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Aliases for FASN Gene

Aliases for FASN Gene

  • Fatty Acid Synthase 2 3
  • FAS 3 4
  • Short Chain Dehydrogenase/Reductase Family 27X, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 27X 2
  • EC 2.3.1.85 4
  • EC 6.3.3.1 63
  • Member 1 2
  • EC 2.3.1 63
  • SDR27X1 3
  • OA-519 3

External Ids for FASN Gene

Summaries for FASN Gene

Entrez Gene Summary for FASN Gene

  • The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]

GeneCards Summary for FASN Gene

FASN (Fatty Acid Synthase) is a Protein Coding gene. Diseases associated with FASN include trophoblastic neoplasm and obesity. Among its related pathways are MAPK signaling pathway and Proteoglycans in cancer. GO annotations related to this gene include protein homodimerization activity and NADPH binding. An important paralog of this gene is OXSM.

UniProtKB/Swiss-Prot for FASN Gene

  • Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein

Gene Wiki entry for FASN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FASN Gene

Genomics for FASN Gene

Genomic Location for FASN Gene

Start:
82,078,338 bp from pter
End:
82,098,332 bp from pter
Size:
19,995 bases
Orientation:
Minus strand

Genomic View for FASN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FASN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FASN Gene

Regulatory Elements for FASN Gene

Proteins for FASN Gene

  • Protein details for FASN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49327-FAS_HUMAN
    Recommended name:
    Fatty acid synthase
    Protein Accession:
    P49327
    Secondary Accessions:
    • Q13479
    • Q16702
    • Q4LE83
    • Q6P4U5
    • Q6SS02
    • Q969R1
    • Q96C68
    • Q96IT0

    Protein attributes for FASN Gene

    Size:
    2511 amino acids
    Molecular mass:
    273427 Da
    Quaternary structure:
    • Homodimer which is arranged in a head to tail fashion.
    Miscellaneous:
    • The relatively low beta-ketoacyl synthase activity may be attributable to the low 4-phosphopantetheine content of the protein
    SequenceCaution:
    • Sequence=AAB35516.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAC50259.1; Type=Miscellaneous discrepancy; Note=Several sequencing errors.; Evidence={ECO:0000305}; Sequence=BAE06070.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FASN Gene

neXtProt entry for FASN Gene

Proteomics data for FASN Gene at MOPED

Selected DME Specific Peptides for FASN Gene

Post-translational modifications for FASN Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys41, Lys70, Lys213, Lys257, Lys298, Lys326, Lys436, Lys528, Lys631, Lys992, Lys1072, Lys1116, Lys1142, Lys1151, Lys1158, Lys1239, Lys1393, Lys1429, Lys1495, Lys1591, Lys1704, Lys1739, Lys1851, Lys1866, Lys1878, Lys1911, Lys1927, Lys2391, Lys2438, and Lys2449

Other Protein References for FASN Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for FASN Gene

Gene Families for FASN Gene

HGNC:
  • SDRA :Short chain dehydrogenase/reductase superfamily / Atypical members

Suggested Antigen Peptide Sequences for FASN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49327

UniProtKB/Swiss-Prot:

FAS_HUMAN
Domain:
  • Contains 1 acyl carrier domain.:
    • P49327
genes like me logo Genes that share domains with FASN: view

Function for FASN Gene

Molecular function for FASN Gene

GENATLAS Biochemistry: fatty acid ethyl ester synthase 1,NADPH dependent
UniProtKB/Swiss-Prot CatalyticActivity: Acetyl-CoA + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + (n+1) CoA + n CO(2) + 2n NADP(+).
UniProtKB/Swiss-Prot CatalyticActivity: Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein].
UniProtKB/Swiss-Prot CatalyticActivity: Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].
UniProtKB/Swiss-Prot CatalyticActivity: Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein].
UniProtKB/Swiss-Prot CatalyticActivity: (3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH.
UniProtKB/Swiss-Prot CatalyticActivity: A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity: An acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH.
UniProtKB/Swiss-Prot CatalyticActivity: Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl-carrier-protein] + oleate.
UniProtKB/Swiss-Prot Function: Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein

Enzyme Numbers (IUBMB) for FASN Gene

Gene Ontology (GO) - Molecular Function for FASN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004312 fatty acid synthase activity TAS --
GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity IEA --
GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity IEA --
GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA --
genes like me logo Genes that share ontologies with FASN: view
genes like me logo Genes that share phenotypes with FASN: view

Animal Models for FASN Gene

MGI Knock Outs for FASN:

No data available for Transcription Factor Targeting and HOMER Transcription for FASN Gene

Localization for FASN Gene

Subcellular locations from UniProtKB/Swiss-Prot for FASN Gene

Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FASN Gene COMPARTMENTS Subcellular localization image for FASN gene
Compartment Confidence
cytosol 4
golgi apparatus 4
plasma membrane 4
nucleus 3
peroxisome 3
extracellular 2
mitochondrion 2
chloroplast 1
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FASN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with FASN: view

Pathways for FASN Gene

SuperPathways for FASN Gene

Superpath Contained pathways
1 Defective BTD causes biotidinase deficiency
2 Allograft rejection
3 Death Receptor Signalling
4 TWEAK Pathway
5 Apoptotic Pathways in Synovial Fibroblasts
genes like me logo Genes that share pathways with FASN: view

Pathways by source for FASN Gene

Gene Ontology (GO) - Biological Process for FASN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IDA 16210410
GO:0006084 acetyl-CoA metabolic process IEA --
GO:0006112 energy reserve metabolic process TAS --
GO:0006631 fatty acid metabolic process TAS 7835891
GO:0006633 fatty acid biosynthetic process IEA --
genes like me logo Genes that share ontologies with FASN: view

Compounds for FASN Gene

(32) HMDB Compounds for FASN Gene

Compound Synonyms Cas Number PubMed IDs
(R)-3-Hydroxydecanoic acid
Not Available
(R)-3-Hydroxydodecanoic acid
Not Available
(R)-3-Hydroxy-hexadecanoic acid
Not Available
(R)-3-Hydroxy-Octadecanoic acid
Not Available
(R)-3-Hydroxyoctanoic acid
Not Available

(2) Drugbank Compounds for FASN Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cerulenin
17397-89-6 target inhibitor
Orlistat
  • (-)-Tetrahydrolipstatin
96829-58-2 target inhibitor

(105) Novoseek inferred chemical compound relationships for FASN Gene

Compound -log(P) Hits PubMed IDs
cerulenin 94.6 28
fatty acid 94.3 293
acetyl-coa 88.8 98
sterol 85.3 72
4-phosphopantetheine 79 5
genes like me logo Genes that share compounds with FASN: view

Transcripts for FASN Gene

Unigene Clusters for FASN Gene

Fatty acid synthase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FASN Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37a · 37b · 37c ^ 38 ^ 39a · 39b · 39c ^ 40a · 40b · 40c ^ 41 ^ 42 ^
SP1:
SP2: - - - - -
SP3:
SP4: -
SP5: - - - - - - -
SP6:

ExUns: 43a · 43b · 43c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for FASN Gene

GeneLoc Exon Structure for
FASN
ECgene alternative splicing isoforms for
FASN

Expression for FASN Gene

mRNA expression in normal human tissues for FASN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FASN Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (8.9), Adipose - Subcutaneous (6.9), and Breast - Mammary Tissue (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FASN Gene

SOURCE GeneReport for Unigene cluster for FASN Gene Hs.83190

mRNA Expression by UniProt/SwissProt for FASN Gene

P49327-FAS_HUMAN
Tissue specificity: Ubiquitous. Prominent expression in brain, lung, and liver.
genes like me logo Genes that share expressions with FASN: view

Orthologs for FASN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FASN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FASN 35
  • 98.79 (n)
  • 98.79 (a)
FASN 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FASN 35
  • 81.78 (n)
  • 79.47 (a)
FASN 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FASN 35
  • 83.25 (n)
  • 81.7 (a)
FASN 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fasn 35
  • 80.91 (n)
  • 81.61 (a)
Fasn 16
Fasn 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FASN 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FASN 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fasn 35
  • 80.63 (n)
  • 82.33 (a)
chicken
(Gallus gallus)
Aves FASN 35
  • 64.78 (n)
  • 66.4 (a)
FASN 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FASN 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fasn 35
  • 62.57 (n)
  • 64.7 (a)
zebrafish
(Danio rerio)
Actinopterygii fasn 36
  • 64 (a)
OneToMany
fasn 36
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17374 36
  • 37 (a)
OneToMany
CG3523 36
  • 42 (a)
OneToMany
v(2)k05816 35
  • 54.54 (n)
  • 46.96 (a)
v(2)k05816 36
  • 43 (a)
OneToMany
v(2)k05816 37
  • 45 (a)
CG17374 37
  • 39 (a)
BcDNA:GH07626 37
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea F32H2.6 36
  • 33 (a)
OneToMany
fasn-1 35
  • 49.54 (n)
  • 44.08 (a)
fasn-1 36
  • 40 (a)
OneToMany
F32H2.5 37
  • 41 (a)
C41A3.1 37
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CEM1 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToOne
Species with no ortholog for FASN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FASN Gene

ENSEMBL:
Gene Tree for FASN (if available)
TreeFam:
Gene Tree for FASN (if available)

Paralogs for FASN Gene

Paralogs for FASN Gene

genes like me logo Genes that share paralogs with FASN: view

Variants for FASN Gene

Sequence variations from dbSNP and Humsavar for FASN Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs15324 -- 82,078,483(-) TTGTT(C/T)TTCAA utr-variant-3-prime
rs1140606 -- 82,096,417(-) CATGT(C/T)CGGGA reference, missense
rs1140607 -- 82,092,985(-) GTGGC(C/T)GTCCT reference, synonymous-codon
rs1140608 -- 82,092,954(-) CCCGG(A/C)GGGTG synonymous-codon, reference
rs1140609 -- 82,092,949(-) AAGGT(C/G)TACAC synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for FASN Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
dgv3333n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
dgv3339n71 CNV Loss 21882294
nsv909151 CNV Gain+Loss 21882294
dgv3340n71 CNV Loss 21882294
dgv3341n71 CNV Loss 21882294
dgv3343n71 CNV Loss 21882294
nsv457975 CNV Loss 19166990
nsv909167 CNV Gain+Loss 21882294
dgv3344n71 CNV Loss 21882294
dgv3345n71 CNV Loss 21882294
nsv909181 CNV Loss 21882294
nsv457976 CNV Gain 19166990
nsv470621 CNV Gain 18288195
nsv909186 CNV Loss 21882294
nsv909188 CNV Loss 21882294
dgv3351n71 CNV Loss 21882294
nsv909192 CNV Gain 21882294
dgv3353n71 CNV Loss 21882294
nsv909198 CNV Loss 21882294
nsv909199 CNV Gain 21882294
nsv909201 CNV Gain+Loss 21882294
esv2716470 CNV Deletion 23290073
esv2716471 CNV Deletion 23290073
nsv909202 CNV Gain 21882294
esv1000741 CNV Deletion 20482838
esv2666752 CNV Deletion 23128226

Relevant External Links for FASN Gene

HapMap Linkage Disequilibrium report
FASN
Human Gene Mutation Database (HGMD)
FASN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FASN Gene

Disorders for FASN Gene

(5) University of Copenhagen DISEASES for FASN Gene

(58) Novoseek inferred disease relationships for FASN Gene

Disease -log(P) Hits PubMed IDs
fatty liver 60.1 10
obesity 56.9 24
cancer 53.7 137
microsatellite instability 52.2 6
prostate cancer 52.2 53

Relevant External Links for FASN

Genetic Association Database (GAD)
FASN
Human Genome Epidemiology (HuGE) Navigator
FASN
Tumor Gene Database (TGDB):
FASN
genes like me logo Genes that share disorders with FASN: view

No data available for UniProtKB/Swiss-Prot for FASN Gene

Publications for FASN Gene

  1. Human fatty acid synthase: properties and molecular cloning. (PMID: 7567999) Jayakumar A. … Wakil S.J. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 23
  2. Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain. (PMID: 15507492) Chakravarty B. … Quiocho F.A. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 23
  3. Fatty acid synthesis: a potential selective target for antineoplastic therapy. (PMID: 8022791) Kuhajda F.P. … Pasternack G.R. (Proc. Natl. Acad. Sci. U.S.A. 1994) 3 4 23
  4. Human fatty acid synthase mRNA: tissue distribution, genetic mapping, and kinetics of decay after glucose deprivation. (PMID: 7595075) Semenkovich C.F. … Fiedorek F.T. Jr. (J. Lipid Res. 1995) 3 4 23
  5. Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat. (PMID: 17618296) Pemble C.W. IV … Lowther W.T. (Nat. Struct. Mol. Biol. 2007) 3 4 23

Products for FASN Gene

  • Addgene plasmids for FASN

Sources for FASN Gene

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