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Aliases for ALDH3B2 Gene

Aliases for ALDH3B2 Gene

  • Aldehyde Dehydrogenase 3 Family Member B2 2 3 5
  • Aldehyde Dehydrogenase 8 2 3 4
  • Aldehyde Dehydrogenase 3 Family, Member B2 2 3
  • Acetaldehyde Dehydrogenase 8 2 3
  • EC 4 63
  • ALDH8 3 4
  • EC 1.2.1 63

External Ids for ALDH3B2 Gene

Previous HGNC Symbols for ALDH3B2 Gene

  • ALDH8

Previous GeneCards Identifiers for ALDH3B2 Gene

  • GC11M069952
  • GC11M069125
  • GC11M067679
  • GC11M067204
  • GC11M067186
  • GC11M067429
  • GC11M063759

Summaries for ALDH3B2 Gene

Entrez Gene Summary for ALDH3B2 Gene

  • This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene of this particular family member is over 10 kb in length. The expression of these transcripts is restricted to the salivary gland among the human tissues examined. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for ALDH3B2 Gene

ALDH3B2 (Aldehyde Dehydrogenase 3 Family Member B2) is a Protein Coding gene. Among its related pathways are Histidine metabolism and Metabolism of xenobiotics by cytochrome P450. GO annotations related to this gene include oxidoreductase activity and 3-chloroallyl aldehyde dehydrogenase activity. An important paralog of this gene is ALDH3B1.

Gene Wiki entry for ALDH3B2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALDH3B2 Gene

Genomics for ALDH3B2 Gene

Regulatory Elements for ALDH3B2 Gene

Enhancers for ALDH3B2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ALDH3B2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ALDH3B2 Gene

67,662,155 bp from pter
67,681,214 bp from pter
19,060 bases
Minus strand

Genomic View for ALDH3B2 Gene

Genes around ALDH3B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALDH3B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALDH3B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALDH3B2 Gene

Proteins for ALDH3B2 Gene

  • Protein details for ALDH3B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Aldehyde dehydrogenase family 3 member B2
    Protein Accession:
    Secondary Accessions:
    • Q53Y98
    • Q8NAL5
    • Q96IB2

    Protein attributes for ALDH3B2 Gene

    385 amino acids
    Molecular mass:
    42635 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ALDH3B2 Gene

Proteomics data for ALDH3B2 Gene at MOPED

Selected DME Specific Peptides for ALDH3B2 Gene

Post-translational modifications for ALDH3B2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALDH3B2 Gene

Domains & Families for ALDH3B2 Gene

Gene Families for ALDH3B2 Gene

Protein Domains for ALDH3B2 Gene

Suggested Antigen Peptide Sequences for ALDH3B2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the aldehyde dehydrogenase family.
  • Belongs to the aldehyde dehydrogenase family.
genes like me logo Genes that share domains with ALDH3B2: view

Function for ALDH3B2 Gene

Molecular function for ALDH3B2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
An aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H.

Enzyme Numbers (IUBMB) for ALDH3B2 Gene

Gene Ontology (GO) - Molecular Function for ALDH3B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004028 3-chloroallyl aldehyde dehydrogenase activity TAS 8890755
GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity EXP,IEA 25286108
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with ALDH3B2: view
genes like me logo Genes that share phenotypes with ALDH3B2: view

Animal Model Products

CRISPR Products

miRNA for ALDH3B2 Gene

miRTarBase miRNAs that target ALDH3B2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ALDH3B2 Gene

Localization for ALDH3B2 Gene

Subcellular locations from

Jensen Localization Image for ALDH3B2 Gene COMPARTMENTS Subcellular localization image for ALDH3B2 gene
Compartment Confidence
extracellular 2
plasma membrane 2
chloroplast 1
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ALDH3B2 Gene

Pathways & Interactions for ALDH3B2 Gene

genes like me logo Genes that share pathways with ALDH3B2: view

UniProtKB/Swiss-Prot P48448-AL3B2_HUMAN

  • Pathway: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.

Interacting Proteins for ALDH3B2 Gene

Gene Ontology (GO) - Biological Process for ALDH3B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006066 alcohol metabolic process TAS 8890755
GO:0006068 ethanol catabolic process IEA --
GO:0006629 lipid metabolic process TAS 8890755
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with ALDH3B2: view

No data available for SIGNOR curated interactions for ALDH3B2 Gene

Drugs & Compounds for ALDH3B2 Gene

(9) Drugs for ALDH3B2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
acetic acid Approved Nutra Full agonist, Agonist 97
3,4-Dihydroxybenzeneacetic acid Experimental Pharma 0
beta-Alanine Experimental Pharma Full agonist, Agonist Endogenous glycine agonist, more selective than taurine (Cat. No. 0209) 0
Chloral hydrate Experimental, Illicit Pharma 14
Phenylacetaldehyde Experimental Pharma 0

(21) Additional Compounds for ALDH3B2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 3,4-Dihydroxyphenylglycolaldehyde
  • 3,4-Dihydroxyphenylglycolic aldehyde
  • a,3,4-Trihydroxy-Benzeneacetaldehyde
  • alpha,3,4-Trihydroxy-Benzeneacetaldehyde
3,4-Dihydroxymandelic acid
  • 3,4 Dihydroxymandelate
  • 3,4 Dihydroxymandelic acid
  • 3,4-Dihydroxymandelate
  • 3,4-Dihydroxyphenylglycolate
  • 3,4-Dihydroxyphenylglycolic acid
  • 3,4-Dihydroxy-Benzeneacetaldehyde
  • Protocatechuatealdehyde
  • 3-Aminopropanal
  • 3-Aminopropionaldehyde
  • beta-Aminopropion aldehyde
genes like me logo Genes that share compounds with ALDH3B2: view

Transcripts for ALDH3B2 Gene

Unigene Clusters for ALDH3B2 Gene

Aldehyde dehydrogenase 3 family, member B2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALDH3B2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - - -
SP3: -
SP4: - - -

Relevant External Links for ALDH3B2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ALDH3B2 Gene

mRNA expression in normal human tissues for ALDH3B2 Gene

mRNA differential expression in normal tissues according to GTEx for ALDH3B2 Gene

This gene is overexpressed in Esophagus - Mucosa (x16.8), Skin - Sun Exposed (Lower leg) (x12.4), and Skin - Not Sun Exposed (Suprapubic) (x12.0).

Protein differential expression in normal tissues from HIPED for ALDH3B2 Gene

This gene is overexpressed in Lung (53.5) and Heart (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ALDH3B2 Gene

SOURCE GeneReport for Unigene cluster for ALDH3B2 Gene Hs.87539

mRNA Expression by UniProt/SwissProt for ALDH3B2 Gene

Tissue specificity: Salivary gland.
genes like me logo Genes that share expression patterns with ALDH3B2: view

Protein tissue co-expression partners for ALDH3B2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ALDH3B2 Gene

Orthologs for ALDH3B2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALDH3B2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ALDH3B2 36
  • 66 (a)
(Canis familiaris)
Mammalia ALDH3B2 36
  • 55 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 36 (a)
(Mus musculus)
Mammalia 1700055N04Rik 36
  • 63 (a)
Aldh3b2 36
  • 65 (a)
(Pan troglodytes)
Mammalia ALDH3B2 36
  • 96 (a)
(Gallus gallus)
Aves -- 36
  • 48 (a)
-- 36
  • 48 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
-- 36
  • 46 (a)
(Danio rerio)
Actinopterygii -- 35
aldh3b1 36
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta Aldh-III 37
  • 53 (a)
Aldh-III 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea alh-4 36
  • 34 (a)
alh-5 36
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HFD1 36
  • 25 (a)
(Zea mays)
Liliopsida Zm.17294 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6683 36
  • 34 (a)
CSA.9635 36
  • 33 (a)
Species with no ortholog for ALDH3B2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ALDH3B2 Gene

Gene Tree for ALDH3B2 (if available)
Gene Tree for ALDH3B2 (if available)

Paralogs for ALDH3B2 Gene

Paralogs for ALDH3B2 Gene

(5) SIMAP similar genes for ALDH3B2 Gene using alignment to 4 proteins: Pseudogenes for ALDH3B2 Gene

genes like me logo Genes that share paralogs with ALDH3B2: view

Variants for ALDH3B2 Gene

Sequence variations from dbSNP and Humsavar for ALDH3B2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs3741178 - 67,666,577(+) ACCTG(C/T)GGCGA reference, missense
rs4646826 - 67,663,729(-) AGCAG(A/C/T)GGCAG intron-variant, reference, missense
rs1551888 - 67,666,398(+) CGCAA(C/T)TCCCT reference, missense
rs6591270 - 67,665,383(+) TGATG(C/T)GGCCC reference, missense
rs2447571 - 67,665,333(+) GCGGC(C/T)GCAGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ALDH3B2 Gene

Variant ID Type Subtype PubMed ID
nsv897801 CNV Loss 21882294
esv2422195 CNV Duplication 17116639
dgv1196n71 CNV Loss 21882294
nsv468606 CNV Gain 19166990
dgv154n27 CNV Loss 19166990
dgv1198n71 CNV Loss 21882294
dgv1199n71 CNV Loss 21882294
nsv468609 CNV Loss 19166990
nsv469963 CNV Loss 18288195
nsv897826 CNV Loss 21882294
esv27185 CNV Loss 19812545
esv2744645 CNV Deletion 23290073
esv2179266 CNV Deletion 18987734
esv2744646 CNV Deletion 23290073
esv1206079 CNV Deletion 17803354
dgv161e201 CNV Deletion 23290073
esv2744648 CNV Deletion 23290073
esv2744649 CNV Deletion 23290073
esv2662033 CNV Deletion 23128226

Variation tolerance for ALDH3B2 Gene

Residual Variation Intolerance Score: 99.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.59; 78.05% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ALDH3B2 Gene

Disorders for ALDH3B2 Gene

Relevant External Links for ALDH3B2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ALDH3B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ALDH3B2 Gene

Publications for ALDH3B2 Gene

  1. Sequencing and expression of the human ALDH8 encoding a new member of the aldehyde dehydrogenase family. (PMID: 8890755) Hsu L.C. … Chang W.-C. (Gene 1996) 2 3 4 67
  2. Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison. (PMID: 9161417) Hsu L.C. … Yoshida A. (Gene 1997) 2 3
  3. Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification. (PMID: 25286108) Kitamura T. … Kihara A. (Biochem. J. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3

Products for ALDH3B2 Gene

Sources for ALDH3B2 Gene