External Ids for FANCE Gene
Previous HGNC Symbols for FANCE Gene
Previous GeneCards Identifiers for FANCE Gene
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group E. [provided by RefSeq, Jul 2008]
GeneCards Summary for FANCE Gene
FANCE (Fanconi Anemia, Complementation Group E) is a Protein Coding gene. Diseases associated with FANCE include fanconi anemia, complementation group e and fance-related fanconi anemia. Among its related pathways are Chks in Checkpoint Regulation and BRCA1 Pathway.
UniProtKB/Swiss-Prot for FANCE Gene
As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2.