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Aliases for FGF14 Gene

Aliases for FGF14 Gene

  • Fibroblast Growth Factor 14 2 3
  • Fibroblast Growth Factor Homologous Factor 4 3 4
  • FGF-14 3 4
  • FHF-4 3 4
  • FHF4 3 4
  • BA397O8.2 3
  • SCA27 3

External Ids for FGF14 Gene

Previous GeneCards Identifiers for FGF14 Gene

  • GC13M100735
  • GC13M096762
  • GC13M101211
  • GC13M100073
  • GC13M101173
  • GC13M102373
  • GC13M082966

Summaries for FGF14 Gene

Entrez Gene Summary for FGF14 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGF14 Gene

FGF14 (Fibroblast Growth Factor 14) is a Protein Coding gene. Diseases associated with FGF14 include spinocerebellar ataxia type27 and spinocerebellar ataxia 27. Among its related pathways are PI3K-Akt signaling pathway and MAPK signaling pathway. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF22.

UniProtKB/Swiss-Prot for FGF14 Gene

  • Probably involved in nervous system development and function

Gene Wiki entry for FGF14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF14 Gene

Genomics for FGF14 Gene

Regulatory Elements for FGF14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FGF14 Gene

101,710,804 bp from pter
102,402,457 bp from pter
691,654 bases
Minus strand

Genomic View for FGF14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for FGF14 Gene

Proteins for FGF14 Gene

  • Protein details for FGF14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibroblast growth factor 14
    Protein Accession:
    Secondary Accessions:
    • Q86YN7
    • Q96QX6

    Protein attributes for FGF14 Gene

    247 amino acids
    Molecular mass:
    27702 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FGF14 Gene


neXtProt entry for FGF14 Gene

Proteomics data for FGF14 Gene at MOPED

Post-translational modifications for FGF14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FGF14 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FGF14 Gene

Domains & Families for FGF14 Gene

Suggested Antigen Peptide Sequences for FGF14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the heparin-binding growth factors family.
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF14: view

No data available for Gene Families for FGF14 Gene

Function for FGF14 Gene

Molecular function for FGF14 Gene

GENATLAS Biochemistry:
fibroblast growth homologous factor 14,expressed principally in the nervous system
UniProtKB/Swiss-Prot Function:
Probably involved in nervous system development and function

Gene Ontology (GO) - Molecular Function for FGF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005104 NOT fibroblast growth factor receptor binding IDA 12815063
GO:0008083 growth factor activity IEA --
GO:0008201 heparin binding IDA 12815063
genes like me logo Genes that share ontologies with FGF14: view
genes like me logo Genes that share phenotypes with FGF14: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGF14

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FGF14 Gene

Localization for FGF14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF14 Gene

Subcellular locations from

Jensen Localization Image for FGF14 Gene COMPARTMENTS Subcellular localization image for FGF14 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for FGF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005622 intracellular IPI 12815063
GO:0005634 nucleus IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with FGF14: view

Pathways & Interactions for FGF14 Gene

genes like me logo Genes that share pathways with FGF14: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for FGF14 Gene

Gene Ontology (GO) - Biological Process for FGF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0007165 signal transduction TAS 8790420
GO:0007254 JNK cascade IPI 12815063
GO:0007267 cell-cell signaling TAS 8790420
GO:0007268 synaptic transmission --
genes like me logo Genes that share ontologies with FGF14: view

No data available for SIGNOR curated interactions for FGF14 Gene

Drugs & Compounds for FGF14 Gene

(1) Additional Compounds for FGF14 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGF14: view

Transcripts for FGF14 Gene

Unigene Clusters for FGF14 Gene

Fibroblast growth factor 14:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FGF14

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGF14 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11
SP1: - - - - - - - - - -
SP2: - - -
SP4: -

Relevant External Links for FGF14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FGF14 Gene

mRNA expression in normal human tissues for FGF14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF14 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.2), Brain - Nucleus accumbens (basal ganglia) (x4.8), Brain - Frontal Cortex (BA9) (x4.8), Brain - Hypothalamus (x4.7), Brain - Cerebellum (x4.6), and Brain - Anterior cingulate cortex (BA24) (x4.0).

Protein differential expression in normal tissues from HIPED for FGF14 Gene

This gene is overexpressed in Plasma (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGF14 Gene

SOURCE GeneReport for Unigene cluster for FGF14 Gene Hs.508616

mRNA Expression by UniProt/SwissProt for FGF14 Gene

Tissue specificity: Nervous system
genes like me logo Genes that share expression patterns with FGF14: view

Protein tissue co-expression partners for FGF14 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for FGF14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF14 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia FGF14 35
  • 92.98 (n)
  • 91.5 (a)
FGF14 36
  • 85 (a)
(Mus musculus)
Mammalia Fgf14 35
  • 95.01 (n)
  • 98.79 (a)
Fgf14 16
Fgf14 36
  • 98 (a)
(Pan troglodytes)
Mammalia FGF14 35
  • 99.73 (n)
  • 100 (a)
FGF14 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fgf14 35
  • 94.33 (n)
  • 98.79 (a)
(Bos Taurus)
Mammalia -- 36
  • 68 (a)
(Monodelphis domestica)
Mammalia FGF14 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia FGF14 36
  • 98 (a)
(Gallus gallus)
Aves FGF14 36
  • 76 (a)
(Anolis carolinensis)
Reptilia FGF14 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf14 35
  • 85.96 (n)
  • 94.74 (a)
Str.13744 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.32735 35
(Danio rerio)
Actinopterygii fgf14 35
  • 80.85 (n)
  • 91.32 (a)
fgf14 36
  • 72 (a)
Species with no ortholog for FGF14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF14 Gene

Gene Tree for FGF14 (if available)
Gene Tree for FGF14 (if available)

Paralogs for FGF14 Gene

Paralogs for FGF14 Gene

(12) SIMAP similar genes for FGF14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FGF14: view

Variants for FGF14 Gene

Sequence variations from dbSNP and Humsavar for FGF14 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
VAR_022735 -
VAR_022736 Spinocerebellar ataxia 27 (SCA27)

Structural Variations from Database of Genomic Variants (DGV) for FGF14 Gene

Variant ID Type Subtype PubMed ID
nsv832702 CNV Gain 17160897
esv270420 CNV Insertion 20981092
esv2662978 CNV Deletion 23128226
esv2665206 CNV Deletion 23128226
esv2098077 CNV Deletion 18987734
esv2747899 CNV Deletion 23290073
nsv826772 CNV Gain 20364138
esv259790 OTHER Complex 20981092
esv2451556 CNV Deletion 19546169
esv2747900 CNV Deletion 23290073
nsv832704 CNV Gain 17160897
nsv1152 CNV Insertion 18451855
nsv832705 CNV Gain 17160897
nsv1153 CNV Loss 18451855
esv34672 CNV Loss 17911159
esv2662927 CNV Deletion 23128226
nsv456098 CNV Gain 19166990
dgv586e1 CNV Complex 17122850
esv9192 CNV Gain 19470904
esv2747901 CNV Deletion 23290073
nsv832706 CNV Gain 17160897
esv1010266 CNV Deletion 20482838
esv2546035 CNV Deletion 19546169
esv3231 CNV Deletion 18987735
esv2747902 CNV Deletion 23290073
esv1625125 CNV Deletion 17803354
nsv1155 CNV Insertion 18451855
esv2747903 CNV Deletion 23290073
esv2005005 CNV Deletion 18987734
esv3297 CNV Deletion 18987735
nsv63965 CNV Loss 16902084
esv2747904 CNV Deletion 23290073
esv2747905 CNV Deletion 23290073
nsv507730 CNV Insertion 20534489
esv2747906 CNV Deletion 23290073
esv2659511 CNV Deletion 23128226
esv2747908 CNV Deletion 23290073
nsv524907 CNV Loss 19592680
nsv819119 CNV Gain 19587683

Variation tolerance for FGF14 Gene

Residual Variation Intolerance Score: 42.94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGF14 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF14 Gene

Disorders for FGF14 Gene

MalaCards: The human disease database

(6) MalaCards diseases for FGF14 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
spinocerebellar ataxia type27
  • sca27
spinocerebellar ataxia 27
  • cerebellar ataxia autosomal dominant fgf14-related
ladd syndrome
  • lacrimoauriculodentodigital syndrome
spinocerebellar ataxia 17
  • spinocerebellar ataxia type 17
- elite association
Search FGF14 in MalaCards View complete list of genes associated with diseases


  • Spinocerebellar ataxia 27 (SCA27) [MIM:609307]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA27 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly progressive disorder, with onset in late-childhood to early adulthood, characterized by ataxia with tremor, orofacial dyskinesia, psychiatric symptoms and cognitive deficits. {ECO:0000269 PubMed:12489043}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FGF14

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FGF14: view

No data available for Genatlas for FGF14 Gene

Publications for FGF14 Gene

  1. Impaired spatial learning and defective theta burst induced LTP in mice lacking fibroblast growth factor 14. (PMID: 17236779) Wozniak D.F. … Ornitz D.M. (Neurobiol. Dis. 2007) 2 23 67
  2. The Effects of TWEAK, Fn14, and TGF-beta1 on Degeneration of Human Intervertebral Disc. (PMID: 20157375) Huh H. … Choi G. (J Korean Neurosurg Soc 2010) 23 67
  3. Tumor necrosis-like weak inducer of apoptosis as a proinflammatory cytokine in human adipocyte cells: up-regulation in severe obesity is mediated by inflammation but not hypoxia. (PMID: 20382683) Vendrell J. … ChacA^n M.R. (J. Clin. Endocrinol. Metab. 2010) 23 67
  4. Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway. (PMID: 20385556) Brown S.A. … Winkles J.A. (J. Biol. Chem. 2010) 23 67
  5. FGF14 regulates the intrinsic excitability of cerebellar Purkinje neurons. (PMID: 18930825) Shakkottai V.G. … Yamada K.A. (Neurobiol. Dis. 2009) 23 67

Products for FGF14 Gene

Sources for FGF14 Gene

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