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Aliases for MS4A2 Gene

Aliases for MS4A2 Gene

  • Membrane-Spanning 4-Domains, Subfamily A, Member 2 2 3
  • FCER1B 3 4 6
  • IgE Fc Receptor Subunit Beta 3 4
  • FCERI 3 4
  • IGER 3 4
  • APY 3 4
  • High Affinity Immunoglobulin Epsilon Receptor Beta-Subunit (FcERI) (IgE Fc Receptor, Beta-Subunit) (Fc Epsilon Receptor I Beta-Chain) 3
  • Membrane-Spanning 4-Domains, Subfamily A, Member 2 (Fc Fragment Of IgE, High Affinity I, Receptor For; Beta Polypeptide) 2
  • Fc Fragment Of IgE, High Affinity I, Receptor For; Beta Polypeptide 3
  • High Affinity Immunoglobulin Epsilon Receptor Subunit Beta 3
  • Immunoglobulin E Receptor, High Affinity, Beta Polypeptide 3
  • Membrane-Spanning 4-Domains Subfamily A Member 2 4
  • High Affinity IgE Receptor Beta Subunit 3
  • Fc Epsilon Receptor I Beta-Chain 4
  • Receptor For; Beta Polypeptide 2
  • IgE Responsiveness (Atopic) 2
  • Fc Fragment Of IgE 2
  • High Affinity I 2
  • IGHER 3
  • ATOPY 3
  • MS4A1 3
  • IGEL 3

External Ids for MS4A2 Gene

Previous Symbols for MS4A2 Gene

  • FCER1B
  • IGER
  • APY

Summaries for MS4A2 Gene

Entrez Gene Summary for MS4A2 Gene

  • The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012]

GeneCards Summary for MS4A2 Gene

MS4A2 (Membrane-Spanning 4-Domains, Subfamily A, Member 2) is a Protein Coding gene. Diseases associated with MS4A2 include hand dermatosis and allergic asthma. Among its related pathways are PI-3K cascade and Immune response Fc epsilon RI pathway. GO annotations related to this gene include protein kinase binding and SH2 domain binding. An important paralog of this gene is MS4A3.

UniProtKB/Swiss-Prot for MS4A2 Gene

  • High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy

Gene Wiki entry for MS4A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A2 Gene

Genomics for MS4A2 Gene

Genomic Location for MS4A2 Gene

Start:
60,088,261 bp from pter
End:
60,098,467 bp from pter
Size:
10,207 bases
Orientation:
Plus strand

Genomic View for MS4A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MS4A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A2 Gene

Regulatory Elements for MS4A2 Gene

Transcription factor binding sites by QIAGEN in the MS4A2 gene promoter:

Proteins for MS4A2 Gene

  • Protein details for MS4A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01362-FCERB_HUMAN
    Recommended name:
    High affinity immunoglobulin epsilon receptor subunit beta
    Protein Accession:
    Q01362
    Secondary Accessions:
    • Q54A81

    Protein attributes for MS4A2 Gene

    Size:
    244 amino acids
    Molecular mass:
    26534 Da
    Quaternary structure:
    • Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Binds LILRB1. Interacts with FGR, FES/FPS and LYN (By similarity).

neXtProt entry for MS4A2 Gene

Proteomics data for MS4A2 Gene at MOPED

Post-translational modifications for MS4A2 Gene

Other Protein References for MS4A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MS4A2 Gene

Domains for MS4A2 Gene

Protein Domains for MS4A2 Gene

UniProtKB/Swiss-Prot:

FCERB_HUMAN
Family:
  • Belongs to the MS4A family.:
    • Q01362
genes like me logo Genes that share domains with MS4A2: view

No data available for Gene Families for MS4A2 Gene

Function for MS4A2 Gene

Molecular function for MS4A2 Gene

GENATLAS Biochemistry: membrane-spanning 4-domains, subfamily A, member 2,cell differentiation antigen CD20 (gp35),37/35kDa,identified by monoclonal antibodies B1,1F5
UniProtKB/Swiss-Prot Function: High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy

Gene Ontology (GO) - Molecular Function for MS4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019767 IgE receptor activity IEA --
GO:0019863 IgE binding IEA --
GO:0019901 protein kinase binding IEA --
GO:0042169 SH2 domain binding IEA --
GO:0051219 phosphoprotein binding IEA --
genes like me logo Genes that share ontologies with MS4A2: view

Phenotypes for MS4A2 Gene

MGI mutant phenotypes for MS4A2:
inferred from 2 alleles
GenomeRNAi human phenotypes for MS4A2:
genes like me logo Genes that share phenotypes with MS4A2: view

Animal Models for MS4A2 Gene

MGI Knock Outs for MS4A2:

miRNA for MS4A2 Gene

miRTarBase miRNAs that target MS4A2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MS4A2 Gene

Localization for MS4A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MS4A2 Gene COMPARTMENTS Subcellular localization image for MS4A2 gene
Compartment Confidence
plasma membrane 4
endosome 2
nucleus 1

Gene Ontology (GO) - Cellular Components for MS4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 1535625
GO:0009897 external side of plasma membrane IEA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with MS4A2: view

Pathways for MS4A2 Gene

genes like me logo Genes that share pathways with MS4A2: view

Pathways by source for MS4A2 Gene

2 GeneGo (Thomson Reuters Life Sciences Research) pathways for MS4A2 Gene
1 BioSystems pathway for MS4A2 Gene
1 Reactome pathway for MS4A2 Gene

Gene Ontology (GO) - Biological Process for MS4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IMP 7920628
GO:0007165 signal transduction --
GO:0007166 cell surface receptor signaling pathway --
GO:0007202 activation of phospholipase C activity IEA --
genes like me logo Genes that share ontologies with MS4A2: view

Compounds for MS4A2 Gene

(1) Drugbank Compounds for MS4A2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Omalizumab
242138-07-4 target antagonist

(1) Novoseek inferred chemical compound relationships for MS4A2 Gene

Compound -log(P) Hits PubMed IDs
allergens 59.6 5
genes like me logo Genes that share compounds with MS4A2: view

Transcripts for MS4A2 Gene

mRNA/cDNA for MS4A2 Gene

Unigene Clusters for MS4A2 Gene

Membrane-spanning 4-domains, subfamily A, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A2 Gene

No ASD Table

Relevant External Links for MS4A2 Gene

GeneLoc Exon Structure for
MS4A2
ECgene alternative splicing isoforms for
MS4A2

Expression for MS4A2 Gene

mRNA expression in normal human tissues for MS4A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MS4A2 Gene

This gene is overexpressed in Lung (5.0).

SOURCE GeneReport for Unigene cluster for MS4A2 Gene Hs.386748

mRNA Expression by UniProt/SwissProt for MS4A2 Gene

Q01362-FCERB_HUMAN
Tissue specificity: Found on the surface of mast cells and basophils
genes like me logo Genes that share expressions with MS4A2: view

Orthologs for MS4A2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MS4A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MS4A2 36
  • 98.5 (n)
  • 97.54 (a)
MS4A2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MS4A2 36
  • 73.08 (n)
  • 56.9 (a)
MS4A2 37
  • 55 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MS4A2 36
  • 75.49 (n)
  • 63.03 (a)
MS4A2 37
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ms4a2 36
  • 76.05 (n)
  • 61.47 (a)
Ms4a2 16
Ms4a2 37
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MS4A2 37
  • 31 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 24 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ms4a2 36
  • 71.99 (n)
  • 56.72 (a)
Species with no ortholog for MS4A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MS4A2 Gene

ENSEMBL:
Gene Tree for MS4A2 (if available)
TreeFam:
Gene Tree for MS4A2 (if available)

Paralogs for MS4A2 Gene

Paralogs for MS4A2 Gene

Selected SIMAP similar genes for MS4A2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MS4A2: view

Variants for MS4A2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A2 Gene

Q01362-FCERB_HUMAN
Variant Glu-237 has been found to be present in about 5.3% of a 1004 individuals population sample in Australia. It seems to be a risk factor for atopic dermatitis and asthma

Sequence variations from dbSNP and Humsavar for MS4A2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs475812 -- 60,092,138(-) CATCA(A/G)GGCAT intron-variant
rs500886 -- 60,092,547(-) aaacc(A/G)aggcg intron-variant
rs500888 -- 60,092,550(-) gggaa(A/G)ccaag intron-variant
rs502419 -- 60,098,702(+) ATGTA(A/G)GGACA downstream-variant-500B
rs502581 -- 60,092,705(-) GGTAA(A/C)ATTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MS4A2 Gene

Variant ID Type Subtype PubMed ID
nsv832173 CNV Gain 17160897
nsv468579 CNV Gain 19166990

Relevant External Links for MS4A2 Gene

HapMap Linkage Disequilibrium report
MS4A2
Human Gene Mutation Database (HGMD)
MS4A2

Disorders for MS4A2 Gene

(1) OMIM Diseases for MS4A2 Gene (147138)

(11) Novoseek inferred disease relationships for MS4A2 Gene

Disease -log(P) Hits PubMed IDs
atopy 88.5 67
dermatitis atopic 76.9 8
asthma allergic 71.8 4
asthma 67.6 17
allergic rhinitis 61.6 3

Relevant External Links for MS4A2

Genetic Association Database (GAD)
MS4A2
Human Genome Epidemiology (HuGE) Navigator
MS4A2
genes like me logo Genes that share disorders with MS4A2: view

No data available for UniProtKB/Swiss-Prot for MS4A2 Gene

Publications for MS4A2 Gene

  1. The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor. (PMID: 1535625) Kuester H. … Kinet J.-P. (J. Biol. Chem. 1992) 3 4 23
  2. A polymorphism of MS4A2 (- 109T > C) encoding the beta-chain of the high-affinity immunoglobulin E receptor (FcepsilonR1beta) is associated with a susceptibility to aspirin-intolerant asthma. (PMID: 16839402) Kim S.H. … Park H.S. (Clin. Exp. Allergy 2006) 3 23 49
  3. [Gene mutation of high affinity immunoglobulin E receptor beta-chain in children with asthma]. (PMID: 17178032) Li M. … Li B. (Zhongguo Dang Dai Er Ke Za Zhi 2006) 3 23 49
  4. Association and functional relevance of E237G, a polymorphism of the high-affinity immunoglobulin E-receptor beta chain gene, to airway hyper-responsiveness. (PMID: 17430357) Kim Y.K. … Kim Y.Y. (Clin. Exp. Allergy 2007) 3 23 49
  5. A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2. (PMID: 20085599) Genuneit J. … Moffatt M.F. (Clin. Exp. Allergy 2009) 3 23 49

Products for MS4A2 Gene

Sources for MS4A2 Gene

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