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Aliases for FER Gene

Aliases for FER Gene

  • Fer (Fps/Fes Related) Tyrosine Kinase 2 3
  • TYK3 3 4 6
  • Fujinami Poultry Sarcoma/Feline Sarcoma-Related Protein Fer 3 4
  • Feline Encephalitis Virus-Related Kinase FER 3 4
  • Phosphoprotein NCP94 2 3
  • Proto-Oncogene C-Fer 3 4
  • Tyrosine Kinase 3 3 4
  • EC 2.7.10.2 4 63
  • P94-Fer 3 4
  • Truncated Fer (Fps/Fes Related) Tyrosine Kinase 3
  • Protein Phosphatase 1, Regulatory Subunit 74 3
  • Tyrosine-Protein Kinase Fer 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 74 2
  • EC 2.7.10 63
  • PPP1R74 3
  • Pe1Fe10 3
  • Pe1Fe13 3
  • Pe1Fe3 3
  • Pe1Fe6 3
  • FerT 3

External Ids for FER Gene

Previous GeneCards Identifiers for FER Gene

  • GC05P107703
  • GC05P108524
  • GC05P108114
  • GC05P108159
  • GC05P108111
  • GC05P103255

Summaries for FER Gene

Entrez Gene Summary for FER Gene

  • Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for FER Gene

FER (Fer (Fps/Fes Related) Tyrosine Kinase) is a Protein Coding gene. Diseases associated with FER include encephalitis and sarcoma. Among its related pathways are PI-3K cascade and Signaling by GPCR. GO annotations related to this gene include actin binding and lipid binding. An important paralog of this gene is MATK.

UniProtKB/Swiss-Prot for FER Gene

  • Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.

Gene Wiki entry for FER Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FER Gene

Genomics for FER Gene

Regulatory Elements for FER Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FER Gene

Start:
108,747,548 bp from pter
End:
109,196,841 bp from pter
Size:
449,294 bases
Orientation:
Plus strand

Genomic View for FER Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FER Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FER Gene

Proteins for FER Gene

  • Protein details for FER Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16591-FER_HUMAN
    Recommended name:
    Tyrosine-protein kinase Fer
    Protein Accession:
    P16591
    Secondary Accessions:
    • B2RCR4
    • B4DSQ2
    • H2FLB8

    Protein attributes for FER Gene

    Size:
    822 amino acids
    Molecular mass:
    94638 Da
    Quaternary structure:
    • Homotrimer. Interacts with ARHGDIA, IRS1, JAK1, NRP1, PIK3R1, PLEC and TMF1. Interacts with PPP1CA and regulates its phosphorylation at Thr-320 (By similarity). Interacts with CTNND1, EGFR, FLT3, PECAM1, PDGFR and STAT3. Interacts (via SH2 domain) with CTTN. Interacts with HSP90; this stabilizes phosphorylated FER and protects FER against proteasomal degradation. Component of a complex that contains at least FER, CTTN and PTK2/FAK1.

    Three dimensional structures from OCA and Proteopedia for FER Gene

    Alternative splice isoforms for FER Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FER Gene

Proteomics data for FER Gene at MOPED

Post-translational modifications for FER Gene

Other Protein References for FER Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for FER Gene

Gene Families for FER Gene

HGNC:
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits
  • SH2D :SH2 domain containing
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P16591

UniProtKB/Swiss-Prot:

FER_HUMAN :
  • P16591
Domain:
  • The coiled coil domains mediate homooligomerization and are required for location at microtubules
  • The N-terminal region including the first coiled coil domain mediates interaction with phosphoinositide-containing membranes
  • Contains 1 F-BAR domain.
  • Contains 1 protein kinase domain.
  • Contains 1 SH2 domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
genes like me logo Genes that share domains with FER: view

Function for FER Gene

Molecular function for FER Gene

GENATLAS Biochemistry: fer (fps/fes related) oncogene homolog
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by phosphatidic acid binding. Activated by hydrogen peroxide (in vitro). Activated by reactive oxygen species (ROS).
UniProtKB/Swiss-Prot Function: Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.

Enzyme Numbers (IUBMB) for FER Gene

Gene Ontology (GO) - Molecular Function for FER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity TAS 2725517
GO:0004715 non-membrane spanning protein tyrosine kinase activity IDA 12972546
GO:0005154 epidermal growth factor receptor binding IDA 21518868
genes like me logo Genes that share ontologies with FER: view
genes like me logo Genes that share phenotypes with FER: view

Animal Model Products

CRISPR Products

miRNA for FER Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FER

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for FER Gene

Localization for FER Gene

Subcellular locations from UniProtKB/Swiss-Prot for FER Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell junction. Membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, cell cortex. Note=Associated with the chromatin. Detected on microtubules in polarized and motile vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell-cell contacts.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FER Gene COMPARTMENTS Subcellular localization image for FER gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 5
cytosol 4

Gene Ontology (GO) - Cellular Components for FER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 colocalizes_with nuclear chromatin IDA 1990274
GO:0005634 nucleus IDA 19147545
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005938 cell cortex IEA --
genes like me logo Genes that share ontologies with FER: view

Pathways for FER Gene

genes like me logo Genes that share pathways with FER: view

Gene Ontology (GO) - Biological Process for FER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IMP 12972546
GO:0000278 mitotic cell cycle IMP 22223638
GO:0001932 regulation of protein phosphorylation ISS --
GO:0006468 protein phosphorylation TAS 2725517
GO:0006935 chemotaxis IBA --
genes like me logo Genes that share ontologies with FER: view

Compounds for FER Gene

(2) HMDB Compounds for FER Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(3) Novoseek inferred chemical compound relationships for FER Gene

Compound -log(P) Hits PubMed IDs
tyrosine 67.1 65
iron 29.5 6
phosphatidylinositol 22.8 4
genes like me logo Genes that share compounds with FER: view

Transcripts for FER Gene

Unigene Clusters for FER Gene

Fer (fps/fes related) tyrosine kinase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FER

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FER

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FER Gene

No ASD Table

Relevant External Links for FER Gene

GeneLoc Exon Structure for
FER
ECgene alternative splicing isoforms for
FER

Expression for FER Gene

mRNA expression in normal human tissues for FER Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FER Gene

SOURCE GeneReport for Unigene cluster for FER Gene Hs.221472

mRNA Expression by UniProt/SwissProt for FER Gene

P16591-FER_HUMAN
Tissue specificity: Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepato carcinoma cell lines (at protein level). Isoform 3 is not detected in normal colon or in normal fibroblasts (at protein level). Widely expressed.
genes like me logo Genes that share expressions with FER: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FER Gene

Orthologs for FER Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FER Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FER 35
  • 99.59 (n)
  • 99.88 (a)
FER 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FER 35
  • 91.16 (n)
  • 94.89 (a)
FER 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FER 35
  • 93.27 (n)
  • 95.62 (a)
FER 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fer 16
Fer 36
  • 93 (a)
OneToOne
Fert2 35
  • 88.44 (n)
  • 93.07 (a)
oppossum
(Monodelphis domestica)
Mammalia FER 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FER 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fert2 35
  • 86.26 (n)
  • 91.71 (a)
chicken
(Gallus gallus)
Aves FER 35
  • 81.31 (n)
  • 87.96 (a)
FER 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FER 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fer 35
  • 73.99 (n)
  • 79.6 (a)
zebrafish
(Danio rerio)
Actinopterygii fer 35
  • 71.1 (n)
  • 77.68 (a)
fer 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003651 35
  • 48.06 (n)
  • 41.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fps85D 35
  • 48.14 (n)
  • 41.3 (a)
Fps85D 36
  • 23 (a)
OneToMany
Fps85D 37
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea B0252.1 36
  • 18 (a)
ManyToMany
C18H7.4 36
  • 32 (a)
ManyToMany
C25A8.5 36
  • 32 (a)
ManyToMany
C34F11.5 36
  • 13 (a)
ManyToMany
C35E7.10 36
  • 31 (a)
ManyToMany
C55C3.4 36
  • 31 (a)
ManyToMany
F22B3.8 36
  • 23 (a)
ManyToMany
F23C8.7 36
  • 32 (a)
ManyToMany
F26E4.5 36
  • 30 (a)
ManyToMany
F57B9.8 36
  • 29 (a)
ManyToMany
F59A3.8 36
  • 22 (a)
ManyToMany
frk-1 36
  • 31 (a)
ManyToMany
kin-14 35
  • 49.42 (n)
  • 40.7 (a)
kin-14 36
  • 33 (a)
ManyToMany
kin-24 36
  • 21 (a)
ManyToMany
kin-26 36
  • 29 (a)
ManyToMany
kin-31 36
  • 28 (a)
ManyToMany
kin-5 36
  • 24 (a)
ManyToMany
kin-6 36
  • 28 (a)
ManyToMany
R05H5.4 36
  • 30 (a)
ManyToMany
spe-8 36
  • 24 (a)
ManyToMany
T06C10.3 36
  • 26 (a)
ManyToMany
T21G5.1 36
  • 23 (a)
ManyToMany
T25B9.4 36
  • 21 (a)
ManyToMany
W01B6.5 36
  • 22 (a)
ManyToMany
W03A5.1 36
  • 15 (a)
ManyToMany
W03F8.2 36
  • 22 (a)
ManyToMany
Y106G6A.1 36
  • 20 (a)
ManyToMany
Y116A8C.24 36
  • 20 (a)
ManyToMany
Y116A8C.38 36
  • 20 (a)
ManyToMany
Y43C5B.2 36
  • 28 (a)
ManyToMany
Y4C6A.1 36
  • 25 (a)
ManyToMany
ZC581.7 36
  • 30 (a)
ManyToMany
ZK593.9 36
  • 20 (a)
ManyToMany
ZK622.1 36
  • 33 (a)
ManyToMany
F59A3.8 37
  • 27 (a)
F23C8.7 37
  • 36 (a)
ZK593.9 37
  • 29 (a)
T25B9.5 37
  • 30 (a)
C25A8.5 37
  • 37 (a)
Y116A8C.38 37
  • 25 (a)
F26E4.5 37
  • 37 (a)
kin-24 37
  • 26 (a)
C35E7.10b 37
  • 38 (a)
W02A2.4 37
  • 28 (a)
frk-1 37
  • 37 (a)
ZC581.7 37
  • 33 (a)
spe-8 37
  • 32 (a)
T21G5.1 37
  • 41 (a)
T25B9.4 37
  • 31 (a)
Y4C6A.1 37
  • 28 (a)
kin-14 37
  • 38 (a)
W01B6.5 37
  • 26 (a)
T14E8.1a 37
  • 35 (a)
T06C10.3 37
  • 36 (a)
Y52D5A.2 37
  • 28 (a)
R05H5.4 37
  • 34 (a)
F57B9.8 37
  • 36 (a)
F09A5.2 37
  • 33 (a)
K09B11.5 37
  • 30 (a)
F01D4.3 37
  • 36 (a)
T14E8.1b 37
  • 35 (a)
C18H7.4 37
  • 33 (a)
R11E3.1 37
  • 32 (a)
C55C3.4 37
  • 37 (a)
kin-26 37
  • 34 (a)
W04G5.10 37
  • 37 (a)
Y69E1A.3 37
  • 30 (a)
kin-23 37
  • 33 (a)
W03F8.2 37
  • 32 (a)
ZK622.1 37
  • 38 (a)
C35E7.10a 37
  • 37 (a)
F46F5.2 37
  • 35 (a)
Y116A8C.24 37
  • 25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC15 36
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for FER:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FER Gene

ENSEMBL:
Gene Tree for FER (if available)
TreeFam:
Gene Tree for FER (if available)

Paralogs for FER Gene

Paralogs for FER Gene

genes like me logo Genes that share paralogs with FER: view

Variants for FER Gene

Sequence variations from dbSNP and Humsavar for FER Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs889269 -- 108,829,744(-) aggga(A/G)agagg intron-variant
rs892009 -- 109,045,249(-) GTAAG(C/T)TATAC intron-variant
rs919220 -- 109,004,782(+) GTTTT(G/T)CACCT intron-variant
rs919771 -- 109,044,718(-) GTTTT(A/G)TCCTT synonymous-codon, reference
rs930220 -- 109,147,804(-) tctct(A/C)tatat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FER Gene

Variant ID Type Subtype PubMed ID
nsv882689 CNV Gain 21882294
nsv471039 CNV Gain 18288195
nsv327356 CNV Insertion 16902084
esv2668245 CNV Deletion 23128226
nsv882691 CNV Loss 21882294
nsv512857 CNV Insertion 21212237
esv2502982 CNV Insertion 19546169
esv2730582 CNV Deletion 23290073
nsv525993 CNV Loss 19592680
esv2450464 CNV Deletion 19546169
esv2677654 CNV Deletion 23128226
nsv4952 CNV Loss 18451855
nsv830443 CNV Gain 17160897
nsv882692 CNV Loss 21882294
dgv6291n71 CNV Loss 21882294
nsv4953 CNV Loss 18451855
nsv509988 CNV Loss 20534489

Relevant External Links for FER Gene

HapMap Linkage Disequilibrium report
FER

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FER Gene

Disorders for FER Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for FER Gene including...

Search for FER Gene in MalaCards »

(1) University of Copenhagen DISEASES for FER Gene

(5) Novoseek inferred disease relationships for FER Gene

Disease -log(P) Hits PubMed IDs
prostate carcinoma 22.4 2
metaplasia 20.3 1
prostate cancer 4.09 8
tumors 0 1
cancer 0 2

Relevant External Links for FER

Genetic Association Database (GAD)
FER
Human Genome Epidemiology (HuGE) Navigator
FER
Tumor Gene Database (TGDB):
FER
genes like me logo Genes that share disorders with FER: view

No data available for UniProtKB/Swiss-Prot for FER Gene

Publications for FER Gene

  1. Nuclear and cytoplasmic location of the FER tyrosine kinase. (PMID: 1990274) Hao Q.-L. … Groffen J. (Mol. Cell. Biol. 1991) 3 4 23
  2. Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER. (PMID: 9722593) Kim L. … Wong T.W. (J. Biol. Chem. 1998) 3 4 23
  3. Identification of Fer tyrosine kinase localized on microtubules as a platelet endothelial cell adhesion molecule-1 phosphorylating kinase in vascular endothelial cells. (PMID: 12972546) Kogata N. … Mochizuki N. (Mol. Biol. Cell 2003) 3 4 23
  4. Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription. (PMID: 14517306) Miravet S. … Garcia de Herreros A. (Mol. Cell. Biol. 2003) 3 4 23
  5. The Fer tyrosine kinase cooperates with interleukin-6 to activate signal transducer and activator of transcription 3 and promote human prostate cancer cell growth. (PMID: 19147545) Zoubeidi A. … Chevalier S. (Mol. Cancer Res. 2009) 3 4 23

Products for FER Gene

  • Addgene plasmids for FER

Sources for FER Gene

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