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Aliases for F10 Gene

Aliases for F10 Gene

  • Coagulation Factor X 2 3
  • Stuart-Prower Factor 3 4
  • EC 4 63
  • Prothrombinase 3
  • Stuart Factor 4
  • Factor Xa 3
  • EC 3.4.21 63
  • FXA 3
  • FX 3

External Ids for F10 Gene

Previous GeneCards Identifiers for F10 Gene

  • GC13P112387
  • GC13P108414
  • GC13P112863
  • GC13P111725
  • GC13P112825
  • GC13P113777
  • GC13P094215

Summaries for F10 Gene

Entrez Gene Summary for F10 Gene

  • This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. [provided by RefSeq, Jul 2008]

GeneCards Summary for F10 Gene

F10 (Coagulation Factor X) is a Protein Coding gene. Diseases associated with F10 include factor x deficiency and hemarthrosis. Among its related pathways are Hemostasis and Formation of Fibrin Clot (Clotting Cascade). GO annotations related to this gene include calcium ion binding and serine-type endopeptidase activity. An important paralog of this gene is HP.

UniProtKB/Swiss-Prot for F10 Gene

  • Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting

Gene Wiki entry for F10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for F10 Gene

Genomics for F10 Gene

Regulatory Elements for F10 Gene

Genomic Location for F10 Gene

113,122,799 bp from pter
113,149,529 bp from pter
26,731 bases
Plus strand

Genomic View for F10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for F10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for F10 Gene

Proteins for F10 Gene

  • Protein details for F10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coagulation factor X
    Protein Accession:
    Secondary Accessions:
    • Q14340

    Protein attributes for F10 Gene

    488 amino acids
    Molecular mass:
    54732 Da
    Quaternary structure:
    • The two chains are formed from a single-chain precursor by the excision of two Arg residues and are held together by 1 or more disulfide bonds. Forms a heterodimer with SERPINA5

    Three dimensional structures from OCA and Proteopedia for F10 Gene

neXtProt entry for F10 Gene

Proteomics data for F10 Gene at MOPED

Post-translational modifications for F10 Gene

  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
  • The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway)
  • The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium
  • Glycosylation at Thr199, Thr211, Asn221, Asn231, and Thr483
  • Modification sites at PhosphoSitePlus

Other Protein References for F10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for F10 (Coagulation Factor X)

Domains for F10 Gene

Suggested Antigen Peptide Sequences for F10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 EGF-like domains.
  • Belongs to the peptidase S1 family.
  • Contains 2 EGF-like domains.
  • Contains 1 Gla (gamma-carboxy-glutamate) domain.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with F10: view

No data available for Gene Families for F10 Gene

Function for F10 Gene

Molecular function for F10 Gene

GENATLAS Biochemistry:
coagulation factor X (Stuart Prower),vitamin K-dependent
UniProtKB/Swiss-Prot CatalyticActivity:
Selective cleavage of Arg- -Thr and then Arg- -Ile bonds in prothrombin to form thrombin
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by SERPINA5 and SERPINA10.
UniProtKB/Swiss-Prot Function:
Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting

Enzyme Numbers (IUBMB) for F10 Gene

Gene Ontology (GO) - Molecular Function for F10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 6323392
GO:0005543 phospholipid binding IDA 17469850
genes like me logo Genes that share ontologies with F10: view
genes like me logo Genes that share phenotypes with F10: view

Animal Models for F10 Gene

MGI Knock Outs for F10:

Animal Model Products

miRNA for F10 Gene

miRTarBase miRNAs that target F10

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for F10

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for F10 Gene

Localization for F10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for F10 Gene


Subcellular locations from

Jensen Localization Image for F10 Gene COMPARTMENTS Subcellular localization image for F10 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
golgi apparatus 4
plasma membrane 3
nucleus 1

Gene Ontology (GO) - Cellular Components for F10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with F10: view

Pathways for F10 Gene

genes like me logo Genes that share pathways with F10: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for F10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis TAS --
GO:0007596 blood coagulation TAS --
GO:0007597 blood coagulation, intrinsic pathway TAS --
GO:0007598 blood coagulation, extrinsic pathway TAS --
GO:0017187 peptidyl-glutamic acid carboxylation TAS --
genes like me logo Genes that share ontologies with F10: view

Drugs for F10 Gene

(42) Drugbank Compounds for F10 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Antihemophilic Factor
  • AHF
Target activator approved, investigational
Fondaparinux sodium
  • Arixtra
114870-03-0 Target inhibitor approved, investigational
  • Calciparine
9005-49-6 Target inhibitor approved, investigational
  • 2-Methyl-1,4-Naphthalenedione
58-27-5 4055 Target activator approved, nutraceutical
  • Apixabanum
503612-47-3 10182969 Target inhibitor approved

(7) ApexBio Compounds for F10 Gene

Compound Action Cas Number
5-R-Rivaroxaban Factor Xa (FXa) inhibitor [865479-71-6]
Apixaban Factor Xa inhibitor [503612-47-3]
BIBR 953 (Dabigatran, Pradaxa) Thrombin inhibitor,potent,reversible and direct [211914-51-1]
BIBR-1048 Thrombin inhibitor [211915-06-9]
CORM-3 Exhibits anti-inflammatory/cardioprotective effects [475473-26-8]
Edoxaban tosylate monohydrate Oral factor Xa inhibitor [1229194-11-9]
Rivaroxaban Factor Xa inhibitor [366789-02-8]

(4) HMDB Compounds for F10 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • LMWH
Fondaparinux sodium
  • Arixtra
  • 2-Methyl-1,4-naftochinon

(115) Novoseek inferred chemical compound relationships for F10 Gene

Compound -log(P) Hits PubMed IDs
rivaroxaban 94.4 98
fondaparinux 94.3 117
apixaban 91.7 36
heparin 88.8 226
heparin pentasaccharide 88.6 9
genes like me logo Genes that share compounds with F10: view

Compound Products

Transcripts for F10 Gene

Unigene Clusters for F10 Gene

Coagulation factor X:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for F10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for F10 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: -

Relevant External Links for F10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for F10 Gene

mRNA expression in normal human tissues for F10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for F10 Gene

This gene is overexpressed in Liver (12.2).

Protein differential expression in normal tissues for F10 Gene

This gene is overexpressed in Serum (35.3), Plasma (16.0), and Synovial fluid (10.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for F10 Gene

SOURCE GeneReport for Unigene cluster for F10 Gene Hs.361463

mRNA Expression by UniProt/SwissProt for F10 Gene

Tissue specificity: Plasma; synthesized in the liver.
genes like me logo Genes that share expressions with F10: view

Expression partners for F10 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for F10 Gene

This gene was present in the common ancestor of animals.

Orthologs for F10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia F10 35
  • 76.88 (n)
  • 70.81 (a)
F10 36
  • 69 (a)
(Canis familiaris)
Mammalia F10 35
  • 79.52 (n)
  • 76.94 (a)
F10 36
  • 73 (a)
(Mus musculus)
Mammalia F10 35
  • 78.04 (n)
  • 77.54 (a)
F10 16
F10 36
  • 74 (a)
(Pan troglodytes)
Mammalia F10 35
  • 99.52 (n)
  • 100 (a)
F10 36
  • 100 (a)
(Rattus norvegicus)
Mammalia F10 35
  • 77.24 (n)
  • 75.63 (a)
(Monodelphis domestica)
Mammalia F10 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia F10 36
  • 63 (a)
(Gallus gallus)
Aves F10 35
  • 60.03 (n)
  • 58.6 (a)
F10 36
  • 56 (a)
(Anolis carolinensis)
Reptilia F10 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia f10 35
  • 57.65 (n)
  • 56.65 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68454 35
(Danio rerio)
Actinopterygii f10 35
  • 58.1 (n)
  • 50.71 (a)
f10 36
  • 45 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9593 35
fruit fly
(Drosophila melanogaster)
Insecta CG11836 37
  • 39 (a)
CG11836 35
  • 49.21 (n)
  • 39.83 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004570 35
  • 45.94 (n)
  • 38.7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
Species with no ortholog for F10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for F10 Gene

Gene Tree for F10 (if available)
Gene Tree for F10 (if available)

Paralogs for F10 Gene

Paralogs for F10 Gene

genes like me logo Genes that share paralogs with F10: view

Variants for F10 Gene

Sequence variations from dbSNP and Humsavar for F10 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs3093268 -- 113,121,343(+) CAGAG(C/G)CTTCG upstream-variant-2KB
rs3093261 -- 113,121,768(+) GCAGT(C/T)GGGTG upstream-variant-2KB
rs147035975 -- 113,131,891(+) GCTTC(C/T)GCCCA intron-variant
rs147052139 -- 113,136,242(+) GTTAA(A/G)ACACG intron-variant
rs147238846 -- 113,143,969(+) GCCGA(C/T)CTGGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for F10 Gene

Variant ID Type Subtype PubMed ID
nsv901039 CNV Loss 21882294
dgv1797n71 CNV Loss 21882294
dgv1798n71 CNV Loss 21882294
nsv901049 CNV Loss 21882294
nsv518044 CNV Gain 19592680
dgv1800n71 CNV Loss 21882294
nsv832724 CNV Loss 17160897
nsv818996 CNV Gain 17921354
nsv901060 CNV Gain 21882294
dgv1801n71 CNV Gain 21882294
nsv826819 CNV Gain 20364138
nsv901064 CNV Gain 21882294
esv2748261 CNV Deletion 23290073
esv1499407 CNV Deletion 17803354
esv2678487 CNV Deletion 23128226
nsv901065 CNV Loss 21882294

Relevant External Links for F10 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for F10 Gene

Disorders for F10 Gene

(1) OMIM Diseases for F10 Gene (613872)


  • Factor X deficiency (FA10D) [MIM:227600]: A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis. {ECO:0000269 PubMed:10468877, ECO:0000269 PubMed:10746568, ECO:0000269 PubMed:11248282, ECO:0000269 PubMed:11728527, ECO:0000269 PubMed:12574802, ECO:0000269 PubMed:12945883, ECO:0000269 PubMed:15075089, ECO:0000269 PubMed:15650540, ECO:0000269 PubMed:17393015, ECO:0000269 PubMed:19135706, ECO:0000269 PubMed:1973167, ECO:0000269 PubMed:1985698, ECO:0000269 PubMed:25313940, ECO:0000269 PubMed:2790181, ECO:0000269 PubMed:7669671, ECO:0000269 PubMed:7860069, ECO:0000269 PubMed:8529633, ECO:0000269 PubMed:8845463, ECO:0000269 PubMed:8910490}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(85) Novoseek inferred disease relationships for F10 Gene

Disease -log(P) Hits PubMed IDs
factor x deficiency 81 3
thromboembolism 80.6 48
scott syndrome 76.1 5
thrombosis 76 59
deep vein thrombosis 71.1 8

Genatlas disease for F10 Gene

bleeding diathesis (FX deficiency)

Relevant External Links for F10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with F10: view

Publications for F10 Gene

  1. Structure of human des(1-45) factor Xa at 2.2-A resolution. (PMID: 8355279) Padmanabhan K. … Kisiel W. (J. Mol. Biol. 1993) 3 4 23
  2. Cloning and expression in COS-1 cells of a full-length cDNA encoding human coagulation factor X. (PMID: 1902434) Messier T.L. … Church W.R. (Gene 1991) 3 4 23
  3. Impaired prothrombinase activity of factor X Gly381Asp results in severe familial CRM+ FX deficiency. (PMID: 12574802) Pinotti M. … Bernardi F. (Thromb. Haemost. 2003) 3 4 23
  4. Characterization of a homozygous Gly11Val mutation in the Gla domain of coagulation factor X. (PMID: 19135706) Chafa O. … LeBonniec B.F. (Thromb. Res. 2009) 3 4 23
  5. Analysis of the novel factor X gene mutation Glu51Lys in two families with factor X-Riyadh anomaly. (PMID: 17393015) Al-Hilali A. … Herrmann F.H. (Thromb. Haemost. 2007) 3 4 23

Products for F10 Gene

Sources for F10 Gene

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