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Aliases for ACSL3 Gene

Aliases for ACSL3 Gene

  • Acyl-CoA Synthetase Long-Chain Family Member 3 2 3
  • FACL3 3 4 6
  • ACS3 3 4 6
  • Fatty-Acid-Coenzyme A Ligase, Long-Chain 3 2 3
  • Long-Chain Acyl-CoA Synthetase 3 3 4
  • EC 6.2.1.3 4 63
  • LACS 3 3 4
  • Long-Chain-Fatty-Acid--CoA Ligase 3 3
  • Lignoceroyl-CoA Synthase 3
  • PRO2194 3
  • LACS3 4

External Ids for ACSL3 Gene

Previous Symbols for ACSL3 Gene

  • FACL3

Summaries for ACSL3 Gene

Entrez Gene Summary for ACSL3 Gene

  • The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACSL3 Gene

ACSL3 (Acyl-CoA Synthetase Long-Chain Family Member 3) is a Protein Coding gene. Diseases associated with ACSL3 include saethre-chotzen syndrome. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include protein kinase binding and long-chain fatty acid-CoA ligase activity. An important paralog of this gene is ACSL4.

UniProtKB/Swiss-Prot for ACSL3 Gene

  • Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins).

Gene Wiki entry for ACSL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSL3 Gene

Genomics for ACSL3 Gene

Genomic Location for ACSL3 Gene

Start:
222,860,934 bp from pter
End:
222,944,639 bp from pter
Size:
83,706 bases
Orientation:
Plus strand

Genomic View for ACSL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACSL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACSL3 Gene

Regulatory Elements for ACSL3 Gene

Proteins for ACSL3 Gene

  • Protein details for ACSL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95573-ACSL3_HUMAN
    Recommended name:
    Long-chain-fatty-acid--CoA ligase 3
    Protein Accession:
    O95573
    Secondary Accessions:
    • Q60I92
    • Q8IUM9

    Protein attributes for ACSL3 Gene

    Size:
    720 amino acids
    Molecular mass:
    80420 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for ACSL3 Gene

Proteomics data for ACSL3 Gene at MOPED

Post-translational modifications for ACSL3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys679

Other Protein References for ACSL3 Gene

Domains for ACSL3 Gene

Gene Families for ACSL3 Gene

HGNC:
  • ACS :Acyl-CoA synthetase family

Protein Domains for ACSL3 Gene

Suggested Antigen Peptide Sequences for ACSL3 Gene

Graphical View of Domain Structure for InterPro Entry

O95573

UniProtKB/Swiss-Prot:

ACSL3_HUMAN
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.:
    • O95573
genes like me logo Genes that share domains with ACSL3: view

Function for ACSL3 Gene

Molecular function for ACSL3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA
UniProtKB/Swiss-Prot Function: Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins).

Enzyme Numbers (IUBMB) for ACSL3 Gene

Gene Ontology (GO) - Molecular Function for ACSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004467 long-chain fatty acid-CoA ligase activity IMP 20219900
GO:0005524 ATP binding IEA --
GO:0019901 protein kinase binding IPI 20605918
GO:0019904 protein domain specific binding IPI 20605918
genes like me logo Genes that share ontologies with ACSL3: view

Phenotypes for ACSL3 Gene

genes like me logo Genes that share phenotypes with ACSL3: view

miRNA for ACSL3 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ACSL3 Gene

Localization for ACSL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACSL3 Gene

Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACSL3 Gene COMPARTMENTS Subcellular localization image for ACSL3 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
mitochondrion 5
peroxisome 5
cytosol 1
extracellular 1
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ACSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IEA --
GO:0005777 peroxisome --
GO:0005778 peroxisomal membrane IEA --
GO:0005783 endoplasmic reticulum IDA 14741744
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with ACSL3: view

Pathways for ACSL3 Gene

genes like me logo Genes that share pathways with ACSL3: view

Gene Ontology (GO) - Biological Process for ACSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001676 long-chain fatty acid metabolic process IMP 20219900
GO:0006633 fatty acid biosynthetic process IEA --
GO:0007420 brain development IEA --
GO:0007584 response to nutrient IEA --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with ACSL3: view

Compounds for ACSL3 Gene

(41) HMDB Compounds for ACSL3 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(1) Drugbank Compounds for ACSL3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Icosapent
  • Eicosapentaenoic acid
10417-94-4 target inducer
genes like me logo Genes that share compounds with ACSL3: view

Transcripts for ACSL3 Gene

Unigene Clusters for ACSL3 Gene

Acyl-CoA synthetase long-chain family member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACSL3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^
SP1: - - - -
SP2: - - - - - -
SP3:
SP4: - - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - -
SP6: -
SP7:
SP8: -
SP9: -
SP10: -
SP11: - - - - - -
SP12:

ExUns: 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15
SP1:
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ACSL3 Gene

GeneLoc Exon Structure for
ACSL3
ECgene alternative splicing isoforms for
ACSL3

Expression for ACSL3 Gene

mRNA expression in normal human tissues for ACSL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACSL3 Gene

SOURCE GeneReport for Unigene cluster for ACSL3 Gene Hs.655772

genes like me logo Genes that share expressions with ACSL3: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACSL3 Gene

Orthologs for ACSL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACSL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACSL3 35
  • 99.77 (n)
  • 100 (a)
ACSL3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACSL3 35
  • 92.22 (n)
  • 95.28 (a)
ACSL3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACSL3 35
  • 90.83 (n)
  • 93.89 (a)
ACSL3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acsl3 35
  • 88.89 (n)
  • 92.92 (a)
Acsl3 16
Acsl3 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACSL3 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACSL3 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acsl3 35
  • 88.06 (n)
  • 92.36 (a)
chicken
(Gallus gallus)
Aves ACSL3 35
  • 79.02 (n)
  • 83.57 (a)
ACSL3 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACSL3 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33876 35
tropical clawed frog
(Silurana tropicalis)
Amphibia acsl4 35
  • 68.55 (n)
  • 75.25 (a)
zebrafish
(Danio rerio)
Actinopterygii acsl3a 36
  • 69 (a)
OneToMany
acsl3b 35
  • 66.76 (n)
  • 74.61 (a)
acsl3b 36
  • 73 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003623 35
  • 51.7 (n)
  • 47.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta Acsl 35
  • 52.6 (n)
  • 50.44 (a)
Acsl 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea acs-17 36
  • 44 (a)
ManyToMany
acs-4 36
  • 43 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAA1 36
  • 30 (a)
ManyToMany
FAA3 36
  • 30 (a)
ManyToMany
FAA3 38
FAA4 36
  • 30 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons LACS8 35
  • 54.37 (n)
  • 48.51 (a)
corn
(Zea mays)
Liliopsida Zm.8032 35
rice
(Oryza sativa)
Liliopsida Os.7310 35
Os05g0317200 35
  • 54.45 (n)
  • 48.53 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.7413 35
Species with no ortholog for ACSL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ACSL3 Gene

ENSEMBL:
Gene Tree for ACSL3 (if available)
TreeFam:
Gene Tree for ACSL3 (if available)

Paralogs for ACSL3 Gene

Paralogs for ACSL3 Gene

Selected SIMAP similar genes for ACSL3 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for ACSL3 Gene

genes like me logo Genes that share paralogs with ACSL3: view

Variants for ACSL3 Gene

Sequence variations from dbSNP and Humsavar for ACSL3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1485 -- 222,928,431(-) TGAGT(C/T)TGAAA intron-variant
rs1486 -- 222,928,401(-) TGAAA(A/G)CAATG intron-variant
rs705727 -- 222,884,844(-) AGGCA(A/G)TAATA intron-variant
rs745246 -- 222,884,065(+) CTGCT(A/G)TTTGT intron-variant
rs795874 -- 222,890,897(-) GGGAG(A/G)CTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACSL3 Gene

Variant ID Type Subtype PubMed ID
nsv3181 CNV Loss 18451855
esv2621841 CNV Deletion 19546169
nsv436299 CNV Deletion 17901297
nsv435722 CNV Deletion 17901297
nsv511839 CNV Loss 21212237
esv2151193 CNV Deletion 18987734
esv997784 CNV Deletion 20482838
esv4072 CNV Deletion 18987735
esv2721520 CNV Deletion 23290073
esv9602 CNV Loss 19470904
esv1240242 CNV Deletion 17803354
esv2652841 CNV Deletion 19546169
esv2721521 CNV Deletion 23290073
esv3725 CNV Deletion 18987735
esv1617678 CNV Deletion 17803354
nsv215259 CNV Loss 16902084
nsv819092 CNV Loss 19587683

Relevant External Links for ACSL3 Gene

HapMap Linkage Disequilibrium report
ACSL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACSL3 Gene

Disorders for ACSL3 Gene

(1) MalaCards Diseases for ACSL3 Gene

Search for ACSL3 Gene in MalaCards »

Relevant External Links for ACSL3

Genetic Association Database (GAD)
ACSL3
genes like me logo Genes that share disorders with ACSL3: view

No data available for UniProtKB/Swiss-Prot for ACSL3 Gene

Publications for ACSL3 Gene

  1. Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells. (PMID: 18003621) Yao H. … Ye J. (J. Biol. Chem. 2008) 3 4
  2. Vitamin D3 inhibits fatty acid synthase expression by stimulating the expression of long-chain fatty-acid-CoA ligase 3 in prostate cancer cells. (PMID: 15556626) Qiao S. … Tuohimaa P. (FEBS Lett. 2004) 3 23
  3. Human acyl-coenzyme A synthetase 3 cDNA and localization of its gene (ACS3) to chromosome band 2q34-q35. (PMID: 9177793) Minekura H. … Yamamoto T.T. (Genomics 1997) 3 4
  4. Genomic organization and transcription units of the human acyl-CoA synthetase 3 gene. (PMID: 11707336) Minekura H. … Yamamoto T.T. (Gene 2001) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ACSL3 Gene

Sources for ACSL3 Gene

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