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Aliases for OR4C6 Gene

Aliases for OR4C6 Gene

  • Olfactory Receptor Family 4 Subfamily C Member 6 2 3 5
  • Olfactory Receptor, Family 4, Subfamily C, Member 6 2 3
  • Olfactory Receptor OR11-138 3 4
  • OR11-138 3

External Ids for OR4C6 Gene

Previous GeneCards Identifiers for OR4C6 Gene

  • GC11U990319
  • GC11P055209
  • GC11P055189
  • GC11P055432

Summaries for OR4C6 Gene

Entrez Gene Summary for OR4C6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4C6 Gene

OR4C6 (Olfactory Receptor Family 4 Subfamily C Member 6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4A5.

UniProtKB/Swiss-Prot for OR4C6 Gene

  • Odorant receptor.

Gene Wiki entry for OR4C6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4C6 Gene

Genomics for OR4C6 Gene

Regulatory Elements for OR4C6 Gene

Enhancers for OR4C6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR4C6 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR4C6 Gene

55,658,587 bp from pter
55,666,189 bp from pter
7,603 bases
Plus strand

Genomic View for OR4C6 Gene

Genes around OR4C6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4C6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4C6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4C6 Gene

Proteins for OR4C6 Gene

  • Protein details for OR4C6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4C6
    Protein Accession:
    Secondary Accessions:
    • B2RP11
    • Q6IFD2

    Protein attributes for OR4C6 Gene

    309 amino acids
    Molecular mass:
    34558 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4C6 Gene

Proteomics data for OR4C6 Gene at MOPED

Post-translational modifications for OR4C6 Gene

  • Glycosylation at Asn 6
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4C6 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4C6 Gene

Domains & Families for OR4C6 Gene

Gene Families for OR4C6 Gene

Protein Domains for OR4C6 Gene

Suggested Antigen Peptide Sequences for OR4C6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4C6: view

Function for OR4C6 Gene

Molecular function for OR4C6 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4C6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with OR4C6: view

Phenotypes for OR4C6 Gene

genes like me logo Genes that share phenotypes with OR4C6: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4C6 Gene

Localization for OR4C6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4C6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR4C6 Gene COMPARTMENTS Subcellular localization image for OR4C6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4C6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR4C6: view

Pathways & Interactions for OR4C6 Gene

genes like me logo Genes that share pathways with OR4C6: view

Pathways by source for OR4C6 Gene

Interacting Proteins for OR4C6 Gene

Gene Ontology (GO) - Biological Process for OR4C6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4C6: view

No data available for SIGNOR curated interactions for OR4C6 Gene

Drugs & Compounds for OR4C6 Gene

No Compound Related Data Available

Transcripts for OR4C6 Gene

mRNA/cDNA for OR4C6 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR4C6 Gene

Olfactory receptor, family 4, subfamily C, member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OR4C6 Gene

No ASD Table

Relevant External Links for OR4C6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR4C6 Gene

mRNA expression in normal human tissues for OR4C6 Gene

mRNA differential expression in normal tissues according to GTEx for OR4C6 Gene

This gene is overexpressed in Minor Salivary Gland (x11.6), Spleen (x6.4), Cervix - Ectocervix (x6.0), and Testis (x4.6).

SOURCE GeneReport for Unigene cluster for OR4C6 Gene Hs.511921

genes like me logo Genes that share expression patterns with OR4C6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR4C6 Gene

Orthologs for OR4C6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4C6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OR4C6 35
  • 77.16 (n)
  • 67.86 (a)
-- 36
  • 70 (a)
-- 36
  • 68 (a)
(Canis familiaris)
Mammalia LOC491531 35
  • 84.63 (n)
  • 81.17 (a)
OR4C6 36
  • 81 (a)
(Mus musculus)
Mammalia Olfr1230 35
  • 78.37 (n)
  • 77.15 (a)
Olfr1230 16
Olfr1189 36
  • 77 (a)
Olfr1230 36
  • 76 (a)
(Pan troglodytes)
Mammalia LOC466887 35
  • 98.6 (n)
  • 97.73 (a)
OR4C6 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Olr693 35
  • 77.26 (n)
  • 76.16 (a)
(Monodelphis domestica)
Mammalia OR4C6 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
-- 36
  • 61 (a)
-- 36
  • 61 (a)
Species with no ortholog for OR4C6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4C6 Gene

Gene Tree for OR4C6 (if available)
Gene Tree for OR4C6 (if available)

Paralogs for OR4C6 Gene

(448) SIMAP similar genes for OR4C6 Gene using alignment to 1 proteins: Pseudogenes for OR4C6 Gene

genes like me logo Genes that share paralogs with OR4C6: view

Variants for OR4C6 Gene

Sequence variations from dbSNP and Humsavar for OR4C6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11230600 - 55,665,564(+) GATCA(C/T)CATGA reference, missense
rs980641 -- 55,657,723(-) CCTAA(G/T)CCTTA upstream-variant-2KB
rs980642 -- 55,657,607(-) AAATC(A/T)ATGCC upstream-variant-2KB
rs1479130 -- 55,660,224(-) ATAGA(C/G/T)ATACA intron-variant
rs7119182 -- 55,662,071(+) TTGGA(C/T)TATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OR4C6 Gene

Variant ID Type Subtype PubMed ID
esv2751030 CNV Gain 17911159
nsv524091 CNV Gain 19592680
nsv821668 CNV Loss 15273396
dgv376e1 CNV Complex 17122850
esv782 CNV CNV 17122850
dgv12n68 CNV Loss 17160897
dgv377e1 CNV Complex 17122850
nsv428256 CNV Loss 18775914
dgv4e49 CNV Loss 18971310
dgv378e1 CNV Complex 17122850
dgv143n27 CNV Loss 19166990
nsv517440 CNV Gain+Loss 19592680
nsv323 CNV Loss 18451855
nsv71 CNV Loss 15895083
nsv437717 CNV Loss 16327808
nsv469957 CNV Gain 18288195
nsv818824 CNV Gain 17921354
dgv144n27 CNV Gain 19166990
dgv145n27 CNV Loss 19166990
dgv146n27 CNV Gain 19166990
nsv508632 CNV Loss 20534489
dgv211e199 CNV Deletion 23128226
nsv443003 CNV Complex 18674749
dgv12n47 CNV Loss 21111241
esv22842 CNV Gain+Loss 19812545
dgv217n67 CNV Loss 20364138
nsv8827 CNV Gain+Loss 18304495
esv33874 CNV Gain 17666407
dgv6n14 CNV Loss 18776910
esv2421634 CNV Deletion 20811451
esv29944 CNV Loss 18421352
nsv469958 CNV Loss 18288195
dgv10n64 CNV Loss 17921354
dgv11n64 CNV Gain+Loss 17921354
dgv381e1 CNV Complex 17122850
dgv382e1 CNV Complex 17122850
nsv442617 CNV CNV 18776908
dgv50e55 CNV Loss 17911159
dgv5e49 CNV Loss 18971310
dgv13n68 CNV Loss 17160897
dgv148n27 CNV Loss 19166990
nsv514622 CNV Loss 21397061
dgv149n27 CNV Loss 19166990
nsv468563 CNV Loss 19166990
dgv212e199 CNV Deletion 23128226
dgv6e49 CNV Loss 18971310
dgv12n64 CNV Loss 17921354
nsv499760 OTHER Inversion 21111241
nsv7218 OTHER Inversion 18451855
dgv213e199 CNV Deletion 23128226

Variation tolerance for OR4C6 Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.31; 85.24% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR4C6 Gene

Disorders for OR4C6 Gene

Relevant External Links for OR4C6

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR4C6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4C6 Gene

Publications for OR4C6 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR4C6 Gene

Sources for OR4C6 Gene