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Aliases for FCER2 Gene

Aliases for FCER2 Gene

  • Fc Fragment Of IgE, Low Affinity II, Receptor For (CD23) 2 3
  • Immunoglobulin E-Binding Factor 3 4
  • Lymphocyte IgE Receptor 3 4
  • Fc-Epsilon-RII 3 4
  • CD23 Antigen 3 4
  • BLAST-2 3 4
  • CLEC4J 3 4
  • CD23A 3 4
  • IGEBF 3 4
  • FCE2 3 4
  • Fc Fragment Of IgE, Low Affinity II, Receptor For (CD23A) 2
  • C-Type Lectin Domain Family 4, Member J 3
  • C-Type Lectin Domain Family 4 Member J 4
  • Immunoglobulin Epsilon-Chain 3
  • CD23 3

External Ids for FCER2 Gene

Previous HGNC Symbols for FCER2 Gene

  • CD23A
  • FCE2

Previous GeneCards Identifiers for FCER2 Gene

  • GC19M007712
  • GC19M007858
  • GC19M007648
  • GC19M007659
  • GC19M007423
  • GC19M007754

Summaries for FCER2 Gene

Entrez Gene Summary for FCER2 Gene

  • The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

GeneCards Summary for FCER2 Gene

FCER2 (Fc Fragment Of IgE, Low Affinity II, Receptor For (CD23)) is a Protein Coding gene. Diseases associated with FCER2 include chronic conjunctivitis and persistent polyclonal b-cell lymphocytosis. Among its related pathways are Signaling by GPCR and GPCR Pathway. GO annotations related to this gene include carbohydrate binding and IgE binding. An important paralog of this gene is CLEC4D.

UniProtKB/Swiss-Prot for FCER2 Gene

  • Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen)

Gene Wiki entry for FCER2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCER2 Gene

Genomics for FCER2 Gene

Regulatory Elements for FCER2 Gene

Genomic Location for FCER2 Gene

Chromosome:
19
Start:
7,688,757 bp from pter
End:
7,702,310 bp from pter
Size:
13,554 bases
Orientation:
Minus strand

Genomic View for FCER2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCER2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCER2 Gene

Proteins for FCER2 Gene

  • Protein details for FCER2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06734-FCER2_HUMAN
    Recommended name:
    Low affinity immunoglobulin epsilon Fc receptor
    Protein Accession:
    P06734

    Protein attributes for FCER2 Gene

    Size:
    321 amino acids
    Molecular mass:
    36469 Da
    Quaternary structure:
    • Homotrimer.
    Miscellaneous:
    • There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes
    SequenceCaution:
    • Sequence=AAA52433.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FCER2 Gene

neXtProt entry for FCER2 Gene

Proteomics data for FCER2 Gene at MOPED

Post-translational modifications for FCER2 Gene

Other Protein References for FCER2 Gene

Antibody Products

  • R&D Systems Antibodies for FCER2 (CD23/Fc epsilon RII)

Protein Products

No data available for DME Specific Peptides for FCER2 Gene

Domains & Families for FCER2 Gene

Gene Families for FCER2 Gene

Suggested Antigen Peptide Sequences for FCER2 Gene

Graphical View of Domain Structure for InterPro Entry

P06734

UniProtKB/Swiss-Prot:

FCER2_HUMAN :
  • Contains 1 C-type lectin domain.
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with FCER2: view

Function for FCER2 Gene

Molecular function for FCER2 Gene

GENATLAS Biochemistry:
immunoglobulin E,low affinity Fc receptor
UniProtKB/Swiss-Prot Function:
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen)

Gene Ontology (GO) - Molecular Function for FCER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding TAS 2529542
GO:0005515 protein binding IPI 25416956
GO:0019863 IgE binding IEA --
GO:0030246 carbohydrate binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FCER2: view
genes like me logo Genes that share phenotypes with FCER2: view

Animal Models for FCER2 Gene

MGI Knock Outs for FCER2:

Animal Model Products

CRISPR Products

miRNA for FCER2 Gene

miRTarBase miRNAs that target FCER2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCER2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FCER2 Gene

Localization for FCER2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCER2 Gene

Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted. Note=Also exists as a soluble excreted form, sCD23.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCER2 Gene COMPARTMENTS Subcellular localization image for FCER2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 3

Gene Ontology (GO) - Cellular Components for FCER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2529542
GO:0009897 external side of plasma membrane IEA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with FCER2: view

Pathways & Interactions for FCER2 Gene

genes like me logo Genes that share pathways with FCER2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for FCER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IEA --
GO:0007219 Notch signaling pathway TAS --
GO:0051000 positive regulation of nitric-oxide synthase activity IDA 7544003
GO:0051712 positive regulation of killing of cells of other organism IDA 7544003
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process IDA 7544003
genes like me logo Genes that share ontologies with FCER2: view

No data available for SIGNOR curated interactions for FCER2 Gene

Drugs & Compounds for FCER2 Gene

(27) Drugs for FCER2 Gene - From: NovoSeek and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cefadroxil Approved, Withdrawn Pharma 8
Ceftriaxone Approved Pharma 104
Dexamethasone Approved, Investigational Pharma Agonist 1806
Fenoterol Approved Pharma Full agonist, Agonist 14
Hydrocortisone Approved Pharma Agonist 550

(21) Additional Compounds for FCER2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
12-O-Tetradecanoylphorbol 13-acetate
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
Allergens
Cycloheximide
Cytochalasin B
genes like me logo Genes that share compounds with FCER2: view

Transcripts for FCER2 Gene

Unigene Clusters for FCER2 Gene

Fc fragment of IgE, low affinity II, receptor for (CD23):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FCER2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCER2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: -
SP5: -
SP6:

Relevant External Links for FCER2 Gene

GeneLoc Exon Structure for
FCER2
ECgene alternative splicing isoforms for
FCER2

Expression for FCER2 Gene

mRNA expression in normal human tissues for FCER2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCER2 Gene

This gene is overexpressed in Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for FCER2 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCER2 Gene



SOURCE GeneReport for Unigene cluster for FCER2 Gene Hs.465778

genes like me logo Genes that share expression patterns with FCER2: view

Protein tissue co-expression partners for FCER2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FCER2 Gene

Orthologs for FCER2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCER2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FCER2 35
  • 75.69 (n)
  • 65.28 (a)
FCER2 36
  • 58 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FCER2 35
  • 78.36 (n)
  • 65.62 (a)
FCER2 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fcer2a 35
  • 70.67 (n)
  • 58.12 (a)
Fcer2a 16
Fcer2a 36
  • 54 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FCER2 35
  • 85.76 (n)
  • 80.91 (a)
FCER2 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fcer2 35
  • 70.13 (n)
  • 58.44 (a)
oppossum
(Monodelphis domestica)
Mammalia FCER2 36
  • 37 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858751 35
  • 50.53 (n)
  • 36.2 (a)
FCER2 36
  • 28 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
OneToMany
Species with no ortholog for FCER2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCER2 Gene

ENSEMBL:
Gene Tree for FCER2 (if available)
TreeFam:
Gene Tree for FCER2 (if available)

Paralogs for FCER2 Gene

genes like me logo Genes that share paralogs with FCER2: view

Variants for FCER2 Gene

Sequence variations from dbSNP and Humsavar for FCER2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs889182 -- 7,700,380(+) TCTTC(A/G)GATTC upstream-variant-2KB, intron-variant
rs1042428 -- 7,690,520(-) ATCAA(C/T)TTCCA synonymous-codon, reference
rs76013233 -- 7,690,599(+) GAAGT(A/G)CCTTG intron-variant
rs76212638 -- 7,692,035(+) GTCCA(A/T)CAACA intron-variant
rs76258959 -- 7,691,078(+) CTAGA(A/G)GCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCER2 Gene

Variant ID Type Subtype PubMed ID
esv2751809 CNV Gain 17911159
nsv910970 CNV Loss 21882294
nsv833731 CNV Loss 17160897
nsv833732 CNV Gain 17160897
esv2718099 CNV Deletion 23290073
esv2405737 CNV Deletion 18987734
esv26340 CNV Gain 19812545
esv8285 CNV Gain 19470904
dgv542e201 CNV Deletion 23290073
dgv543e201 CNV Deletion 23290073
esv8263 CNV Loss 19470904
esv2718104 CNV Deletion 23290073

Variation tolerance for FCER2 Gene

Residual Variation Intolerance Score: 97.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.75; 86.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCER2 Gene

HapMap Linkage Disequilibrium report
FCER2
Human Gene Mutation Database (HGMD)
FCER2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCER2 Gene

Disorders for FCER2 Gene

MalaCards: The human disease database

(18) MalaCards diseases for FCER2 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
chronic conjunctivitis
  • chronic conjunctivitis nos
persistent polyclonal b-cell lymphocytosis
  • ppbl
intrinsic asthma
dendritic cell sarcoma
  • dendritic cell sarcoma, not otherwise specified
idiopathic neutropenia
  • ni-cina
- elite association
Search FCER2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FCER2

Genetic Association Database (GAD)
FCER2
Human Genome Epidemiology (HuGE) Navigator
FCER2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCER2
genes like me logo Genes that share disorders with FCER2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCER2 Gene

Publications for FCER2 Gene

  1. Molecular blocking of CD23 supports its role in the pathogenesis of arthritis. (PMID: 19279679) Rambert J. … Mossalayi M.D. (PLoS ONE 2009) 23 67
  2. The cut-off levels of CD23 expression in the differential diagnosis of MCL and CLL. (PMID: 18381689) Barna G. … Matolcsy A. (Hematol Oncol 2008) 23 67
  3. The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10. (PMID: 17389606) Lemieux G.A. … Werb Z. (J. Biol. Chem. 2007) 23 67
  4. Soluble CD23 monomers inhibit and oligomers stimulate IGE synthesis in human B cells. (PMID: 17576766) McCloskey N. … Gould H.J. (J. Biol. Chem. 2007) 23 67
  5. Decoding IgE Fc receptors. (PMID: 17496343) Zhang M. … Agrawal D.K. (Immunol. Res. 2007) 23 67

Products for FCER2 Gene

Sources for FCER2 Gene

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