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Aliases for FOXK1 Gene

Aliases for FOXK1 Gene

  • Forkhead Box K1 2 3 5
  • Myocyte Nuclear Factor 3 4
  • MNF 3 4
  • FOXK1L 3

External Ids for FOXK1 Gene

Previous GeneCards Identifiers for FOXK1 Gene

  • GC07U901483
  • GC07P004588
  • GC07P004496

Summaries for FOXK1 Gene

GeneCards Summary for FOXK1 Gene

FOXK1 (Forkhead Box K1) is a Protein Coding gene. Diseases associated with FOXK1 include Contagious Pustular Dermatitis and Thyroid Angiosarcoma. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXP3.

UniProtKB/Swiss-Prot for FOXK1 Gene

  • Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity).

Gene Wiki entry for FOXK1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXK1 Gene

Genomics for FOXK1 Gene

Regulatory Elements for FOXK1 Gene

Enhancers for FOXK1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FOXK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FOXK1 Gene

Chromosome:
7
Start:
4,644,691 bp from pter
End:
4,771,443 bp from pter
Size:
126,753 bases
Orientation:
Plus strand

Genomic View for FOXK1 Gene

Genes around FOXK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXK1 Gene

Proteins for FOXK1 Gene

  • Protein details for FOXK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P85037-FOXK1_HUMAN
    Recommended name:
    Forkhead box protein K1
    Protein Accession:
    P85037

    Protein attributes for FOXK1 Gene

    Size:
    733 amino acids
    Molecular mass:
    75457 Da
    Quaternary structure:
    • Interacts with SIN3B to form a complex which represses transcription.

    Alternative splice isoforms for FOXK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXK1 Gene

Proteomics data for FOXK1 Gene at MOPED

Post-translational modifications for FOXK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FOXK1 (FOXK1)
  • Abcam antibodies for FOXK1

No data available for DME Specific Peptides for FOXK1 Gene

Domains & Families for FOXK1 Gene

Gene Families for FOXK1 Gene

Suggested Antigen Peptide Sequences for FOXK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P85037

UniProtKB/Swiss-Prot:

FOXK1_HUMAN :
  • Contains 1 FHA domain.
Domain:
  • Contains 1 FHA domain.
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXK1: view

Function for FOXK1 Gene

Molecular function for FOXK1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity).

Gene Ontology (GO) - Molecular Function for FOXK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA,IBA --
GO:0005515 protein binding IEA,IPI 21903422
genes like me logo Genes that share ontologies with FOXK1: view
genes like me logo Genes that share phenotypes with FOXK1: view

Animal Models for FOXK1 Gene

MGI Knock Outs for FOXK1:

Animal Model Products

miRNA for FOXK1 Gene

miRTarBase miRNAs that target FOXK1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXK1 Gene

Localization for FOXK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXK1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXK1 Gene COMPARTMENTS Subcellular localization image for FOXK1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2

No data available for Gene Ontology (GO) - Cellular Components for FOXK1 Gene

Pathways & Interactions for FOXK1 Gene

SuperPathways for FOXK1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007517 muscle organ development IEA --
GO:0030154 cell differentiation IEA,IBA --
GO:0030308 negative regulation of cell growth IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with FOXK1: view

No data available for Pathways by source and SIGNOR curated interactions for FOXK1 Gene

Drugs & Compounds for FOXK1 Gene

No Compound Related Data Available

Transcripts for FOXK1 Gene

mRNA/cDNA for FOXK1 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXK1 Gene

Forkhead box K1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXK1 Gene

No ASD Table

Relevant External Links for FOXK1 Gene

GeneLoc Exon Structure for
FOXK1
ECgene alternative splicing isoforms for
FOXK1

Expression for FOXK1 Gene

mRNA expression in normal human tissues for FOXK1 Gene

Protein differential expression in normal tissues from HIPED for FOXK1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FOXK1 Gene



SOURCE GeneReport for Unigene cluster for FOXK1 Gene Hs.487393

mRNA Expression by UniProt/SwissProt for FOXK1 Gene

P85037-FOXK1_HUMAN
Tissue specificity: Expressed both developing and adult tissues. In adults, significant expression is seen in tumors of the brain, colon and lymph node.
genes like me logo Genes that share expression patterns with FOXK1: view

Protein tissue co-expression partners for FOXK1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FOXK1 Gene

Orthologs for FOXK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOXK1 35
  • 87.45 (n)
  • 92.76 (a)
FOXK1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXK1 35
  • 88.11 (n)
  • 93.62 (a)
FOXK1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxk1 35
  • 85.77 (n)
  • 92.28 (a)
Foxk1 16
Foxk1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOXK1 35
  • 99.32 (n)
  • 99.73 (a)
FOXK1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxk1 35
  • 85.62 (n)
  • 91.97 (a)
oppossum
(Monodelphis domestica)
Mammalia FOXK1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOXK1 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOXK1 35
  • 76.24 (n)
  • 86.5 (a)
FOXK1 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXK1 36
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii foxk1 35
  • 71.29 (n)
  • 76.89 (a)
wufi75f05 35
foxk1 36
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta fd68A 36
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FKH1 36
  • 14 (a)
ManyToMany
FKH2 36
  • 11 (a)
ManyToMany
FHL1 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9506 36
  • 37 (a)
OneToMany
Species with no ortholog for FOXK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXK1 Gene

ENSEMBL:
Gene Tree for FOXK1 (if available)
TreeFam:
Gene Tree for FOXK1 (if available)

Paralogs for FOXK1 Gene

(2) SIMAP similar genes for FOXK1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FOXK1: view

Variants for FOXK1 Gene

Sequence variations from dbSNP and Humsavar for FOXK1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs955194 -- 4,686,601(-) TATCA(C/T)GGAGA intron-variant
rs1001396 -- 4,679,000(+) TTCTG(C/T)ATCAC intron-variant
rs6950090 -- 4,727,412(+) ccggg(G/T)tcaag intron-variant
rs1053753 -- 4,762,404(+) GCTGT(A/G)ACCAC reference, synonymous-codon
rs6952604 -- 4,731,904(+) CCAGC(C/T)GTCCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXK1 Gene

Variant ID Type Subtype PubMed ID
dgv2050e1 CNV Complex 17122850
nsv508442 CNV Loss 20534489
nsv887377 CNV Loss 21882294
dgv7134n71 CNV Loss 21882294
esv2678462 CNV Deletion 23128226
esv2157596 CNV Deletion 18987734
nsv887379 CNV Loss 21882294
nsv471293 CNV Loss 18288195
dgv7135n71 CNV Loss 21882294
nsv823994 CNV Gain 20364138
nsv8033 CNV Loss 18304495
esv2380266 CNV Deletion 18987734
nsv366495 CNV Loss 16902084
esv2664593 CNV Deletion 23128226

Variation tolerance for FOXK1 Gene

Residual Variation Intolerance Score: 6.33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.80; 73.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXK1 Gene

Human Gene Mutation Database (HGMD)
FOXK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXK1 Gene

Disorders for FOXK1 Gene

MalaCards: The human disease database

(12) MalaCards diseases for FOXK1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
contagious pustular dermatitis
  • ecthyma contagiosum
thyroid angiosarcoma
  • hemangiosarcoma of the thyroid
thyroid sarcoma
  • sarcoma of the thyroid gland
pericardial mesothelioma
  • malignant mesothelioma of pericardium
pericardium cancer
  • malignant neoplasm of pericardium
- elite association - COSMIC cancer census association via MalaCards
Search FOXK1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FOXK1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXK1
genes like me logo Genes that share disorders with FOXK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOXK1 Gene

Publications for FOXK1 Gene

  1. Identification and characterization of human FOXK1 gene in silico. (PMID: 15202027) Katoh M. … Katoh M. (Int. J. Mol. Med. 2004) 2 3 4 67
  2. Identification and characterization of a novel human FOXK1 gene in silico. (PMID: 15289879) Huang J.T. … Lee V. (Int. J. Oncol. 2004) 3 23
  3. BRCA1-associated protein 1 (BAP1) deubiquitinase antagonizes the ubiquitin-mediated activation of FoxK2 target genes. (PMID: 25451922) Okino Y. … Machida Y.J. (J. Biol. Chem. 2015) 3
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  5. FOXKs promote Wnt/I^-catenin signaling by translocating DVL into the nucleus. (PMID: 25805136) Wang W. … Chen J. (Dev. Cell 2015) 3

Products for FOXK1 Gene

Sources for FOXK1 Gene

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