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Aliases for FAU Gene

Subcategory (RNA class) for FAU Gene

lncRNA

Aliases for FAU Gene

  • Finkel-Biskis-Reilly Murine Sarcoma Virus (FBR-MuSV) Ubiquitously Expressed 2 3
  • Finkel-Biskis-Reilly Murine Sarcoma Virus (FBR-MuSV) Ubiquitously Expressed (Fox Derived) 2 3
  • Monoclonal Nonspecific Suppressor Factor Beta 2 3
  • Ribosomal Protein S30 2 3
  • Ubiquitin-Like Protein Fubi And Ribosomal Protein S30 3
  • FBR-MuSV-Associated Ubiquitously Expressed 3
  • FAU-Encoded Ubiquitin-Like Protein 3
  • Ubiquitin-Like-S30 Fusion Protein 3
  • 40S Ribosomal Protein S30 3
  • MNSFbeta 3
  • RPS30 3
  • FAU1 3
  • Fub1 3
  • Fubi 3
  • Asr1 3
  • S30 3

External Ids for FAU Gene

ORGUL Members for FAU Gene

Previous GeneCards Identifiers for FAU Gene

  • GC11M067403
  • GC11M066569
  • GC11M065138
  • GC11M064663
  • GC11M064644
  • GC11M064888
  • GC11M061214

Summaries for FAU Gene

Entrez Gene Summary for FAU Gene

  • This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein consisting of the ubiquitin-like protein fubi at the N terminus and ribosomal protein S30 at the C terminus. It has been proposed that the fusion protein is post-translationally processed to generate free fubi and free ribosomal protein S30. Fubi is a member of the ubiquitin family, and ribosomal protein S30 belongs to the S30E family of ribosomal proteins. Whereas the function of fubi is currently unknown, ribosomal protein S30 is a component of the 40S subunit of the cytoplasmic ribosome and displays antimicrobial activity. Pseudogenes derived from this gene are present in the genome. Similar to ribosomal protein S30, ribosomal proteins S27a and L40 are synthesized as fusion proteins with ubiquitin. [provided by RefSeq, Nov 2014]

GeneCards Summary for FAU Gene

FAU (Finkel-Biskis-Reilly Murine Sarcoma Virus (FBR-MuSV) Ubiquitously Expressed) is a Protein Coding gene, and is affiliated with the lncRNA class. Diseases associated with FAU include sarcoma. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

Gene Wiki entry for FAU Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAU Gene

Genomics for FAU Gene

Regulatory Elements for FAU Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAU Gene

Start:
65,120,627 bp from pter
End:
65,122,473 bp from pter
Size:
1,847 bases
Orientation:
Minus strand

Genomic View for FAU Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAU Gene

Proteins for FAU Gene

  • Protein details for FAU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35544-UBIM_HUMAN
    Recommended name:
    Ubiquitin-like protein FUBI
    Protein Accession:
    P35544
    Secondary Accessions:
    • Q9H5V4

    Protein attributes for FAU Gene

    Size:
    74 amino acids
    Molecular mass:
    7760 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This protein is synthesized with ribosomal S30 as its C-terminal extension

    Three dimensional structures from OCA and Proteopedia for FAU Gene

  • Protein details for FAU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62861-RS30_HUMAN
    Recommended name:
    40S ribosomal protein S30
    Protein Accession:
    P62861
    Secondary Accessions:
    • Q05472
    • Q95261
    • Q9H5V4

    Protein attributes for FAU Gene

    Size:
    59 amino acids
    Molecular mass:
    6648 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This ribosomal protein is synthesized as a C-terminal extension protein (CEP) of a ubiquitin-like protein
    SequenceCaution:
    • Sequence=AAH33877.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ87877.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15515.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA46714.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA46716.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAG46772.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FAU Gene

neXtProt entry for FAU Gene

Proteomics data for FAU Gene at MOPED

Post-translational modifications for FAU Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAU Gene

Antibody Products

No data available for DME Specific Peptides for FAU Gene

Domains for FAU Gene

Gene Families for FAU Gene

HGNC:
  • RPS :S ribosomal proteins

Protein Domains for FAU Gene

Suggested Antigen Peptide Sequences for FAU Gene

Graphical View of Domain Structure for InterPro Entry

P62861

UniProtKB/Swiss-Prot:

RS30_HUMAN :
  • P62861
Family:
  • Belongs to the ribosomal protein S30e family.
  • Belongs to the ubiquitin family.
genes like me logo Genes that share domains with FAU: view

Function for FAU Gene

Molecular function for FAU Gene

GENATLAS Biochemistry:
Finkel-Biskis-Reilly (FBR)-murine sarcoma virus associated,ubiquitously expressed,viral FOX homolog

Gene Ontology (GO) - Molecular Function for FAU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 8395683
GO:0003735 structural constituent of ribosome IDA 15883184
GO:0005515 protein binding --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with FAU: view
genes like me logo Genes that share phenotypes with FAU: view

miRNA for FAU Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAU

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAU Gene

Localization for FAU Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAU Gene COMPARTMENTS Subcellular localization image for FAU gene
Compartment Confidence
cytosol 5
nucleus 3

Gene Ontology (GO) - Cellular Components for FAU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005615 extracellular space IDA 12860195
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with FAU: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAU Gene

Pathways for FAU Gene

SuperPathways for FAU Gene

Superpath Contained pathways
1 Influenza Viral RNA Transcription and Replication
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 CFTR translational fidelity (class I mutations)
.54
4 Disease
5 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
genes like me logo Genes that share pathways with FAU: view

Pathways by source for FAU Gene

1 KEGG pathway for FAU Gene
1 GeneGo (Thomson Reuters) pathway for FAU Gene

Gene Ontology (GO) - Biological Process for FAU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002227 innate immune response in mucosa IDA 12860195
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
genes like me logo Genes that share ontologies with FAU: view

Compounds for FAU Gene

(1) Novoseek inferred chemical compound relationships for FAU Gene

Compound -log(P) Hits PubMed IDs
arsenite 54.2 1
genes like me logo Genes that share compounds with FAU: view

Transcripts for FAU Gene

mRNA/cDNA for FAU Gene

Unigene Clusters for FAU Gene

Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAU

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAU Gene

No ASD Table

Relevant External Links for FAU Gene

GeneLoc Exon Structure for
FAU
ECgene alternative splicing isoforms for
FAU

Expression for FAU Gene

mRNA expression in normal human tissues for FAU Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for FAU Gene

This gene is overexpressed in Bone (8.1), Bone marrow stromal cell (6.1), and Liver (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAU Gene

SOURCE GeneReport for Unigene cluster for FAU Gene Hs.387208

genes like me logo Genes that share expressions with FAU: view

Expression partners for FAU Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAU Gene

Orthologs for FAU Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAU Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAU 35
  • 90.98 (n)
  • 96.99 (a)
FAU 36
  • 72 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia FAU 35
  • 92.23 (n)
  • 97.74 (a)
-- 36
  • 68 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Fau 35
  • 91.48 (n)
  • 97.74 (a)
Fau 16
Fau 36
  • 98 (a)
OneToMany
Gm9843 36
  • 98 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia FAU 35
  • 99.75 (n)
  • 100 (a)
FAU 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100360647 35
  • 91.23 (n)
  • 98.5 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 83 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC89853 35
  • 75.69 (n)
  • 80.45 (a)
Str.17035 35
zebrafish
(Danio rerio)
Actinopterygii faua 35
  • 72.93 (n)
  • 78.2 (a)
zgc73171 35
faua 36
  • 76 (a)
ManyToMany
faub 36
  • 72 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000654 35
  • 60.68 (n)
  • 54.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpS30 35
  • 63.28 (n)
  • 59.37 (a)
RpS30 36
  • 56 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rps-30 35
  • 58.07 (n)
  • 56.25 (a)
rps-30 36
  • 55 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS30B 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6329 35
Species with no ortholog for FAU:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAU Gene

ENSEMBL:
Gene Tree for FAU (if available)
TreeFam:
Gene Tree for FAU (if available)

Paralogs for FAU Gene

Selected SIMAP similar genes for FAU Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for FAU Gene

genes like me logo Genes that share paralogs with FAU: view

No data available for Paralogs for FAU Gene

Variants for FAU Gene

Sequence variations from dbSNP and Humsavar for FAU Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs9333582 -- 65,120,144(-) TGGCC(A/G)GACTT downstream-variant-500B
rs536527434 -- 65,120,157(+) CAGTC(A/G)CAGAG downstream-variant-500B
rs544839961 -- 65,120,145(+) AGTCC(A/G)GCCAG downstream-variant-500B
VAR_019644 -
VAR_019643 -

Structural Variations from Database of Genomic Variants (DGV) for FAU Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV Gain 19592680
dgv1174n71 CNV Loss 21882294

Relevant External Links for FAU Gene

HapMap Linkage Disequilibrium report
FAU

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAU Gene

Disorders for FAU Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for FAU Gene in MalaCards »

(1) Diseases for FAU Gene including...

(3) Novoseek inferred disease relationships for FAU Gene

Disease -log(P) Hits PubMed IDs
sarcoma 67.9 8
osteosarcoma 40.5 1
tumors 0 5
genes like me logo Genes that share disorders with FAU: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for FAU Gene

Publications for FAU Gene

  1. Genomic structure and expression of the human fau gene: encoding the ribosomal protein S30 fused to a ubiquitin-like protein. (PMID: 1326960) Kas K. … Merregaert J. (Biochem. Biophys. Res. Commun. 1992) 3 4 23
  2. fau cDNA encodes a ubiquitin-like-S30 fusion protein and is expressed as an antisense sequence in the Finkel-Biskis-Reilly murine sarcoma virus. (PMID: 8395683) Michiels L. … Merregaert J. (Oncogene 1993) 3 4 23
  3. Assignment of the human FAU gene to a subregion of chromosome 11q13. (PMID: 8406491) Kas K. … Larsson C. (Genomics 1993) 2 3 23
  4. fau and its ubiquitin-like domain (FUBI) transforms human osteogenic sarcoma (HOS) cells to anchorage-independence. (PMID: 12660817) Rossman T.G. … Komissarova E.V. (Oncogene 2003) 3 23
  5. Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer. (PMID: 19671159) Pickard M.R. … Williams G.T. (Breast Cancer Res. 2009) 3 23

Products for FAU Gene

Sources for FAU Gene

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