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Aliases for ETV4 Gene

Aliases for ETV4 Gene

  • Ets Variant 4 2 3
  • Ets Variant Gene 4 (E1A Enhancer-Binding Protein, E1AF) 2 3
  • Polyomavirus Enhancer Activator 3 Homolog 3 4
  • Adenovirus E1A Enhancer-Binding Protein 3 4
  • E1A-F 3 4
  • E1AF 3 4
  • PEA3 3 4
  • EWS Protein/E1A Enhancer Binding Protein Chimera 3
  • E1A Enhancer Binding Protein 2
  • ETS Translocation Variant 4 3
  • Protein PEA3 4
  • PEAS3 3

External Ids for ETV4 Gene

Previous GeneCards Identifiers for ETV4 Gene

  • GC17U990026
  • GC17M043782
  • GC17M041615
  • GC17M042080
  • GC17M038960
  • GC17M037370
  • GC17M041605

Summaries for ETV4 Gene

GeneCards Summary for ETV4 Gene

ETV4 (Ets Variant 4) is a Protein Coding gene. Diseases associated with ETV4 include ewing sarcoma and extraosseous ewing's sarcoma. Among its related pathways are Prostate Cancer and Transcriptional misregulation in cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ETV2.

UniProtKB/Swiss-Prot for ETV4 Gene

  • Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the core-binding sequence is 5[AC]GGA[AT]GT-3.

Gene Wiki entry for ETV4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ETV4 Gene

Genomics for ETV4 Gene

Regulatory Elements for ETV4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ETV4 Gene

Start:
43,527,843 bp from pter
End:
43,579,620 bp from pter
Size:
51,778 bases
Orientation:
Minus strand

Genomic View for ETV4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ETV4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETV4 Gene

Proteins for ETV4 Gene

  • Protein details for ETV4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43268-ETV4_HUMAN
    Recommended name:
    ETS translocation variant 4
    Protein Accession:
    P43268
    Secondary Accessions:
    • A8K314
    • B7Z5J3
    • B7Z9J6
    • Q96AW9

    Protein attributes for ETV4 Gene

    Size:
    484 amino acids
    Molecular mass:
    53938 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA95991.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ETV4 Gene

    Alternative splice isoforms for ETV4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ETV4 Gene

Proteomics data for ETV4 Gene at MOPED

Post-translational modifications for ETV4 Gene

  • Sumoylated; enhanced upon ERK/MAP kinase pathway activation, it positively regulates the transcriptional activator capacity. Sumoylation at Lys-96 probably requires phosphorylation at Ser-101. Transiently polysumoylated and desumoylated by SENP1. Sumoylation is a prerequisite to polyubiquitination which in turn increases proteasomal-mediated degradation. Probably polyubiquitinated by RNF4 and deubiquitinated by USP2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ETV4 Gene

Domains for ETV4 Gene

Protein Domains for ETV4 Gene

Graphical View of Domain Structure for InterPro Entry

P43268

UniProtKB/Swiss-Prot:

ETV4_HUMAN :
  • P43268
Domain:
  • Contains 1 ETS DNA-binding domain.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ETV4: view

No data available for Gene Families for ETV4 Gene

Function for ETV4 Gene

Molecular function for ETV4 Gene

GENATLAS Biochemistry: ETS variant gene 4,divergent member of the winged helix-turn-helix superfamily,activating matrix metalloproteinase genes,associated with invasion and metastasis of tumor cell
UniProtKB/Swiss-Prot Function: Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the core-binding sequence is 5[AC]GGA[AT]GT-3.

Gene Ontology (GO) - Molecular Function for ETV4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 14625302
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IC --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity --
genes like me logo Genes that share ontologies with ETV4: view
genes like me logo Genes that share phenotypes with ETV4: view

Animal Models for ETV4 Gene

MGI Knock Outs for ETV4:

Animal Model Products

CRISPR Products

miRNA for ETV4 Gene

miRTarBase miRNAs that target ETV4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ETV4 Gene

Localization for ETV4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ETV4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ETV4 Gene COMPARTMENTS Subcellular localization image for ETV4 gene
Compartment Confidence
nucleus 5
extracellular 1

Gene Ontology (GO) - Cellular Components for ETV4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with ETV4: view

Pathways for ETV4 Gene

genes like me logo Genes that share pathways with ETV4: view

Pathways by source for ETV4 Gene

1 Qiagen pathway for ETV4 Gene
2 BioSystems pathways for ETV4 Gene
1 KEGG pathway for ETV4 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ETV4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0008045 motor neuron axon guidance IEA --
GO:0010628 positive regulation of gene expression --
genes like me logo Genes that share ontologies with ETV4: view

Compounds for ETV4 Gene

(16) Novoseek inferred chemical compound relationships for ETV4 Gene

Compound -log(P) Hits PubMed IDs
dc-chol 57.1 1
12-o-tetradecanoylphorbol 13-acetate 46.1 3
chloramphenicol 26.4 2
matrigel 21.5 1
phorbol 21.5 1
genes like me logo Genes that share compounds with ETV4: view

Transcripts for ETV4 Gene

Unigene Clusters for ETV4 Gene

Ets variant 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ETV4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ETV4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - -
SP6: -
SP7:
SP8: - - - -
SP9: - - - -
SP10: - -
SP11: - - - - -
SP12: - - -

ExUns: 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ETV4 Gene

GeneLoc Exon Structure for
ETV4
ECgene alternative splicing isoforms for
ETV4

Expression for ETV4 Gene

mRNA expression in normal human tissues for ETV4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ETV4 Gene

This gene is overexpressed in Pituitary (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ETV4 Gene

SOURCE GeneReport for Unigene cluster for ETV4 Gene Hs.434059

genes like me logo Genes that share expressions with ETV4: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ETV4 Gene

Orthologs for ETV4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ETV4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ETV4 35
  • 99.59 (n)
  • 99.38 (a)
ETV4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ETV4 35
  • 93.46 (n)
  • 95.45 (a)
ETV4 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ETV4 35
  • 92.77 (n)
  • 94.83 (a)
PEA3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Etv4 35
  • 90.34 (n)
  • 92.55 (a)
Etv4 16
Etv4 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ETV4 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ETV4 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Etv4 35
  • 90.5 (n)
  • 92.77 (a)
chicken
(Gallus gallus)
Aves ETV4 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ETV4 36
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii -- 35
etv4 35
  • 67.67 (n)
  • 65.66 (a)
etv4 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ets96B 36
  • 22 (a)
OneToMany
Species with no ortholog for ETV4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ETV4 Gene

ENSEMBL:
Gene Tree for ETV4 (if available)
TreeFam:
Gene Tree for ETV4 (if available)

Paralogs for ETV4 Gene

Paralogs for ETV4 Gene

Selected SIMAP similar genes for ETV4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ETV4: view

Variants for ETV4 Gene

Sequence variations from dbSNP and Humsavar for ETV4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1050315 -- 43,527,931(-) TTCTT(C/T)TGCCC utr-variant-3-prime
rs1140492 -- 43,527,934(-) CCTTT(C/T)TTTTG utr-variant-3-prime
rs2242598 -- 43,533,030(-) ATTCC(A/G)GAGCC intron-variant
rs2271959 -- 43,545,372(+) TCTGC(G/T)AGAAG intron-variant
rs2293015 -- 43,544,631(+) CTGGC(A/G)GCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ETV4 Gene

Variant ID Type Subtype PubMed ID
nsv470588 CNV Gain 18288195
nsv833453 CNV Gain+Loss 17160897
nsv2059 CNV Insertion 18451855

Relevant External Links for ETV4 Gene

HapMap Linkage Disequilibrium report
ETV4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ETV4 Gene

Disorders for ETV4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for ETV4 Gene including...

Search for ETV4 Gene in MalaCards »

(3) University of Copenhagen DISEASES for ETV4 Gene

(19) Novoseek inferred disease relationships for ETV4 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 47.1 38
metastasis 44.5 15
tumors 42 60
ovarian cancer 35.7 3
mammary tumor 35.7 3
genes like me logo Genes that share disorders with ETV4: view

No data available for UniProtKB/Swiss-Prot for ETV4 Gene

Publications for ETV4 Gene

  1. Genomic organization of the human e1af gene, a member of Ets transcription factors. (PMID: 10564827) Coutte L. … de Launoit Y. (Gene 1999) 3 4 23
  2. Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family. (PMID: 8441666) Higashino F. … Fujinaga K. (Nucleic Acids Res. 1993) 3 4 23
  3. Assignment of the ets-related transcription factor E1A-F gene (ETV4) to human chromosome region 17q21. (PMID: 8530053) Isobe M. … Fujinaga K. (Genomics 1995) 2 3 23
  4. PEA3 is the second Ets family transcription factor involved in tumor progression in ovarian carcinoma. (PMID: 12684413) Davidson B. … Reich R. (Clin. Cancer Res. 2003) 3 23
  5. The clinical role of the PEA3 transcription factor in ovarian and breast carcinoma in effusions. (PMID: 15387369) Davidson B. … Kopolovic J. (Clin. Exp. Metastasis 2004) 3 23

Products for ETV4 Gene

Sources for ETV4 Gene

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