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Aliases for MAPK15 Gene

Aliases for MAPK15 Gene

  • Mitogen-Activated Protein Kinase 15 2 3 5
  • Extracellular Signal Regulated Kinase 8 2 3
  • Extracellular Signal-Regulated Kinase 7 3 4
  • Extracellular Signal-Regulated Kinase 8 3 4
  • MAP Kinase 15 3 4
  • EC 4 63
  • MAPK 15 3 4
  • ERK-7 3 4
  • ERK-8 3 4
  • ERK7 3 4
  • ERK8 3 4
  • Extracellular Regulated Kinase 8 Delta 3
  • EC 2.7.11 63

External Ids for MAPK15 Gene

Previous GeneCards Identifiers for MAPK15 Gene

  • GC08P144871
  • GC08P144798
  • GC08P140051

Summaries for MAPK15 Gene

GeneCards Summary for MAPK15 Gene

MAPK15 (Mitogen-Activated Protein Kinase 15) is a Protein Coding gene. Among its related pathways are MAPK Pathway and TNF Signaling (sino). GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.

UniProtKB/Swiss-Prot for MAPK15 Gene

  • In vitro, phosphorylates MBP.

Gene Wiki entry for MAPK15 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK15 Gene

Genomics for MAPK15 Gene

Regulatory Elements for MAPK15 Gene

Enhancers for MAPK15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAPK15 on UCSC Golden Path with GeneCards custom track

Promoters for MAPK15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAPK15 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAPK15 Gene

143,716,259 bp from pter
143,722,463 bp from pter
6,205 bases
Plus strand

Genomic View for MAPK15 Gene

Genes around MAPK15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK15 Gene

Proteins for MAPK15 Gene

  • Protein details for MAPK15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitogen-activated protein kinase 15
    Protein Accession:
    Secondary Accessions:
    • Q2TCF9
    • Q8N362

    Protein attributes for MAPK15 Gene

    544 amino acids
    Molecular mass:
    59832 Da
    Quaternary structure:
    • Interacts with CSK/c-Src, ABL1, RET and TGFB1I1.

    Alternative splice isoforms for MAPK15 Gene


neXtProt entry for MAPK15 Gene

Proteomics data for MAPK15 Gene at MOPED

Selected DME Specific Peptides for MAPK15 Gene

Post-translational modifications for MAPK15 Gene

  • Dually phosphorylated on Thr-175 and Tyr-177, which activates the enzyme. Autophosphorylated on threonine and tyrosine residues in vitro.
  • Ubiquitinated. Ubiquitination may allow its tight kinase activity regulation and rapid turnover. May be ubiquitinated by a SCF E3 ligase (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPK15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for MAPK15 Gene

Protein Domains for MAPK15 Gene

Suggested Antigen Peptide Sequences for MAPK15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The N-terminal region (1-20) is the minimal region necessary for ubiquitination and further proteasomal degradation.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
  • The N-terminal region (1-20) is the minimal region necessary for ubiquitination and further proteasomal degradation.
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK15: view

Function for MAPK15 Gene

Molecular function for MAPK15 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by threonine and tyrosine phosphorylation. Inhibited by dual specificity phosphatases, such as DUSP1 (By similarity).
UniProtKB/Swiss-Prot Function:
In vitro, phosphorylates MBP.

Enzyme Numbers (IUBMB) for MAPK15 Gene

genes like me logo Genes that share phenotypes with MAPK15: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MAPK15

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MAPK15 Gene

Localization for MAPK15 Gene

Subcellular locations from

Jensen Localization Image for MAPK15 Gene COMPARTMENTS Subcellular localization image for MAPK15 gene
Compartment Confidence
extracellular 5
nucleus 4
mitochondrion 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAPK15 Gene

Pathways & Interactions for MAPK15 Gene

genes like me logo Genes that share pathways with MAPK15: view

Pathways by source for MAPK15 Gene

1 Sino Biological pathway for MAPK15 Gene
2 Tocris pathways for MAPK15 Gene

SIGNOR curated interactions for MAPK15 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MAPK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0006468 protein phosphorylation IEA --
GO:0031398 positive regulation of protein ubiquitination IEA --
GO:0032355 response to estradiol IEA --
GO:0046777 protein autophosphorylation IDA 11875070
genes like me logo Genes that share ontologies with MAPK15: view

Drugs & Compounds for MAPK15 Gene

(1) Drugs for MAPK15 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for MAPK15 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MAPK15: view

Transcripts for MAPK15 Gene

Unigene Clusters for MAPK15 Gene

Mitogen-activated protein kinase 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK15 Gene

No ASD Table

Relevant External Links for MAPK15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAPK15 Gene

mRNA expression in normal human tissues for MAPK15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAPK15 Gene

This gene is overexpressed in Fallopian Tube (x6.0), Testis (x4.9), Cervix - Endocervix (x4.4), and Thyroid (x4.2).

Protein differential expression in normal tissues from HIPED for MAPK15 Gene

This gene is overexpressed in Spinal cord (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAPK15 Gene

SOURCE GeneReport for Unigene cluster for MAPK15 Gene Hs.493169

mRNA Expression by UniProt/SwissProt for MAPK15 Gene

Tissue specificity: Widely expressed with a maximal expression in lung and kidney.
genes like me logo Genes that share expression patterns with MAPK15: view

Protein tissue co-expression partners for MAPK15 Gene

Primer Products

Orthologs for MAPK15 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAPK15 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MAPK15 35
  • 78.38 (n)
  • 72.37 (a)
MAPK15 36
  • 72 (a)
(Canis familiaris)
Mammalia MAPK15 35
  • 79.2 (n)
  • 73.15 (a)
MAPK15 36
  • 71 (a)
(Mus musculus)
Mammalia Mapk15 35
  • 76.36 (n)
  • 72.42 (a)
Mapk15 16
Mapk15 36
  • 69 (a)
(Pan troglodytes)
Mammalia MAPK15 35
  • 97.79 (n)
  • 97.02 (a)
MAPK15 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Mapk15 35
  • 75.98 (n)
  • 72.05 (a)
(Monodelphis domestica)
Mammalia MAPK15 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia MAPK15 36
  • 70 (a)
(Gallus gallus)
Aves MAPK15 35
  • 57.16 (n)
  • 52.09 (a)
MAPK15 36
  • 44 (a)
(Anolis carolinensis)
Reptilia MAPK15 36
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk15 35
  • 57.12 (n)
  • 52.54 (a)
(Danio rerio)
Actinopterygii mapk15 35
  • 55.56 (n)
  • 53.65 (a)
mapk15 36
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta Erk7 35
  • 55.02 (n)
  • 47.89 (a)
Erk7 36
  • 22 (a)
(Caenorhabditis elegans)
Secernentea C05D10.2 35
  • 55.27 (n)
  • 58.62 (a)
C05D10.2 36
  • 46 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8827 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
Species with no ortholog for MAPK15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPK15 Gene

Gene Tree for MAPK15 (if available)
Gene Tree for MAPK15 (if available)

Paralogs for MAPK15 Gene

(23) SIMAP similar genes for MAPK15 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MAPK15: view

No data available for Paralogs for MAPK15 Gene

Variants for MAPK15 Gene

Sequence variations from dbSNP and Humsavar for MAPK15 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs60732298 - 143,719,423(+) CGGCA(A/C/T)GTCCA reference, missense
rs56038219 - 143,722,129(+) GCACC(C/T)CTGCC reference, missense, utr-variant-3-prime
rs4072747 -- 143,718,721(+) CCCCC(C/G)AGGTT intron-variant
rs11136319 -- 143,722,756(+) AGGGA(C/T)GTAGG downstream-variant-500B
rs11776672 -- 143,717,295(+) AGGGT(A/G)GGGGC intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MAPK15 Gene

Variant ID Type Subtype PubMed ID
dgv7935n71 CNV Loss 21882294
dgv7938n71 CNV Loss 21882294
dgv7939n71 CNV Loss 21882294
dgv7940n71 CNV Loss 21882294
nsv891747 CNV Loss 21882294
nsv466007 CNV Loss 19166990
nsv519816 CNV Loss 19592680
nsv891751 CNV Loss 21882294
dgv7941n71 CNV Loss 21882294
nsv6441 CNV Insertion 18451855
nsv824777 CNV Loss 20364138
dgv7942n71 CNV Loss 21882294

Variation tolerance for MAPK15 Gene

Residual Variation Intolerance Score: 97.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.03; 75.05% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MAPK15 Gene

Disorders for MAPK15 Gene

Relevant External Links for MAPK15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MAPK15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAPK15 Gene

Publications for MAPK15 Gene

  1. ERK8, a new member of the mitogen-activated protein kinase family. (PMID: 11875070) Abe M.K. … Rosner M.R. (J. Biol. Chem. 2002) 2 3 4 23 67
  2. Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer. (PMID: 20395206) Xu Y.M. … Dong Z. (Cancer Res. 2010) 3 23
  3. Regulation of the activity and expression of ERK8 by DNA damage. (PMID: 19166846) Klevernic I.V. … Cohen P. (FEBS Lett. 2009) 3 23
  4. Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene. (PMID: 16484222) Iavarone C. … Chiariello M. (J. Biol. Chem. 2006) 3 23
  5. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5. (PMID: 16624805) Saelzler M.P. … Abe M.K. (J. Biol. Chem. 2006) 3 23

Products for MAPK15 Gene

Sources for MAPK15 Gene