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Aliases for FGF2 Gene

Aliases for FGF2 Gene

  • Fibroblast Growth Factor 2 2 3
  • Fibroblast Growth Factor 2 (Basic) 2 3 5
  • Heparin-Binding Growth Factor 2 3 4
  • HBGF-2 3 4
  • FGF-2 3 4
  • BFGF 3 4
  • FGFB 3 4
  • Basic Fibroblast Growth Factor BFGF 3
  • Basic Fibroblast Growth Factor 4
  • Prostatropin 3

External Ids for FGF2 Gene

Previous HGNC Symbols for FGF2 Gene

  • FGFB

Previous GeneCards Identifiers for FGF2 Gene

  • GC04P124660
  • GC04P124027
  • GC04P124141
  • GC04P124206
  • GC04P124105
  • GC04P123747
  • GC04P119474

Summaries for FGF2 Gene

Entrez Gene Summary for FGF2 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGF2 Gene

FGF2 (Fibroblast Growth Factor 2) is a Protein Coding gene. Diseases associated with FGF2 include corneal neovascularization and chronic myocardial ischemia. Among its related pathways are Degradation of the extracellular matrix and Signaling by GPCR. GO annotations related to this gene include cytokine activity and heparin binding. An important paralog of this gene is FGF1.

UniProtKB/Swiss-Prot for FGF2 Gene

  • Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.

Gene Wiki entry for FGF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF2 Gene

Genomics for FGF2 Gene

Regulatory Elements for FGF2 Gene

Promoters for FGF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FGF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FGF2 Gene

Chromosome:
4
Start:
122,826,708 bp from pter
End:
122,898,236 bp from pter
Size:
71,529 bases
Orientation:
Plus strand

Genomic View for FGF2 Gene

Genes around FGF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF2 Gene

Proteins for FGF2 Gene

  • Protein details for FGF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09038-FGF2_HUMAN
    Recommended name:
    Fibroblast growth factor 2
    Protein Accession:
    P09038
    Secondary Accessions:
    • A4LBB8
    • O00527
    • P78443
    • Q16443
    • Q5PY50
    • Q7KZ11
    • Q7KZ72
    • Q9UC54
    • Q9UCS5
    • Q9UCS6

    Protein attributes for FGF2 Gene

    Size:
    288 amino acids
    Molecular mass:
    30770 Da
    Quaternary structure:
    • Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP3 (PubMed:18669637).
    Miscellaneous:
    • This protein binds heparin more strongly than does aFGF.
    SequenceCaution:
    • Sequence=AAA52448.1; Type=Frameshift; Positions=25, 82, 98, 133; Evidence={ECO:0000305}; Sequence=AAB21432.2; Type=Frameshift; Positions=25; Evidence={ECO:0000305}; Sequence=AAB21432.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=ABO43041.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=ABO43041.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=CAA28027.1; Type=Frameshift; Positions=25, 102; Evidence={ECO:0000305}; Sequence=CAA28027.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=CAA73868.1; Type=Frameshift; Positions=25; Evidence={ECO:0000305}; Sequence=CAA73868.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=EAX05222.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAX05222.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FGF2 Gene

    Alternative splice isoforms for FGF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGF2 Gene

Proteomics data for FGF2 Gene at MOPED

Post-translational modifications for FGF2 Gene

  • Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion.
  • Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FGF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FGF2 (FGF2)

No data available for DME Specific Peptides for FGF2 Gene

Domains & Families for FGF2 Gene

Gene Families for FGF2 Gene

Suggested Antigen Peptide Sequences for FGF2 Gene

Graphical View of Domain Structure for InterPro Entry

P09038

UniProtKB/Swiss-Prot:

FGF2_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF2: view

Function for FGF2 Gene

Molecular function for FGF2 Gene

GENATLAS Biochemistry:
fibroblast growth factor 2,basic,multifunctional protein,144kDa,expressed by brain,retina cartilage,inducer of anteroposterior neural pattern,essential for FGF8 and FGF10 reciprocal regulation loop in limb induction in mouse. FGF2 expression is under the control of an antisense transcript (see NUDT6)
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Retains almost half of its activity after treatment at pH 2.0 for 3 hours at 20 degrees Celsius. {ECO:0000269 PubMed:1721615}; Temperature dependence: Inactivated after 3 minutes at 60 degrees Celsius or 1 minute at 80 degrees Celsius. {ECO:0000269 PubMed:1721615};
UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.

LifeMap Function Summary for FGF2 Gene

It affects the following cells:
FGF2 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for FGF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005104 fibroblast growth factor receptor binding IPI 10830168
GO:0005125 cytokine activity IDA 18059339
genes like me logo Genes that share ontologies with FGF2: view
genes like me logo Genes that share phenotypes with FGF2: view

Animal Models for FGF2 Gene

MGI Knock Outs for FGF2:

Animal Model Products

miRNA for FGF2 Gene

miRTarBase miRNAs that target FGF2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGF2 Gene

Localization for FGF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF2 Gene

Secreted. Nucleus. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGF2 Gene COMPARTMENTS Subcellular localization image for FGF2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3
cytoskeleton 2
mitochondrion 2
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for FGF2 Gene

Pathways & Interactions for FGF2 Gene

SuperPathways for FGF2 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Apoptotic Pathways in Synovial Fibroblasts
3 PI3K events in ERBB4 signaling
4 SHC-mediated cascade-FGFR4
5 GPCR Pathway
genes like me logo Genes that share pathways with FGF2: view

SIGNOR curated interactions for FGF2 Gene

Gene Ontology (GO) - Biological Process for FGF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000187 activation of MAPK activity TAS 9712850
GO:0001525 angiogenesis IEA --
GO:0001658 branching involved in ureteric bud morphogenesis IDA 12631064
genes like me logo Genes that share ontologies with FGF2: view

Drugs & Compounds for FGF2 Gene

(76) Drugs for FGF2 Gene - From: Novoseek, HMDB, DrugBank, ClinicalTrials, PharmGKB, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pentosan Polysulfate Approved Pharma inhibitor, Target, antagonist 0
Sirolimus Approved, Investigational Pharma inhibitor, Target, other/unknown Kinase Inhibitors, Mammalian target of rapamycin (mTOR) inhibitors 1797
Sucralfate Approved Pharma Target, agonist 9
Heparin Approved, Investigational Pharma Antagonist 719,239
Fluvoxamine Approved, Investigational Pharma 46

(56) Additional Compounds for FGF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGF2: view

Transcripts for FGF2 Gene

mRNA/cDNA for FGF2 Gene

Unigene Clusters for FGF2 Gene

Fibroblast growth factor 2 (basic):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGF2 Gene

No ASD Table

Relevant External Links for FGF2 Gene

GeneLoc Exon Structure for
FGF2
ECgene alternative splicing isoforms for
FGF2

Expression for FGF2 Gene

mRNA expression in normal human tissues for FGF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FGF2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (19.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FGF2 Gene



SOURCE GeneReport for Unigene cluster for FGF2 Gene Hs.284244

mRNA Expression by UniProt/SwissProt for FGF2 Gene

P09038-FGF2_HUMAN
Tissue specificity: Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.
genes like me logo Genes that share expression patterns with FGF2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for FGF2 Gene

Orthologs for FGF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FGF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FGF2 35
  • 95.27 (n)
  • 98.71 (a)
FGF2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGF2 35
  • 93.98 (n)
  • 97.42 (a)
FGF2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgf2 35
  • 89.61 (n)
  • 95.45 (a)
Fgf2 16
Fgf2 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FGF2 35
  • 99.42 (n)
  • 98.96 (a)
FGF2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgf2 35
  • 89.18 (n)
  • 97.4 (a)
oppossum
(Monodelphis domestica)
Mammalia FGF2 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGF2 35
  • 83.98 (n)
  • 92.21 (a)
BFGF 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGF2 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf2 35
  • 75.54 (n)
  • 83.12 (a)
African clawed frog
(Xenopus laevis)
Amphibia fgf2-prov 35
zebrafish
(Danio rerio)
Actinopterygii fgf2 35
  • 69.06 (n)
  • 75.82 (a)
fgf2 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bnl 36
  • 7 (a)
OneToMany
Species with no ortholog for FGF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF2 Gene

ENSEMBL:
Gene Tree for FGF2 (if available)
TreeFam:
Gene Tree for FGF2 (if available)

Paralogs for FGF2 Gene

Paralogs for FGF2 Gene

(19) SIMAP similar genes for FGF2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FGF2: view

Variants for FGF2 Gene

Sequence variations from dbSNP and Humsavar for FGF2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs411027 -- 122,829,112(-) AAGGC(A/G)AATCG intron-variant
rs416124 -- 122,831,505(-) CACTT(A/G)CCAGA intron-variant
rs416947 -- 122,838,596(+) AATTC(C/T)GCATG intron-variant
rs421184 -- 122,829,417(+) CCTCA(A/G)CAAAA intron-variant
rs167428 -- 122,852,284(+) TCCAA(C/T)ACCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGF2 Gene

Variant ID Type Subtype PubMed ID
esv2673015 CNV Deletion 23128226
nsv879867 CNV Gain 21882294

Variation tolerance for FGF2 Gene

Residual Variation Intolerance Score: 42.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGF2 Gene

HapMap Linkage Disequilibrium report
FGF2
Human Gene Mutation Database (HGMD)
FGF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF2 Gene

Disorders for FGF2 Gene

MalaCards: The human disease database

(58) MalaCards diseases for FGF2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
corneal neovascularization
chronic myocardial ischemia
apert syndrome
  • acrocephalosyndactyly
chronic ulcer of skin
  • chronic wounds
myelofibrosis
  • agnogenic myeloid metaplasia
- elite association - COSMIC cancer census association via MalaCards
Search FGF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FGF2

Genetic Association Database (GAD)
FGF2
Human Genome Epidemiology (HuGE) Navigator
FGF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGF2
genes like me logo Genes that share disorders with FGF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGF2 Gene

Publications for FGF2 Gene

  1. VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis. (PMID: 17204151) Butt C. … Rahman P. (BMC Musculoskelet Disord 2007) 3 48 67
  2. A novel role of fibroblast growth factor-2 and pentosan polysulfate in the pathogenesis of intestinal bleeding in mice. (PMID: 17071728) Jerebtsova M. … Ray P.E. (Am. J. Physiol. Heart Circ. Physiol. 2007) 23 25 26
  3. Cellular and molecular mechanisms of gastric ulcer healing. Is the quality of mucosal scar affected by treatment? (PMID: 8578218) Tarnawski A. … Sarfeh I.J. (Scand. J. Gastroenterol. Suppl. 1995) 23 25 26
  4. 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Src-mediated Egr-1-dependent rapid induction of FGF-2 expression. (PMID: 20053757) Kundumani-Sridharan V. … Rao G.N. (Blood 2010) 3 23
  5. Expression of Efp, VEGF and bFGF in normal, hyperplastic and malignant endometrial tissue. (PMID: 20127022) Dai H. … Dai S. (Oncol. Rep. 2010) 3 23

Products for FGF2 Gene

Sources for FGF2 Gene

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