Free for academic non-profit institutions. Other users need a Commercial license

Aliases for F2RL1 Gene

Aliases for F2RL1 Gene

  • F2R Like Trypsin Receptor 1 2 3
  • Coagulation Factor II (Thrombin) Receptor-Like 1 2 3 5
  • Coagulation Factor II Receptor-Like 1 3 4
  • G-Protein Coupled Receptor 11 3 4
  • Thrombin Receptor-Like 1 3 4
  • GPR11 3 4
  • PAR2 3 4
  • Proteinase-Activated Receptor-2 2
  • Protease-Activated Receptor 2 3
  • PAR-2 4

External Ids for F2RL1 Gene

Previous HGNC Symbols for F2RL1 Gene

  • GPR11

Previous GeneCards Identifiers for F2RL1 Gene

  • GC05P074920
  • GC05P076349
  • GC05P076153
  • GC05P076198
  • GC05P076150
  • GC05P071322
  • GC05P076120

Summaries for F2RL1 Gene

Entrez Gene Summary for F2RL1 Gene

  • Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence. [provided by RefSeq, Jul 2008]

GeneCards Summary for F2RL1 Gene

F2RL1 (F2R Like Trypsin Receptor 1) is a Protein Coding gene. Diseases associated with F2RL1 include Pulmonary Vein Stenosis and Vulvovaginitis. Among its related pathways are Peptide ligand-binding receptors and p70S6K Signaling. GO annotations related to this gene include G-protein coupled receptor activity and receptor activity. An important paralog of this gene is GPR132.

UniProtKB/Swiss-Prot for F2RL1 Gene

  • Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as G alpha-q, G alpha-11, G alpha-14, G alpha-12 and G alpha-13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to G alpha-q/11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at Ser-536; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of G alpha-q/11 and involves promotion of cofilin dephosphoryltaion and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immnune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders.

Tocris Summary for F2RL1 Gene

  • Protease-activated receptors (PARs, also known as thrombin receptors) are G-protein-coupled receptors, activated by cleavage of their N-terminal domains by serine proteases. Hydrolysis reveals a tethered peptide ligand, which affects transmembrane signaling.

Gene Wiki entry for F2RL1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for F2RL1 Gene

Genomics for F2RL1 Gene

Regulatory Elements for F2RL1 Gene

Enhancers for F2RL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around F2RL1 on UCSC Golden Path with GeneCards custom track

Promoters for F2RL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around F2RL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for F2RL1 Gene

Chromosome:
5
Start:
76,818,933 bp from pter
End:
76,835,315 bp from pter
Size:
16,383 bases
Orientation:
Plus strand

Genomic View for F2RL1 Gene

Genes around F2RL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
F2RL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for F2RL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for F2RL1 Gene

Proteins for F2RL1 Gene

  • Protein details for F2RL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55085-PAR2_HUMAN
    Recommended name:
    Proteinase-activated receptor 2
    Protein Accession:
    P55085
    Secondary Accessions:
    • Q13317
    • Q13346
    • Q53XJ8

    Protein attributes for F2RL1 Gene

    Size:
    397 amino acids
    Molecular mass:
    44126 Da
    Quaternary structure:
    • Interacts with TLR4, COPS5 and TMED2. Interacts with GNAQ, GNA11, GNA12, GNA13 and GNA14 (By similarity).
    Miscellaneous:
    • Synthetic PAR agonist peptides (APs) that mimic the first six amino acids of the newly formed N-terminus activate the native, uncleaved receptor nonenzymatically by binding directly to the corresponding second extracellular loop to mediate signaling.

neXtProt entry for F2RL1 Gene

Proteomics data for F2RL1 Gene at MOPED

Post-translational modifications for F2RL1 Gene

  • A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand. Activating serine proteases include trypsin, mast cell tryptase, coagulation factors VII and Xa, myeloblastin/PRTN3 and membrane-type serine protease 1/ST14. Proposed subsequent cleaveage by serine proteases is leading to receptor deactivation and include neutrophil elastase and cathepsin G. At least in part, implicated proteases are also shown to activate the receptor; the glycosylation status of the receptor is thought to contribute to the difference. In addition to conventional trypsin-like proteases is proposed to be activated by other proteases and glycosidases derived from bacteria, fungi and insects: serine protease allergens such as dust mite Der p3 and Der p9 and mold Pen c13, Porphyromonas gingivalis arginine-specific (trypsin-like) cysteine proteinases called gingipains, Streptomyces griseus exogenous chitinase, and an Alternaria alternata aspartate protease. Cleavage by the Alternaria alternata aspartate protease generates non-conventional processed forms.
  • Monoubiquitinated by CBL at the plasma membrane and in early endosomes; not required for receptor endocytosis but for translocation to late endosomes or lysosomes. Deubiquitination involves STAMBP and USP8; required for lysosomal trafficking and receptor degradation.
  • Multiple phosphorylated on serine and threonine residues in the cytoplasmic region upon receptor activation; required for receptor desensitization and recruitment of beta-arrestin.
  • N-glycosylated and sialylated.
  • Ubiquitination at Lys 368
  • Glycosylation at Asn 30, Thr 45, and Asn 222
  • Modification sites at PhosphoSitePlus

Other Protein References for F2RL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for F2RL1 (F2RL1)

No data available for DME Specific Peptides for F2RL1 Gene

Domains & Families for F2RL1 Gene

Gene Families for F2RL1 Gene

HGNC:
IUPHAR :

Suggested Antigen Peptide Sequences for F2RL1 Gene

Graphical View of Domain Structure for InterPro Entry

P55085

UniProtKB/Swiss-Prot:

PAR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with F2RL1: view

Function for F2RL1 Gene

Molecular function for F2RL1 Gene

GENATLAS Biochemistry:
coagulation factor II (thrombin) receptor proteinase-activated receptor 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as G alpha-q, G alpha-11, G alpha-14, G alpha-12 and G alpha-13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to G alpha-q/11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at Ser-536; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of G alpha-q/11 and involves promotion of cofilin dephosphoryltaion and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immnune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders.

Gene Ontology (GO) - Molecular Function for F2RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA,ISS --
genes like me logo Genes that share ontologies with F2RL1: view
genes like me logo Genes that share phenotypes with F2RL1: view

Animal Models for F2RL1 Gene

MGI Knock Outs for F2RL1:

Animal Model Products

  • Taconic Biosciences Mouse Models for F2RL1

miRNA for F2RL1 Gene

miRTarBase miRNAs that target F2RL1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for F2RL1 Gene

Localization for F2RL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for F2RL1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for F2RL1 Gene COMPARTMENTS Subcellular localization image for F2RL1 gene
Compartment Confidence
cytosol 5
endosome 5
plasma membrane 5
golgi apparatus 4
extracellular 2

Gene Ontology (GO) - Cellular Components for F2RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol ISS --
GO:0031143 pseudopodium IEA,ISS --
genes like me logo Genes that share ontologies with F2RL1: view

Pathways & Interactions for F2RL1 Gene

genes like me logo Genes that share pathways with F2RL1: view

Pathways by source for F2RL1 Gene

SIGNOR curated interactions for F2RL1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for F2RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002286 T cell activation involved in immune response IEA,ISS --
GO:0002690 positive regulation of leukocyte chemotaxis IDA 17991872
GO:0002741 positive regulation of cytokine secretion involved in immune response IDA 11441110
GO:0003104 positive regulation of glomerular filtration IEA,ISS --
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with F2RL1: view

Drugs & Compounds for F2RL1 Gene

(48) Drugs for F2RL1 Gene - From: ApexBio, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-furoyl-LIGRL[N-(Alexa Fluor 594)-O]-NH<sub>2 </sub> Pharma 0
2-furoyl-LIGRL[N[<sup>3</sup>H]propionyl]-O-NH<sub>2</sub> Pharma 0
2-furoyl-LIGRLO-amide Pharma Full agonist, Agonist 0
SLIGKV-NH<sub>2</sub> Pharma Agonist 0
SLIGRL-NH<sub>2</sub> Pharma Agonist 0

(47) Additional Compounds for F2RL1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AY-NH2
352017-71-1
SLIGKV-NH2
190383-13-2
SLIGRL-NH2
171436-38-7
TFLLR-NH2
197794-83-5
Thrombin Receptor Agonist Peptide
137339-65-2

(5) Tocris Compounds for F2RL1 Gene

Compound Action Cas Number
AY-NH2 Selective PAR4 agonist 352017-71-1
SLIGKV-NH2 PAR2 receptor agonist 190383-13-2
SLIGRL-NH2 PAR2-activating peptide 171436-38-7
TFLLR-NH2 PAR1-activating peptide 197794-83-5
Thrombin Receptor Agonist Peptide Causes platelet aggregation and secretion 137339-65-2

(1) ApexBio Compounds for F2RL1 Gene

Compound Action Cas Number
Thrombin Receptor Activator for Peptide 5 (TRAP-5) 141685-53-2
genes like me logo Genes that share compounds with F2RL1: view

Drug Products

Transcripts for F2RL1 Gene

mRNA/cDNA for F2RL1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for F2RL1 Gene

Coagulation factor II (thrombin) receptor-like 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for F2RL1 Gene

No ASD Table

Relevant External Links for F2RL1 Gene

GeneLoc Exon Structure for
F2RL1
ECgene alternative splicing isoforms for
F2RL1

Expression for F2RL1 Gene

mRNA expression in normal human tissues for F2RL1 Gene

mRNA differential expression in normal tissues according to GTEx for F2RL1 Gene

This gene is overexpressed in Colon - Transverse (x9.4), Skin - Not Sun Exposed (Suprapubic) (x6.6), and Skin - Sun Exposed (Lower leg) (x5.3).

Protein differential expression in normal tissues from HIPED for F2RL1 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for F2RL1 Gene



SOURCE GeneReport for Unigene cluster for F2RL1 Gene Hs.744181

mRNA Expression by UniProt/SwissProt for F2RL1 Gene

P55085-PAR2_HUMAN
Tissue specificity: Widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon. Moderate expression is detected in many organs, but none in brain or skeletal muscle.
genes like me logo Genes that share expression patterns with F2RL1: view

Protein tissue co-expression partners for F2RL1 Gene

Primer Products

Orthologs for F2RL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for F2RL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia F2RL1 35
  • 85.86 (n)
  • 87.3 (a)
F2RL1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia F2RL1 35
  • 85.2 (n)
  • 83.69 (a)
F2RL1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia F2rl1 35
  • 82.17 (n)
  • 83.96 (a)
F2rl1 16
F2rl1 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia F2RL1 35
  • 99.66 (n)
  • 99.24 (a)
F2RL1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia F2rl1 35
  • 80.39 (n)
  • 82.62 (a)
oppossum
(Monodelphis domestica)
Mammalia F2RL1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia F2RL1 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves F2RL1 35
  • 71.02 (n)
  • 73 (a)
F2RL1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia f2rl1 35
  • 66.95 (n)
  • 65.13 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5507 35
zebrafish
(Danio rerio)
Actinopterygii f2rl1.2 35
  • 58.69 (n)
  • 54.85 (a)
f2rl1.1 36
  • 48 (a)
OneToMany
f2rl1.2 36
  • 49 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9406 35
Species with no ortholog for F2RL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for F2RL1 Gene

ENSEMBL:
Gene Tree for F2RL1 (if available)
TreeFam:
Gene Tree for F2RL1 (if available)

Paralogs for F2RL1 Gene

Paralogs for F2RL1 Gene

(23) SIMAP similar genes for F2RL1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with F2RL1: view

Variants for F2RL1 Gene

Sequence variations from dbSNP and Humsavar for F2RL1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs2243072 - 76,819,244(+) TCTCT(C/T)CTGCA reference, missense
rs2243062 - 76,833,416(+) GCTGC(A/C/G/T)ATCTT reference, missense
rs2243083 - 76,833,478(+) TTGTC(A/G/T)CTGTC reference, missense
rs616235 - 76,832,696(-) ATCTA(C/T)TGGTT reference, missense
rs2884706 -- 76,824,264(+) tagac(A/G)gagct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for F2RL1 Gene

Variant ID Type Subtype PubMed ID
nsv882210 CNV Gain 21882294
nsv882211 CNV Loss 21882294
esv994503 CNV Deletion 20482838

Variation tolerance for F2RL1 Gene

Residual Variation Intolerance Score: 54.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for F2RL1 Gene

Human Gene Mutation Database (HGMD)
F2RL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for F2RL1 Gene

Disorders for F2RL1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for F2RL1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pulmonary vein stenosis
  • pulmonary veins stenosis
vulvovaginitis
  • vulvo-vaginitis
papillary adenocarcinoma
  • infiltrating and papillary adenocarcinoma
irritant dermatitis
  • irritant contact dermatitis
gastroesophageal reflux
  • gastroesophageal reflux disease
- elite association - COSMIC cancer census association via MalaCards
Search F2RL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for F2RL1

Genetic Association Database (GAD)
F2RL1
Human Genome Epidemiology (HuGE) Navigator
F2RL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
F2RL1
genes like me logo Genes that share disorders with F2RL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for F2RL1 Gene

Publications for F2RL1 Gene

  1. Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2. (PMID: 7556175) Nystedt S. … Sundelin J. (Eur. J. Biochem. 1995) 2 3 4 67
  2. Proteinase-activated receptor-2 mediated inhibition of TNFalpha- stimulated JNK activation - a novel paradigm for G(q/11) linked GPCRs. (PMID: 19781631) McIntosh K. … Plevin R. (Cell. Signal. 2010) 3 23
  3. Increased mast cell expression of PAR-2 in skin inflammatory diseases and release of IL-8 upon PAR-2 activation. (PMID: 19889021) Carvalho R.F. … Harvima I.T. (Exp. Dermatol. 2010) 3 23
  4. Activation of proteinase-activated receptor 2 stimulates soluble vascular endothelial growth factor receptor 1 release via epidermal growth factor receptor transactivation in endothelial cells. (PMID: 20124108) Al-Ani B. … Ahmed A. (Hypertension 2010) 3 23
  5. Mitochondrial reactive oxygen species: a common pathway for PAR1- and PAR2-mediated tissue factor induction in human endothelial cells. (PMID: 18983479) Banfi C. … Mussoni L. (J. Thromb. Haemost. 2009) 3 23

Products for F2RL1 Gene

Sources for F2RL1 Gene

Content