ACSL1 Gene(Protein Coding)

Acyl-CoA Synthetase Long-Chain Family Member 1

GCID:: GC04M184755

GIFtS:: 65

Genes Participants

Aliases for ACSL1 Gene

Acyl-CoA Synthetase Long-Chain Family Member 1 ² ³ ⁵
Fatty-Acid-Coenzyme A Ligase, Long-Chain 2 ² ³
Long-Chain Fatty-Acid-Coenzyme A Ligase 1 ² ³
Long-Chain Fatty Acid-CoA Ligase 2 ³ ⁴
Long-Chain Acyl-CoA Synthetase 1 ³ ⁴
Long-Chain Acyl-CoA Synthetase 2 ³ ⁴
Lignoceroyl-CoA Synthase ² ³
Palmitoyl-CoA Ligase 1 ³ ⁴
Palmitoyl-CoA Ligase 2 ³ ⁴
Acyl-CoA Synthetase 1 ³ ⁴
EC 6.2.1.3 ⁴ ⁶³
LACS 1 ³ ⁴

LACS 2 ³ ⁴
FACL2 ³ ⁴
FACL1 ³ ⁴
LACS1 ³ ⁴
LACS2 ³ ⁴
ACS1 ³ ⁴
LACS ³ ⁴
Fatty-Acid-Coenzyme A Ligase, Long-Chain 1 ³
Paltimoyl-CoA Ligase 1 ³
EC 6.2.1 ⁶³

External Ids for ACSL1 Gene

HGNC: 3569
Entrez Gene: 2180
Ensembl: ENSG00000151726
OMIM: 152425
UniProtKB: P33121

Previous HGNC Symbols for ACSL1 Gene

FACL2

Previous GeneCards Identifiers for ACSL1 Gene

GC04M186373
GC04M186051
GC04M185914
GC04M185676
GC04M181430

Export aliases for ACSL1 gene to outside databases

Summaries for ACSL1 Gene

Entrez Gene Summary for ACSL1 Gene

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for ACSL1 Gene

ACSL1 (Acyl-CoA Synthetase Long-Chain Family Member 1) is a Protein Coding gene. Diseases associated with ACSL1 include Very Long-Chain Acyl-Coenzyme A Dehydrogenase Deficiency and Hodgkin's Lymphoma, Mixed Cellularity. Among its related pathways are alpha-linolenic (omega3) and linoleic (omega6) acid metabolism and Glucose / Energy Metabolism. GO annotations related to this gene include long-chain fatty acid-CoA ligase activity. An important paralog of this gene is ACSBG2.

UniProtKB/Swiss-Prot for ACSL1 Gene

ACSL1_HUMAN,P33121

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.

Gene Wiki entry for ACSL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSL1 Gene

Genomics for ACSL1 Gene

Regulatory Elements for ACSL1 Gene

Enhancers for ACSL1 Gene

GeneHancer Identifier	Score	Enhancer Sources	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites within enhancer	Other Gene Targets for Enhancer

Enhancers around ACSL1 on UCSC Golden Path with GeneCards custom track

Promoters for ACSL1 Gene

Ensembl Regulatory Elements (ENSRs)	TSS Distance (bp)	Size (bp)	Binding Sites for Transcription Factors within promoters

ENSRs around ACSL1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ACSL1 gene promoter:

See All at QIAGEN

Regulatory Element Products

SwitchGear ACSL1 promoter sequence
- S710352
- S714596
- S714602
- S714688
- S722928
- S722933
- S722949
Browse SwitchGear Promoter luciferase reporter plasmids

Genomic Location for ACSL1 Gene

Chromosome:: 4

Start:: 184,755,595 bp from pter
End:: 184,826,818 bp from pter

Size:: 71,224 bases
Orientation:: Minus strand

Genomic View for ACSL1 Gene

Genes around ACSL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

4q35.1 by Ensembl
4q35.1 by Entrez Gene
4q35.1 by HGNC

ACSL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for ACSL1 Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ACSL1 Gene

Proteins for ACSL1 Gene

Protein details for ACSL1 Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

P33121-ACSL1_HUMAN

Recommended name:

Long-chain-fatty-acid--CoA ligase 1

Protein Accession:

P33121

Secondary Accessions:
- B7Z452
- D3DP57
- P41215
- Q8N8V7
- Q8TA99
Protein attributes for ACSL1 Gene
Size:

698 amino acids

Molecular mass:

77943 Da

Cofactor:

Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Quaternary structure:

No Data Available

SequenceCaution:
Sequence=BAC04704.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Alternative splice isoforms for ACSL1 Gene
UniProtKB/Swiss-Prot:
P33121-1

P33121-2

P33121-3

neXtProt entry for ACSL1 Gene

Proteomics data for ACSL1 Gene at MOPED

Protein Expression for ACSL1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for ACSL1 Gene

P33121:

Post-translational modifications for ACSL1 Gene

Ubiquitination at Lys 216, Lys 395, Lys 419, and Lys 532
- NX_P33121
Glycosylation at Ser 135
- NX_P33121
Modification sites at PhosphoSitePlus
- P33121

Other Protein References for ACSL1 Gene

ENSEMBL proteins:

REFSEQ proteins:

Antibody Products

EMD Millipore Complete listing of Mono and Polychlonal Antibodies for ACSL1

Browse R&D Systems for Antibodies

Cell Signaling Technology (CST) Antibodies for ACSL1 (ACSL1)

OriGene Antibodies for ACSL1
- TA309563
- TA319649
- TA331164
- TA331165
Custom Antibody Services

Novus Biologicals Antibodies for ACSL1

Search for Antibodies for ACSL1 at Abcam

Browse Antibodies at Cloud-Clone Corp.

Invitrogen Antibodies for ACSL1

antibodies-online Antibodies for ACSL1: See all 66

GeneTex ACSL1 antibody for ACSL1

ProSci Antibodies for ACSL1
- ACSL1 Antibody
Custom Antibody Services

Santa Cruz Biotechnology (SCBT) Antibodies for ACSL1
- ACSL1 (H-65)
- ACSL1 (C-16)

Protein Products

Browse Purified and Recombinant Proteins at EMD Millipore

Browse R&D Systems for Human Recombinant Proteins

Browse Enzo Life Sciences for proteins

OriGene Purified Proteins for ACSL1
- NM_001995
- NM_001995
Search Origene for MassSpec and Protein Over-expression Lysates for ACSL1
Origene Custom Protein Services for ACSL1

GenScript Custom Purified and Recombinant Proteins Services for ACSL1

Novus Biologicals proteins for ACSL1

Browse ProSpec Recombinant Proteins

Browse Proteins at Cloud-Clone Corp.

Search eBioscience for ACSL1 related proteins

antibodies-online Proteins for ACSL1: See all 5
Search antibodies-online for peptides

Search GeneTex for Proteins for ACSL1

Search for Proteins for ACSL1 at Abcam

Assay Products

Browse Kits and Assays available from EMD Millipore

Browse R&D Systems for biochemical assays

GenScript Custom Assay Services for ACSL1

Browse Enzo Life Sciences for kits & assays

Browse Assay Kits at Cloud-Clone Corp.

Search eBioscience for ACSL1 related elisas

antibodies-online Kits for ACSL1: See all 2

Search for Assays for ACSL1 at Abcam

Domains & Families for ACSL1 Gene

Gene Families for ACSL1 Gene

HGNC:

40 : Acyl-CoA synthetase family

Protein Domains for ACSL1 Gene

InterPro:

Blocks:

AMP-binding signature

ProtoNet:

P33121

Suggested Antigen Peptide Sequences for ACSL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P33121

UniProtKB/Swiss-Prot:

ACSL1_HUMAN :

Belongs to the ATP-dependent AMP-binding enzyme family.

Family:

Belongs to the ATP-dependent AMP-binding enzyme family.

Function for ACSL1 Gene

Molecular function for ACSL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

ACSL1_HUMAN,P33121

UniProtKB/Swiss-Prot Function:

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.

ACSL1_HUMAN,P33121

Enzyme Numbers (IUBMB) for ACSL1 Gene

EC 6.2.1.3 ⁶³ ⁴
EC 6.2.1 ⁶³

Phenotypes for ACSL1 Gene

MGI mutant phenotypes for ACSL1:

inferred from 1 alleles

GenomeRNAi human phenotypes for ACSL1:

Animal Model Products

Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study

ViGene Biosciences lentiviral particle packaged cDNA for ACSL1 gene
- LH874572
ViGene Biosciences ready-to-package AAV shRNAs for ACSL1 gene
- SH874572
Search ViGene Biosciences for ACSL1

CRISPR Products

OriGene CRISPR knockouts for ACSL1
- KN208196
- KN300757

Santa Cruz Biotechnology (SCBT) CRISPR for ACSL1

GenScript: Design CRISPR guide RNA sequences for ACSL1

miRNA for ACSL1 Gene

miRTarBase miRNAs that target ACSL1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACSL1 Gene

Localization for ACSL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACSL1 Gene

Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.

P33121-ACSL1_HUMAN

Subcellular locations from

COMPARTMENTS

Jensen Localization Image for ACSL1 Gene

Compartment	Confidence
endoplasmic reticulum	5
mitochondrion	5
peroxisome	5
cytosol	3
nucleus	3
plasma membrane	3
chloroplast	1
extracellular	1

Gene Ontology (GO) - Cellular Components for ACSL1 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IDA	22022213
GO:0016020	membrane	IDA	19946888

Pathways & Interactions for ACSL1 Gene

SuperPathways for ACSL1 Gene

More details on SuperPathways for ACSL1

	Superpath	Contained pathways
1	Fatty Acyl-CoA Biosynthesis	Fatty Acyl-CoA Biosynthesis .65 Triglyceride Biosynthesis .65 Synthesis of very long-chain fatty acyl-CoAs .53	fatty acid activation 1 stearate biosynthesis 1
2	Metabolism	Metabolic pathways .38 Metabolism .38	Metabolism of lipids and lipoproteins .35
3	alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 1 alpha-linolenic acid (ALA) metabolism 1	Linoleic acid (LA) metabolism 1
4	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Fatty acid, triacylglycerol, and ketone body metabolism .52 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) .52	PPARA activates gene expression .51
5	gamma-linolenate biosynthesis	fatty acid beta-oxidation .30 gamma-linolenate biosynthesis .30	icosapentaenoate biosynthesis II (metazoa) 1

Pathways by source for ACSL1 Gene

1 Cell Signaling Technology pathway for ACSL1 Gene

Glucose / Energy Metabolism

9 BioSystems pathways for ACSL1 Gene

11 Reactome pathways for ACSL1 Gene

7 KEGG pathways for ACSL1 Gene

Interacting Proteins for ACSL1 Gene

http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000281455%0d%0a9606.ENSP00000325690%0d%0a9606.ENSP00000300651%0d%0a9606.ENSP00000455307%0d%0a9606.ENSP00000351894%0d%0a9606.ENSP00000262188%0d%0a — STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins: ENSP00000281455 P33121-ACSL1_HUMAN for ACSL1 Gene via STRING I2D

Symbol	External ID(s)	Details
ABCD2	ENSP00000310688 ²⁰ Q9UBJ2 ²¹	STRING: ENSP00000310688 I2D: score=1
CYB5A	ENSP00000341625 ²⁰ P00167 ²¹	STRING: ENSP00000341625 I2D: score=1
CYB5R3	ENSP00000354468 ²⁰ P00387 ²¹	STRING: ENSP00000354468 I2D: score=1
EPHX1	ENSP00000272167 ²⁰ P07099 ²¹	STRING: ENSP00000272167 I2D: score=1
NMT1	ENSP00000258960 ²⁰ P30419 ²¹	STRING: ENSP00000258960 I2D: score=1

Gene Ontology (GO) - Biological Process for ACSL1 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006641	triglyceride metabolic process	IEA	--
GO:0007584	response to nutrient	IEA	--
GO:0010033	response to organic substance	IEA	--
GO:0019432	triglyceride biosynthetic process	TAS	--
GO:0033211	adiponectin-activated signaling pathway	IEA	--

No data available for SIGNOR curated interactions for ACSL1 Gene

Drugs & Compounds for ACSL1 Gene

(10) Drugs for ACSL1 Gene - From: DrugBank, HMDB, and Novoseek

Name	Status	Disease Links	Group	Role	Clinical Trials
Adenosine monophosphate	Approved	MalaCards Medline Plus	Nutra	Target, product of	0
Adenosine triphosphate	Approved	MalaCards Medline Plus	Nutra	Target	0
Diphosphate	Experimental	MalaCards Medline Plus	Pharma		0
Palmitic Acid	Experimental	MalaCards Medline Plus	Pharma	Full agonist, Agonist	22
Propionyl-CoA	Experimental	MalaCards Medline Plus	Pharma		0

(42) Additional Compounds for ACSL1 Gene - From: HMDB and Novoseek

Name	Synonyms	CAS Number	PubChem IDs	PubMed IDs
(2E)-Decenoyl-CoA	(E)-S-2-decenoate (E)-S-2-decenoate CoA (E)-S-2-decenoate Coenzyme A (E)-S-2-decenoic acid 2-trans-Decenoyl-CoA	MalaCards Medline Plus	10018-95-8	5280768
(2E)-Dodecenoyl-CoA	(2E)-Dodec-2-enoyl-CoA (2E)-Dodec-2-enoyl-Coenzyme A 2-trans-Dodecenoyl-CoA 2-trans-Dodecenoyl-Coenzyme A	MalaCards Medline Plus	1066-12-2	45266564
(2E)-Hexadecenoyl-CoA	(2E)-Hexadecenoyl-CoA (2E)-Hexadecenoyl-Coenzyme A trans-2-Hexadecenoyl-CoA trans-2-Hexadecenoyl-Coenzyme A	MalaCards Medline Plus	4460-95-1	46173176
(2E)-Octenoyl-CoA	(E)-S-2-octenoate (E)-S-2-octenoate CoA (E)-S-2-octenoate Coenzyme A (E)-S-2-octenoic acid 2,3-trans-Octenoyl coenzyme A	MalaCards Medline Plus	10018-94-7	5280769
(2E)-Tetradecenoyl-CoA	(2E)-Tetradecenoyl-CoA (2E)-Tetradecenoyl-Coenzyme A Trans-tetra-dec-2-enoyl-CoA Trans-tetra-dec-2-enoyl-CoA. Trans-tetra-dec-2-enoyl-Coenzyme A	MalaCards Medline Plus	38795-33-4	5280767

Drug Products

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ACSL1

Browse compounds at ApexBio

Transcripts for ACSL1 Gene

mRNA/cDNA for ACSL1 Gene

(12) REFSEQ mRNAs :

(10) Additional mRNA sequences :

(416) Selected AceView cDNA sequences:

(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACSL1 Gene

Acyl-CoA synthetase long-chain family member 1:

Hs.406678

Representative Sequences:

NM_001995

CRISPR Products

OriGene CRISPR knockouts for ACSL1
- KN208196
- KN300757

Santa Cruz Biotechnology (SCBT) CRISPR for ACSL1

GenScript: Design CRISPR guide RNA sequences for ACSL1

miRNA Products

Search ViGene Biosciences for ACSL1

SwitchGear ACSL1 3' UTR sequence
Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhibitory RNA Products

Origene siRNA, mouse_rna, rat_shrna, shRNA, and RNAi products in human, mouse, rat for ACSL1
Browse OriGene Inhibitory RNA Products For ACSL1

ViGene Biosciences ready-to-package AAV shRNAs for ACSL1 gene
- SH874572

Search Santa Cruz Biotechnology (SCBT) for ACSL1 siRNA/shRNA

Clone Products

OriGene clones in human for ACSL1
OriGene ORF clones in human,mouse,rat for ACSL1
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

GenScript: Next-day shipping cDNA clones in your preferred vector

Sino Biological Human cDNA Clone for ACSL1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat

Search Addgene for plasmids for ACSL1

Flow Cytometry Products

eBioscience FlowRNA Probe Sets

Alternative Splicing Database (ASD) splice patterns (SP) for ACSL1 Gene

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b	^	8	^	9a	·	9b	^	10a	·	10b	·	10c	^	11a	·	11b	·	11c	^	12a	·
SP1:																	-		-		-		-		-		-								-		-
SP2:
SP3:											-		-		-		-		-		-		-		-		-								-		-
SP4:
SP5:																											-								-		-
SP6:													-		-		-		-		-		-		-		-								-		-
SP7:															-		-		-		-		-		-		-								-		-
SP8:																					-		-		-		-								-		-
SP9:																											-				-				-		-
SP10:																																			-		-
SP11:			-		-		-		-		-		-		-		-		-		-		-		-		-								-		-
SP12:											-		-		-		-		-		-		-		-		-		-		-				-		-
SP13:											-		-		-		-		-		-		-		-		-
SP14:																											-								-		-
SP15:
SP16:																					-		-		-		-
SP17:											-		-		-		-		-		-		-		-		-
SP18:
SP19:
SP20:
SP21:

ExUns:	12b	^	13a	·	13b	^	14	^	15	^	16	^	17	^	18	^	19a	·	19b	^	20	^	21	^	22a	·	22b	·	22c	^	23a	·	23b	·	23c	^	24	^	25	^	26	^	27a	·	27b	·	27c	^	28	^	29	^
SP1:											-								-				-		-				-						-
SP2:																																			-								-
SP3:
SP4:											-								-		-
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:																			-				-		-
SP20:
SP21:																													-

ExUns:	30	^	31a	·	31b	·	31c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for ACSL1 Gene

GeneLoc Exon Structure for: ACSL1
ECgene alternative splicing isoforms for: ACSL1

Expression for ACSL1 Gene

mRNA expression in normal human tissues for ACSL1 Gene

mRNA expression by BioGPS for ACSL1 Gene

mRNA differential expression in normal tissues according to GTEx for ACSL1 Gene

This gene is overexpressed in Whole Blood (x14.4), Liver (x6.1), and Muscle - Skeletal (x5.8).

Protein differential expression in normal tissues from HIPED for ACSL1 Gene

This gene is overexpressed in Liver (24.5), Nasopharynx (14.4), and Heart (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACSL1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACSL1 Gene

Integrated proteomics: cell line protein expression from ProteomicsDB, MOPED and MaxQB for ACSL1 Gene

SOURCE GeneReport for Unigene cluster for ACSL1 Gene Hs.406678

mRNA Expression by UniProt/SwissProt for ACSL1 Gene

P33121-ACSL1_HUMAN

Tissue specificity: Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas.

Protein tissue co-expression partners for ACSL1 Gene

Primer Products

OriGene qPCR primer pairs for ACSL1
- HP205752
OriGene qPCR primer pairs and template standards for ACSL1
- HK200540

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ACSL1 Gene

Orthologs for ACSL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACSL1 Gene

Organism	Taxonomy	Gene	Similarity	Type	Details
cow (Bos Taurus)	Mammalia	ACSL1 ³⁵	85.63 (n) 88.54 (a)		537161 NM_001076085.1 NP_001069553.1
cow (Bos Taurus)	Mammalia	ACSL1 ³⁶	90 (a)	OneToOne	27:14223449-14288333
dog (Canis familiaris)	Mammalia	ACSL1 ³⁵	86.91 (n) 90.26 (a)		475631 XM_005629987.1 XP_005630044.1
dog (Canis familiaris)	Mammalia	ACSL1 ³⁶	90 (a)	OneToOne	16:45735582-45806294
mouse (Mus musculus)	Mammalia	Acsl1 ³⁵	84 (n) 83.95 (a)		14081 NM_007981.3 NP_032007.2
		Acsl1 ¹⁶			46471041
		Acsl1 ³⁶	85 (a)	OneToOne	8:46471041-46536051
chimpanzee (Pan troglodytes)	Mammalia	ACSL1 ³⁵	99.43 (n) 99.14 (a)		461631 XM_003310581.2 XP_003310629.1
chimpanzee (Pan troglodytes)	Mammalia	ACSL1 ³⁶	99 (a)	OneToOne	4:188088434-188136623
rat (Rattus norvegicus)	Mammalia	Acsl1 ³⁵	83.67 (n) 84.81 (a)		25288 NM_012820.1 NP_036952.1
oppossum (Monodelphis domestica)	Mammalia	ACSL1 ³⁶	85 (a)	OneToOne	5:80494543-80562299
platypus (Ornithorhynchus anatinus)	Mammalia	ACSL1 ³⁶	80 (a)	OneToOne	Contig2827:15309-49517
chicken (Gallus gallus)	Aves	ACSL1 ³⁵	73.78 (n) 76.79 (a)		422547 NM_001012578.1 NP_001012596.1
chicken (Gallus gallus)	Aves	ACSL1 ³⁶	78 (a)	OneToOne	4:38883037-38919985
lizard (Anolis carolinensis)	Reptilia	ACSL1 ³⁶	79 (a)	OneToOne	5:113179027-113229865
tropical clawed frog (Silurana tropicalis)	Amphibia	acsl1 ³⁵	71.35 (n) 75.36 (a)		448565 NM_001006829.1 NP_001006830.1
tropical clawed frog (Silurana tropicalis)	Amphibia	Str.1693 ³⁵			CF592300.1
zebrafish (Danio rerio)	Actinopterygii	acsl1a ³⁶	70 (a)	OneToMany	1:16279346-16329447
zebrafish (Danio rerio)	Actinopterygii	acsl1b ³⁶	63 (a)	OneToMany	14:931645-969245
fruit fly (Drosophila melanogaster)	Insecta	CG3961 ³⁶	47 (a)	OneToMany	3L:18871350-18883583
worm (Caenorhabditis elegans)	Secernentea	acs-13 ³⁶	47 (a)	ManyToMany	I:511048-516456
worm (Caenorhabditis elegans)	Secernentea	acs-5 ³⁶	44 (a)	ManyToMany	III:13540138-13543534
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	FAA2 ³⁶	30 (a)	OneToMany	V:184541-186775
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	FAA2 ³⁸
thale cress (Arabidopsis thaliana)	eudicotyledons	LACS7 ³⁵	51.53 (n) 43.93 (a)		832820 NM_122642.4 NP_198112.2
soybean (Glycine max)	eudicotyledons	Gma.7613 ³⁵			46731428
wheat (Triticum aestivum)	Liliopsida	Ta.9051 ³⁵			CA595234.1
sea squirt (Ciona savignyi)	Ascidiacea	-- ³⁶	52 (a)	ManyToMany	reftig_9:949897-960338
sea squirt (Ciona savignyi)	Ascidiacea	CSA.10659 ³⁶	49 (a)	ManyToMany	reftig_9:939466-949712

Species with no ortholog for ACSL1:

A. gosspyii yeast (Ashbya gossypii)
Actinobacteria (Mycobacterium tuberculosis)
African clawed frog (Xenopus laevis)
African malaria mosquito (Anopheles gambiae)
Alicante grape (Vitis vinifera)
alpha proteobacteria (Wolbachia pipientis)
amoeba (Dictyostelium discoideum)
Archea (Pyrococcus horikoshii)
barley (Hordeum vulgare)
beta proteobacteria (Neisseria meningitidis)
bread mold (Neurospora crassa)
Chromalveolata (Phytophthora infestans)
common water flea (Daphnia pulex)
corn (Zea mays)
E. coli (Escherichia coli)
filamentous fungi (Aspergillus nidulans)
Firmicute bacteria (Streptococcus pneumoniae)
fission yeast (Schizosaccharomyces pombe)
green algae (Chlamydomonas reinhardtii)
honey bee (Apis mellifera)
K. lactis yeast (Kluyveromyces lactis)
loblloly pine (Pinus taeda)
malaria parasite (Plasmodium falciparum)
medicago trunc (Medicago Truncatula)
moss (Physcomitrella patens)
orangutan (Pongo pygmaeus)
pig (Sus scrofa)
rainbow trout (Oncorhynchus mykiss)
rice (Oryza sativa)
rice blast fungus (Magnaporthe grisea)
schistosome parasite (Schistosoma mansoni)
sea anemone (Nematostella vectensis)
sea urchin (Strongylocentrotus purpuratus)
sorghum (Sorghum bicolor)
stem rust fungus (Puccinia graminis)
sugarcane (Saccharum officinarum)
tomato (Lycopersicon esculentum)
toxoplasmosis (Toxoplasma gondii)
Trichoplax (Trichoplax adhaerens)

Evolution for ACSL1 Gene

ENSEMBL:: Gene Tree for ACSL1 (if available)
TreeFam:: Gene Tree for ACSL1 (if available)

Paralogs for ACSL1 Gene

(6) SIMAP similar genes for ACSL1 Gene using alignment to 10 proteins:

Variants for ACSL1 Gene

Sequence variations from dbSNP and Humsavar for ACSL1 Gene

SNP ID	Clin	Chr 04 pos	Sequence Context	Type
rs8086	--	184,756,267(-)	GTGAC(A/G)CCTGA	utr-variant-3-prime
rs879779	--	184,783,045(-)	CCGTC(C/T)CTGGC	intron-variant
rs902172	--	184,782,201(+)	CTATA(C/T)AGCTG	intron-variant
rs902177	--	184,807,685(+)	AAACT(C/T)TGGAT	intron-variant, upstream-variant-2KB
rs735948	--	184,795,335(+)	ATTTC(C/T)GTCCT	intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACSL1 Gene

Variant ID	Type	Subtype	PubMed ID
nsv830168	CNV	Loss	17160897
esv2662137	CNV	Deletion	23128226
nsv822880	CNV	Gain	20364138
esv28765	CNV	Loss	19812545

Variation tolerance for ACSL1 Gene

Residual Variation Intolerance Score: 20.9% of all genes are more intolerant (likely to be disease-causing)

Gene Damage Index Score: 1.62; 31.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACSL1 Gene

Human Gene Mutation Database (HGMD): ACSL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACSL1 Gene

Disorders for ACSL1 Gene

(2) MalaCards diseases for ACSL1 Gene - From: DISEASES and GeneCards

Disorder	Aliases	PubMed IDs
very long-chain acyl-coenzyme a dehydrogenase deficiency	very long-chain acyl-coa dehydrogenase deficiency
hodgkin's lymphoma, mixed cellularity	hodgkin lymphoma, mixed cellularity

- elite association - COSMIC cancer census association via MalaCards

Search ACSL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ACSL1

Genetic Association Database (GAD): ACSL1
Human Genome Epidemiology (HuGE) Navigator: ACSL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:: ACSL1

Export disorders for ACSL1 gene to outside databases

No data available for UniProtKB/Swiss-Prot and Genatlas for ACSL1 Gene

Publications for ACSL1 Gene

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) ³ ⁴⁸ ⁶⁷
Chromosomal localization of the human gene for palmitoyl-CoA ligase (FACL1). (PMID: 1531127) Stanczak H. … Singh I. (Cytogenet. Cell Genet. 1992) ² ³
Structure and regulation of rat long-chain acyl-CoA synthetase. (PMID: 2341402) Suzuki H. … Yamamoto T. (J. Biol. Chem. 1990) ² ³
ACSL1 Is Associated With Fetal Programming of Insulin Sensitivity and Cellular Lipid Content. (PMID: 25915184) Joseph R. … StA1nkel W. (Mol. Endocrinol. 2015) ³
Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) ³