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Aliases for F3 Gene

Aliases for F3 Gene

  • Coagulation Factor III (Thromboplastin, Tissue Factor) 2 3
  • TFA 3 6
  • TF 3 4
  • Coagulation Factor III 4
  • Thromboplastin 4
  • Tissue Factor 3
  • CD142 Antigen 4
  • CD142 3

External Ids for F3 Gene

Previous GeneCards Identifiers for F3 Gene

  • GC01M095396
  • GC01M094200
  • GC01M094345
  • GC01M094706
  • GC01M094994
  • GC01M093116

Summaries for F3 Gene

Entrez Gene Summary for F3 Gene

  • This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

GeneCards Summary for F3 Gene

F3 (Coagulation Factor III (Thromboplastin, Tissue Factor)) is a Protein Coding gene. Diseases associated with F3 include heparin-induced thrombocytopenia and carotid artery thrombosis. Among its related pathways are Hemostasis and Formation of Fibrin Clot (Clotting Cascade). GO annotations related to this gene include phospholipid binding and protease binding.

UniProtKB/Swiss-Prot for F3 Gene

  • Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.

Gene Wiki entry for F3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for F3 Gene

Genomics for F3 Gene

Regulatory Elements for F3 Gene

Genomic Location for F3 Gene

Start:
94,529,176 bp from pter
End:
94,541,857 bp from pter
Size:
12,682 bases
Orientation:
Minus strand

Genomic View for F3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for F3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for F3 Gene

Proteins for F3 Gene

  • Protein details for F3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13726-TF_HUMAN
    Recommended name:
    Tissue factor
    Protein Accession:
    P13726
    Secondary Accessions:
    • D3DT47
    • Q6FHG2
    • Q86WH4

    Protein attributes for F3 Gene

    Size:
    295 amino acids
    Molecular mass:
    33068 Da
    Quaternary structure:
    • Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.

    Three dimensional structures from OCA and Proteopedia for F3 Gene

    Alternative splice isoforms for F3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for F3 Gene

Proteomics data for F3 Gene at MOPED

Post-translational modifications for F3 Gene

  • Glycosylation at Asn156 and Asn169
  • Modification sites at PhosphoSitePlus

Other Protein References for F3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for F3 Gene

Domains for F3 Gene

Gene Families for F3 Gene

HGNC:
  • CD :CD molecules

Suggested Antigen Peptide Sequences for F3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P13726

UniProtKB/Swiss-Prot:

TF_HUMAN :
  • P13726
Family:
  • Belongs to the tissue factor family.
genes like me logo Genes that share domains with F3: view

Function for F3 Gene

Molecular function for F3 Gene

GENATLAS Biochemistry: coagulation factor III,single chain glycoprotein,44kDa,initiating blood coagulation by complexing with F7
UniProtKB/Swiss-Prot Function: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
UniProtKB/Swiss-Prot Induction: TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF-alpha, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a component of cellular immune response.

Gene Ontology (GO) - Molecular Function for F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 3455766
GO:0004896 cytokine receptor activity IBA --
GO:0005515 protein binding IPI 15522303
GO:0005543 phospholipid binding IDA 17469850
genes like me logo Genes that share ontologies with F3: view
genes like me logo Genes that share phenotypes with F3: view

Animal Models for F3 Gene

MGI Knock Outs for F3:
  • F3 tm1.1Dwr
  • F3 tm1Jld
  • F3 tm1Gjb
  • F3 tm1Dwr
  • F3 tm1Dco

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for F3 Gene

Localization for F3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for F3 Gene

Isoform 1: Membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for F3 Gene COMPARTMENTS Subcellular localization image for F3 gene
Compartment Confidence
extracellular 5
peroxisome 3
plasma membrane 3
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 19065458
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IDA 17898544
GO:0016021 integral component of membrane IBA --
GO:0031012 extracellular matrix IDA 2704749
genes like me logo Genes that share ontologies with F3: view

Pathways for F3 Gene

genes like me logo Genes that share pathways with F3: view

Gene Ontology (GO) - Biological Process for F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IDA 17898544
GO:0002541 activation of plasma proteins involved in acute inflammatory response IDA 17469850
GO:0002543 activation of blood coagulation via clotting cascade IC 17469850
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 17898544
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with F3: view

Compounds for F3 Gene

(134) Novoseek inferred chemical compound relationships for F3 Gene

Compound -log(P) Hits PubMed IDs
fibrinogen 91 147
heparin 90.5 228
ecarin 84.7 31
argatroban 84.4 61
hirudin 83.2 72

(1) PharmGKB related drug/compound annotations for F3 Gene

Drug/compound Annotation
simvastatin CA
genes like me logo Genes that share compounds with F3: view

Transcripts for F3 Gene

Unigene Clusters for F3 Gene

Coagulation factor III (thromboplastin, tissue factor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for F3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - -
SP2: - -
SP3: - - - - - -
SP4: - - -
SP5:
SP6: -
SP7:
SP8: - - -

Relevant External Links for F3 Gene

GeneLoc Exon Structure for
F3
ECgene alternative splicing isoforms for
F3

Expression for F3 Gene

mRNA expression in normal human tissues for F3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for F3 Gene

SOURCE GeneReport for Unigene cluster for F3 Gene Hs.62192

mRNA Expression by UniProt/SwissProt for F3 Gene

P13726-TF_HUMAN
Tissue specificity: Lung, placenta and pancreas.
genes like me logo Genes that share expressions with F3: view

No data available for mRNA differential expression in normal tissues for F3 Gene

Orthologs for F3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for F3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia F3 35
  • 99.1 (n)
  • 98.31 (a)
F3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia F3 35
  • 79.68 (n)
  • 69.86 (a)
F3 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia F3 35
  • 82.08 (n)
  • 72.6 (a)
TF 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia F3 35
  • 69.54 (n)
  • 56.83 (a)
F3 16
F3 36
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia F3 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia F3 36
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia F3 35
  • 67.96 (n)
  • 57.04 (a)
chicken
(Gallus gallus)
Aves F3 35
  • 56.42 (n)
  • 48.52 (a)
F3 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia F3 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia f3 35
  • 53.19 (n)
  • 44.04 (a)
zebrafish
(Danio rerio)
Actinopterygii f3a 35
  • 48.76 (n)
  • 40.8 (a)
f3a 36
  • 32 (a)
OneToMany
f3b 36
  • 30 (a)
OneToMany
Species with no ortholog for F3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for F3 Gene

ENSEMBL:
Gene Tree for F3 (if available)
TreeFam:
Gene Tree for F3 (if available)

Paralogs for F3 Gene

Pseudogenes.org Pseudogenes for F3 Gene

genes like me logo Genes that share paralogs with F3: view

No data available for Paralogs for F3 Gene

Variants for F3 Gene

Sequence variations from dbSNP and Humsavar for F3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3354 -- 94,530,263(+) CCATT(A/C/G/T)GTTAC utr-variant-3-prime
rs5901 - 94,533,194(-) ATGAA(C/T)GGACT reference, missense
rs337594 -- 94,531,468(+) agcta(A/C)ttttt intron-variant
rs337595 -- 94,531,514(+) ccagg(A/C)tggtc intron-variant
rs592435 -- 94,534,661(+) TACCT(C/G)GAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for F3 Gene

Variant ID Type Subtype PubMed ID
nsv871764 CNV Loss 21882294
nsv1899 CNV Insertion 18451855
dgv270n71 CNV Loss 21882294

Relevant External Links for F3 Gene

HapMap Linkage Disequilibrium report
F3
Human Gene Mutation Database (HGMD)
F3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for F3 Gene

Disorders for F3 Gene

(96) Novoseek inferred disease relationships for F3 Gene

Disease -log(P) Hits PubMed IDs
partial thromboplastin time prolonged 91.4 82
coagulopathy 89.1 107
thrombosis 85.5 125
bleeding 85.5 134
disseminated intravascular coagulation 84.1 63

Relevant External Links for F3

Genetic Association Database (GAD)
F3
Human Genome Epidemiology (HuGE) Navigator
F3
genes like me logo Genes that share disorders with F3: view

No data available for UniProtKB/Swiss-Prot for F3 Gene

Publications for F3 Gene

  1. Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. (PMID: 12652293) Bogdanov V.Y. … Nemerson Y. (Nat. Med. 2003) 3 4 23
  2. Genetic variations in the tissue factor gene are associated with clinical outcome in acute coronary syndrome and expression levels in human monocytes. (PMID: 16239598) MAolarstig A. … Siegbahn A. (Arterioscler. Thromb. Vasc. Biol. 2005) 3 23 48
  3. Tissue factor +5466A>G polymorphism determines thrombin formation following vascular injury and thrombin-lowering effects of simvastatin in patients with ischemic heart disease. (PMID: 19027114) Undas A. … Tracz W. (Atherosclerosis 2009) 3 23 48
  4. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. (PMID: 19168442) Eisenreich A. … Rauch U. (Circ. Res. 2009) 3 4 23
  5. NF-kappaB transcription factor p50 critically regulates tissue factor in deep vein thrombosis. (PMID: 19095643) Li Y.D. … Geng J.G. (J. Biol. Chem. 2009) 3 23

Products for F3 Gene

  • Addgene plasmids for F3

Sources for F3 Gene

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