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Aliases for FASN Gene

Aliases for FASN Gene

  • Fatty Acid Synthase 2 3 5
  • FAS 3 4
  • Short Chain Dehydrogenase/Reductase Family 27X, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 27X 2
  • EC 2.3.1.85 4
  • EC 6.3.3.1 63
  • Member 1 2
  • EC 2.3.1 63
  • SDR27X1 3
  • OA-519 3

External Ids for FASN Gene

Previous GeneCards Identifiers for FASN Gene

  • GC17M079459
  • GC17M9J0077
  • GC17M080572
  • GC17M077629
  • GC17M080037
  • GC17M075436

Summaries for FASN Gene

Entrez Gene Summary for FASN Gene

  • The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]

GeneCards Summary for FASN Gene

FASN (Fatty Acid Synthase) is a Protein Coding gene. Diseases associated with FASN include fatty liver disease and obesity. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include poly(A) RNA binding and identical protein binding. An important paralog of this gene is OXSM.

UniProtKB/Swiss-Prot for FASN Gene

  • Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.

Tocris Summary for FASN Gene

Gene Wiki entry for FASN Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FASN Gene

Genomics for FASN Gene

Regulatory Elements for FASN Gene

Promoters for FASN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FASN on UCSC Golden Path with GeneCards custom track

Genomic Location for FASN Gene

Chromosome:
17
Start:
82,078,333 bp from pter
End:
82,098,332 bp from pter
Size:
20,000 bases
Orientation:
Minus strand

Genomic View for FASN Gene

Genes around FASN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FASN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FASN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FASN Gene

Proteins for FASN Gene

  • Protein details for FASN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49327-FAS_HUMAN
    Recommended name:
    Fatty acid synthase
    Protein Accession:
    P49327
    Secondary Accessions:
    • Q13479
    • Q16702
    • Q4LE83
    • Q6P4U5
    • Q6SS02
    • Q969R1
    • Q96C68
    • Q96IT0

    Protein attributes for FASN Gene

    Size:
    2511 amino acids
    Molecular mass:
    273427 Da
    Quaternary structure:
    • Homodimer which is arranged in a head to tail fashion.
    Miscellaneous:
    • The relatively low beta-ketoacyl synthase activity may be attributable to the low 4-phosphopantetheine content of the protein.
    SequenceCaution:
    • Sequence=AAB35516.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAC50259.1; Type=Miscellaneous discrepancy; Note=Several sequencing errors.; Evidence={ECO:0000305}; Sequence=BAE06070.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FASN Gene

neXtProt entry for FASN Gene

Proteomics data for FASN Gene at MOPED

Selected DME Specific Peptides for FASN Gene

Post-translational modifications for FASN Gene

  • Ubiquitination at Lys 41, Lys 213, Lys 257, Lys 326, Lys 631, Lys 992, Lys 1116, Lys 1142, Lys 1151, Lys 1158, Lys 1393, Lys 1495, Lys 1704, Lys 1739, Lys 1851, Lys 1866, Lys 1878, Lys 1911, Lys 1927, Lys 2438, and Lys 2449
  • Modification sites at PhosphoSitePlus

Other Protein References for FASN Gene

Antibody Products

  • R&D Systems Antibodies for FASN (Fatty Acid Synthase/FASN)
  • Cell Signaling Technology (CST) Antibodies for FASN (FASN)

Domains & Families for FASN Gene

Gene Families for FASN Gene

Suggested Antigen Peptide Sequences for FASN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49327

UniProtKB/Swiss-Prot:

FAS_HUMAN :
  • Contains 1 acyl carrier domain.
Domain:
  • Contains 1 acyl carrier domain.
genes like me logo Genes that share domains with FASN: view

Function for FASN Gene

Molecular function for FASN Gene

GENATLAS Biochemistry:
fatty acid ethyl ester synthase 1,NADPH dependent
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + (n+1) CoA + n CO(2) + 2n NADP(+).
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein].
UniProtKB/Swiss-Prot CatalyticActivity:
Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein].
UniProtKB/Swiss-Prot CatalyticActivity:
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH.
UniProtKB/Swiss-Prot CatalyticActivity:
A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
An acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH.
UniProtKB/Swiss-Prot CatalyticActivity:
Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl-carrier-protein] + oleate.
UniProtKB/Swiss-Prot Function:
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.

Enzyme Numbers (IUBMB) for FASN Gene

Gene Ontology (GO) - Molecular Function for FASN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004312 fatty acid synthase activity IEA,TAS --
GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity IEA --
GO:0004317 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity IEA --
GO:0004319 enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity IEA --
genes like me logo Genes that share ontologies with FASN: view
genes like me logo Genes that share phenotypes with FASN: view

Animal Models for FASN Gene

MGI Knock Outs for FASN:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FASN Gene

Localization for FASN Gene

Subcellular locations from UniProtKB/Swiss-Prot for FASN Gene

Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FASN Gene COMPARTMENTS Subcellular localization image for FASN gene
Compartment Confidence
cytosol 5
extracellular 5
golgi apparatus 5
plasma membrane 5
mitochondrion 3
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for FASN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with FASN: view

Pathways & Interactions for FASN Gene

genes like me logo Genes that share pathways with FASN: view

SIGNOR curated interactions for FASN Gene

Is activated by:

Gene Ontology (GO) - Biological Process for FASN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006084 acetyl-CoA metabolic process IEA --
GO:0006112 energy reserve metabolic process TAS --
GO:0009058 biosynthetic process IEA --
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process TAS --
GO:0044255 cellular lipid metabolic process TAS --
genes like me logo Genes that share ontologies with FASN: view

Drugs & Compounds for FASN Gene

(63) Drugs for FASN Gene - From: Novoseek, HMDB, DGIdb, DrugBank, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Orlistat Approved, Investigational Pharma inhibitor, Target Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 52
Cerulenin Approved Pharma Target, inhibitor 0
Isoniazid Approved Pharma 142
malonyl-coa Experimental Pharma 0
oleic acid Experimental Pharma Full agonist, Agonist 0

(72) Additional Compounds for FASN Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
(R)-3-Hydroxydecanoic acid
(R)-3-Hydroxydodecanoic acid
(R)-3-Hydroxy-hexadecanoic acid

(1) ApexBio Compounds for FASN Gene

Compound Action Cas Number
Isoniazid 54-85-3
genes like me logo Genes that share compounds with FASN: view

Transcripts for FASN Gene

Unigene Clusters for FASN Gene

Fatty acid synthase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FASN Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37a · 37b · 37c ^ 38 ^ 39a · 39b · 39c ^ 40a · 40b · 40c ^ 41 ^ 42 ^
SP1:
SP2: - - - - -
SP3:
SP4: -
SP5: - - - - - - -
SP6:

ExUns: 43a · 43b · 43c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for FASN Gene

GeneLoc Exon Structure for
FASN
ECgene alternative splicing isoforms for
FASN

Expression for FASN Gene

mRNA expression in normal human tissues for FASN Gene

mRNA differential expression in normal tissues according to GTEx for FASN Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x8.9), Adipose - Subcutaneous (x6.9), and Breast - Mammary Tissue (x4.9).

Protein differential expression in normal tissues from HIPED for FASN Gene

This gene is overexpressed in Milk (12.0), Liver (8.2), and Breast (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FASN Gene



SOURCE GeneReport for Unigene cluster for FASN Gene Hs.83190

mRNA Expression by UniProt/SwissProt for FASN Gene

P49327-FAS_HUMAN
Tissue specificity: Ubiquitous. Prominent expression in brain, lung, and liver.
genes like me logo Genes that share expression patterns with FASN: view

Protein tissue co-expression partners for FASN Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FASN Gene

Orthologs for FASN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FASN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FASN 35
  • 81.78 (n)
  • 79.47 (a)
FASN 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FASN 35
  • 83.25 (n)
  • 81.7 (a)
FASN 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fasn 35
  • 80.91 (n)
  • 81.61 (a)
Fasn 16
Fasn 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FASN 35
  • 98.79 (n)
  • 98.79 (a)
FASN 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fasn 35
  • 80.63 (n)
  • 82.33 (a)
oppossum
(Monodelphis domestica)
Mammalia FASN 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FASN 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves FASN 35
  • 64.78 (n)
  • 66.4 (a)
FASN 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FASN 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fasn 35
  • 62.57 (n)
  • 64.7 (a)
zebrafish
(Danio rerio)
Actinopterygii fasn 36
  • 64 (a)
OneToMany
fasn 36
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH07626 37
  • 48 (a)
CG17374 37
  • 39 (a)
v(2)k05816 37
  • 45 (a)
v(2)k05816 35
  • 54.54 (n)
  • 46.96 (a)
CG17374 36
  • 37 (a)
OneToMany
CG3523 36
  • 42 (a)
OneToMany
v(2)k05816 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C41A3.1 37
  • 34 (a)
F32H2.5 37
  • 41 (a)
fasn-1 35
  • 49.54 (n)
  • 44.08 (a)
F32H2.6 36
  • 33 (a)
OneToMany
fasn-1 36
  • 40 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CEM1 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToOne
Species with no ortholog for FASN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FASN Gene

ENSEMBL:
Gene Tree for FASN (if available)
TreeFam:
Gene Tree for FASN (if available)

Paralogs for FASN Gene

Paralogs for FASN Gene

genes like me logo Genes that share paralogs with FASN: view

Variants for FASN Gene

Sequence variations from dbSNP and Humsavar for FASN Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2228305 - 82,084,916(-) CCCAC(A/G)TCCCG reference, missense
rs561903908 - 82,083,992(+) AGACG(C/T)GGCAG reference, missense
rs2228307 - 82,083,019(-) GCTAC(A/G)TCATC reference, missense
rs15324 -- 82,078,483(-) TTGTT(C/T)TTCAA utr-variant-3-prime
rs1140606 -- 82,096,417(-) CATGT(C/T)CGGGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FASN Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
dgv3333n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
dgv3339n71 CNV Loss 21882294
nsv909151 CNV Gain+Loss 21882294
dgv3340n71 CNV Loss 21882294
dgv3341n71 CNV Loss 21882294
dgv3343n71 CNV Loss 21882294
nsv457975 CNV Loss 19166990
nsv909167 CNV Gain+Loss 21882294
dgv3344n71 CNV Loss 21882294
dgv3345n71 CNV Loss 21882294
nsv909181 CNV Loss 21882294
nsv457976 CNV Gain 19166990
nsv470621 CNV Gain 18288195
nsv909186 CNV Loss 21882294
nsv909188 CNV Loss 21882294
dgv3351n71 CNV Loss 21882294
nsv909192 CNV Gain 21882294
dgv3353n71 CNV Loss 21882294
nsv909198 CNV Loss 21882294
nsv909199 CNV Gain 21882294
nsv909201 CNV Gain+Loss 21882294
esv2716470 CNV Deletion 23290073
esv2716471 CNV Deletion 23290073
nsv909202 CNV Gain 21882294
esv1000741 CNV Deletion 20482838
esv2666752 CNV Deletion 23128226

Variation tolerance for FASN Gene

Residual Variation Intolerance Score: 1.84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.91; 74.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FASN Gene

HapMap Linkage Disequilibrium report
FASN
Human Gene Mutation Database (HGMD)
FASN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FASN Gene

Disorders for FASN Gene

MalaCards: The human disease database

(5) MalaCards diseases for FASN Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
fatty liver disease
  • alcoholic fatty liver
obesity
  • obesity, association with
prostate cancer
  • prostate cancer, hereditary, 5
breast cancer
  • breast cancer, invasive ductal
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search FASN in MalaCards View complete list of genes associated with diseases

Relevant External Links for FASN

Genetic Association Database (GAD)
FASN
Human Genome Epidemiology (HuGE) Navigator
FASN
Tumor Gene Database (TGDB):
FASN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FASN
genes like me logo Genes that share disorders with FASN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FASN Gene

Publications for FASN Gene

  1. Human fatty acid synthase: properties and molecular cloning. (PMID: 7567999) Jayakumar A. … Wakil S.J. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 23 67
  2. Practical, catalytic, asymmetric synthesis of beta-lactones via a sequential ketene dimerization/hydrogenation process: inhibitors of the thioesterase domain of fatty acid synthase. (PMID: 16749788) Purohit V.C. … Romo D. (J. Org. Chem. 2006) 23 25 26
  3. Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents? (PMID: 17168665) Lupu R. … Menendez J.A. (Curr Pharm Biotechnol 2006) 23 25 26
  4. Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene. (PMID: 15870086) Menendez J.A. … Lupu R. (Ann. Oncol. 2005) 23 25 26
  5. Fatty acid metabolism as a target for obesity treatment. (PMID: 15878185) Ronnett G.V. … Tu Y. (Physiol. Behav. 2005) 23 25 26

Products for FASN Gene

  • Addgene plasmids for FASN

Sources for FASN Gene

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