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Aliases for FCGR2B Gene

Aliases for FCGR2B Gene

  • Fc Fragment Of IgG Receptor IIb 2 3 5
  • Fc Fragment Of IgG, Low Affinity IIb, Receptor For (CD32) 2 3
  • Fc Fragment Of IgG, Low Affinity IIb, Receptor (CD32) 2 3
  • Fc Gamma Receptor IIb 2 3
  • IgG Fc Receptor II-B 3 4
  • Fc-Gamma RII-B 3 4
  • Fc-Gamma-RIIb 3 4
  • FcRII-B 3 4
  • CDw32 3 4
  • IGFR2 3 4
  • FCG2 3 4
  • CD32 3 4
  • Low Affinity Immunoglobulin Gamma Fc Region Receptor II-B 3
  • Fc Fragment Of IgG, Low Affinity II, Receptor For (CD32) 3
  • Fc Gamma RIIb 3
  • CD32 Antigen 4
  • FCGR2 3
  • CD32B 3

External Ids for FCGR2B Gene

Previous HGNC Symbols for FCGR2B Gene

  • FCG2
  • FCGR2

Previous GeneCards Identifiers for FCGR2B Gene

  • GC01P159267
  • GC01P157283
  • GC01P158328
  • GC01P158820
  • GC01P158365
  • GC01P159899
  • GC01P161552
  • GC01P132877

Summaries for FCGR2B Gene

Entrez Gene Summary for FCGR2B Gene

  • The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

CIViC summary for FCGR2B Gene

GeneCards Summary for FCGR2B Gene

FCGR2B (Fc Fragment Of IgG Receptor IIb) is a Protein Coding gene. Diseases associated with FCGR2B include Systemic Lupus Erythematosus and Malaria. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Phospholipase-C Pathway. GO annotations related to this gene include IgG binding. An important paralog of this gene is FCGR2C.

UniProtKB/Swiss-Prot for FCGR2B Gene

  • Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.

Gene Wiki entry for FCGR2B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGR2B Gene

Genomics for FCGR2B Gene

Regulatory Elements for FCGR2B Gene

Enhancers for FCGR2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G161611 2 FANTOM5 Ensembl ENCODE dbSUPER 27.7 -50.8 -50815 2.6 HDGF PKNOX1 CREB3L1 ARNT SIN3A FEZF1 ZNF2 ZNF766 ZNF143 KLF13 FCGR2B ATF6 FCGR2C FCGR3B DUSP12 HSPA6 HSPA7 FCRLB FCGR3A TRL-CAA6-1
GH01G161620 1.9 FANTOM5 Ensembl ENCODE dbSUPER 27.8 -40.0 -40036 4.6 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZNF766 SP3 JUNB REST FCGR2B FCGR3B ATF6 FCGR3A FCGR2A GC01P161621
GH01G161642 1.6 Ensembl ENCODE dbSUPER 25.3 -19.7 -19715 2.8 HDGF PKNOX1 CREB3L1 ARNT SIN3A FEZF1 ZNF2 ZNF766 KLF13 DEK FCGR2B FCGR2C ATF6 DUSP12 FCRLB FCGR3B HSPA7
GH01G161649 1.1 dbSUPER 28.2 -12.2 -12177 1.9 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZNF766 KLF13 SP3 REST FCGR2B FCGR3B HSPA7 ATF6
GH01G161635 1.1 Ensembl dbSUPER 28.1 -27.0 -27015 1.8 HDAC1 PKNOX1 ARNT ZBTB40 CEBPB ZEB2 ZNF592 MEF2D CREB3 MTA1 FCGR2B FCGR3B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FCGR2B on UCSC Golden Path with GeneCards custom track

Genomic Location for FCGR2B Gene

Chromosome:
1
Start:
161,663,115 bp from pter
End:
161,678,654 bp from pter
Size:
15,540 bases
Orientation:
Plus strand

Genomic View for FCGR2B Gene

Genes around FCGR2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCGR2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCGR2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCGR2B Gene

Proteins for FCGR2B Gene

  • Protein details for FCGR2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31994-FCG2B_HUMAN
    Recommended name:
    Low affinity immunoglobulin gamma Fc region receptor II-b
    Protein Accession:
    P31994
    Secondary Accessions:
    • A6H8N3
    • O95649
    • Q53X85
    • Q5VXA9
    • Q8NIA1

    Protein attributes for FCGR2B Gene

    Size:
    310 amino acids
    Molecular mass:
    34044 Da
    Quaternary structure:
    • Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D/SHIP1. Interacts with FGR. Interacts with LYN.
    SequenceCaution:
    • Sequence=CAA35645.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FCGR2B Gene

    Alternative splice isoforms for FCGR2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCGR2B Gene

Post-translational modifications for FCGR2B Gene

  • Phosphorylated by the SRC-type Tyr-kinases LYN and BLK.
  • Glycosylation at Asn106, Asn180, and isoforms=2, 3187
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for FCGR2B (Fc gamma RIIB/CD32b)
  • R&D Systems Antibodies for FCGR2B (Fc gamma RIIB/C (CD32b/c))

Assay Products

  • Cloud-Clone Corp. Assay Kits for FCGR2B

No data available for DME Specific Peptides for FCGR2B Gene

Domains & Families for FCGR2B Gene

Protein Domains for FCGR2B Gene

Suggested Antigen Peptide Sequences for FCGR2B Gene

Graphical View of Domain Structure for InterPro Entry

P31994

UniProtKB/Swiss-Prot:

FCG2B_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
genes like me logo Genes that share domains with FCGR2B: view

Function for FCGR2B Gene

Molecular function for FCGR2B Gene

GENATLAS Biochemistry:
immunoglobulin G,low affinity Fc receptor 2B (see IGFCR),maintaining gamma immune system homeostasis through negative regulation of immune responses mediated by receptors that bear the I,dysregulated by chromosomal translocation in malignant lymphoma
UniProtKB/Swiss-Prot Function:
Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.

Gene Ontology (GO) - Molecular Function for FCGR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 8577729
GO:0019864 IgG binding IEA --
genes like me logo Genes that share ontologies with FCGR2B: view
genes like me logo Genes that share phenotypes with FCGR2B: view

Animal Models for FCGR2B Gene

MGI Knock Outs for FCGR2B:

Animal Model Products

CRISPR Products

miRNA for FCGR2B Gene

miRTarBase miRNAs that target FCGR2B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FCGR2B Gene

Localization for FCGR2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCGR2B Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCGR2B gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FCGR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FCGR2B: view

Pathways & Interactions for FCGR2B Gene

genes like me logo Genes that share pathways with FCGR2B: view

Pathways by source for FCGR2B Gene

Gene Ontology (GO) - Biological Process for FCGR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 2142460
GO:0007165 signal transduction TAS 2142460
GO:0016032 viral process IEA --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with FCGR2B: view

No data available for SIGNOR curated interactions for FCGR2B Gene

Drugs & Compounds for FCGR2B Gene

(40) Drugs for FCGR2B Gene - From: DrugBank, DGIdb, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Abciximab Approved Pharma Target 65
Adalimumab Approved Pharma Target 494
Alefacept Approved, Withdrawn Pharma Target 40
alemtuzumab Approved, Investigational Pharma Target Therapeutic Antibodies 310
Anti-thymocyte Globulin (Rabbit) Approved Pharma Target 0

(6) Additional Compounds for FCGR2B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FCGR2B: view

Transcripts for FCGR2B Gene

Unigene Clusters for FCGR2B Gene

Fc fragment of IgG, low affinity IIb, receptor (CD32):
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCGR2B Gene

No ASD Table

Relevant External Links for FCGR2B Gene

GeneLoc Exon Structure for
FCGR2B
ECgene alternative splicing isoforms for
FCGR2B

Expression for FCGR2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCGR2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCGR2B Gene

This gene is overexpressed in Whole Blood (x6.8).

Protein differential expression in normal tissues from HIPED for FCGR2B Gene

This gene is overexpressed in Blymphocyte (47.4), Placenta (10.0), and Urinary Bladder (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCGR2B Gene



Protein tissue co-expression partners for FCGR2B Gene

NURSA nuclear receptor signaling pathways regulating expression of FCGR2B Gene:

FCGR2B

SOURCE GeneReport for Unigene cluster for FCGR2B Gene:

Hs.654395

mRNA Expression by UniProt/SwissProt for FCGR2B Gene:

P31994-FCG2B_HUMAN
Tissue specificity: Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.

Evidence on tissue expression from TISSUES for FCGR2B Gene

  • Blood(4.6)
  • Skin(4.4)
  • Lymph node(2.9)
  • Spleen(2.8)
  • Heart(2.1)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with FCGR2B: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FCGR2B Gene

Orthologs for FCGR2B Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCGR2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCGR2B 34 35
  • 99.12 (n)
dog
(Canis familiaris)
Mammalia FCGR2B 34
  • 74.56 (n)
-- 35
  • 60 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fcgr2b 34 16 35
  • 74.17 (n)
Fcgr3 35
  • 46 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia FCGR2C 34 35
  • 72.44 (n)
FCGR2 35
  • 53 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Fcgr2b 34
  • 70.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 42 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 26 (a)
OneToMany
Species where no ortholog for FCGR2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCGR2B Gene

ENSEMBL:
Gene Tree for FCGR2B (if available)
TreeFam:
Gene Tree for FCGR2B (if available)

Paralogs for FCGR2B Gene

genes like me logo Genes that share paralogs with FCGR2B: view

Variants for FCGR2B Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FCGR2B Gene

FCG2B_HUMAN-P31994
Note=FCGR2B polymorphisms can influence susceptibility or resistance to malaria [MIM:611162].

Sequence variations from dbSNP and Humsavar for FCGR2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1050501 other 161,674,008(+) TGGGA(C/T)TGCTG downstream-variant-500B, reference, missense
rs1000035949 -- 161,660,013(+) CTTTC(A/C)CTTTC intron-variant
rs1000428236 -- 161,656,154(+) GCCCA(C/G)CCTCA intron-variant
rs1001028923 -- 161,651,316(+) TTCTT(C/T)TGCCA intron-variant
rs1001099411 -- 161,677,783(+) ACATC(A/T)AGGCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FCGR2B Gene

Variant ID Type Subtype PubMed ID
dgv24n16 CNV insertion 17901297
dgv447n100 CNV gain 25217958
dgv448n100 CNV loss 25217958
dgv449n100 CNV gain+loss 25217958
dgv450n100 CNV gain 25217958
dgv451n100 CNV loss 25217958
dgv452n100 CNV gain+loss 25217958
dgv453n100 CNV gain 25217958
dgv454n100 CNV gain+loss 25217958
dgv455n100 CNV loss 25217958
dgv4n68 CNV gain+loss 17160897
dgv5e203 CNV gain+loss 21179565
dgv605n54 CNV loss 21841781
dgv606n54 CNV loss 21841781
dgv85n67 CNV loss 20364138
dgv8e55 CNV gain 17911159
esv2758972 CNV gain+loss 17122850
esv28122 CNV gain+loss 19812545
esv3325 CNV loss 18987735
esv33393 CNV gain+loss 17666407
esv3541689 CNV deletion 23714750
esv3584532 CNV gain 24956385
esv5752 CNV loss 19470904
esv997087 CNV loss 20482838
nsv1003502 CNV gain 25217958
nsv1003686 CNV loss 25217958
nsv1014271 CNV loss 25217958
nsv1161862 CNV duplication 26073780
nsv428257 CNV loss 18775914
nsv437224 CNV loss 16327808
nsv442209 CNV gain 18776908
nsv464173 CNV gain 19166990
nsv464184 CNV gain 19166990
nsv482140 CNV gain 20164927
nsv509546 CNV insertion 20534489
nsv514915 CNV gain 21397061
nsv517640 CNV gain+loss 19592680
nsv519779 CNV loss 19592680
nsv548074 CNV loss 21841781
nsv548075 CNV gain 21841781
nsv818489 CNV gain 17921354
nsv820341 CNV duplication 20802225
nsv821621 CNV loss 15273396
nsv825176 CNV gain 20364138
nsv8502 CNV loss 18304495
nsv946468 CNV duplication 23825009
nsv946470 CNV duplication 23825009
nsv997927 CNV gain 25217958

Variation tolerance for FCGR2B Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.59; 82.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCGR2B Gene

Human Gene Mutation Database (HGMD)
FCGR2B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCGR2B

Disorders for FCGR2B Gene

MalaCards: The human disease database

(8) MalaCards diseases for FCGR2B Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
systemic lupus erythematosus
  • lupus nephritis
malaria
  • malaria, severe
measles
  • morbilli
cryptococcal meningitis
  • meningitis cryptococcal
multifocal motor neuropathy
  • mmn
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

FCG2B_HUMAN
  • Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269 PubMed:12115230, ECO:0000269 PubMed:20385827}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for FCGR2B

Genetic Association Database (GAD)
FCGR2B
Human Genome Epidemiology (HuGE) Navigator
FCGR2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCGR2B
genes like me logo Genes that share disorders with FCGR2B: view

No data available for Genatlas for FCGR2B Gene

Publications for FCGR2B Gene

  1. A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus. (PMID: 20385827) Willcocks L.C. … Smith K.G. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4 46 64
  2. Genetic susceptibility and haplotype analysis between Fcgamma receptor IIB and IIIA gene with systemic lupus erythematosus in Chinese population. (PMID: 18625651) Pan F. … Ye D.Q. (Lupus 2008) 3 22 46 64
  3. The combined genotypes of stimulatory and inhibitory Fc gamma receptors associated with systemic lupus erythematosus and periodontitis in Japanese adults. (PMID: 17335370) Kobayashi T. … Yoshie H. (J. Periodontol. 2007) 3 22 46 64
  4. Association of Fcgamma receptor IIB gene polymorphism with genetic susceptibility to systemic lupus erythematosus in Chinese populations--a family-based association study. (PMID: 16531013) Pan F. … Ye D. (J. Dermatol. Sci. 2006) 3 22 46 64
  5. The functional variant of the inhibitory Fcgamma receptor IIb (CD32B) is associated with the rate of radiologic joint damage and dendritic cell function in rheumatoid arthritis. (PMID: 17133580) Radstake T.R. … van Riel P.L. (Arthritis Rheum. 2006) 3 22 46 64

Products for FCGR2B Gene

Sources for FCGR2B Gene

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