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Aliases for FOXK1 Gene

Aliases for FOXK1 Gene

  • Forkhead Box K1 2 3
  • Myocyte Nuclear Factor 3 4
  • MNF 3 4
  • Forkhead Box Protein K1 3
  • FOXK1L 3

External Ids for FOXK1 Gene

Summaries for FOXK1 Gene

GeneCards Summary for FOXK1 Gene

FOXK1 (Forkhead Box K1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and magnesium ion binding. An important paralog of this gene is FOXK2.

UniProtKB/Swiss-Prot for FOXK1 Gene

  • Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity).

Gene Wiki entry for FOXK1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXK1 Gene

Genomics for FOXK1 Gene

Genomic Location for FOXK1 Gene

Start:
4,682,299 bp from pter
End:
4,771,443 bp from pter
Size:
89,145 bases
Orientation:
Plus strand

Genomic View for FOXK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXK1 Gene

Regulatory Elements for FOXK1 Gene

Proteins for FOXK1 Gene

  • Protein details for FOXK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P85037-FOXK1_HUMAN
    Recommended name:
    Forkhead box protein K1
    Protein Accession:
    P85037
    Secondary Accessions:

    Protein attributes for FOXK1 Gene

    Size:
    733 amino acids
    Molecular mass:
    75457 Da
    Quaternary structure:
    • Interacts with SIN3B to form a complex which represses transcription.

    Alternative splice isoforms for FOXK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXK1 Gene

Proteomics data for FOXK1 Gene at MOPED

Post-translational modifications for FOXK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXK1 Gene

Domains for FOXK1 Gene

Gene Families for FOXK1 Gene

HGNC:
  • FOX :Forkhead boxes

Protein Domains for FOXK1 Gene

UniProtKB/Swiss-Prot:

FOXK1_HUMAN
Domain:
  • Contains 1 FHA domain.:
    • P85037
  • Contains 1 fork-head DNA-binding domain.:
    • P85037
genes like me logo Genes that share domains with FOXK1: view

Function for FOXK1 Gene

Molecular function for FOXK1 Gene

UniProtKB/Swiss-Prot Function: Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity).

Gene Ontology (GO) - Molecular Function for FOXK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0005515 protein binding IPI 21903422
genes like me logo Genes that share ontologies with FOXK1: view
genes like me logo Genes that share phenotypes with FOXK1: view

Animal Models for FOXK1 Gene

MGI Knock Outs for FOXK1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FOXK1 Gene

Localization for FOXK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXK1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXK1 Gene COMPARTMENTS Subcellular localization image for FOXK1 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for FOXK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with FOXK1: view

Pathways for FOXK1 Gene

SuperPathways for FOXK1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0007517 muscle organ development IEA --
GO:0009653 anatomical structure morphogenesis IBA --
genes like me logo Genes that share ontologies with FOXK1: view

No data available for Pathways by source for FOXK1 Gene

Transcripts for FOXK1 Gene

mRNA/cDNA for FOXK1 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXK1 Gene

Forkhead box K1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXK1 Gene

No ASD Table

Relevant External Links for FOXK1 Gene

GeneLoc Exon Structure for
FOXK1
ECgene alternative splicing isoforms for
FOXK1

Expression for FOXK1 Gene

mRNA expression in normal human tissues for FOXK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FOXK1 Gene

SOURCE GeneReport for Unigene cluster for FOXK1 Gene Hs.487393

mRNA Expression by UniProt/SwissProt for FOXK1 Gene

P85037-FOXK1_HUMAN
Tissue specificity: Expressed both developing and adult tissues. In adults, significant expression is seen in tumors of the brain, colon and lymph node.
genes like me logo Genes that share expressions with FOXK1: view

Orthologs for FOXK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXK1 36
  • 99.32 (n)
  • 99.73 (a)
FOXK1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FOXK1 36
  • 87.45 (n)
  • 92.76 (a)
FOXK1 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXK1 36
  • 88.11 (n)
  • 93.62 (a)
FOXK1 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxk1 36
  • 85.77 (n)
  • 92.28 (a)
Foxk1 16
Foxk1 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FOXK1 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOXK1 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxk1 36
  • 85.62 (n)
  • 91.97 (a)
chicken
(Gallus gallus)
Aves FOXK1 36
  • 76.24 (n)
  • 86.5 (a)
FOXK1 37
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXK1 37
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii foxk1 36
  • 71.29 (n)
  • 76.89 (a)
foxk1 37
  • 71 (a)
OneToOne
wufi75f05 36
fruit fly
(Drosophila melanogaster)
Insecta fd68A 37
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FHL1 39
FKH1 37
  • 14 (a)
ManyToMany
FKH2 37
  • 11 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9506 37
  • 37 (a)
OneToMany
Species with no ortholog for FOXK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXK1 Gene

ENSEMBL:
Gene Tree for FOXK1 (if available)
TreeFam:
Gene Tree for FOXK1 (if available)

Paralogs for FOXK1 Gene

Selected SIMAP similar genes for FOXK1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FOXK1: view

Variants for FOXK1 Gene

Sequence variations from dbSNP and Humsavar for FOXK1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs11628 -- 4,771,170(+) CAGGC(A/G)ACCTG utr-variant-3-prime
rs11727 -- 4,762,811(-) GGAGC(A/G)GAGGG utr-variant-3-prime
rs15715 -- 4,762,342(-) AGAGG(C/G/T)GGAGG missense, reference
rs188511 -- 4,768,240(+) ccatt(C/T)tcctg utr-variant-3-prime
rs365991 -- 4,771,670(+) CCCGA(C/G)CCCCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FOXK1 Gene

Variant ID Type Subtype PubMed ID
dgv2050e1 CNV Complex 17122850
nsv508442 CNV Loss 20534489
nsv887377 CNV Loss 21882294
dgv7134n71 CNV Loss 21882294
esv2678462 CNV Deletion 23128226
esv2157596 CNV Deletion 18987734
nsv887379 CNV Loss 21882294
nsv471293 CNV Loss 18288195
dgv7135n71 CNV Loss 21882294
nsv823994 CNV Gain 20364138
nsv8033 CNV Loss 18304495
esv2380266 CNV Deletion 18987734
nsv366495 CNV Loss 16902084
esv2664593 CNV Deletion 23128226

Relevant External Links for FOXK1 Gene

HapMap Linkage Disequilibrium report
FOXK1
Human Gene Mutation Database (HGMD)
FOXK1

Disorders for FOXK1 Gene

(1) University of Copenhagen DISEASES for FOXK1 Gene

genes like me logo Genes that share disorders with FOXK1: view

No data available for UniProtKB/Swiss-Prot for FOXK1 Gene

Publications for FOXK1 Gene

  1. Identification and characterization of a novel human FOXK1 gene in silico. (PMID: 15289879) Huang J.T. … Lee V. (Int. J. Oncol. 2004) 3 4 23
  2. Identification and characterization of human FOXK1 gene in silico. (PMID: 15202027) Katoh M. … Katoh M. (Int. J. Mol. Med. 2004) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for FOXK1 Gene

Sources for FOXK1 Gene

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