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Aliases for FGF1 Gene

Aliases for FGF1 Gene

  • Fibroblast Growth Factor 1 2 3
  • Fibroblast Growth Factor 1 (Acidic) 2 3 5
  • Heparin-Binding Growth Factor 1 2 3 4
  • Endothelial Cell Growth Factor 2 4
  • HBGF-1 3 4
  • FGF-1 3 4
  • AFGF 3 4
  • FGFA 3 4
  • ECGF 3 4
  • Endothelial Cell Growth Factor, Alpha 3
  • Endothelial Cell Growth Factor, Beta 3
  • Beta-Endothelial Cell Growth Factor 3
  • Acidic Fibroblast Growth Factor 4
  • ECGF-Beta 3
  • FGF-Alpha 3
  • GLIO703 3
  • Alpha 2
  • ECGFA 3
  • ECGFB 3
  • HBGF1 3
  • Beta 2

External Ids for FGF1 Gene

Previous HGNC Symbols for FGF1 Gene

  • FGFA

Previous GeneCards Identifiers for FGF1 Gene

  • GC05M141873
  • GC05M142001
  • GC05M141953
  • GC05M137120

Summaries for FGF1 Gene

Entrez Gene Summary for FGF1 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]

GeneCards Summary for FGF1 Gene

FGF1 (Fibroblast Growth Factor 1) is a Protein Coding gene. Diseases associated with FGF1 include familial glomangioma and blount's disease. Among its related pathways are Hippo signaling pathway and MAPK signaling pathway. GO annotations related to this gene include growth factor activity and Hsp70 protein binding. An important paralog of this gene is FGF2.

UniProtKB/Swiss-Prot for FGF1 Gene

  • Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.

Gene Wiki entry for FGF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF1 Gene

Genomics for FGF1 Gene

Regulatory Elements for FGF1 Gene

Enhancers for FGF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FGF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FGF1 Gene

Chromosome:
5
Start:
142,592,178 bp from pter
End:
142,698,070 bp from pter
Size:
105,893 bases
Orientation:
Minus strand

Genomic View for FGF1 Gene

Genes around FGF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF1 Gene

Proteins for FGF1 Gene

  • Protein details for FGF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05230-FGF1_HUMAN
    Recommended name:
    Fibroblast growth factor 1
    Protein Accession:
    P05230
    Secondary Accessions:
    • B2R5T0
    • D3DQF2
    • P07502
    • Q16588

    Protein attributes for FGF1 Gene

    Size:
    155 amino acids
    Molecular mass:
    17460 Da
    Quaternary structure:
    • Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1 (By similarity). Interacts with S100A13. Interacts with LRRC59. Interacts with CSNKA, CSNKB and FIBP. While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1.

    Three dimensional structures from OCA and Proteopedia for FGF1 Gene

    Alternative splice isoforms for FGF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGF1 Gene

Proteomics data for FGF1 Gene at MOPED

Post-translational modifications for FGF1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FGF1 (FGF1)

No data available for DME Specific Peptides for FGF1 Gene

Domains & Families for FGF1 Gene

Gene Families for FGF1 Gene

Graphical View of Domain Structure for InterPro Entry

P05230

UniProtKB/Swiss-Prot:

FGF1_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF1: view

Function for FGF1 Gene

Molecular function for FGF1 Gene

GENATLAS Biochemistry:
fibroblast growth factor 1,acidic (endothelial cell),associated with S100A13 and p40 extracellular domain of synaptotagmin 1 (SYT1) for the release of signal peptide-less FGF1 in a temperature stress-induced pathway,mainly expressed in brain,and delinating a retrocaudal boundary in the granule cell layer of the (murine) cerebellar cortex,also expressed in the retina (accessible to pharmacologic regulation)
UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.

Gene Ontology (GO) - Molecular Function for FGF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
genes like me logo Genes that share ontologies with FGF1: view
genes like me logo Genes that share phenotypes with FGF1: view

Animal Models for FGF1 Gene

MGI Knock Outs for FGF1:

Animal Model Products

  • Taconic Biosciences Mouse Models for FGF1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGF1 Gene

Localization for FGF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF1 Gene

Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FGF1 Gene COMPARTMENTS Subcellular localization image for FGF1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
cytoskeleton 3
plasma membrane 3
endoplasmic reticulum 2
mitochondrion 2
endosome 1
golgi apparatus 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FGF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 18400376
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FGF1: view

Pathways & Interactions for FGF1 Gene

SuperPathways for FGF1 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Apoptotic Pathways in Synovial Fibroblasts
3 PI3K events in ERBB4 signaling
4 SHC-mediated cascade-FGFR4
5 GPCR Pathway
genes like me logo Genes that share pathways with FGF1: view

SIGNOR curated interactions for FGF1 Gene

Activates:

Gene Ontology (GO) - Biological Process for FGF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity TAS --
GO:0001525 angiogenesis IEA --
GO:0001759 organ induction IEA --
GO:0007165 signal transduction NAS 3778488
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with FGF1: view

Drugs & Compounds for FGF1 Gene

(45) Drugs for FGF1 Gene - From: DrugBank, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pentosan Polysulfate Approved Pharma inhibitor, Target, antagonist 0
Amlexanox Approved, Investigational Pharma Target, inhibitor 3
Heparin Approved, Investigational Pharma Antagonist 761,246
Pazopanib Approved Pharma Target, inhibitor VEFGR, c-Kit, and PDGFR inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Votrient Approved April 2012/ Approved October of 2009 Pharma 0

(55) Additional Compounds for FGF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGF1: view

Transcripts for FGF1 Gene

Unigene Clusters for FGF1 Gene

Fibroblast growth factor 1 (acidic):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FGF1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - -
SP10: - - - - -
SP11: - -
SP12:
SP13:
SP14: - - - - - - - - - - -
SP15: - - - - -
SP16: - -

ExUns: 10h · 10i · 10j
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for FGF1 Gene

GeneLoc Exon Structure for
FGF1
ECgene alternative splicing isoforms for
FGF1

Expression for FGF1 Gene

mRNA expression in normal human tissues for FGF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.1), Brain - Substantia nigra (x6.3), Brain - Hippocampus (x5.0), Brain - Amygdala (x4.9), Brain - Putamen (basal ganglia) (x4.6), and Brain - Hypothalamus (x4.0).

Protein differential expression in normal tissues from HIPED for FGF1 Gene

This gene is overexpressed in Spinal cord (24.3), Frontal cortex (11.4), Retina (10.3), and Brain (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FGF1 Gene



SOURCE GeneReport for Unigene cluster for FGF1 Gene Hs.483635

mRNA Expression by UniProt/SwissProt for FGF1 Gene

P05230-FGF1_HUMAN
Tissue specificity: Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with FGF1: view

Protein tissue co-expression partners for FGF1 Gene

Primer Products

In Situ Assay Products

Orthologs for FGF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FGF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FGF1 35
  • 91.4 (n)
  • 92.26 (a)
FGF1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGF1 35
  • 94.84 (n)
  • 98.71 (a)
FGF1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgf1 35
  • 90.54 (n)
  • 95.48 (a)
Fgf1 16
Fgf1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FGF1 35
  • 99.35 (n)
  • 100 (a)
FGF1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgf1 35
  • 89.25 (n)
  • 95.48 (a)
oppossum
(Monodelphis domestica)
Mammalia FGF1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGF1 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGF1 35
  • 79.78 (n)
  • 90.32 (a)
FGF1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGF1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf1 35
  • 69.25 (n)
  • 76.13 (a)
zebrafish
(Danio rerio)
Actinopterygii fgf1a 36
  • 54 (a)
ManyToMany
fgf1b 36
  • 51 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta bnl 36
  • 6 (a)
OneToMany
Species with no ortholog for FGF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF1 Gene

ENSEMBL:
Gene Tree for FGF1 (if available)
TreeFam:
Gene Tree for FGF1 (if available)

Paralogs for FGF1 Gene

Paralogs for FGF1 Gene

genes like me logo Genes that share paralogs with FGF1: view

Variants for FGF1 Gene

Sequence variations from dbSNP and Humsavar for FGF1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs17223632 - 142,614,066(-) TCCAG(A/G)GAATT reference, missense
rs3457 -- 142,680,926(-) TGATT(C/T)GGTGG intron-variant
rs758200 -- 142,610,105(-) GAACA(C/G)TGCAG intron-variant
rs920998 -- 142,608,952(+) GACCT(C/T)CCCTT intron-variant
rs920999 -- 142,608,976(+) GGCAG(C/T)GGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FGF1 Gene

Variant ID Type Subtype PubMed ID
nsv823281 CNV Loss 20364138
dgv1046e199 CNV Deletion 23128226
nsv830510 CNV Gain 17160897
nsv525272 CNV Loss 19592680
esv2665244 CNV Deletion 23128226
esv27821 CNV Loss 19812545
nsv517346 CNV Loss 19592680
esv2421733 CNV Deletion 20811451
nsv441966 CNV CNV 18776908
nsv514325 CNV Loss 21397061
nsv882993 CNV Loss 21882294

Variation tolerance for FGF1 Gene

Residual Variation Intolerance Score: 40% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FGF1 Gene

HapMap Linkage Disequilibrium report
FGF1
Human Gene Mutation Database (HGMD)
FGF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF1 Gene

Disorders for FGF1 Gene

MalaCards: The human disease database

(31) MalaCards diseases for FGF1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
familial glomangioma
  • hereditary glomangioma
blount's disease
  • blount disease
peripheral artery disease
  • peripheral arterial diseases
limb ischemia
dental pulp necrosis
  • necrosis of the pulp
- elite association - COSMIC cancer census association via MalaCards
Search FGF1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FGF1

Genetic Association Database (GAD)
FGF1
Human Genome Epidemiology (HuGE) Navigator
FGF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FGF1
genes like me logo Genes that share disorders with FGF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGF1 Gene

Publications for FGF1 Gene

  1. Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization. (PMID: 3523756) Jaye M. … Drohan W.N. (Science 1986) 2 3 4 67
  2. Molecular mechanism of inhibition of nonclassical FGF-1 export. (PMID: 16300395) Rajalingam D. … Yu C. (Biochemistry 2005) 23 25 26
  3. NMR characterization of copper and lipid interactions of the C2B domain of synaptotagmin I-relevance to the non-classical secretion of the human acidic fibroblast growth factor (hFGF-1). (PMID: 19835837) Kathir K.M. … Kumar T.K. (Biochim. Biophys. Acta 2010) 3 23
  4. Structural basis of conserved cysteine in the fibroblast growth factor family: evidence for a vestigial half-cystine. (PMID: 19683004) Lee J. … Blaber M. (J. Mol. Biol. 2009) 3 23
  5. Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. (PMID: 19574212) Zakrzewska M. … Olsnes S. (J. Biol. Chem. 2009) 3 23

Products for FGF1 Gene

Sources for FGF1 Gene

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