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Aliases for FGF2 Gene

Aliases for FGF2 Gene

  • Fibroblast Growth Factor 2 (Basic) 2 3
  • FGFB 3 4 6
  • Heparin-Binding Growth Factor 2 3 4
  • HBGF-2 3 4
  • FGF-2 3 4
  • BFGF 3 4
  • Basic Fibroblast Growth Factor BFGF 3
  • Basic Fibroblast Growth Factor 4
  • Fibroblast Growth Factor 2 3
  • Prostatropin 3

External Ids for FGF2 Gene

Previous Symbols for FGF2 Gene

  • FGFB

Summaries for FGF2 Gene

Entrez Gene Summary for FGF2 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGF2 Gene

FGF2 (Fibroblast Growth Factor 2 (Basic)) is a Protein Coding gene. Diseases associated with FGF2 include intravascular papillary endothelial hyperplasia and chronic myocardial ischemia. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include cytokine activity and heparin binding. An important paralog of this gene is FGF1.

UniProtKB/Swiss-Prot for FGF2 Gene

  • Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.

Gene Wiki entry for FGF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF2 Gene

Genomics for FGF2 Gene

Genomic Location for FGF2 Gene

Start:
122,826,708 bp from pter
End:
122,898,236 bp from pter
Size:
71,529 bases
Orientation:
Plus strand

Genomic View for FGF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FGF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF2 Gene

Regulatory Elements for FGF2 Gene

Proteins for FGF2 Gene

  • Protein details for FGF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09038-FGF2_HUMAN
    Recommended name:
    Fibroblast growth factor 2
    Protein Accession:
    P09038
    Secondary Accessions:
    • A4LBB8
    • O00527
    • P78443
    • Q16443
    • Q5PY50
    • Q7KZ11
    • Q7KZ72
    • Q9UC54
    • Q9UCS5
    • Q9UCS6

    Protein attributes for FGF2 Gene

    Size:
    288 amino acids
    Molecular mass:
    30770 Da
    Quaternary structure:
    • Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2.
    Miscellaneous:
    • This protein binds heparin more strongly than does aFGF
    SequenceCaution:
    • Sequence=AAA52448.1; Type=Frameshift; Positions=25, 82, 98, 133; Evidence={ECO:0000305}; Sequence=AAB21432.2; Type=Frameshift; Positions=25; Evidence={ECO:0000305}; Sequence=AAB21432.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=ABO43041.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=ABO43041.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=CAA28027.1; Type=Frameshift; Positions=25, 102; Evidence={ECO:0000305}; Sequence=CAA28027.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=CAA73868.1; Type=Frameshift; Positions=25; Evidence={ECO:0000305}; Sequence=CAA73868.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=EAX05222.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAX05222.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FGF2 Gene

    Alternative splice isoforms for FGF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGF2 Gene

Proteomics data for FGF2 Gene at MOPED

Post-translational modifications for FGF2 Gene

  • Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion.
  • Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FGF2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FGF2 Gene

Domains for FGF2 Gene

Gene Families for FGF2 Gene

HGNC:

UniProtKB/Swiss-Prot:

FGF2_HUMAN
Family:
  • Belongs to the heparin-binding growth factors family.:
    • P09038
genes like me logo Genes that share domains with FGF2: view

Function for FGF2 Gene

Molecular function for FGF2 Gene

GENATLAS Biochemistry: fibroblast growth factor 2,basic,multifunctional protein,144kDa,expressed by brain,retina cartilage,inducer of anteroposterior neural pattern,essential for FGF8 and FGF10 reciprocal regulation loop in limb induction in mouse. FGF2 expression is under the control of an antisense transcript (see NUDT6)
UniProtKB/Swiss-Prot BiophysicochemicalProperties: pH dependence: Retains almost half of its activity after treatment at pH 2.0 for 3 hours at 20 degrees Celsius. {ECO:0000269 PubMed:1721615}; Temperature dependence: Inactivated after 3 minutes at 60 degrees Celsius or 1 minute at 80 degrees Celsius. {ECO:0000269 PubMed:1721615};
UniProtKB/Swiss-Prot Function: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.

LifeMap Function Summary for FGF2 Gene

It affects the following cells:
FGF2 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for FGF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005104 fibroblast growth factor receptor binding IPI 10830168
GO:0005125 cytokine activity IDA 18059339
GO:0005515 protein binding IPI 10490103
GO:0008083 growth factor activity IDA 18059339
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with FGF2: view
genes like me logo Genes that share phenotypes with FGF2: view

Animal Models for FGF2 Gene

MGI Knock Outs for FGF2:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FGF2 Gene

Localization for FGF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF2 Gene

Secreted. Nucleus. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGF2 Gene COMPARTMENTS Subcellular localization image for FGF2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 3
cytosol 2
endoplasmic reticulum 2
plasma membrane 2
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FGF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 2435575
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol --
genes like me logo Genes that share ontologies with FGF2: view

Pathways for FGF2 Gene

SuperPathways for FGF2 Gene

Superpath Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
2 PI-3K cascade
3 Signaling by FGFR
4 FGFR ligand binding and activation
5 GPCR Pathway
genes like me logo Genes that share pathways with FGF2: view

Gene Ontology (GO) - Biological Process for FGF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity --
GO:0000187 activation of MAPK activity TAS 9712850
GO:0001525 angiogenesis --
GO:0001658 branching involved in ureteric bud morphogenesis IDA 12631064
GO:0001759 organ induction --
genes like me logo Genes that share ontologies with FGF2: view

Compounds for FGF2 Gene

(1) HMDB Compounds for FGF2 Gene

Compound Synonyms Cas Number PubMed IDs
Heparin
  • Arteven
9005-49-6

(6) Drugbank Compounds for FGF2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid
target
1,4-Dideoxy-O2-Sulfo-Glucuronic Acid
target
N,O6-Disulfo-Glucosamine
target
Pentosan Polysulfate
37300-21-3 target antagonist
Sirolimus
  • (-)-Rapamycin
53123-88-9 target other/unknown

(123) Novoseek inferred chemical compound relationships for FGF2 Gene

Compound -log(P) Hits PubMed IDs
vegf 92.1 579
heparan sulfate 80.6 193
matrigel 79.9 92
heparin 76.7 356
pd 173074 70.9 3
genes like me logo Genes that share compounds with FGF2: view

Transcripts for FGF2 Gene

mRNA/cDNA for FGF2 Gene

Unigene Clusters for FGF2 Gene

Fibroblast growth factor 2 (basic):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FGF2 Gene

No ASD Table

Relevant External Links for FGF2 Gene

GeneLoc Exon Structure for
FGF2
ECgene alternative splicing isoforms for
FGF2

Expression for FGF2 Gene

mRNA expression in normal human tissues for FGF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FGF2 Gene

SOURCE GeneReport for Unigene cluster for FGF2 Gene Hs.284244

mRNA Expression by UniProt/SwissProt for FGF2 Gene

P09038-FGF2_HUMAN
Tissue specificity: Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.
genes like me logo Genes that share expressions with FGF2: view

Orthologs for FGF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FGF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGF2 36
  • 99.42 (n)
  • 98.96 (a)
FGF2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FGF2 36
  • 95.27 (n)
  • 98.71 (a)
FGF2 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGF2 36
  • 93.98 (n)
  • 97.42 (a)
FGF2 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgf2 36
  • 89.61 (n)
  • 95.45 (a)
Fgf2 16
Fgf2 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FGF2 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgf2 36
  • 89.18 (n)
  • 97.4 (a)
chicken
(Gallus gallus)
Aves BFGF 37
  • 90 (a)
OneToOne
FGF2 36
  • 83.98 (n)
  • 92.21 (a)
lizard
(Anolis carolinensis)
Reptilia FGF2 37
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia fgf2-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf2 36
  • 75.54 (n)
  • 83.12 (a)
zebrafish
(Danio rerio)
Actinopterygii fgf2 36
  • 69.06 (n)
  • 75.82 (a)
fgf2 37
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bnl 37
  • 7 (a)
OneToMany
Species with no ortholog for FGF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF2 Gene

ENSEMBL:
Gene Tree for FGF2 (if available)
TreeFam:
Gene Tree for FGF2 (if available)

Paralogs for FGF2 Gene

Paralogs for FGF2 Gene

Selected SIMAP similar genes for FGF2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FGF2: view

Variants for FGF2 Gene

Sequence variations from dbSNP and Humsavar for FGF2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs167428 -- 122,852,284(+) TCCAA(C/T)ACCTT intron-variant
rs172621 -- 122,847,606(+) CACTC(C/T)ATCTA intron-variant
rs177814 -- 122,830,841(+) AAAAA(A/C/T)GAGAG intron-variant
rs184278 -- 122,862,061(-) tgagg(C/T)gatga intron-variant
rs308372 -- 122,872,335(-) ccttc(A/C)cattc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGF2 Gene

Variant ID Type Subtype PubMed ID
esv2673015 CNV Deletion 23128226
nsv879867 CNV Gain 21882294

Relevant External Links for FGF2 Gene

HapMap Linkage Disequilibrium report
FGF2
Human Gene Mutation Database (HGMD)
FGF2

Disorders for FGF2 Gene

(96) Novoseek inferred disease relationships for FGF2 Gene

Disease -log(P) Hits PubMed IDs
neovascularization 82 113
tumors 72 296
corneal neovascularization 65.2 21
solid tumor 59.2 37
metastasis 57.2 135

Relevant External Links for FGF2

Genetic Association Database (GAD)
FGF2
Human Genome Epidemiology (HuGE) Navigator
FGF2
genes like me logo Genes that share disorders with FGF2: view

No data available for UniProtKB/Swiss-Prot for FGF2 Gene

Publications for FGF2 Gene

  1. Enhancement of fibroblast growth factor (FGF) activity by an FGF- binding protein. (PMID: 11509569) Tassi E. … Wellstein A. (J. Biol. Chem. 2001) 3 4 23
  2. Genetic variation and plasma level of the basic fibroblast growth factor in proliferative diabetic retinopathy. (PMID: 17997184) Beranek M. … Vasku A. (Diabetes Res. Clin. Pract. 2008) 3 23 49
  3. Basic fibroblast growth factor activates the MAPK and NFkappaB pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes. (PMID: 17724016) Muddasani P. … Im H.J. (J. Biol. Chem. 2007) 3 23
  4. FGF2 transcript levels are positively correlated with EGF and IGF-1 in the malignant endometrium. (PMID: 18006148) Soufla G. … Spandidos D.A. (Cancer Lett. 2008) 3 23
  5. Negative feedback for endothelial apoptosis: a potential physiological role for fibroblast growth factor. (PMID: 18025790) Bolitho C. … Zoellner H. (J. Vasc. Res. 2008) 3 23

Products for FGF2 Gene

  • Addgene plasmids for FGF2

Sources for FGF2 Gene

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