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Aliases for ETS2 Gene

Aliases for ETS2 Gene

  • V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 2 2 3
  • V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 (Avian) 2
  • V-Ets Avian Erythroblastosis Virus E2 Oncogene Homolog 2 3
  • V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 3
  • Protein C-Ets-2 3
  • Oncogene ETS-2 3
  • ETS2IT1 3

External Ids for ETS2 Gene

Previous GeneCards Identifiers for ETS2 Gene

  • GC21P036755
  • GC21P039097
  • GC21P039098
  • GC21P039099
  • GC21P040177
  • GC21P025647

Summaries for ETS2 Gene

Entrez Gene Summary for ETS2 Gene

  • This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for ETS2 Gene

ETS2 (V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 2) is a Protein Coding gene. Diseases associated with ETS2 include frey syndrome. Among its related pathways are Ras signaling pathway and ERK Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and glucocorticoid receptor binding. An important paralog of this gene is ETV2.

UniProtKB/Swiss-Prot for ETS2 Gene

  • Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.

Gene Wiki entry for ETS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ETS2 Gene

Genomics for ETS2 Gene

Regulatory Elements for ETS2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ETS2 Gene

Start:
38,805,307 bp from pter
End:
38,824,955 bp from pter
Size:
19,649 bases
Orientation:
Plus strand

Genomic View for ETS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ETS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETS2 Gene

Proteins for ETS2 Gene

  • Protein details for ETS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15036-ETS2_HUMAN
    Recommended name:
    Protein C-ets-2
    Protein Accession:
    P15036
    Secondary Accessions:
    • A6NM68
    • D3DSH6
    • Q53Y89

    Protein attributes for ETS2 Gene

    Size:
    469 amino acids
    Molecular mass:
    53001 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ETS2 Gene

neXtProt entry for ETS2 Gene

Proteomics data for ETS2 Gene at MOPED

Post-translational modifications for ETS2 Gene

  • Phosphorylation by CDK10 at Ser-220 and Ser-225 creates a phosphodegron that targets ETS2 for proteasomal degradation.
  • Ubiquitination at Lys427
  • Modification sites at PhosphoSitePlus

Other Protein References for ETS2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ETS2 Gene

Domains for ETS2 Gene

Suggested Antigen Peptide Sequences for ETS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15036

UniProtKB/Swiss-Prot:

ETS2_HUMAN :
  • P15036
Domain:
  • Contains 1 ETS DNA-binding domain.
  • Contains 1 PNT (pointed) domain.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ETS2: view

No data available for Gene Families for ETS2 Gene

Function for ETS2 Gene

Molecular function for ETS2 Gene

GENATLAS Biochemistry:
avian erythroblastosis virus E26 (v-ets) oncogene homolog 2,activating stromelysin-1 (MMP3) and collagenase 1 (MMP8) promoters,likely involved in skeletal development,required to maintain the transformed state of human prostate cancer cells
UniProtKB/Swiss-Prot Function:
Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.

Gene Ontology (GO) - Molecular Function for ETS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding --
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 12637547
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 12637547
GO:0003677 DNA binding TAS 10918595
genes like me logo Genes that share ontologies with ETS2: view
genes like me logo Genes that share phenotypes with ETS2: view

Animal Models for ETS2 Gene

MGI Knock Outs for ETS2:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ETS2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ETS2 Gene

Localization for ETS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ETS2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ETS2 Gene COMPARTMENTS Subcellular localization image for ETS2 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for ETS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16780588
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ETS2: view

Pathways for ETS2 Gene

genes like me logo Genes that share pathways with ETS2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for ETS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 12637547
GO:0001501 skeletal system development TAS 8596630
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with ETS2: view

Compounds for ETS2 Gene

(11) Novoseek inferred chemical compound relationships for ETS2 Gene

Compound -log(P) Hits PubMed IDs
oligonucleotide 27 1
phorbol 20.1 2
pd 98,059 19.2 1
threonine 8.98 5
matrigel 7.19 2
genes like me logo Genes that share compounds with ETS2: view

Transcripts for ETS2 Gene

Unigene Clusters for ETS2 Gene

V-ets erythroblastosis virus E26 oncogene homolog 2 (avian):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ETS2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ETS2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - -
SP2: - -
SP3:
SP4: - - - - - -
SP5: - -
SP6: -
SP7: -

Relevant External Links for ETS2 Gene

GeneLoc Exon Structure for
ETS2
ECgene alternative splicing isoforms for
ETS2

Expression for ETS2 Gene

mRNA expression in normal human tissues for ETS2 Gene

SOURCE GeneReport for Unigene cluster for ETS2 Gene Hs.644231

genes like me logo Genes that share expressions with ETS2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for ETS2 Gene

Orthologs for ETS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ETS2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ETS2 35
  • 87.49 (n)
  • 91.68 (a)
ETS2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ETS2 35
  • 88.12 (n)
  • 91.19 (a)
ETS2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ets2 35
  • 85.94 (n)
  • 91.86 (a)
Ets2 16
Ets2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ETS2 35
  • 99.34 (n)
  • 99.51 (a)
ETS2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ets2 35
  • 86.71 (n)
  • 91.9 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ETS2 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves ETS2 35
  • 76.33 (n)
  • 79.53 (a)
ETS2 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ETS2 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ets2 35
  • 70.17 (n)
  • 69.53 (a)
Str.3274 35
African clawed frog
(Xenopus laevis)
Amphibia ets2a-A 35
zebrafish
(Danio rerio)
Actinopterygii ets2 35
  • 64.56 (n)
  • 62.15 (a)
ets2 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pnt 37
  • 84 (a)
pnt 36
  • 27 (a)
OneToMany
Species with no ortholog for ETS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ETS2 Gene

ENSEMBL:
Gene Tree for ETS2 (if available)
TreeFam:
Gene Tree for ETS2 (if available)

Paralogs for ETS2 Gene

Paralogs for ETS2 Gene

Selected SIMAP similar genes for ETS2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ETS2 Gene

genes like me logo Genes that share paralogs with ETS2: view

Variants for ETS2 Gene

Sequence variations from dbSNP and Humsavar for ETS2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs530 -- 38,823,353(-) ATTAT(A/T)ATAAT utr-variant-3-prime
rs711 -- 38,823,135(+) GCACC(A/G)GGAAG utr-variant-3-prime
rs11254 -- 38,824,464(+) AAAGT(C/T)CGACA utr-variant-3-prime
rs374575 -- 38,821,990(+) TCTGC(C/T)GACCA intron-variant
rs434421 -- 38,822,313(+) CCACT(C/T)GGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ETS2 Gene

Variant ID Type Subtype PubMed ID
nsv3518 CNV Insertion 18451855

Relevant External Links for ETS2 Gene

HapMap Linkage Disequilibrium report
ETS2

PCR Panel Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ETS2 Gene

Disorders for ETS2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ETS2 Gene in MalaCards »

(1) Diseases for ETS2 Gene including...

(3) University of Copenhagen DISEASES for ETS2 Gene

(20) Novoseek inferred disease relationships for ETS2 Gene

Disease -log(P) Hits PubMed IDs
erythroblastosis 75.2 5
choriocarcinoma 60.9 5
down syndrome 53.3 13
leukemia 25.8 4
breast cancer 15.4 11

Relevant External Links for ETS2

Genetic Association Database (GAD)
ETS2
Human Genome Epidemiology (HuGE) Navigator
ETS2
Tumor Gene Database (TGDB):
ETS2
genes like me logo Genes that share disorders with ETS2: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for ETS2 Gene

Publications for ETS2 Gene

  1. Molecular organization and differential polyadenylation sites of the human ETS2 gene. (PMID: 2250910) Watson D.K. … Papas T.S. (Oncogene 1990) 3 4 23
  2. Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice. (PMID: 8596630) Sumarsono S.H. … Kola I. (Nature 1996) 3 23
  3. The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner. (PMID: 9334186) Basuyaux J.P. … ButticA" G. (J. Biol. Chem. 1997) 3 23
  4. p300/cAMP-responsive element-binding protein interactions with ets-1 and ets-2 in the transcriptional activation of the human stromelysin promoter. (PMID: 10358095) Jayaraman G. … Thimmapaya B. (J. Biol. Chem. 1999) 3 23
  5. Transcription factors Ets1, Ets2, and Elf1 exhibit differential localization in human endometrium across the menstrual cycle and alternate isoforms in cultured endometrial cells. (PMID: 10377039) Kilpatrick L.M. … Salamonsen L.A. (Biol. Reprod. 1999) 3 23

Products for ETS2 Gene

  • Addgene plasmids for ETS2

Sources for ETS2 Gene

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