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Aliases for FGF4 Gene

Aliases for FGF4 Gene

  • Fibroblast Growth Factor 4 2 3
  • Transforming Protein KS3 2 3 4
  • Heparin Secretory Transforming Protein 1 2 3
  • Heparin Secretory-Transforming Protein 1 3 4
  • Heparin-Binding Growth Factor 4 3 4
  • Kaposi Sarcoma Oncogene 2 3
  • HBGF-4 3 4
  • HSTF-1 3 4
  • HSTF1 3 4
  • FGF-4 3 4
  • HST-1 3 4
  • HST 3 4
  • Human Stomach Cancer, Transforming Factor From FGF-Related Oncogene 3
  • Transforming Factor From FGF-Related Oncogene 2
  • Fibroblast Growth Factor 4 Splice Isoform 3
  • Human Stomach Cancer 2
  • Oncogene HST 3
  • K-FGF 3
  • KFGF 3
  • KS3 4

External Ids for FGF4 Gene

Previous HGNC Symbols for FGF4 Gene

  • HSTF1

Previous GeneCards Identifiers for FGF4 Gene

  • GC11M072083
  • GC11M071274
  • GC11M069835
  • GC11M069361
  • GC11M069362
  • GC11M069297
  • GC11M069588
  • GC11M065883

Summaries for FGF4 Gene

Entrez Gene Summary for FGF4 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGF4 Gene

FGF4 (Fibroblast Growth Factor 4) is a Protein Coding gene. Diseases associated with FGF4 include teratocarcinoma and embryonal cancer. Among its related pathways are PI3K-Akt signaling pathway and PI3K/AKT Signaling in Cancer. GO annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF22.

UniProtKB/Swiss-Prot for FGF4 Gene

  • Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.

Gene Wiki entry for FGF4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF4 Gene

Genomics for FGF4 Gene

Regulatory Elements for FGF4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FGF4 Gene

69,759,043 bp from pter
69,775,403 bp from pter
16,361 bases
Minus strand

Genomic View for FGF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for FGF4 Gene

Proteins for FGF4 Gene

  • Protein details for FGF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibroblast growth factor 4
    Protein Accession:
    Secondary Accessions:
    • B7U994

    Protein attributes for FGF4 Gene

    206 amino acids
    Molecular mass:
    22048 Da
    Quaternary structure:
    • Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.

    Three dimensional structures from OCA and Proteopedia for FGF4 Gene

    Alternative splice isoforms for FGF4 Gene


neXtProt entry for FGF4 Gene

Proteomics data for FGF4 Gene at MOPED

Post-translational modifications for FGF4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FGF4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FGF4 Gene

Domains & Families for FGF4 Gene

Gene Families for FGF4 Gene

Suggested Antigen Peptide Sequences for FGF4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the heparin-binding growth factors family.
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF4: view

Function for FGF4 Gene

Molecular function for FGF4 Gene

GENATLAS Biochemistry:
fibroblast growth factor 4,basic,HST oncogene homolog,controlling limb development at the proximodistal axis,involved in anteroposterior polarization of the bud through a positive feedback loop controlled by SHH expression,expressed in ectoderm under SHH control
UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.

LifeMap Function Summary for FGF4 Gene

It affects the following cells:
FGF4 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for FGF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005104 fibroblast growth factor receptor binding IEA --
GO:0005515 protein binding --
GO:0008083 growth factor activity IEA --
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with FGF4: view
genes like me logo Genes that share phenotypes with FGF4: view

Animal Models for FGF4 Gene

MGI Knock Outs for FGF4:

Animal Model Products

miRNA for FGF4 Gene

miRTarBase miRNAs that target FGF4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FGF4 Gene

Localization for FGF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF4 Gene


Subcellular locations from

Jensen Localization Image for FGF4 Gene COMPARTMENTS Subcellular localization image for FGF4 gene
Compartment Confidence
extracellular 4
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FGF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005622 intracellular TAS --
genes like me logo Genes that share ontologies with FGF4: view

Pathways & Interactions for FGF4 Gene

SuperPathways for FGF4 Gene

Superpath Contained pathways
1 Interleukin receptor SHC signaling
2 Apoptotic Pathways in Synovial Fibroblasts
3 PI3K/AKT Signaling in Cancer
4 SHC-mediated cascade-FGFR1
5 GPCR Pathway
genes like me logo Genes that share pathways with FGF4: view

PCR Array Products

SIGNOR curated interactions for FGF4 Gene


Gene Ontology (GO) - Biological Process for FGF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0001502 cartilage condensation IEA --
GO:0001934 positive regulation of protein phosphorylation --
GO:0007165 signal transduction TAS 2959959
genes like me logo Genes that share ontologies with FGF4: view

Drugs & Compounds for FGF4 Gene

(10) Drugs for FGF4 Gene - From: NovoSeek, HMDB, DrugBank, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pentosan Polysulfate Approved Pharma inhibitor, Target 0
Heparin Approved, Investigational Pharma Antagonist 672,226
Neomycin Approved Pharma 37
Suramin Approved Pharma Activator 18
Tamoxifen Approved Pharma Antagonist ER antagonist, Anti-Estrogens 341

(9) Additional Compounds for FGF4 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
heparan sulfate
  • alpha-Idosane
  • Heparan N-sulfate
  • Heparan N-sulphate
  • Heparan sulfate
  • Heparan sulphate
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
genes like me logo Genes that share compounds with FGF4: view

Transcripts for FGF4 Gene

mRNA/cDNA for FGF4 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FGF4 Gene

Fibroblast growth factor 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FGF4 Gene

No ASD Table

Relevant External Links for FGF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FGF4 Gene

mRNA expression in normal human tissues for FGF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF4 Gene

This gene is overexpressed in Nerve - Tibial (x43.8) and Testis (x8.1).

Protein differential expression in normal tissues from HIPED for FGF4 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGF4 Gene

SOURCE GeneReport for Unigene cluster for FGF4 Gene Hs.1755

genes like me logo Genes that share expression patterns with FGF4: view

Protein tissue co-expression partners for FGF4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FGF4 Gene

Orthologs for FGF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FGF4 35
  • 91.89 (n)
  • 92.97 (a)
FGF4 36
  • 90 (a)
(Canis familiaris)
Mammalia FGF4 35
  • 93.87 (n)
  • 94.05 (a)
FGF4 36
  • 93 (a)
(Mus musculus)
Mammalia Fgf4 35
  • 84.78 (n)
  • 87.28 (a)
Fgf4 16
Fgf4 36
  • 82 (a)
(Pan troglodytes)
Mammalia FGF4 35
  • 99.51 (n)
  • 99.03 (a)
FGF4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fgf4 35
  • 81.73 (n)
  • 82.53 (a)
(Monodelphis domestica)
Mammalia FGF4 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia FGF4 36
  • 67 (a)
(Gallus gallus)
Aves FGF4 35
  • 73.63 (n)
  • 75.95 (a)
FGF4 36
  • 54 (a)
(Anolis carolinensis)
Reptilia FGF4 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf4 35
  • 67.71 (n)
  • 73.58 (a)
African clawed frog
(Xenopus laevis)
Amphibia fgfe-A 35
(Danio rerio)
Actinopterygii fgf4 35
  • 64.57 (n)
  • 68.55 (a)
fgf4 35
fgf4 36
  • 62 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.125 36
  • 21 (a)
Species with no ortholog for FGF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF4 Gene

Gene Tree for FGF4 (if available)
Gene Tree for FGF4 (if available)

Paralogs for FGF4 Gene

Paralogs for FGF4 Gene

(15) SIMAP similar genes for FGF4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FGF4: view

Variants for FGF4 Gene

Sequence variations from dbSNP and Humsavar for FGF4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs713216 -- 69,764,324(-) CCTGC(G/T)ACGCT intron-variant
rs713217 -- 69,764,302(-) ATCAC(A/G)GCCGT intron-variant
rs871346 -- 69,771,019(+) TCTTG(A/G)CATTT intron-variant
rs1944130 -- 69,767,755(-) CACAG(C/T)GAGTG intron-variant
rs1944132 -- 69,760,811(+) GTGTC(A/G)GGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGF4 Gene

Variant ID Type Subtype PubMed ID
dgv16n68 CNV Loss 17160897
nsv825973 CNV Gain 20364138
nsv832199 CNV Gain+Loss 17160897
nsv832200 CNV Loss 17160897
nsv508640 CNV Loss 20534489

Variation tolerance for FGF4 Gene

Gene Damage Index Score: 0.26; 5.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGF4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF4 Gene

Disorders for FGF4 Gene

MalaCards: The human disease database

(8) MalaCards diseases for FGF4 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
  • mixed embryonal carcinoma and teratoma
embryonal cancer
  • embryo neoplasm
apert syndrome
  • acrocephalosyndactyly
renpenning syndrome
  • shs
kaposi sarcoma
  • kaposi's sarcoma
- elite association
Search FGF4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FGF4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Tumor Gene Database (TGDB):
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FGF4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGF4 Gene

Publications for FGF4 Gene

  1. Tumor growth dependent on Kaposi's sarcoma-derived fibroblast growth factor inhibited by pentosan polysulfate. (PMID: 1708834) Wellstein A. … Lippman M.E. (J. Natl. Cancer Inst. 1991) 23 25 26 67
  2. Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4. (PMID: 20084082) Huang C. … Chen C.D. (Cell Res. 2010) 23 67
  3. Heparan sulfation-dependent fibroblast growth factor signaling maintains embryonic stem cells primed for differentiation in a heterogeneous state. (PMID: 19937756) Lanner F. … Farnebo F. (Stem Cells 2010) 23 67
  4. PARP1 poly(ADP-ribosyl)ates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiation. (PMID: 19531481) Gao F. … Jin Y. (J. Biol. Chem. 2009) 23 67
  5. Pleiotropic function of FGF-4: its role in development and stem cells. (PMID: 18792115) Kosaka N. … Ochiya T. (Dev. Dyn. 2009) 23 67

Products for FGF4 Gene

Sources for FGF4 Gene

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