Aliases for ETV1 Gene
External Ids for ETV1 Gene
Previous GeneCards Identifiers for ETV1 Gene
This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2016]
GeneCards Summary for ETV1 Gene
ETV1 (ETS Variant 1) is a Protein Coding gene. Diseases associated with ETV1 include Ewing Sarcoma and Gastrointestinal Stromal Tumor. Among its related pathways are Development_TGF-beta receptor signaling and MAPK-Erk Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is ETV5.
UniProtKB/Swiss-Prot for ETV1 Gene
Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5-CGGA[AT]-3.