Free for academic non-profit institutions. Other users need a Commercial license

Aliases for F3 Gene

Aliases for F3 Gene

  • Coagulation Factor III, Tissue Factor 2 3
  • Coagulation Factor III (Thromboplastin, Tissue Factor) 2 3 5
  • TF 3 4
  • Coagulation Factor III 4
  • Thromboplastin 4
  • Tissue Factor 2
  • CD142 Antigen 4
  • CD142 3
  • TFA 3

External Ids for F3 Gene

Previous GeneCards Identifiers for F3 Gene

  • GC01M095396
  • GC01M094200
  • GC01M094345
  • GC01M094706
  • GC01M094994
  • GC01M093116

Summaries for F3 Gene

Entrez Gene Summary for F3 Gene

  • This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

GeneCards Summary for F3 Gene

F3 (Coagulation Factor III, Tissue Factor) is a Protein Coding gene. Diseases associated with F3 include disseminated intravascular coagulation and carotid artery thrombosis. Among its related pathways are AGE-RAGE signaling pathway in diabetic complications and Complement and coagulation cascades. GO annotations related to this gene include phospholipid binding and cytokine receptor activity.

UniProtKB/Swiss-Prot for F3 Gene

  • Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.

Gene Wiki entry for F3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for F3 Gene

Genomics for F3 Gene

Regulatory Elements for F3 Gene

Enhancers for F3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around F3 on UCSC Golden Path with GeneCards custom track

Promoters for F3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around F3 on UCSC Golden Path with GeneCards custom track

Genomic Location for F3 Gene

Chromosome:
1
Start:
94,529,176 bp from pter
End:
94,541,857 bp from pter
Size:
12,682 bases
Orientation:
Minus strand

Genomic View for F3 Gene

Genes around F3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
F3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for F3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for F3 Gene

Proteins for F3 Gene

  • Protein details for F3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13726-TF_HUMAN
    Recommended name:
    Tissue factor
    Protein Accession:
    P13726
    Secondary Accessions:
    • D3DT47
    • Q6FHG2
    • Q86WH4

    Protein attributes for F3 Gene

    Size:
    295 amino acids
    Molecular mass:
    33068 Da
    Quaternary structure:
    • Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.

    Three dimensional structures from OCA and Proteopedia for F3 Gene

    Alternative splice isoforms for F3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for F3 Gene

Proteomics data for F3 Gene at MOPED

Post-translational modifications for F3 Gene

  • Glycosylation at Asn 156 and Asn 169
  • Modification sites at PhosphoSitePlus

Other Protein References for F3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for F3 (Coagulation Factor III/Tissue Factor)

No data available for DME Specific Peptides for F3 Gene

Domains & Families for F3 Gene

Gene Families for F3 Gene

Suggested Antigen Peptide Sequences for F3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P13726

UniProtKB/Swiss-Prot:

TF_HUMAN :
  • Belongs to the tissue factor family.
Family:
  • Belongs to the tissue factor family.
genes like me logo Genes that share domains with F3: view

Function for F3 Gene

Molecular function for F3 Gene

GENATLAS Biochemistry:
coagulation factor III,single chain glycoprotein,44kDa,initiating blood coagulation by complexing with F7
UniProtKB/Swiss-Prot Function:
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
UniProtKB/Swiss-Prot Induction:
TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF-alpha, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a component of cellular immune response.
genes like me logo Genes that share phenotypes with F3: view

Animal Models for F3 Gene

MGI Knock Outs for F3:
  • F3 tm1.1Dwr
  • F3 tm1Jld
  • F3 tm1Gjb
  • F3 tm1Dwr
  • F3 tm1Dco

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for F3 Gene

Localization for F3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for F3 Gene

Isoform 1: Membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for F3 Gene COMPARTMENTS Subcellular localization image for F3 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 3
peroxisome 3
cytoskeleton 2
nucleus 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with F3: view

Pathways & Interactions for F3 Gene

genes like me logo Genes that share pathways with F3: view

Pathways by source for F3 Gene

SIGNOR curated interactions for F3 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002543 activation of blood coagulation via clotting cascade IC 17469850
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 17898544
GO:0009266 response to temperature stimulus IEA --
GO:0009611 response to wounding IEA --
GO:0009612 response to mechanical stimulus IEA --
genes like me logo Genes that share ontologies with F3: view

Drugs & Compounds for F3 Gene

(69) Drugs for F3 Gene - From: DrugBank, PharmGKB, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 499
Coagulation factor VIIa Approved Pharma Target 0
[2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA Experimental Pharma Target 0
{5-(5-AMINO-1H-PYRROLO[3,2-B]PYRIDIN-2-YL)-6-HYDROXY-3'-NITRO-BIPHENYL-3-YL]-ACETIC ACID Experimental Pharma Target 0
2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE Experimental Pharma Target 0

(72) Additional Compounds for F3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) ApexBio Compounds for F3 Gene

Compound Action Cas Number
5-R-Rivaroxaban Factor Xa (FXa) inhibitor 865479-71-6
BIBR 953 (Dabigatran, Pradaxa) Thrombin inhibitor,potent,reversible and direct 211914-51-1
CORM-3 Exhibits anti-inflammatory/cardioprotective effects 475473-26-8
genes like me logo Genes that share compounds with F3: view

Transcripts for F3 Gene

Unigene Clusters for F3 Gene

Coagulation factor III (thromboplastin, tissue factor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for F3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - -
SP2: - -
SP3: - - - - - -
SP4: - - -
SP5:
SP6: -
SP7:
SP8: - - -

Relevant External Links for F3 Gene

GeneLoc Exon Structure for
F3
ECgene alternative splicing isoforms for
F3

Expression for F3 Gene

mRNA expression in normal human tissues for F3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for F3 Gene

This gene is overexpressed in Frontal cortex (16.3), Retina (15.6), and Pancreas (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for F3 Gene



SOURCE GeneReport for Unigene cluster for F3 Gene Hs.62192

mRNA Expression by UniProt/SwissProt for F3 Gene

P13726-TF_HUMAN
Tissue specificity: Lung, placenta and pancreas.
genes like me logo Genes that share expression patterns with F3: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for F3 Gene

Orthologs for F3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for F3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia F3 35
  • 79.68 (n)
  • 69.86 (a)
F3 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia F3 35
  • 82.08 (n)
  • 72.6 (a)
TF 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia F3 35
  • 69.54 (n)
  • 56.83 (a)
F3 16
F3 36
  • 53 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia F3 35
  • 99.1 (n)
  • 98.31 (a)
F3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia F3 35
  • 67.96 (n)
  • 57.04 (a)
oppossum
(Monodelphis domestica)
Mammalia F3 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia F3 36
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves F3 35
  • 56.42 (n)
  • 48.52 (a)
F3 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia F3 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia f3 35
  • 53.19 (n)
  • 44.04 (a)
zebrafish
(Danio rerio)
Actinopterygii f3a 35
  • 48.76 (n)
  • 40.8 (a)
f3a 36
  • 32 (a)
OneToMany
f3b 36
  • 30 (a)
OneToMany
Species with no ortholog for F3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for F3 Gene

ENSEMBL:
Gene Tree for F3 (if available)
TreeFam:
Gene Tree for F3 (if available)

Paralogs for F3 Gene

Pseudogenes.org Pseudogenes for F3 Gene

genes like me logo Genes that share paralogs with F3: view

No data available for Paralogs for F3 Gene

Variants for F3 Gene

Sequence variations from dbSNP and Humsavar for F3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs5901 - 94,533,194(-) ATGAA(A/C/T)GGACT reference, missense
rs3917604 - 94,540,363(-) GCACT(A/G)CAAAT reference, missense
rs3917627 - 94,533,248(-) CAACA(A/G)TTCAG reference, missense
rs3789683 - 94,530,506(+) CCACT(C/T)CTGCC reference, missense
rs3354 -- 94,530,263(+) CCATT(A/C/G/T)GTTAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for F3 Gene

Variant ID Type Subtype PubMed ID
nsv871764 CNV Loss 21882294
nsv1899 CNV Insertion 18451855
dgv270n71 CNV Loss 21882294

Variation tolerance for F3 Gene

Residual Variation Intolerance Score: 67.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.34; 41.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for F3 Gene

HapMap Linkage Disequilibrium report
F3
Human Gene Mutation Database (HGMD)
F3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for F3 Gene

Disorders for F3 Gene

MalaCards: The human disease database

(108) MalaCards diseases for F3 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search F3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for F3

Genetic Association Database (GAD)
F3
Human Genome Epidemiology (HuGE) Navigator
F3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
F3
genes like me logo Genes that share disorders with F3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for F3 Gene

Publications for F3 Gene

  1. Tissue factor +5466A>G polymorphism determines thrombin formation following vascular injury and thrombin-lowering effects of simvastatin in patients with ischemic heart disease. (PMID: 19027114) Undas A. … Tracz W. (Atherosclerosis 2009) 3 23 48 67
  2. PML/RARalpha fusion protein transactivates the tissue factor promoter through a GAGC-containing element without direct DNA association. (PMID: 20133705) Yan J. … Xi X. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 23
  3. Cystine 186-cystine 209 disulfide bond is not essential for the procoagulant activity of tissue factor or for its de-encryption. (PMID: 20237315) Kothari H. … Pendurthi U.R. (Blood 2010) 3 23
  4. Role of PDI in regulating tissue factor: FVIIa activity. (PMID: 20163832) Popescu N.I. … Lupu F. (Thromb. Res. 2010) 3 23
  5. Recent estimates of the structure of the factor VIIa (FVIIa)/tissue factor (TF) and factor Xa (FXa) ternary complex. (PMID: 20156644) Lee C.J. … Pedersen L.G. (Thromb. Res. 2010) 3 23

Products for F3 Gene

Sources for F3 Gene

Content