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FABP2 Gene(Protein Coding)

Fatty Acid Binding Protein 2

GCID:
GC04M119317
GIFtS:
64
Genes Participants
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Aliases for FABP2 Gene

Aliases for FABP2 Gene

  • Fatty Acid Binding Protein 2 2 3
  • Fatty Acid Binding Protein 2, Intestinal 2 3 5
  • Intestinal-Type Fatty Acid-Binding Protein 3 4
  • Fatty Acid-Binding Protein 2 3 4
  • I-FABP 3 4
  • FABPI 3 4

External Ids for FABP2 Gene

Previous GeneCards Identifiers for FABP2 Gene

  • GC04M120996
  • GC04M120518
  • GC04M120631
  • GC04M120697
  • GC04M120596
  • GC04M120238
  • GC04M115960

Summaries for FABP2 Gene

Entrez Gene Summary for FABP2 Gene

  • The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. [provided by RefSeq, Jul 2008]

GeneCards Summary for FABP2 Gene

FABP2 (Fatty Acid Binding Protein 2) is a Protein Coding gene. Diseases associated with FABP2 include Perinatal Necrotizing Enterocolitis and Acute Vascular Insufficiency Of Intestine. Among its related pathways are Metabolism and PPAR signaling pathway. GO annotations related to this gene include transporter activity and fatty acid binding.

UniProtKB/Swiss-Prot for FABP2 Gene

  • FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.

Gene Wiki entry for FABP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FABP2 Gene

Genomics for FABP2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for FABP2 Gene

Enhancers for FABP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FABP2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FABP2 gene promoter:

Genomic Location for FABP2 Gene

Chromosome:
4
Start:
119,317,250 bp from pter
End:
119,322,390 bp from pter
Size:
5,141 bases
Orientation:
Minus strand

Genomic View for FABP2 Gene

Genes around FABP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FABP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FABP2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FABP2 Gene

Proteins for FABP2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FABP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12104-FABPI_HUMAN
    Recommended name:
    Fatty acid-binding protein, intestinal
    Protein Accession:
    P12104
    Secondary Accessions:
    • Q2NKJ1

    Protein attributes for FABP2 Gene

    Size:
    132 amino acids
    Molecular mass:
    15207 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FABP2 Gene

neXtProt entry for FABP2 Gene

Proteomics data for FABP2 Gene at MOPED

Protein Expression for FABP2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FABP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FABP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FABP2 Gene

Domains & Families for FABP2 Gene

Gene Families for FABP2 Gene

HGNC:

Protein Domains for FABP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FABP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P12104

UniProtKB/Swiss-Prot:

FABPI_HUMAN :
  • Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Domain:
  • Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with FABP2: view

Function for FABP2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for FABP2 Gene

GENATLAS Biochemistry:
fatty acid binding protein 2,intestinal
UniProtKB/Swiss-Prot Function:
FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.
UniProtKB/Swiss-Prot Induction:
By EGF.

Gene Ontology (GO) - Molecular Function for FABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005504 fatty acid binding IEA --
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with FABP2: view

Phenotypes for FABP2 Gene

MGI mutant phenotypes for FABP2:
inferred from 1 alleles
GenomeRNAi human phenotypes for FABP2:
genes like me logo Genes that share phenotypes with FABP2: view

Animal Models for FABP2 Gene

MGI Knock Outs for FABP2:

Animal Model Products

  • Taconic Biosciences Mouse Models for FABP2

miRNA for FABP2 Gene

miRTarBase miRNAs that target FABP2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FABP2 Gene

Localization for FABP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FABP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FABP2 Gene COMPARTMENTS Subcellular localization image for FABP2 gene
Compartment Confidence
cytosol 5
cytoskeleton 3
nucleus 3
plasma membrane 3
extracellular 2
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for FABP2 Gene

Pathways & Interactions for FABP2 Gene

genes like me logo Genes that share pathways with FABP2: view

Interacting Proteins for FABP2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000274024%0d%0a9606.ENSP00000391490%0d%0a9606.ENSP00000300086%0d%0a9606.ENSP00000366927%0d%0a
Selected Interacting proteins: ENSP00000274024 P12104-FABPI_HUMAN for FABP2 Gene via STRING I2D UniProtKB

Gene Ontology (GO) - Biological Process for FABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with FABP2: view

No data available for SIGNOR curated interactions for FABP2 Gene

Drugs & Compounds for FABP2 Gene

Products:

  1. Drug

(24) Drugs for FABP2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Estradiol Approved, Investigational Pharma Carrier Sex hormone 1235
Ibuprofen Approved Pharma Channel blocker, Target, binder 467
Sulfinpyrazone Approved Pharma Carrier 0
arachidonic acid Experimental Nutra Activator, Carrier 27
MYRISTIC ACID Experimental Pharma Carrier 0

(47) Additional Compounds for FABP2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
 10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
 1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
 4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
 10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
 38795-33-4
genes like me logo Genes that share compounds with FABP2: view

Transcripts for FABP2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FABP2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FABP2 Gene

Fatty acid binding protein 2, intestinal:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FABP2 Gene

No ASD Table

Relevant External Links for FABP2 Gene

GeneLoc Exon Structure for
FABP2
ECgene alternative splicing isoforms for
FABP2

Expression for FABP2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for FABP2 Gene

mRNA expression in normal human tissues for FABP2 Gene
mRNA expression by BioGPS for FABP2 GenemRNA expression by GTEx for FABP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FABP2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x41.4) and Colon - Transverse (x10.1).

Protein differential expression in normal tissues from HIPED for FABP2 Gene

This gene is overexpressed in Fetal gut (37.0) and Pancreatic juice (29.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FABP2 Gene



SOURCE GeneReport for Unigene cluster for FABP2 Gene Hs.282265

mRNA Expression by UniProt/SwissProt for FABP2 Gene

P12104-FABPI_HUMAN
Tissue specificity: Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum.
genes like me logo Genes that share expression patterns with FABP2: view

Protein tissue co-expression partners for FABP2 Gene

- Elite partner

Primer Products

Orthologs for FABP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FABP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia FABP2 35
  • 86.11 (n)
  • 84.09 (a)
FABP2 36
  • 78 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia FABP2 35
  • 89.14 (n)
  • 86.36 (a)
FABP2 36
  • 86 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Fabp2 35
  • 82.07 (n)
  • 78.03 (a)
Fabp2 16
Fabp2 36
  • 78 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia FABP2 35
  • 97.73 (n)
  • 96.97 (a)
FABP2 36
  • 97 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Fabp2 35
  • 83.08 (n)
  • 81.82 (a)
oppossum
(Monodelphis domestica)
 Mammalia FABP2 36
  • 78 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia FABP2 36
  • 77 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves FABP2 35
  • 71.46 (n)
  • 70.45 (a)
FABP2 36
  • 70 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia FABP2 36
  • 72 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia fabp2 35
  • 70.74 (n)
  • 71.76 (a)
African clawed frog
(Xenopus laevis)
 Amphibia fabp2-A 35
zebrafish
(Danio rerio)
 Actinopterygii fabp2 35
  • 67.94 (n)
  • 67.18 (a)
fabp2 36
  • 67 (a)
 OneToOne
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.9035 35
fruit fly
(Drosophila melanogaster)
 Insecta fabp 36
  • 27 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea lbp-5 36
  • 29 (a)
 ManyToMany
lbp-6 36
  • 29 (a)
 ManyToMany
lbp-7 36
  • 26 (a)
 ManyToMany
lbp-8 36
  • 23 (a)
 ManyToMany
lbp-9 36
  • 23 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.4242 36
  • 33 (a)
 OneToOne
Species with no ortholog for FABP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FABP2 Gene

ENSEMBL:
Gene Tree for FABP2 (if available)
TreeFam:
Gene Tree for FABP2 (if available)

Paralogs for FABP2 Gene

(13) SIMAP similar genes for FABP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FABP2: view

No data available for Paralogs for FABP2 Gene

Variants for FABP2 Gene

Sequence variations from dbSNP and Humsavar for FABP2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1799883 - 119,320,747(-) CAAGC(A/C/G/T)CTTTT reference, missense
rs2964 -- 119,318,976(+) ATAAA(C/T)AGTTC utr-variant-3-prime
rs878372 -- 119,317,625(-) CTTAC(G/T)ACTTG utr-variant-3-prime
rs714899 -- 119,321,880(+) AGGGA(A/G)AATAT intron-variant
rs907204 -- 119,317,499(+) AACAC(A/G)CAGTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FABP2 Gene

Variant ID Type Subtype PubMed ID
nsv879840 CNV Gain 21882294

Variation tolerance for FABP2 Gene

Residual Variation Intolerance Score: 63.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FABP2 Gene

Human Gene Mutation Database (HGMD)
FABP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FABP2 Gene

Disorders for FABP2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for FABP2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
perinatal necrotizing enterocolitis
  • enterocolitis necrotizing
acute vascular insufficiency of intestine
  • acute gastrointestinal tract vascular insuffic.
refractory celiac disease
  • refractory cd
morbid obesity
  • severe obesity
intestinal atresia
- elite association - COSMIC cancer census association via MalaCards
Search FABP2 in MalaCards View complete list of genes associated with diseases

Genatlas disease for FABP2 Gene

insulin resistance,increased fatty oxidation in Pima Indian population (FABP2 polymorphism,A94T)

Relevant External Links for FABP2

Genetic Association Database (GAD)
FABP2
Human Genome Epidemiology (HuGE) Navigator
FABP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FABP2
genes like me logo Genes that share disorders with FABP2: view

No data available for UniProtKB/Swiss-Prot for FABP2 Gene

Publications for FABP2 Gene

  1. An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. (PMID: 7883976) Baier L.J. … Prochazka M. (J. Clin. Invest. 1995) 3 4 48 67
  2. The Ala54Thr polymorphism in the fatty acid-binding protein 2 (FABP2) gene is associated with hearing impairment: a preliminary report. (PMID: 20202768) Uchida Y. … Shimokata H. (Auris Nasus Larynx 2010) 3 23
  3. Functional polymorphisms to modulate luminal lipid exposure and risk of colorectal cancer. (PMID: 20308031) Kato I. … Severson R.K. (Cancer Epidemiol 2010) 3 23
  4. Association between functional FABP2 promoter haplotypes and body mass index: analyses of 8072 participants of the KORA cohort study. (PMID: 19156719) BAPhme M. … Illig T. (Mol Nutr Food Res 2009) 3 23
  5. Thr54 allele of fatty-acid binding protein 2 gene is associated with obesity but not type 2 diabetes mellitus in a Caucasian population. (PMID: 19324445) Tavridou A. … Manolopoulos V.G. (Diabetes Res. Clin. Pract. 2009) 3 23

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