Aliases for FABP2 Gene
Aliases for FABP2 Gene
External Ids for FABP2 Gene
- HGNC: 3556
- Entrez Gene: 2169
- Ensembl: ENSG00000145384
- OMIM: 134640
- UniProtKB: P12104
Previous GeneCards Identifiers for FABP2 Gene
- GC04M120996
- GC04M120518
- GC04M120631
- GC04M120697
- GC04M120596
- GC04M120238
- GC04M115960
Summaries for FABP2 Gene
-
The protein encoded by this gene is an intracellular fatty acid-binding protein that participates in the uptake, intracellular metabolism, and transport of long-chain fatty acids. The encoded protein is also involved in the modulation of cell growth and proliferation. This protein binds saturated long-chain fatty acids with high affinity, and may act as a lipid sensor to maintain energy homeostasis. [provided by RefSeq, Aug 2017]
GeneCards Summary for FABP2 Gene
FABP2 (Fatty Acid Binding Protein 2) is a Protein Coding gene. Diseases associated with FABP2 include Perinatal Necrotizing Enterocolitis and Refractory Celiac Disease. Among its related pathways are Lipoprotein metabolism and Fat digestion and absorption. Gene Ontology (GO) annotations related to this gene include transporter activity and fatty acid binding.
UniProtKB/Swiss-Prot for FABP2 Gene
-
FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FABP2 Gene
Genomics for FABP2 Gene
GeneHancer (GH) Regulatory Elements for FABP2 Gene
- Top Transcription factor binding sites by QIAGEN in the FABP2 gene promoter:
Regulatory Element Products
Genomic Locations for FABP2 Gene
- chr4:119,317,250-119,322,390
- (GRCh38/hg38)
- Size:
- 5,141 bases
- Orientation:
- Minus strand
- chr4:120,238,405-120,243,545
- (GRCh37/hg19)
Genomic View for FABP2 Gene
- Cytogenetic band:
-
- 4q26 by Ensembl
- 4q26 by Entrez Gene
- 4q26 by HGNC


RefSeq DNA sequence for FABP2 Gene
Proteins for FABP2 Gene
-
Protein details for FABP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P12104-FABPI_HUMAN
- Recommended name:
- Fatty acid-binding protein, intestinal
- Protein Accession:
- P12104
- Q2NKJ1
Protein attributes for FABP2 Gene
- Size:
- 132 amino acids
- Molecular mass:
- 15207 Da
- Quaternary structure:
- No Data Available
Protein Expression for FABP2 Gene
Post-translational modifications for FABP2 Gene
Other Protein References for FABP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for FABP2 (FABP2/I-FABP)
-
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-
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-
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-
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Protein Products
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-
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ProSci Proteins for FABP2
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Abcam proteins for FABP2
Assay Products
- R&D Systems ELISAs and other biochemical assays for FABP2 (FABP2/I-FABP)
-
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No data available for DME Specific Peptides for FABP2 Gene
Domains & Families for FABP2 Gene
Gene Families for FABP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for FABP2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FABP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P12104UniProtKB/Swiss-Prot:
FABPI_HUMAN :- Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
- Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
- Domain:
-
- Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
- Family:
-
- Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Function for FABP2 Gene
Molecular function for FABP2 Gene
- GENATLAS Biochemistry:
- fatty acid binding protein 2,intestinal
- UniProtKB/Swiss-Prot Function:
- FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.
- UniProtKB/Swiss-Prot Induction:
- By EGF.
Phenotypes From GWAS Catalog for FABP2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005504 | fatty acid binding | IEA | -- |
GO:0005515 | protein binding | IPI | 21044950 |
GO:0008289 | lipid binding | IEA | -- |
Phenotypes for FABP2 Gene
- MGI mutant phenotypes for FABP2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for FABP2:
Animal Models for FABP2 Gene
- MGI Knock Outs for FABP2:
-
- Fabp2 tm1Mto
Animal Model Products
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-
-
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-
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-
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miRNA for FABP2 Gene
- miRTarBase miRNAs that target FABP2
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for FABP2
-
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Cell Line Products
-
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-
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-
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FABP2 Gene
Localization for FABP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FABP2 Gene
- Cytoplasm.
- Actin filaments (2)
- Cytosol (2)
- Plasma membrane (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005622 | intracellular | IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for FABP2 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Lipoprotein metabolism | ||
2 | Metabolism |
.37
|
|
3 | Fat digestion and absorption | ||
4 | PPAR signaling pathway |
Pathways by source for FABP2 Gene
2 KEGG pathways for FABP2 Gene
Interacting Proteins for FABP2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006810 | transport | IEA | -- |
GO:0007586 | digestion | TAS | 7883976 |
GO:0019433 | triglyceride catabolic process | TAS | -- |
No data available for SIGNOR curated interactions for FABP2 Gene
Drugs & Compounds for FABP2 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Dexibuprofen | Approved, Investigational | Pharma | Target, binder | 0 | ||
Estradiol | Approved, Investigational, Vet_approved | Pharma | Carrier | Sex hormone | 1400 | |
Ibuprofen | Approved | Pharma | Channel blocker, Target, binder | 547 | ||
Palmitic Acid | Approved, Experimental | Pharma | Full agonist, Agonist, Carrier | 23 | ||
Sulfinpyrazone | Approved | Pharma | Carrier | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
(2E)-Decenoyl-CoA |
|
10018-95-8 |
|
|||
(2E)-Dodecenoyl-CoA |
|
1066-12-2 |
|
|||
(2E)-Hexadecenoyl-CoA |
|
4460-95-1 |
|
|||
(2E)-Octenoyl-CoA |
|
10018-94-7 |
|
|||
(2E)-Tetradecenoyl-CoA |
|
38795-33-4 |
|
Transcripts for FABP2 Gene
mRNA/cDNA for FABP2 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (13) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FABP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FABP2
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-
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-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for FABP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for FABP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for FABP2 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FABP2 Gene
NURSA nuclear receptor signaling pathways regulating expression of FABP2 Gene:
FABP2SOURCE GeneReport for Unigene cluster for FABP2 Gene:
Hs.282265mRNA Expression by UniProt/SwissProt for FABP2 Gene:
P12104-FABPI_HUMANEvidence on tissue expression from TISSUES for FABP2 Gene
- Intestine(4.8)
- Blood(2)
Primer Products
-
OriGene qPCR primer pairs for FABP2
-
OriGene qPCR primer pairs and template standards for FABP2
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FABP2 Gene
Orthologs for FABP2 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | FABP2 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | FABP2 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | FABP2 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Fabp2 33 |
|
||
mouse (Mus musculus) |
Mammalia | Fabp2 33 16 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | FABP2 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | FABP2 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | FABP2 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | FABP2 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | fabp2 33 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | fabp2-A 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | fabp2 33 34 |
|
||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9035 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | fabp 34 |
|
OneToMany | |
worm (Caenorhabditis elegans) |
Secernentea | lbp-5 34 |
|
ManyToMany | |
lbp-6 34 |
|
ManyToMany | |||
lbp-7 34 |
|
ManyToMany | |||
lbp-8 34 |
|
ManyToMany | |||
lbp-9 34 |
|
ManyToMany | |||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4242 34 |
|
OneToOne |
- Species where no ortholog for FABP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FABP2 Gene
(13) SIMAP similar genes for FABP2 Gene using alignment to 1 proteins:
No data available for Paralogs for FABP2 Gene
Variants for FABP2 Gene
SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1799883 | benign, FATTY ACID-BINDING PROTEIN, INTESTINAL, POLYMORPHISM OF | 119,320,747(-) | T/A/C/G | coding_sequence_variant, missense_variant | |
rs1000171132 | -- | 119,322,499(-) | C/A | upstream_transcript_variant | |
rs10003567 | -- | 119,320,519(-) | C/T | intron_variant | |
rs10006259 | -- | 119,320,990(-) | C/T | intron_variant | |
rs10006877 | -- | 119,321,638(-) | C/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3601966 | CNV | gain | 21293372 |
Additional Variant Information for FABP2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FABP2 Gene
Disorders for FABP2 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
perinatal necrotizing enterocolitis |
|
|
refractory celiac disease |
|
|
acute vascular insufficiency of intestine |
|
|
ileitis |
|
|
morbid obesity |
|
Genatlas disease for FABP2 Gene
Additional Disease Information for FABP2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot for FABP2 Gene
Publications for FABP2 Gene
- The Ala54Thr polymorphism in the fatty acid-binding protein 2 (FABP2) gene is associated with hearing impairment: a preliminary report. (PMID: 20202768) Uchida Y … Shimokata H (Auris, nasus, larynx 2010) 3 22 44 58
- Functional polymorphisms to modulate luminal lipid exposure and risk of colorectal cancer. (PMID: 20308031) Kato I … Severson RK (Cancer epidemiology 2010) 3 22 44 58
- Association between functional FABP2 promoter haplotypes and body mass index: analyses of 8072 participants of the KORA cohort study. (PMID: 19156719) Böhme M … Illig T (Molecular nutrition & food research 2009) 3 22 44 58
- Thr54 allele of fatty-acid binding protein 2 gene is associated with obesity but not type 2 diabetes mellitus in a Caucasian population. (PMID: 19324445) Tavridou A … Manolopoulos VG (Diabetes research and clinical practice 2009) 3 22 44 58
- Ala54Thr polymorphism of the fatty acid binding protein 2 gene and saturated fat intake in relation to lipid levels and insulin resistance: the Coronary Artery Risk Development in Young Adults (CARDIA) study. (PMID: 19439328) Chamberlain AM … Boerwinkle E (Metabolism: clinical and experimental 2009) 3 22 44 58
Products for FABP2 Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 175 available FABP2 Antibodies ranked by validation data
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- ViGene Biosciences adenoviral particle packaged cDNA for FABP2 gene
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Sources for FABP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew