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Aliases for FDX1 Gene

Aliases for FDX1 Gene

  • Ferredoxin 1 2 3
  • ADX 3 4 6
  • Adrenal Ferredoxin 3 4
  • Hepatoredoxin 3 4
  • Ferredoxin-1 3 4
  • Adrenodoxin, Mitochondrial 3
  • Mitochondrial Adrenodoxin 3
  • Adrenodoxin 2
  • LOH11CR1D 3
  • FDX 3

External Ids for FDX1 Gene

Previous HGNC Symbols for FDX1 Gene

  • FDX

Previous GeneCards Identifiers for FDX1 Gene

  • GC11P112572
  • GC11P111771
  • GC11P110334
  • GC11P109838
  • GC11P109805
  • GC11P106225

Summaries for FDX1 Gene

Entrez Gene Summary for FDX1 Gene

  • This gene encodes a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to mitochondrial cytochrome P450, involved in steroid, vitamin D, and bile acid metabolism. Pseudogenes of this functional gene are found on chromosomes 20 and 21. [provided by RefSeq, Aug 2011]

GeneCards Summary for FDX1 Gene

FDX1 (Ferredoxin 1) is a Protein Coding gene. Diseases associated with FDX1 include congenital adrenal insufficiency and lipoid adrenal hyperplasia. Among its related pathways are Metabolism and Mitochondrial Iron-Sulfur Cluster Biogenesis. GO annotations related to this gene include electron carrier activity and 2 iron, 2 sulfur cluster binding. An important paralog of this gene is ENSG00000167807.

UniProtKB/Swiss-Prot for FDX1 Gene

  • Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage.

Gene Wiki entry for FDX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FDX1 Gene

Genomics for FDX1 Gene

Regulatory Elements for FDX1 Gene

Genomic Location for FDX1 Gene

Start:
110,429,883 bp from pter
End:
110,464,884 bp from pter
Size:
35,002 bases
Orientation:
Plus strand

Genomic View for FDX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FDX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FDX1 Gene

Proteins for FDX1 Gene

  • Protein details for FDX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10109-ADX_HUMAN
    Recommended name:
    Adrenodoxin, mitochondrial
    Protein Accession:
    P10109
    Secondary Accessions:
    • B0YJ14
    • Q53YD6

    Protein attributes for FDX1 Gene

    Size:
    184 amino acids
    Molecular mass:
    19393 Da
    Cofactor:
    Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Note=Binds 1 [2Fe-2S] cluster.;
    Quaternary structure:
    • Interacts with CYP11A1.

    Three dimensional structures from OCA and Proteopedia for FDX1 Gene

neXtProt entry for FDX1 Gene

Proteomics data for FDX1 Gene at MOPED

Post-translational modifications for FDX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FDX1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FDX1 Gene

Domains for FDX1 Gene

Protein Domains for FDX1 Gene

Suggested Antigen Peptide Sequences for FDX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10109

UniProtKB/Swiss-Prot:

ADX_HUMAN :
  • P10109
Domain:
  • Contains 1 2Fe-2S ferredoxin-type domain.
Family:
  • Belongs to the adrenodoxin/putidaredoxin family.
genes like me logo Genes that share domains with FDX1: view

No data available for Gene Families for FDX1 Gene

Function for FDX1 Gene

Molecular function for FDX1 Gene

GENATLAS Biochemistry: ferredoxin,ion sulfur electron transport protein for mitochondrial P450s
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Redox potential: E(0) is -448 mV.;
UniProtKB/Swiss-Prot Function: Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage.

Gene Ontology (GO) - Molecular Function for FDX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding TAS 2969697
GO:0009055 electron carrier activity IDA 21636783
GO:0051536 iron-sulfur cluster binding --
GO:0051537 2 iron, 2 sulfur cluster binding IDA 21636783
genes like me logo Genes that share ontologies with FDX1: view

miRNA for FDX1 Gene

miRTarBase miRNAs that target FDX1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FDX1 Gene

Localization for FDX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FDX1 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FDX1 Gene COMPARTMENTS Subcellular localization image for FDX1 gene
Compartment Confidence
mitochondrion 5
chloroplast 2
endoplasmic reticulum 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FDX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with FDX1: view

Pathways for FDX1 Gene

genes like me logo Genes that share pathways with FDX1: view

Pathways by source for FDX1 Gene

Gene Ontology (GO) - Biological Process for FDX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006694 steroid biosynthetic process --
GO:0006700 C21-steroid hormone biosynthetic process TAS --
GO:0006805 xenobiotic metabolic process TAS --
GO:0008202 steroid metabolic process TAS --
GO:0008203 cholesterol metabolic process IDA 21636783
genes like me logo Genes that share ontologies with FDX1: view

Compounds for FDX1 Gene

(1) Drugbank Compounds for FDX1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Mitotane
53-19-0 target unknown

(37) Novoseek inferred chemical compound relationships for FDX1 Gene

Compound -log(P) Hits PubMed IDs
putidaredoxin 79.8 4
22r-hydroxycholesterol 79.6 3
18-hydroxycorticosterone 75.1 2
steroid 68.1 17
iron-sulfur 67.2 10
genes like me logo Genes that share compounds with FDX1: view

Transcripts for FDX1 Gene

mRNA/cDNA for FDX1 Gene

(173) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FDX1 Gene

Ferredoxin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FDX1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1:
SP2:

Relevant External Links for FDX1 Gene

GeneLoc Exon Structure for
FDX1
ECgene alternative splicing isoforms for
FDX1

Expression for FDX1 Gene

mRNA expression in normal human tissues for FDX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FDX1 Gene

This gene is overexpressed in Adrenal Gland (21.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FDX1 Gene

SOURCE GeneReport for Unigene cluster for FDX1 Gene Hs.744

mRNA Expression by UniProt/SwissProt for FDX1 Gene

P10109-ADX_HUMAN
Tissue specificity: Highest levels in the adrenal gland (at protein level). Also detected in kidney and testis (at protein level).
genes like me logo Genes that share expressions with FDX1: view

Orthologs for FDX1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FDX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FDX1 35
  • 99.46 (n)
  • 99.46 (a)
FDX1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FDX1 35
  • 77.59 (n)
  • 72.88 (a)
FDX1 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FDX1 35
  • 84.18 (n)
  • 79.1 (a)
FDX1 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fdx1 35
  • 77.36 (n)
  • 77.72 (a)
Fdx1 16
Fdx1 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FDX1 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FDX1 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fdx1 35
  • 77.9 (n)
  • 78.26 (a)
chicken
(Gallus gallus)
Aves FDX1 35
  • 76.25 (n)
  • 79.31 (a)
FDX1 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FDX1 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fdx1 35
  • 72.18 (n)
  • 80.99 (a)
Str.909 35
zebrafish
(Danio rerio)
Actinopterygii Dr.13680 35
fdx1 35
  • 69.05 (n)
  • 68.75 (a)
fdx1 36
  • 47 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003212 35
  • 52.32 (n)
  • 52.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1319 35
  • 61.01 (n)
  • 63.39 (a)
CG1319 36
  • 49 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YAH1 36
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4213 36
  • 36 (a)
OneToOne
Species with no ortholog for FDX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FDX1 Gene

ENSEMBL:
Gene Tree for FDX1 (if available)
TreeFam:
Gene Tree for FDX1 (if available)

Paralogs for FDX1 Gene

Paralogs for FDX1 Gene

Selected SIMAP similar genes for FDX1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FDX1 Gene

genes like me logo Genes that share paralogs with FDX1: view

Variants for FDX1 Gene

Sequence variations from dbSNP and Humsavar for FDX1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs13075 -- 110,463,038(+) TTATT(A/G)ACCTT utr-variant-3-prime
rs920722 -- 110,455,816(+) ATAGC(A/G)TTGGA intron-variant
rs935135 -- 110,459,171(+) CCACC(A/G)GTTTG intron-variant
rs1042198 -- 110,430,109(+) GTTCC(A/C/G)GACCG utr-variant-5-prime
rs1042288 -- 110,462,884(+) TCTGT(A/G)CTAGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FDX1 Gene

Variant ID Type Subtype PubMed ID
nsv898391 CNV Loss 21882294

Relevant External Links for FDX1 Gene

HapMap Linkage Disequilibrium report
FDX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FDX1 Gene

Disorders for FDX1 Gene

(2) Novoseek inferred disease relationships for FDX1 Gene

Disease -log(P) Hits PubMed IDs
xanthomatosis cerebrotendinous 68.9 1
choriocarcinoma 32.4 1

Relevant External Links for FDX1

Genetic Association Database (GAD)
FDX1
Human Genome Epidemiology (HuGE) Navigator
FDX1
genes like me logo Genes that share disorders with FDX1: view

No data available for UniProtKB/Swiss-Prot for FDX1 Gene

Publications for FDX1 Gene

  1. Electrochemical behaviour of human adrenodoxin on a pyrolytic graphite electrode. (PMID: 12699818) Johnson D. … Martin L.L. (Bioelectrochemistry 2003) 3 4 23
  2. Molecular cloning and sequence analysis of human placental ferredoxin. (PMID: 2969697) Mittal S. … Vickery L.E. (Arch. Biochem. Biophys. 1988) 2 3 4
  3. Cloning and structure of the human adrenodoxin gene. (PMID: 3229285) Chang C.-Y. … Chung B.-C. (DNA 1988) 3 4
  4. 1H NMR spectra of vertebrate [2Fe-2S] ferredoxins. Hyperfine resonances suggest different electron delocalization patterns from plant ferredoxins. (PMID: 1909889) Skjeldal L. … Vickery L.E. (Biochemistry 1991) 3 4
  5. Human adrenodoxin: cloning of three cDNAs and cycloheximide enhancement in JEG-3 cells. (PMID: 3343244) Picado-Leonard J. … Miller W.L. (J. Biol. Chem. 1988) 3 4

Products for FDX1 Gene

  • Addgene plasmids for FDX1

Sources for FDX1 Gene

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