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Aliases for SP8 Gene

Aliases for SP8 Gene

  • Sp8 Transcription Factor 2 3
  • Specificity Protein 8 3 4
  • BTD 3 6
  • Transcription Factor Sp8 3

External Ids for SP8 Gene

Summaries for SP8 Gene

Entrez Gene Summary for SP8 Gene

  • The protein encoded by this gene is an SP family transcription factor that in mouse has been shown to be essential for proper limb development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for SP8 Gene

SP8 (Sp8 Transcription Factor) is a Protein Coding gene. Diseases associated with SP8 include skin papilloma and bipolar i disorder. Among its related pathways are Disease and Metabolism. An important paralog of this gene is KLF2.

UniProtKB/Swiss-Prot for SP8 Gene

  • Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity).

Gene Wiki entry for SP8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SP8 Gene

Genomics for SP8 Gene

Genomic Location for SP8 Gene

20,782,274 bp from pter
20,786,889 bp from pter
4,616 bases
Minus strand

Genomic View for SP8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SP8 Gene

Regulatory Elements for SP8 Gene

Proteins for SP8 Gene

  • Protein details for SP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor Sp8
    Protein Accession:
    Secondary Accessions:
    • Q7Z615
    • Q7Z616
    • Q96MJ1

    Protein attributes for SP8 Gene

    490 amino acids
    Molecular mass:
    48674 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB71297.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SP8 Gene


neXtProt entry for SP8 Gene

Proteomics data for SP8 Gene at MOPED

Post-translational modifications for SP8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SP8 Gene

No data available for DME Specific Peptides for SP8 Gene

Domains for SP8 Gene

Gene Families for SP8 Gene

  • ZNF :Zinc fingers, C2H2-type
  • SP :Specificity protein transcription factors

Protein Domains for SP8 Gene


  • Belongs to the Sp1 C2H2-type zinc-finger protein family.:
    • Q8IXZ3
  • Contains 3 C2H2-type zinc fingers.:
    • Q8IXZ3
genes like me logo Genes that share domains with SP8: view

Function for SP8 Gene

Molecular function for SP8 Gene

UniProtKB/Swiss-Prot Function: Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity).

Gene Ontology (GO) - Molecular Function for SP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SP8: view
genes like me logo Genes that share phenotypes with SP8: view

Animal Models for SP8 Gene

MGI Knock Outs for SP8:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SP8 Gene

Localization for SP8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SP8 Gene


Subcellular locations from

Jensen Localization Image for SP8 Gene COMPARTMENTS Subcellular localization image for SP8 gene
Compartment Confidence
nucleus 4
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SP8: view

Pathways for SP8 Gene

SuperPathways for SP8 Gene

genes like me logo Genes that share pathways with SP8: view

Gene Ontology (GO) - Biological Process for SP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0009953 dorsal/ventral pattern formation IEA --
GO:0009954 proximal/distal pattern formation IEA --
GO:0030326 embryonic limb morphogenesis IEA --
genes like me logo Genes that share ontologies with SP8: view

Transcripts for SP8 Gene

Unigene Clusters for SP8 Gene

Sp8 transcription factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SP8 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP2: -

Relevant External Links for SP8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SP8 Gene

mRNA expression in normal human tissues for SP8 Gene

mRNA differential expression in normal tissues according to GTEx for SP8 Gene

This gene is overexpressed in Prostate (17.5), Skin - Sun Exposed (Lower leg) (5.7), Brain - Anterior cingulate cortex (BA24) (4.9), and Brain - Frontal Cortex (BA9) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SP8 Gene

SOURCE GeneReport for Unigene cluster for SP8 Gene Hs.195922

genes like me logo Genes that share expressions with SP8: view

Orthologs for SP8 Gene

This gene was present in the common ancestor of animals.

Orthologs for SP8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SP8 36
  • 99.61 (n)
  • 99.61 (a)
SP8 37
  • 100 (a)
(Bos Taurus)
Mammalia SP8 36
  • 93.07 (n)
  • 98.27 (a)
SP8 37
  • 99 (a)
(Mus musculus)
Mammalia Sp8 36
  • 88.07 (n)
  • 96.71 (a)
Sp8 16
Sp8 37
  • 98 (a)
(Monodelphis domestica)
Mammalia SP8 37
  • 95 (a)
(Rattus norvegicus)
Mammalia Sp8 36
  • 88.96 (n)
  • 96.83 (a)
(Gallus gallus)
Aves SP8 36
  • 86.89 (n)
  • 90.7 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 38 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9284 36
tropical clawed frog
(Silurana tropicalis)
Amphibia sp8 36
  • 72.18 (n)
  • 77.76 (a)
(Danio rerio)
Actinopterygii Dr.16588 36
sp8a 37
  • 76 (a)
sp8b 36
  • 72.2 (n)
  • 81.99 (a)
sp8b 37
  • 81 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sp1 37
  • 34 (a)
(Caenorhabditis elegans)
Secernentea sptf-2 36
  • 47.58 (n)
  • 55.8 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11111 36
Species with no ortholog for SP8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SP8 Gene

Gene Tree for SP8 (if available)
Gene Tree for SP8 (if available)

Paralogs for SP8 Gene

genes like me logo Genes that share paralogs with SP8: view

Variants for SP8 Gene

Sequence variations from dbSNP and Humsavar for SP8 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs727398 -- 20,788,088(-) AAGAG(A/G)CAGTG upstream-variant-2KB
rs2390362 -- 20,787,916(+) CTTTA(A/G)AAGTG upstream-variant-2KB
rs2390363 -- 20,788,035(+) GGTAA(A/G)AAATT upstream-variant-2KB
rs2390364 -- 20,788,044(+) TTGAA(A/G)AGCGT upstream-variant-2KB
rs2390365 -- 20,788,063(+) ATTTA(A/C/G)AAATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SP8 Gene

Variant ID Type Subtype PubMed ID
nsv824024 CNV Gain 20364138

Relevant External Links for SP8 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for SP8 Gene

(1) University of Copenhagen DISEASES for SP8 Gene

Relevant External Links for SP8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SP8: view

No data available for UniProtKB/Swiss-Prot for SP8 Gene

Publications for SP8 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genomic structure and cloning of two transcript isoforms of human Sp8. (PMID: 15533246) Milona M.-A. … Edgar A.J. (BMC Genomics 2004) 3 4
  4. Genome-wide association study of bipolar I disorder in the Han Chinese population. (PMID: 20386566) Lee M.T. … Cheng A.T. (Mol. Psychiatry 2011) 3 49
  5. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 49

Products for SP8 Gene

Sources for SP8 Gene

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