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Aliases for FCAR Gene

Aliases for FCAR Gene

  • Fc Fragment Of IgA Receptor 2 3 5
  • Fc Fragment Of IgA, Receptor For 2 3
  • CD89 3 4
  • Fc Alpha Receptor 3
  • IgA Fc Receptor 4
  • CD89 Antigen 4
  • CTB-61M7.2 3
  • FcalphaRI 3

External Ids for FCAR Gene

Previous GeneCards Identifiers for FCAR Gene

  • GC19P056248
  • GC19P055810
  • GC19P060006
  • GC19P060077
  • GC19P055386
  • GC19P051708
  • GC19P054893
  • GC19P054902

Summaries for FCAR Gene

Entrez Gene Summary for FCAR Gene

  • This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FCAR Gene

FCAR (Fc Fragment Of IgA Receptor) is a Protein Coding gene. Diseases associated with FCAR include iga glomerulonephritis and lymphocytic colitis. Among its related pathways are Phagosome and Staphylococcus aureus infection. GO annotations related to this gene include IgA binding. An important paralog of this gene is KIR2DL4.

UniProtKB/Swiss-Prot for FCAR Gene

  • Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.

Gene Wiki entry for FCAR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCAR Gene

Genomics for FCAR Gene

Regulatory Elements for FCAR Gene

Promoters for FCAR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FCAR on UCSC Golden Path with GeneCards custom track

Genomic Location for FCAR Gene

Chromosome:
19
Start:
54,874,093 bp from pter
End:
54,891,420 bp from pter
Size:
17,328 bases
Orientation:
Plus strand

Genomic View for FCAR Gene

Genes around FCAR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCAR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCAR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for FCAR Gene

  • Protein details for FCAR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24071-FCAR_HUMAN
    Recommended name:
    Immunoglobulin alpha Fc receptor
    Protein Accession:
    P24071
    Secondary Accessions:
    • Q13603
    • Q13604
    • Q15727
    • Q15728
    • Q1AJL7
    • Q1AJL8
    • Q1AJL9
    • Q53X38
    • Q53X39
    • Q92587
    • Q92588
    • Q92590
    • Q92592
    • Q92593
    • Q9UEK0

    Protein attributes for FCAR Gene

    Size:
    287 amino acids
    Molecular mass:
    32265 Da
    Quaternary structure:
    • Associates with the Fc epsilon RI gamma 2 receptor inducing tyrosine phosphorylation of gamma 2.

    Three dimensional structures from OCA and Proteopedia for FCAR Gene

    Alternative splice isoforms for FCAR Gene

neXtProt entry for FCAR Gene

Proteomics data for FCAR Gene at MOPED

Post-translational modifications for FCAR Gene

  • Glycosylation at Asn 65, Asn 79, Asn 141, Asn 177, Asn 186, and Asn 198
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for FCAR Gene

Domains & Families for FCAR Gene

Protein Domains for FCAR Gene

Suggested Antigen Peptide Sequences for FCAR Gene

Graphical View of Domain Structure for InterPro Entry

P24071

UniProtKB/Swiss-Prot:

FCAR_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with FCAR: view

Function for FCAR Gene

Molecular function for FCAR Gene

GENATLAS Biochemistry:
immunoglobulin A,Fc receptor expressed on granulocyte,monocyte,macrophage,T cell,B cell,complexing with a cytoplasmic homodimer gamma subunit with the immunoreceptor based inhibitory motif (ITIM),natural killer inhibitory receptor family
UniProtKB/Swiss-Prot Function:
Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.

Phenotypes for FCAR Gene

genes like me logo Genes that share phenotypes with FCAR: view

miRNA for FCAR Gene

miRTarBase miRNAs that target FCAR

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FCAR Gene

Localization for FCAR Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCAR Gene

Isoform A.1: Cell membrane; Single-pass type I membrane protein.
Isoform A.2: Cell membrane; Single-pass type I membrane protein.
Isoform A.3: Cell membrane; Single-pass type I membrane protein.
Isoform B: Secreted.
Isoform B-delta-S2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCAR Gene COMPARTMENTS Subcellular localization image for FCAR gene
Compartment Confidence
extracellular 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for FCAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 2258698
genes like me logo Genes that share ontologies with FCAR: view

Pathways & Interactions for FCAR Gene

genes like me logo Genes that share pathways with FCAR: view

Pathways by source for FCAR Gene

2 KEGG pathways for FCAR Gene

Gene Ontology (GO) - Biological Process for FCAR Gene

None

No data available for SIGNOR curated interactions for FCAR Gene

Drugs & Compounds for FCAR Gene

(2) Drugs for FCAR Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for FCAR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FCAR: view

Transcripts for FCAR Gene

Unigene Clusters for FCAR Gene

Fc fragment of IgA, receptor for:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCAR Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c
SP1: - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - - - - -
SP7: - - -
SP8:
SP9: - - - -

Relevant External Links for FCAR Gene

GeneLoc Exon Structure for
FCAR
ECgene alternative splicing isoforms for
FCAR

Expression for FCAR Gene

mRNA expression in normal human tissues for FCAR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCAR Gene

This gene is overexpressed in Whole Blood (x46.8).

Protein differential expression in normal tissues from HIPED for FCAR Gene

This gene is overexpressed in Monocytes (44.2) and Neutrophil (24.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCAR Gene



SOURCE GeneReport for Unigene cluster for FCAR Gene Hs.659872

mRNA Expression by UniProt/SwissProt for FCAR Gene

P24071-FCAR_HUMAN
Tissue specificity: Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces.
genes like me logo Genes that share expression patterns with FCAR: view

Protein tissue co-expression partners for FCAR Gene

- Elite partner

In Situ Assay Products

Orthologs for FCAR Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCAR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FCAR 35
  • 72.84 (n)
  • 56.23 (a)
FCAR 36
  • 55 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FCAR 35
  • 98.21 (n)
  • 97.5 (a)
PT-FCAR 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fcar 35
  • 68.01 (n)
  • 54.04 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 4 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 29 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 9 (a)
OneToMany
Species with no ortholog for FCAR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCAR Gene

ENSEMBL:
Gene Tree for FCAR (if available)
TreeFam:
Gene Tree for FCAR (if available)

Paralogs for FCAR Gene

(4) SIMAP similar genes for FCAR Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FCAR: view

Variants for FCAR Gene

Sequence variations from dbSNP and Humsavar for FCAR Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_049996 -
VAR_049997 -
rs34625687 -- 54,879,677(+) TCACA(-/T)TTTTT intron-variant
rs72230191 -- 54,878,875(+) CTTGC(-/T)TTTTT intron-variant
rs137943766 -- 54,881,880(+) GTCTC(-/AAATAAAT/AAATAAATAAATAAATAAATAAAT)AAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCAR Gene

Variant ID Type Subtype PubMed ID
dgv1119e1 CNV Complex 17122850
esv2667609 CNV Deletion 23128226
esv2718872 CNV Deletion 23290073
dgv1126e1 CNV Complex 17122850
nsv428372 CNV Gain+Loss 18775914
dgv1127e1 CNV Complex 17122850
dgv1128e1 CNV Complex 17122850
nsv469656 CNV Gain 16826518
nsv471706 CNV Loss 15918152
dgv438n27 CNV Gain 19166990
nsv912443 CNV Loss 21882294
nsv520644 CNV Loss 19592680
nsv833880 CNV Loss 17160897

Variation tolerance for FCAR Gene

Residual Variation Intolerance Score: 94.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.39; 63.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FCAR Gene

HapMap Linkage Disequilibrium report
FCAR
Human Gene Mutation Database (HGMD)
FCAR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCAR Gene

Disorders for FCAR Gene

MalaCards: The human disease database

(3) MalaCards diseases for FCAR Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
iga glomerulonephritis
  • berger's iga or igg nephropathy
lymphocytic colitis
  • colitis, lymphocytic
clostridium difficile colitis
  • pseudomembranous colitis
- elite association - COSMIC cancer census association via MalaCards
Search FCAR in MalaCards View complete list of genes associated with diseases

Relevant External Links for FCAR

Genetic Association Database (GAD)
FCAR
Human Genome Epidemiology (HuGE) Navigator
FCAR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FCAR
genes like me logo Genes that share disorders with FCAR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCAR Gene

Publications for FCAR Gene

  1. Genetic variants of the IgA Fc receptor (FcalphaR, CD89) promoter in chronic hepatitis C patients. (PMID: 17033823) Watanabe A. … Ra C. (Immunogenetics 2006) 3 23 48 67
  2. The gene for the human IgA Fc receptor maps to 19q13.4. (PMID: 1577457) Kremer E.J. … Maliszewski C.R. (Hum. Genet. 1992) 2 3 23
  3. Functionality of the IgA Fc receptor (FcalphaR, CD89) is down-regulated by extensive engagement of FcepsilonRI. (PMID: 18700185) Matsui T. … Ra C. (Clin. Immunol. 2008) 3 23
  4. IgA Fc receptor I signals apoptosis through the FcRgamma ITAM and affects tumor growth. (PMID: 16990604) Kanamaru Y. … Monteiro R.C. (Blood 2007) 3 23
  5. Differential expression and function of IgA receptors (CD89 and CD71) during maturation of dendritic cells. (PMID: 15371488) Pasquier B. … Monteiro R.C. (J. Leukoc. Biol. 2004) 3 23

Products for FCAR Gene

Sources for FCAR Gene

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