Aliases for MECOM Gene
External Ids for MECOM Gene
Previous HGNC Symbols for MECOM Gene
Previous GeneCards Identifiers for MECOM Gene
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
GeneCards Summary for MECOM Gene
MECOM (MDS1 And EVI1 Complex Locus) is a Protein Coding gene. Diseases associated with MECOM include acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2) and pallister-hall syndrome. Among its related pathways are MAPK signaling pathway and Pathways in cancer. GO annotations related to this gene include nucleic acid binding and protein homodimerization activity. An important paralog of this gene is PRDM16.
UniProtKB/Swiss-Prot for MECOM Gene
Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.