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Aliases for SP8 Gene

Aliases for SP8 Gene

  • Sp8 Transcription Factor 2 3 5
  • Specificity Protein 8 3 4
  • BTD 3

External Ids for SP8 Gene

Previous GeneCards Identifiers for SP8 Gene

  • GC07U990363
  • GC07M020532
  • GC07M020568
  • GC07M020566
  • GC07M020595

Summaries for SP8 Gene

Entrez Gene Summary for SP8 Gene

  • The protein encoded by this gene is an SP family transcription factor that in mouse has been shown to be essential for proper limb development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for SP8 Gene

SP8 (Sp8 Transcription Factor) is a Protein Coding gene. Diseases associated with SP8 include skin papilloma and bipolar i disorder. Among its related pathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. An important paralog of this gene is SP4.

UniProtKB/Swiss-Prot for SP8 Gene

  • Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity).

Gene Wiki entry for SP8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SP8 Gene

Genomics for SP8 Gene

Regulatory Elements for SP8 Gene

Promoters for SP8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SP8 on UCSC Golden Path with GeneCards custom track

Genomic Location for SP8 Gene

Chromosome:
7
Start:
20,781,467 bp from pter
End:
20,786,889 bp from pter
Size:
5,423 bases
Orientation:
Minus strand

Genomic View for SP8 Gene

Genes around SP8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SP8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SP8 Gene

Proteins for SP8 Gene

  • Protein details for SP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXZ3-SP8_HUMAN
    Recommended name:
    Transcription factor Sp8
    Protein Accession:
    Q8IXZ3
    Secondary Accessions:
    • Q7Z615
    • Q7Z616
    • Q96MJ1

    Protein attributes for SP8 Gene

    Size:
    490 amino acids
    Molecular mass:
    48674 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71297.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SP8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SP8 Gene

Proteomics data for SP8 Gene at MOPED

Post-translational modifications for SP8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SP8 Gene

No data available for DME Specific Peptides for SP8 Gene

Domains & Families for SP8 Gene

Protein Domains for SP8 Gene

Suggested Antigen Peptide Sequences for SP8 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IXZ3

UniProtKB/Swiss-Prot:

SP8_HUMAN :
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with SP8: view

Function for SP8 Gene

Molecular function for SP8 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity).
genes like me logo Genes that share phenotypes with SP8: view

Animal Models for SP8 Gene

MGI Knock Outs for SP8:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SP8 Gene

Localization for SP8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SP8 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SP8 Gene COMPARTMENTS Subcellular localization image for SP8 gene
Compartment Confidence
nucleus 5
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for SP8 Gene

Pathways & Interactions for SP8 Gene

genes like me logo Genes that share pathways with SP8: view

Gene Ontology (GO) - Biological Process for SP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0009954 proximal/distal pattern formation IEA --
GO:0030326 embryonic limb morphogenesis IEA --
genes like me logo Genes that share ontologies with SP8: view

No data available for SIGNOR curated interactions for SP8 Gene

Drugs & Compounds for SP8 Gene

No Compound Related Data Available

Transcripts for SP8 Gene

Unigene Clusters for SP8 Gene

Sp8 transcription factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SP8 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for SP8 Gene

GeneLoc Exon Structure for
SP8
ECgene alternative splicing isoforms for
SP8

Expression for SP8 Gene

mRNA expression in normal human tissues for SP8 Gene

mRNA differential expression in normal tissues according to GTEx for SP8 Gene

This gene is overexpressed in Prostate (x17.5), Skin - Sun Exposed (Lower leg) (x5.7), Brain - Anterior cingulate cortex (BA24) (x4.9), and Brain - Frontal Cortex (BA9) (x4.3).

Protein differential expression in normal tissues from HIPED for SP8 Gene

This gene is overexpressed in Pancreatic juice (53.8) and Adipocyte (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SP8 Gene



SOURCE GeneReport for Unigene cluster for SP8 Gene Hs.195922

genes like me logo Genes that share expression patterns with SP8: view

Protein tissue co-expression partners for SP8 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SP8 Gene

Orthologs for SP8 Gene

This gene was present in the common ancestor of animals.

Orthologs for SP8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SP8 35
  • 99.61 (n)
  • 99.61 (a)
SP8 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SP8 36
  • 99 (a)
OneToOne
SP8 35
  • 93.07 (n)
  • 98.27 (a)
mouse
(Mus musculus)
Mammalia Sp8 36
  • 98 (a)
OneToOne
Sp8 35
  • 88.07 (n)
  • 96.71 (a)
Sp8 16
oppossum
(Monodelphis domestica)
Mammalia SP8 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sp8 35
  • 88.96 (n)
  • 96.83 (a)
chicken
(Gallus gallus)
Aves SP8 35
  • 86.89 (n)
  • 90.7 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.9284 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sp8 35
  • 72.18 (n)
  • 77.76 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.16588 35
sp8b 35
  • 72.2 (n)
  • 81.99 (a)
sp8a 36
  • 76 (a)
OneToMany
sp8b 36
  • 81 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sp1 36
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sptf-2 35
  • 47.58 (n)
  • 55.8 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11111 35
Species with no ortholog for SP8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SP8 Gene

ENSEMBL:
Gene Tree for SP8 (if available)
TreeFam:
Gene Tree for SP8 (if available)

Paralogs for SP8 Gene

Paralogs for SP8 Gene

genes like me logo Genes that share paralogs with SP8: view

Variants for SP8 Gene

Sequence variations from dbSNP and Humsavar for SP8 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2390362 -- 20,787,916(+) CTTTA(A/G)AAGTG upstream-variant-2KB
rs2390363 -- 20,788,035(+) GGTAA(A/G)AAATT upstream-variant-2KB
rs2390364 -- 20,788,044(+) TTGAA(A/G)AGCGT upstream-variant-2KB
rs2390365 -- 20,788,063(+) ATTTA(A/C/G)AAATT upstream-variant-2KB
rs5882772 -- 20,781,583(+) GGCTC(-/A)AGGAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SP8 Gene

Variant ID Type Subtype PubMed ID
nsv824024 CNV Gain 20364138

Variation tolerance for SP8 Gene

Gene Damage Index Score: 5.10; 69.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SP8 Gene

HapMap Linkage Disequilibrium report
SP8
Human Gene Mutation Database (HGMD)
SP8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SP8 Gene

Disorders for SP8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SP8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
skin papilloma
  • cutaneous papilloma
bipolar i disorder
- elite association - COSMIC cancer census association via MalaCards
Search SP8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SP8

Genetic Association Database (GAD)
SP8
Human Genome Epidemiology (HuGE) Navigator
SP8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SP8
genes like me logo Genes that share disorders with SP8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SP8 Gene

Publications for SP8 Gene

  1. Genome-wide association study of bipolar I disorder in the Han Chinese population. (PMID: 20386566) Lee M.T. … Cheng A.T. (Mol. Psychiatry 2011) 3 48 67
  2. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3
  3. Genetic variants on 3q21 and in the Sp8 transcription factor gene (SP8) as susceptibility loci for psychotic disorders: a genetic association study. (PMID: 23967141) Kondo K. … Iwata N. (PLoS ONE 2013) 3
  4. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3
  5. Genome-wide association of lipid-lowering response to statins in combined study populations. (PMID: 20339536) Barber M.J. … Krauss R.M. (PLoS ONE 2010) 3

Products for SP8 Gene

Sources for SP8 Gene

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