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Aliases for FGF6 Gene

Aliases for FGF6 Gene

  • Fibroblast Growth Factor 6 2 3 5
  • Heparin Secretory-Transforming Protein 2 3 4
  • Heparin-Binding Growth Factor 6 3 4
  • HBGF-6 3 4
  • HSTF-2 3 4
  • FGF-6 3 4
  • HST-2 3 4
  • HST2 3 4
  • HSTF2 4

External Ids for FGF6 Gene

Previous GeneCards Identifiers for FGF6 Gene

  • GC12M004280
  • GC12M004435
  • GC12M004422
  • GC12M004543

Summaries for FGF6 Gene

Entrez Gene Summary for FGF6 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGF6 Gene

FGF6 (Fibroblast Growth Factor 6) is a Protein Coding gene. Diseases associated with FGF6 include Breast Cancer. Among its related pathways are RET signaling and p70S6K Signaling. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF4.

UniProtKB/Swiss-Prot for FGF6 Gene

  • Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration.

Gene Wiki entry for FGF6 Gene

Additional gene information for FGF6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF6 Gene

Genomics for FGF6 Gene

Regulatory Elements for FGF6 Gene

Enhancers for FGF6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H004414 0.9 Ensembl ENCODE 11.4 +30.5 30455 0.9 L3MBTL2 NRF1 BHLHE40 MNT GATA3 POLR2A IKZF1 FOXP2 RCOR1 FGF6 FGF23 C12orf4 RAD51AP1
GH12H004472 0.8 FANTOM5 ENCODE 12.2 -26.7 -26716 0.4 IKZF1 ETV6 SPI1 FGF6 C12orf4
GH12H004506 0.8 ENCODE 11.4 -61.6 -61603 1.8 ELF3 SOX13 FOXA2 TBL1XR1 SAP130 MLX BATF ZNF644 YY1 EED FGF6 FGF23 C12orf4 RAD51AP1 TIGAR
GH12H004484 0.5 ENCODE 11.1 -39.0 -39036 0.2 ZNF316 ZNF366 HLF PRDM1 MAFK FGF6 C12orf4
GH12H004392 0.5 FANTOM5 11.1 +53.0 52955 0.2 EGR1 NR2F2 FGF6 C12orf4 RAD51AP1 FGF23
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FGF6 on UCSC Golden Path with GeneCards custom track

Genomic Locations for FGF6 Gene

Genomic Locations for FGF6 Gene
17,460 bases
Minus strand

Genomic View for FGF6 Gene

Genes around FGF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF6 Gene

Proteins for FGF6 Gene

  • Protein details for FGF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibroblast growth factor 6
    Protein Accession:
    Secondary Accessions:
    • Q0VAE1

    Protein attributes for FGF6 Gene

    208 amino acids
    Molecular mass:
    22905 Da
    Quaternary structure:
    • Interacts with FGFR1, FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
    • Sequence=CAA40359.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA40360.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FGF6 Gene

Post-translational modifications for FGF6 Gene

  • Glycosylation at posLast=4545
  • Modification sites at PhosphoSitePlus

Other Protein References for FGF6 Gene

No data available for DME Specific Peptides for FGF6 Gene

Domains & Families for FGF6 Gene

Gene Families for FGF6 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for FGF6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the heparin-binding growth factors family.
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF6: view

Function for FGF6 Gene

Molecular function for FGF6 Gene

GENATLAS Biochemistry:
fibroblast growth factor 6,basic,HST oncogene homolog,expressed during embryonic development and in adult testis,heart,skeletal muscle,mitogenic for fibroblasts and endothelial cells
UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration.

Phenotypes From GWAS Catalog for FGF6 Gene

Gene Ontology (GO) - Molecular Function for FGF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005104 fibroblast growth factor receptor binding IEA --
GO:0008083 growth factor activity IEA,TAS --
GO:0016303 1-phosphatidylinositol-3-kinase activity TAS --
genes like me logo Genes that share ontologies with FGF6: view
genes like me logo Genes that share phenotypes with FGF6: view

Animal Models for FGF6 Gene

MGI Knock Outs for FGF6:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FGF6 Gene

Localization for FGF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF6 Gene

Secreted, extracellular space.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGF6 gene
Compartment Confidence
extracellular 5
plasma membrane 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FGF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005622 intracellular IEA --
GO:0042383 sarcolemma IEA --
genes like me logo Genes that share ontologies with FGF6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FGF6 Gene

Pathways & Interactions for FGF6 Gene

SuperPathway Contained pathways
1 RET signaling
2 Downstream signaling of activated FGFR2
3 Apoptotic Pathways in Synovial Fibroblasts
4 GPCR Pathway
5 PI3K/AKT activation
genes like me logo Genes that share pathways with FGF6: view

SIGNOR curated interactions for FGF6 Gene


Gene Ontology (GO) - Biological Process for FGF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001502 cartilage condensation IEA --
GO:0001525 angiogenesis IEA --
GO:0007165 signal transduction TAS 2649847
GO:0007267 cell-cell signaling TAS 2649847
genes like me logo Genes that share ontologies with FGF6: view

Drugs & Compounds for FGF6 Gene

(1) Drugs for FGF6 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist 874,274
genes like me logo Genes that share compounds with FGF6: view

Transcripts for FGF6 Gene

mRNA/cDNA for FGF6 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FGF6 Gene

Fibroblast growth factor 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGF6 Gene

No ASD Table

Relevant External Links for FGF6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FGF6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FGF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF6 Gene

This gene is overexpressed in Muscle - Skeletal (x50.3).

NURSA nuclear receptor signaling pathways regulating expression of FGF6 Gene:


SOURCE GeneReport for Unigene cluster for FGF6 Gene:


mRNA Expression by UniProt/SwissProt for FGF6 Gene:

Tissue specificity: Leukemia cell lines with platelet/ megakaryocytic differentiation potential.

Evidence on tissue expression from TISSUES for FGF6 Gene

  • Muscle(2.4)
genes like me logo Genes that share expression patterns with FGF6: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF6 Gene

Orthologs for FGF6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FGF6 34 33
  • 99.04 (n)
(Canis familiaris)
Mammalia FGF6 34 33
  • 93.59 (n)
(Bos Taurus)
Mammalia FGF6 34 33
  • 89.9 (n)
(Rattus norvegicus)
Mammalia Fgf6 33
  • 89.74 (n)
(Mus musculus)
Mammalia Fgf6 34 16 33
  • 88.62 (n)
(Monodelphis domestica)
Mammalia FGF6 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia FGF6 34
  • 63 (a)
(Gallus gallus)
Aves FGF6 34 33
  • 65.21 (n)
(Anolis carolinensis)
Reptilia FGF6 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf6 33
  • 65.95 (n)
(Danio rerio)
Actinopterygii fgf6b 34
  • 64 (a)
fgf6a 34
  • 63 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.125 34
  • 24 (a)
Species where no ortholog for FGF6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF6 Gene

Gene Tree for FGF6 (if available)
Gene Tree for FGF6 (if available)

Paralogs for FGF6 Gene

Paralogs for FGF6 Gene

(13) SIMAP similar genes for FGF6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FGF6: view

Variants for FGF6 Gene

Sequence variations from dbSNP and Humsavar for FGF6 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000138042 -- 4,435,383(+) CCTGC(C/T)CCTTC intron-variant
rs1000283530 -- 4,444,036(+) TTTAG(A/C)TAGTC intron-variant
rs1001113210 -- 4,446,186(+) CAGGG(A/G)TGGGA upstream-variant-2KB
rs1001302295 -- 4,439,421(+) ATCTT(A/G)AGGTG intron-variant, utr-variant-3-prime
rs1001366457 -- 4,440,738(+) GCATA(A/G)GGGCA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FGF6 Gene

Variant ID Type Subtype PubMed ID
nsv585 CNV deletion 18451855
nsv557123 CNV gain 21841781
nsv483060 CNV loss 15286789
nsv475734 CNV novel sequence insertion 20440878
nsv1040098 CNV gain 25217958
esv33276 CNV gain 17666407

Variation tolerance for FGF6 Gene

Residual Variation Intolerance Score: 65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.94; 74.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGF6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF6 Gene

Disorders for FGF6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FGF6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search FGF6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FGF6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Tumor Gene Database (TGDB):
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FGF6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGF6 Gene

Publications for FGF6 Gene

  1. Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization. (PMID: 1549352) Iida S … Terada M (Oncogene 1992) 3 4 22 60
  2. Putative structure of the FGF6 gene product and role of the signal peptide. (PMID: 1886714) Coulier F … Birnbaum D (Oncogene 1991) 3 4 22 60
  3. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. (PMID: 16597617) Zhang X … Ornitz DM (The Journal of biological chemistry 2006) 2 3 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Increased expression of fibroblast growth factor 6 in human prostatic intraepithelial neoplasia and prostate cancer. (PMID: 10945637) Ropiquet F … Ittmann M (Cancer research 2000) 3 22 60

Products for FGF6 Gene

Sources for FGF6 Gene

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