Aliases for GPC4 Gene
External Ids for GPC4 Gene
Previous GeneCards Identifiers for GPC4 Gene
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. [provided by RefSeq, Jul 2008]
GeneCards Summary for GPC4 Gene
GPC4 (Glypican 4) is a Protein Coding gene. Diseases associated with GPC4 include gpc4-related simpson-golabi-behmel syndrome type 1 and simpson-golabi-behmel syndrome, type 1. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include heparan sulfate proteoglycan binding. An important paralog of this gene is GPC5.
UniProtKB/Swiss-Prot for GPC4 Gene
Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity).