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Aliases for FDXR Gene

Aliases for FDXR Gene

  • Ferredoxin Reductase 2 3 4
  • Adrenodoxin Reductase 2 3 4
  • ADXR 3 4 6
  • Adrenodoxin-NADP(+) Reductase 2 3
  • Ferredoxin--NADP(+) Reductase 3 4
  • AR 3 4
  • NADPH:Adrenodoxin Oxidoreductase, Mitochondrial 3
  • EC 1.18.1.2 63
  • EC 1.18.1.6 4

External Ids for FDXR Gene

Previous HGNC Symbols for FDXR Gene

  • ADXR

Previous GeneCards Identifiers for FDXR Gene

  • GC17M072875
  • GC17M075917
  • GC17M073322
  • GC17M073455
  • GC17M070370
  • GC17M072858
  • GC17M068269

Summaries for FDXR Gene

Entrez Gene Summary for FDXR Gene

  • This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for FDXR Gene

FDXR (Ferredoxin Reductase) is a Protein Coding gene. Diseases associated with FDXR include locked-in syndrome and congenital adrenal insufficiency. Among its related pathways are Pathways in cancer and Akt Signaling. GO annotations related to this gene include NADPH binding and NADPH-adrenodoxin reductase activity.

UniProtKB/Swiss-Prot for FDXR Gene

  • Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver

Gene Wiki entry for FDXR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FDXR Gene

Genomics for FDXR Gene

Regulatory Elements for FDXR Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FDXR Gene

Start:
74,862,497 bp from pter
End:
74,873,031 bp from pter
Size:
10,535 bases
Orientation:
Minus strand

Genomic View for FDXR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FDXR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FDXR Gene

Proteins for FDXR Gene

  • Protein details for FDXR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22570-ADRO_HUMAN
    Recommended name:
    NADPH:adrenodoxin oxidoreductase, mitochondrial
    Protein Accession:
    P22570
    Secondary Accessions:
    • B4DDI7
    • B4DHX5
    • B4DQQ4
    • B4DX24
    • B7Z7G2
    • E7EQC1
    • Q13716
    • Q4PJI0
    • Q9BU12

    Protein attributes for FDXR Gene

    Size:
    491 amino acids
    Molecular mass:
    53837 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Monomer. Interacts directly with FDX1.

    Alternative splice isoforms for FDXR Gene

neXtProt entry for FDXR Gene

Proteomics data for FDXR Gene at MOPED

Post-translational modifications for FDXR Gene

  • Ubiquitination at Lys209
  • Modification sites at PhosphoSitePlus

Domains for FDXR Gene

Graphical View of Domain Structure for InterPro Entry

P22570

UniProtKB/Swiss-Prot:

ADRO_HUMAN :
  • P22570
Family:
  • Belongs to the ferredoxin--NADP reductase type 1 family.
genes like me logo Genes that share domains with FDXR: view

No data available for Gene Families for FDXR Gene

Function for FDXR Gene

Molecular function for FDXR Gene

GENATLAS Biochemistry: ferredoxin oxidoreductase,electron transport flavoprotein for mitochondrial P450s
UniProtKB/Swiss-Prot CatalyticActivity: 2 reduced adrenodoxin + NADP(+) = 2 oxidized adrenodoxin + NADPH
UniProtKB/Swiss-Prot Function: Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver

Enzyme Numbers (IUBMB) for FDXR Gene

Gene Ontology (GO) - Molecular Function for FDXR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004324 ferredoxin-NADP+ reductase activity TAS 2845396
GO:0005515 protein binding IPI 18319262
GO:0015039 NADPH-adrenodoxin reductase activity IBA --
GO:0016491 oxidoreductase activity --
GO:0070402 NADPH binding --
genes like me logo Genes that share ontologies with FDXR: view

Phenotypes for FDXR Gene

GenomeRNAi human phenotypes for FDXR:
genes like me logo Genes that share phenotypes with FDXR: view

miRNA for FDXR Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FDXR

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for FDXR Gene

Localization for FDXR Gene

Subcellular locations from UniProtKB/Swiss-Prot for FDXR Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FDXR Gene COMPARTMENTS Subcellular localization image for FDXR gene
Compartment Confidence
mitochondrion 5
chloroplast 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for FDXR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with FDXR: view

Pathways for FDXR Gene

genes like me logo Genes that share pathways with FDXR: view

UniProtKB/Swiss-Prot P22570-ADRO_HUMAN

  • Pathway: Steroid metabolism; cholesterol metabolism

Gene Ontology (GO) - Biological Process for FDXR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy TAS 2845396
GO:0006694 steroid biosynthetic process TAS 1863359
GO:0006700 C21-steroid hormone biosynthetic process TAS --
GO:0006744 ubiquinone biosynthetic process IBA --
GO:0006805 xenobiotic metabolic process TAS --
genes like me logo Genes that share ontologies with FDXR: view

Compounds for FDXR Gene

(3) HMDB Compounds for FDXR Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
NADP
  • Adenine-nicotinamide dinucleotide phosphate
53-59-8
NADPH
  • 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
53-57-6

(2) Drugbank Compounds for FDXR Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2'-Monophosphoadenosine 5'-Diphosphoribose
target
Flavin-Adenine Dinucleotide
146-14-5 target

(26) Novoseek inferred chemical compound relationships for FDXR Gene

Compound -log(P) Hits PubMed IDs
carbazole 79.5 6
putidaredoxin 72 2
nadph 69.9 25
iron-sulfur 64.2 4
nadp+ 61.7 3
genes like me logo Genes that share compounds with FDXR: view

Transcripts for FDXR Gene

Unigene Clusters for FDXR Gene

Ferredoxin reductase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FDXR

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FDXR Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6:
SP7: - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - -
SP10: - - - - - -
SP11: - - - - -
SP12: - - - - -
SP13: - - - -
SP14: - - - -
SP15: -
SP16: - - - - - -

ExUns: 12 ^ 13 ^ 14 ^ 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for FDXR Gene

GeneLoc Exon Structure for
FDXR
ECgene alternative splicing isoforms for
FDXR

Expression for FDXR Gene

mRNA expression in normal human tissues for FDXR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FDXR Gene

This gene is overexpressed in Adrenal Gland (20.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FDXR Gene

SOURCE GeneReport for Unigene cluster for FDXR Gene Hs.69745

genes like me logo Genes that share expressions with FDXR: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FDXR Gene

Orthologs for FDXR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FDXR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FDXR 35
  • 97.39 (n)
  • 96.08 (a)
FDXR 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FDXR 35
  • 83.95 (n)
  • 79.8 (a)
FDXR 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FDXR 35
  • 88.93 (n)
  • 90.14 (a)
FDXR 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fdxr 35
  • 85.74 (n)
  • 87.37 (a)
Fdxr 16
Fdxr 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FDXR 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FDXR 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fdxr 35
  • 85.88 (n)
  • 87.37 (a)
chicken
(Gallus gallus)
Aves FDXR 35
  • 68.84 (n)
  • 69.13 (a)
lizard
(Anolis carolinensis)
Reptilia FDXR 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8959 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fdxr 35
  • 67.58 (n)
  • 70.02 (a)
Str.11467 35
zebrafish
(Danio rerio)
Actinopterygii fdxr 36
  • 59 (a)
OneToOne
LOC100536115 35
  • 63.14 (n)
  • 63.74 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005419 35
  • 53.64 (n)
  • 51.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta dare 35
  • 55.84 (n)
  • 51.64 (a)
dare 36
  • 48 (a)
OneToOne
dare 37
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea Y62E10A.6 36
  • 36 (a)
OneToOne
Y62E10A.6 37
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARH1 36
  • 34 (a)
OneToOne
ARH1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G32360 35
  • 51 (n)
  • 49.89 (a)
rice
(Oryza sativa)
Liliopsida Os02g0277600 35
  • 52.68 (n)
  • 50.79 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08005 35
  • 53.08 (n)
  • 47.01 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arh1 35
  • 46.02 (n)
  • 42.57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToOne
Species with no ortholog for FDXR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FDXR Gene

ENSEMBL:
Gene Tree for FDXR (if available)
TreeFam:
Gene Tree for FDXR (if available)

Paralogs for FDXR Gene

No data available for Paralogs for FDXR Gene

Variants for FDXR Gene

Sequence variations from dbSNP and Humsavar for FDXR Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs492095 -- 74,872,953(-) TGCTG(C/T)TCCCA utr-variant-5-prime, nc-transcript-variant
rs499995 -- 74,870,636(-) GGGGG(C/T)TGGAG intron-variant, upstream-variant-2KB
rs500145 -- 74,870,585(-) GCTGA(G/T)CCTGA intron-variant, upstream-variant-2KB
rs500887 -- 74,870,554(-) TAAGC(C/T)TTCCA intron-variant, upstream-variant-2KB
rs500997 -- 74,870,514(-) tttga(A/G)atgga intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FDXR Gene

Variant ID Type Subtype PubMed ID
nsv908743 CNV Loss 21882294
nsv518292 CNV Loss 19592680
nsv908744 CNV Loss 21882294
dgv3253n71 CNV Loss 21882294
nsv833540 CNV Loss 17160897
dgv3254n71 CNV Loss 21882294

Relevant External Links for FDXR Gene

HapMap Linkage Disequilibrium report
FDXR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FDXR Gene

Disorders for FDXR Gene

(2) University of Copenhagen DISEASES for FDXR Gene

(4) Novoseek inferred disease relationships for FDXR Gene

Disease -log(P) Hits PubMed IDs
tuberculosis 18.9 5
colon cancer 0 2
colorectal cancer 0 6
tumors 0 7

Relevant External Links for FDXR

Genetic Association Database (GAD)
FDXR
Human Genome Epidemiology (HuGE) Navigator
FDXR
genes like me logo Genes that share disorders with FDXR: view

No data available for UniProtKB/Swiss-Prot for FDXR Gene

Publications for FDXR Gene

  1. Cloning and sequence of the human adrenodoxin reductase gene. (PMID: 2236061) Lin D. … Miller W.L. (Proc. Natl. Acad. Sci. U.S.A. 1990) 3 4 23
  2. The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis. (PMID: 12370809) Liu G. … Chen X. (Oncogene 2002) 3 23
  3. Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells. (PMID: 18319262) Trapasso F. … Croce C.M. (J. Biol. Chem. 2008) 3 23
  4. Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions. (PMID: 19004824) Pichiorri F. … Huebner K. (J. Biol. Chem. 2009) 3 23
  5. Regional mapping of genes encoding human steroidogenic enzymes: P450scc to 15q23-q24, adrenodoxin to 11q22; adrenodoxin reductase to 17q24-q25; and P450c17 to 10q24-q25. (PMID: 1863359) Sparkes R.S. … Miller W.L. (DNA Cell Biol. 1991) 3 23

Products for FDXR Gene

  • Addgene plasmids for FDXR

Sources for FDXR Gene

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