Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FGF4 Gene

Aliases for FGF4 Gene

  • Fibroblast Growth Factor 4 2 3
  • Transforming Protein KS3 2 3 4
  • Heparin Secretory Transforming Protein 1 2 3
  • Heparin Secretory-Transforming Protein 1 3 4
  • Heparin-Binding Growth Factor 4 3 4
  • Kaposi Sarcoma Oncogene 2 3
  • HBGF-4 3 4
  • HSTF-1 3 4
  • HSTF1 3 4
  • FGF-4 3 4
  • HST-1 3 4
  • HST 3 4
  • Human Stomach Cancer, Transforming Factor From FGF-Related Oncogene 3
  • Transforming Factor From FGF-Related Oncogene 2
  • Fibroblast Growth Factor 4 Splice Isoform 3
  • Kaposi Sarcoma Oncogene) 6
  • Human Stomach Cancer 2
  • Oncogene HST 3
  • K-FGF 3
  • KFGF 3
  • KS3 4

External Ids for FGF4 Gene

Previous Symbols for FGF4 Gene

  • HSTF1

Summaries for FGF4 Gene

Entrez Gene Summary for FGF4 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGF4 Gene

FGF4 (Fibroblast Growth Factor 4) is a Protein Coding gene. Diseases associated with FGF4 include gallbladder squamous cell carcinoma and stomach cancer. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF22.

UniProtKB/Swiss-Prot for FGF4 Gene

  • Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.

Gene Wiki entry for FGF4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF4 Gene

Genomics for FGF4 Gene

Genomic Location for FGF4 Gene

Start:
69,762,363 bp from pter
End:
69,775,403 bp from pter
Size:
13,041 bases
Orientation:
Minus strand

Genomic View for FGF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF4 Gene

Regulatory Elements for FGF4 Gene

Proteins for FGF4 Gene

  • Protein details for FGF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08620-FGF4_HUMAN
    Recommended name:
    Fibroblast growth factor 4
    Protein Accession:
    P08620
    Secondary Accessions:
    • B7U994

    Protein attributes for FGF4 Gene

    Size:
    206 amino acids
    Molecular mass:
    22048 Da
    Quaternary structure:
    • Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.

    Three dimensional structures from OCA and Proteopedia for FGF4 Gene

    Alternative splice isoforms for FGF4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGF4 Gene

Proteomics data for FGF4 Gene at MOPED

Post-translational modifications for FGF4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FGF4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FGF4 Gene

Domains for FGF4 Gene

Gene Families for FGF4 Gene

HGNC:

UniProtKB/Swiss-Prot:

FGF4_HUMAN
Family:
  • Belongs to the heparin-binding growth factors family.:
    • P08620
genes like me logo Genes that share domains with FGF4: view

Function for FGF4 Gene

Molecular function for FGF4 Gene

GENATLAS Biochemistry: fibroblast growth factor 4,basic,HST oncogene homolog,controlling limb development at the proximodistal axis,involved in anteroposterior polarization of the bud through a positive feedback loop controlled by SHH expression,expressed in ectoderm under SHH control
UniProtKB/Swiss-Prot Function: Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.

Gene Ontology (GO) - Molecular Function for FGF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005104 fibroblast growth factor receptor binding IEA --
GO:0005515 protein binding --
GO:0008083 growth factor activity IEA --
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with FGF4: view
genes like me logo Genes that share phenotypes with FGF4: view

Animal Models for FGF4 Gene

MGI Knock Outs for FGF4:

miRNA for FGF4 Gene

miRTarBase miRNAs that target FGF4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FGF4 Gene

Localization for FGF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGF4 Gene COMPARTMENTS Subcellular localization image for FGF4 gene
Compartment Confidence
extracellular 4
cytosol 2
nucleus 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FGF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with FGF4: view

Pathways for FGF4 Gene

SuperPathways for FGF4 Gene

Superpath Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
2 PI-3K cascade
3 Signaling by FGFR
4 FGFR ligand binding and activation
5 GPCR Pathway
genes like me logo Genes that share pathways with FGF4: view

Gene Ontology (GO) - Biological Process for FGF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001502 cartilage condensation IEA --
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0007165 signal transduction TAS 2959959
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007267 cell-cell signaling TAS 2959959
genes like me logo Genes that share ontologies with FGF4: view

Compounds for FGF4 Gene

(1) HMDB Compounds for FGF4 Gene

Compound Synonyms Cas Number PubMed IDs
Heparin
  • Arteven
9005-49-6

(1) Drugbank Compounds for FGF4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Pentosan Polysulfate
37300-21-3 target inhibitor

(17) Novoseek inferred chemical compound relationships for FGF4 Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 46.1 24
heparin 38.9 18
heparan sulfate 32.9 6
vegf 27.8 11
matrigel 26.9 3
genes like me logo Genes that share compounds with FGF4: view

Transcripts for FGF4 Gene

mRNA/cDNA for FGF4 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FGF4 Gene

Fibroblast growth factor 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FGF4 Gene

No ASD Table

Relevant External Links for FGF4 Gene

GeneLoc Exon Structure for
FGF4
ECgene alternative splicing isoforms for
FGF4

Expression for FGF4 Gene

mRNA expression in normal human tissues for FGF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF4 Gene

This gene is overexpressed in Nerve - Tibial (43.8) and Testis (8.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FGF4 Gene

SOURCE GeneReport for Unigene cluster for FGF4 Gene Hs.1755

genes like me logo Genes that share expressions with FGF4: view

Orthologs for FGF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGF4 36
  • 99.51 (n)
  • 99.03 (a)
FGF4 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FGF4 36
  • 91.89 (n)
  • 92.97 (a)
FGF4 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGF4 36
  • 93.87 (n)
  • 94.05 (a)
FGF4 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgf4 36
  • 84.78 (n)
  • 87.28 (a)
Fgf4 16
Fgf4 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FGF4 37
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGF4 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgf4 36
  • 81.73 (n)
  • 82.53 (a)
chicken
(Gallus gallus)
Aves FGF4 36
  • 73.63 (n)
  • 75.95 (a)
FGF4 37
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGF4 37
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia fgfe-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf4 36
  • 67.71 (n)
  • 73.58 (a)
zebrafish
(Danio rerio)
Actinopterygii fgf4 36
  • 64.57 (n)
  • 68.55 (a)
fgf4 36
fgf4 37
  • 62 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.125 37
  • 21 (a)
OneToMany
Species with no ortholog for FGF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF4 Gene

ENSEMBL:
Gene Tree for FGF4 (if available)
TreeFam:
Gene Tree for FGF4 (if available)

Paralogs for FGF4 Gene

Paralogs for FGF4 Gene

Selected SIMAP similar genes for FGF4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FGF4: view

Variants for FGF4 Gene

Sequence variations from dbSNP and Humsavar for FGF4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs713216 -- 69,764,324(-) CCTGC(G/T)ACGCT intron-variant
rs713217 -- 69,764,302(-) ATCAC(A/G)GCCGT intron-variant
rs871346 -- 69,771,019(+) TCTTG(A/G)CATTT intron-variant
rs1944130 -- 69,767,755(-) CACAG(C/T)GAGTG intron-variant
rs2070678 -- 69,774,374(-) AGGTC(C/T)GGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGF4 Gene

Variant ID Type Subtype PubMed ID
dgv16n68 CNV Loss 17160897
nsv825973 CNV Gain 20364138
nsv832199 CNV Gain+Loss 17160897
nsv832200 CNV Loss 17160897
nsv508640 CNV Loss 20534489

Relevant External Links for FGF4 Gene

HapMap Linkage Disequilibrium report
FGF4

Disorders for FGF4 Gene

(34) Novoseek inferred disease relationships for FGF4 Gene

Disease -log(P) Hits PubMed IDs
carcinoma embryonal 71.9 23
teratocarcinoma 52.9 1
prolactinoma 44 9
pituitary tumors 35.9 2
apert syndrome 35.7 1

Relevant External Links for FGF4

Genetic Association Database (GAD)
FGF4
Human Genome Epidemiology (HuGE) Navigator
FGF4
Tumor Gene Database (TGDB):
FGF4
genes like me logo Genes that share disorders with FGF4: view

No data available for UniProtKB/Swiss-Prot for FGF4 Gene

Publications for FGF4 Gene

  1. Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis. (PMID: 11486033) Bellosta P. … Mohammadi M. (Mol. Cell. Biol. 2001) 3 4 23
  2. Fibroblast growth factor 4 and its novel splice isoform have opposing effects on the maintenance of human embryonic stem cell self- renewal. (PMID: 18192227) Mayshar Y. … Benvenisty N. (Stem Cells 2008) 3 4 23
  3. Rearrangement and expression of myeov and hst in NIH/3T3 transfectants: a caveat for the interpretation of DNA transfection analyses. (PMID: 17390055) Brecht M. … Janssen J.W. (Oncol. Rep. 2007) 3 23
  4. FGF4 and retinoic acid direct differentiation of hESCs into PDX1-expressing foregut endoderm in a time- and concentration-dependent manner. (PMID: 19277121) Johannesson M. … Semb H. (PLoS ONE 2009) 3 23
  5. Receptor specificity of the fibroblast growth factor family. (PMID: 8663044) Ornitz D.M. … Goldfarb M. (J. Biol. Chem. 1996) 3 4

Products for FGF4 Gene

Sources for FGF4 Gene

Back to Top

Content