGF 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia figf 35
  • 63.41 (n)
  • 59.76 (a)
zebrafish
(Danio rerio)
Actinopterygii figf 35
  • 56.28 (n)
  • 49.18 (a)
figf 36
  • 42 (a)
OneToOne
Species with no ortholog for FIGF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FIGF Gene

ENSEMBL:
Gene Tree for FIGF (if available)
TreeFam:
Gene Tree for FIGF (if available)

Paralogs for FIGF Gene

Paralogs for FIGF Gene

(1) SIMAP similar genes for FIGF Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FIGF: view

Variants for FIGF Gene

Structural Variations from Database of Genomic Variants (DGV) for FIGF Gene

Variant ID Type Subtype PubMed ID
nsv528343 CNV Gain 19592680
nsv6813 CNV Loss 18451855

Variation tolerance for FIGF Gene

Residual Variation Intolerance Score: 56.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.35; 41.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FIGF Gene

HapMap Linkage Disequilibrium report
FIGF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for FIGF Gene

Disorders for FIGF Gene

MalaCards: The human disease database

(12) MalaCards diseases for FIGF Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
lymphangioleiomyomatosis
  • lymphangioleiomyomatosis, somatic
congenital lymphedema
  • milroy disease
breast ductal carcinoma
  • duct carcinoma, nos
esophageal cancer
  • esophageal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search FIGF in MalaCards View complete list of genes associated with diseases

Relevant External Links for FIGF

Genetic Association Database (GAD)
FIGF
Human Genome Epidemiology (HuGE) Navigator
FIGF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FIGF
genes like me logo Genes that share disorders with FIGF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FIGF Gene

Publications for FIGF Gene

  1. Human FIGF: cloning, gene structure, and mapping to chromosome Xp22.1 between the PIGA and the GRPR genes. (PMID: 9479493) Rocchigiani M. … Oliviero S. (Genomics 1998) 2 3 4 23 67
  2. [Expression of VEGF-C and VEGF-D in gastric carcinoma and its relationship with lymph node metastases]. (PMID: 20448355) Wang W. … Tang L. (Zhong Nan Da Xue Xue Bao Yi Xue Ban 2010) 3 23
  3. [Expressions of VEGF-C and VEGF-D and their correlation with lymphangiogenesis and angiogenesis in gallbladder carcinoma]. (PMID: 20450586) Jiang L. … Wang X.X. (Zhonghua Zhong Liu Za Zhi 2010) 3 23
  4. Vascular endothelial growth factor D and intratumoral lymphatics as independent prognostic factors in epithelial ovarian carcinoma. (PMID: 19226617) Li L. … Ma J. (Anat Rec (Hoboken) 2009) 3 23
  5. [Relationship between clinicopathologic characteristics and expression of VEGF-C and VEGF-D in esophageal squamous cancer]. (PMID: 19462898) Jiang M. … Hou M. (Sichuan Da Xue Xue Bao Yi Xue Ban 2009) 3 23

Products for FIGF Gene

Sources for FIGF Gene

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