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Aliases for FCGR2B Gene

Aliases for FCGR2B Gene

  • Fc Fragment Of IgG, Low Affinity IIb, Receptor (CD32) 2 3
  • Fc Fragment Of IgG, Low Affinity IIb, Receptor For (CD32) 2 3
  • IgG Fc Receptor II-B 3 4
  • Fc-Gamma RII-B 3 4
  • Fc-Gamma-RIIb 3 4
  • FcRII-B 3 4
  • CDW32 3 4
  • IGFR2 3 4
  • CD32 3 4
  • FCG2 3 4
  • Fc Fragment Of IgG, Low Affinity II, Receptor For (CD32) 3
  • Fc Gamma RIIb 3
  • CD32 Antigen 4
  • CD32B 3
  • FCGR2 3

External Ids for FCGR2B Gene

Previous HGNC Symbols for FCGR2B Gene

  • FCG2
  • FCGR2

Previous GeneCards Identifiers for FCGR2B Gene

  • GC01P159267
  • GC01P157283
  • GC01P158328
  • GC01P158820
  • GC01P158365
  • GC01P159899
  • GC01P132877

Summaries for FCGR2B Gene

Entrez Gene Summary for FCGR2B Gene

  • The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for FCGR2B Gene

FCGR2B (Fc Fragment Of IgG, Low Affinity IIb, Receptor (CD32)) is a Protein Coding gene. Diseases associated with FCGR2B include systemic lupus erythematosus and cystic fibrosis. Among its related pathways are Immune System and Phospholipase-C Pathway. GO annotations related to this gene include IgG binding. An important paralog of this gene is FCRL2.

UniProtKB/Swiss-Prot for FCGR2B Gene

  • Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis

Gene Wiki entry for FCGR2B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGR2B Gene

Genomics for FCGR2B Gene

Regulatory Elements for FCGR2B Gene

Genomic Location for FCGR2B Gene

Chromosome:
1
Start:
161,581,311 bp from pter
End:
161,678,654 bp from pter
Size:
97,344 bases
Orientation:
Plus strand

Genomic View for FCGR2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCGR2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCGR2B Gene

Proteins for FCGR2B Gene

  • Protein details for FCGR2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31994-FCG2B_HUMAN
    Recommended name:
    Low affinity immunoglobulin gamma Fc region receptor II-b
    Protein Accession:
    P31994
    Secondary Accessions:
    • A6H8N3
    • O95649
    • Q53X85
    • Q5VXA9
    • Q8NIA1

    Protein attributes for FCGR2B Gene

    Size:
    310 amino acids
    Molecular mass:
    34044 Da
    Quaternary structure:
    • Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D/SHIP1. Interacts with FGR. Interacts with LYN.
    SequenceCaution:
    • Sequence=CAA35645.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FCGR2B Gene

    Alternative splice isoforms for FCGR2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCGR2B Gene

Proteomics data for FCGR2B Gene at MOPED

Post-translational modifications for FCGR2B Gene

  • Phosphorylated by the SRC-type Tyr-kinases LYN and BLK.
  • Glycosylation at Asn 106, Asn 180, and Asn 187
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for FCGR2B (Fc gamma RIIB/CD32b)
  • R&D Systems Antibodies for FCGR2B (Fc gamma RIIB/C (CD32b/c))

No data available for DME Specific Peptides for FCGR2B Gene

Domains & Families for FCGR2B Gene

Gene Families for FCGR2B Gene

Protein Domains for FCGR2B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FCGR2B Gene

Graphical View of Domain Structure for InterPro Entry

P31994

UniProtKB/Swiss-Prot:

FCG2B_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with FCGR2B: view

Function for FCGR2B Gene

Molecular function for FCGR2B Gene

GENATLAS Biochemistry:
immunoglobulin G,low affinity Fc receptor 2B (see IGFCR),maintaining gamma immune system homeostasis through negative regulation of immune responses mediated by receptors that bear the I,dysregulated by chromosomal translocation in malignant lymphoma
UniProtKB/Swiss-Prot Function:
Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis

Gene Ontology (GO) - Molecular Function for FCGR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 8577729
GO:0019864 IgG binding IEA --
genes like me logo Genes that share ontologies with FCGR2B: view
genes like me logo Genes that share phenotypes with FCGR2B: view

Animal Models for FCGR2B Gene

MGI Knock Outs for FCGR2B:

Animal Model Products

CRISPR Products

miRNA for FCGR2B Gene

miRTarBase miRNAs that target FCGR2B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCGR2B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FCGR2B Gene

Localization for FCGR2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCGR2B Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCGR2B Gene COMPARTMENTS Subcellular localization image for FCGR2B gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for FCGR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FCGR2B: view

Pathways & Interactions for FCGR2B Gene

genes like me logo Genes that share pathways with FCGR2B: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for FCGR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 2142460
GO:0007165 signal transduction TAS 2142460
GO:0016032 viral process IEA --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with FCGR2B: view

No data available for SIGNOR curated interactions for FCGR2B Gene

Drugs & Compounds for FCGR2B Gene

(36) Drugs for FCGR2B Gene - From: NovoSeek, DGIdb, DrugBank, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Daclizumab Approved, Investigational Pharma Target 94,126
Antithymocyte globulin Approved Pharma binder, Target 0
Abciximab Approved Pharma Target 63
Adalimumab Approved Pharma Target 411
Alefacept Approved, Withdrawn Pharma Target 40

(7) Additional Compounds for FCGR2B Gene - From: NovoSeek

genes like me logo Genes that share compounds with FCGR2B: view

Transcripts for FCGR2B Gene

Unigene Clusters for FCGR2B Gene

Fc fragment of IgG, low affinity IIb, receptor (CD32):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCGR2B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCGR2B Gene

No ASD Table

Relevant External Links for FCGR2B Gene

GeneLoc Exon Structure for
FCGR2B
ECgene alternative splicing isoforms for
FCGR2B

Expression for FCGR2B Gene

mRNA expression in normal human tissues for FCGR2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCGR2B Gene

This gene is overexpressed in Whole Blood (x6.8).

Protein differential expression in normal tissues from HIPED for FCGR2B Gene

This gene is overexpressed in Blymphocyte (47.4), Placenta (10.0), and Urinary Bladder (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCGR2B Gene



SOURCE GeneReport for Unigene cluster for FCGR2B Gene Hs.654395

mRNA Expression by UniProt/SwissProt for FCGR2B Gene

P31994-FCG2B_HUMAN
Tissue specificity: Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells
genes like me logo Genes that share expression patterns with FCGR2B: view

Protein tissue co-expression partners for FCGR2B Gene

Primer Products

In Situ Assay Products

Orthologs for FCGR2B Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCGR2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FCGR2C 35
  • 72.44 (n)
  • 59.56 (a)
FCGR2 36
  • 53 (a)
ManyToMany
FCGR2C 36
  • 51 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia FCGR2B 35
  • 74.56 (n)
  • 59.01 (a)
-- 36
  • 60 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fcgr2b 35
  • 74.17 (n)
  • 63.25 (a)
Fcgr2b 16
Fcgr2b 36
  • 50 (a)
ManyToMany
Fcgr3 36
  • 46 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia FCGR2B 35
  • 99.12 (n)
  • 99.62 (a)
FCGR2B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fcgr2b 35
  • 70.67 (n)
  • 60.08 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 26 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
Species with no ortholog for FCGR2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCGR2B Gene

ENSEMBL:
Gene Tree for FCGR2B (if available)
TreeFam:
Gene Tree for FCGR2B (if available)

Paralogs for FCGR2B Gene

genes like me logo Genes that share paralogs with FCGR2B: view

Variants for FCGR2B Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FCGR2B Gene

P31994-FCG2B_HUMAN
Note=FCGR2B polymorphisms can influence susceptibility or resistance to malaria [MIM:611162]

Sequence variations from dbSNP and Humsavar for FCGR2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs844 -- 161,677,743(+) CAAAT(A/G)ACCGA utr-variant-3-prime
rs1043 -- 161,677,739(+) GTCCC(A/G)AATGC utr-variant-3-prime
rs922087 -- 161,670,305(+) TCCCT(C/T)GGGTC intron-variant
rs1050499 - 161,673,197(+) GCTGT(A/T)CTCAT reference, missense
rs1050501 Pathogenic, - 161,674,008(+) TGGGA(C/T)TGCTG missense, reference, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FCGR2B Gene

Variant ID Type Subtype PubMed ID
dgv133e1 CNV Complex 17122850
dgv4n68 CNV Gain+Loss 17160897
nsv428257 CNV Loss 18775914
esv28122 CNV Gain+Loss 19812545
dgv8e55 CNV Gain 17911159
dgv135e1 CNV Complex 17122850
dgv136e1 CNV Complex 17122850
nsv8502 CNV Loss 18304495
esv33393 CNV Gain+Loss 17666407
nsv519779 CNV Loss 19592680
nsv464173 CNV Gain 19166990
nsv825176 CNV Gain 20364138
nsv820341 CNV Duplication 20802225
dgv398n71 CNV Gain 21882294
esv997087 CNV Loss 20482838
dgv85n67 CNV Loss 20364138
nsv818489 CNV Gain 17921354
nsv517640 CNV Gain+Loss 19592680
dgv137e1 CNV Complex 17122850
dgv138e1 CNV Complex 17122850
dgv139e1 CNV Complex 17122850
nsv514915 CNV Complex 21397061
nsv442209 CNV CNV 18776908
nsv509546 CNV Insertion 20534489
nsv821621 CNV Loss 15273396
dgv24n16 CNV Insertion 17901297
esv3325 CNV Deletion 18987735
esv5752 CNV Loss 19470904
dgv140e1 CNV Complex 17122850
nsv437224 CNV Loss 16327808
nsv482140 CNV Gain 20164927
nsv464184 CNV Gain 19166990

Variation tolerance for FCGR2B Gene

Residual Variation Intolerance Score: 50.36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.59; 82.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCGR2B Gene

HapMap Linkage Disequilibrium report
FCGR2B
Human Gene Mutation Database (HGMD)
FCGR2B

Disorders for FCGR2B Gene

MalaCards: The human disease database

(14) MalaCards diseases for FCGR2B Gene - From: OMIM, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
systemic lupus erythematosus
  • lupus nephritis
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
chronic polyneuropathy
demyelinating polyneuropathy
  • peripheral demyelinating neuropathy
follicular lymphoma
  • lymphoma, follicular
- elite association

UniProtKB/Swiss-Prot

FCG2B_HUMAN
  • Note=A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression.
  • Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269 PubMed:12115230, ECO:0000269 PubMed:20385827}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for FCGR2B

Genetic Association Database (GAD)
FCGR2B
Human Genome Epidemiology (HuGE) Navigator
FCGR2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCGR2B
genes like me logo Genes that share disorders with FCGR2B: view

No data available for Genatlas for FCGR2B Gene

Publications for FCGR2B Gene

  1. Antigen-induced oligomerization of the B cell receptor is an early target of Fc gamma RIIB inhibition. (PMID: 20083655) Liu W. … Pierce S.K. (J. Immunol. 2010) 23 67
  2. IgG antibodies produced during subcutaneous allergen immunotherapy mediate inhibition of basophil activation via a mechanism involving both FcgammaRIIA and FcgammaRIIB. (PMID: 20004689) Cady C.T. … Cambier J.C. (Immunol. Lett. 2010) 23 67
  3. FcgammaRIIB in autoimmunity and infection: evolutionary and therapeutic implications. (PMID: 20414206) Smith K.G. … Clatworthy M.R. (Nat. Rev. Immunol. 2010) 23 67
  4. Utilization of immunoglobulin G Fc receptors by human immunodeficiency virus type 1: a specific role for antibodies against the membrane-proximal external region of gp41. (PMID: 19458010) Perez L.G. … Montefiori D.C. (J. Virol. 2009) 23 67
  5. Identification of a high affinity FcgammaRIIA-binding peptide that distinguishes FcgammaRIIA from FcgammaRIIB and exploits FcgammaRIIA-mediated phagocytosis and degradation. (PMID: 18957413) Berntzen G. … Sandlie I. (J. Biol. Chem. 2009) 23 67

Products for FCGR2B Gene

Sources for FCGR2B Gene

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