Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ETS2 Gene

Aliases for ETS2 Gene

  • ETS Proto-Oncogene 2, Transcription Factor 2 3
  • V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 2 2 3 5
  • V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 (Avian) 2
  • V-Ets Avian Erythroblastosis Virus E2 Oncogene Homolog 2 3
  • V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 3
  • Oncogene ETS-2 3
  • ETS2IT1 3

External Ids for ETS2 Gene

Previous GeneCards Identifiers for ETS2 Gene

  • GC21P036755
  • GC21P039097
  • GC21P039098
  • GC21P039099
  • GC21P040177
  • GC21P025647

Summaries for ETS2 Gene

Entrez Gene Summary for ETS2 Gene

  • This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for ETS2 Gene

ETS2 (ETS Proto-Oncogene 2, Transcription Factor) is a Protein Coding gene. Diseases associated with ETS2 include Choriocarcinoma and Down Syndrome. Among its related pathways are HTLV-I infection and Dorso-ventral axis formation. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is ETV2.

UniProtKB/Swiss-Prot for ETS2 Gene

  • Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.

Gene Wiki entry for ETS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ETS2 Gene

Genomics for ETS2 Gene

Regulatory Elements for ETS2 Gene

Enhancers for ETS2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ETS2 on UCSC Golden Path with GeneCards custom track

Promoters for ETS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ETS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ETS2 Gene

Chromosome:
21
Start:
38,805,307 bp from pter
End:
38,824,955 bp from pter
Size:
19,649 bases
Orientation:
Plus strand

Genomic View for ETS2 Gene

Genes around ETS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ETS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ETS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETS2 Gene

Proteins for ETS2 Gene

  • Protein details for ETS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15036-ETS2_HUMAN
    Recommended name:
    Protein C-ets-2
    Protein Accession:
    P15036
    Secondary Accessions:
    • A6NM68
    • D3DSH6
    • Q53Y89

    Protein attributes for ETS2 Gene

    Size:
    469 amino acids
    Molecular mass:
    53001 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ETS2 Gene

neXtProt entry for ETS2 Gene

Proteomics data for ETS2 Gene at MOPED

Post-translational modifications for ETS2 Gene

  • Phosphorylation by CDK10 at Ser-220 and Ser-225 creates a phosphodegron that targets ETS2 for proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ETS2 Gene

No data available for DME Specific Peptides for ETS2 Gene

Domains & Families for ETS2 Gene

Gene Families for ETS2 Gene

Suggested Antigen Peptide Sequences for ETS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15036

UniProtKB/Swiss-Prot:

ETS2_HUMAN :
  • Contains 1 ETS DNA-binding domain.
  • Belongs to the ETS family.
Domain:
  • Contains 1 ETS DNA-binding domain.
  • Contains 1 PNT (pointed) domain.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ETS2: view

Function for ETS2 Gene

Molecular function for ETS2 Gene

GENATLAS Biochemistry:
avian erythroblastosis virus E26 (v-ets) oncogene homolog 2,activating stromelysin-1 (MMP3) and collagenase 1 (MMP8) promoters,likely involved in skeletal development,required to maintain the transformed state of human prostate cancer cells
UniProtKB/Swiss-Prot Function:
Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.

Gene Ontology (GO) - Molecular Function for ETS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 12637547
GO:0005515 protein binding IPI 11909962
GO:0035259 glucocorticoid receptor binding IEA --
genes like me logo Genes that share ontologies with ETS2: view
genes like me logo Genes that share phenotypes with ETS2: view

Animal Models for ETS2 Gene

MGI Knock Outs for ETS2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ETS2 Gene

Localization for ETS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ETS2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ETS2 Gene COMPARTMENTS Subcellular localization image for ETS2 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for ETS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ETS2: view

Pathways & Interactions for ETS2 Gene

genes like me logo Genes that share pathways with ETS2: view

SIGNOR curated interactions for ETS2 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ETS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007498 mesoderm development IEA --
GO:0030154 cell differentiation IBA --
GO:0045893 positive regulation of transcription, DNA-templated IDA 11909962
genes like me logo Genes that share ontologies with ETS2: view

Drugs & Compounds for ETS2 Gene

(4) Drugs for ETS2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(7) Additional Compounds for ETS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ETS2: view

Transcripts for ETS2 Gene

Unigene Clusters for ETS2 Gene

V-ets erythroblastosis virus E26 oncogene homolog 2 (avian):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ETS2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - -
SP2: - -
SP3:
SP4: - - - - - -
SP5: - -
SP6: -
SP7: -

Relevant External Links for ETS2 Gene

GeneLoc Exon Structure for
ETS2
ECgene alternative splicing isoforms for
ETS2

Expression for ETS2 Gene

mRNA expression in normal human tissues for ETS2 Gene

SOURCE GeneReport for Unigene cluster for ETS2 Gene Hs.644231

genes like me logo Genes that share expression patterns with ETS2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ETS2 Gene

Orthologs for ETS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ETS2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ETS2 35
  • 87.49 (n)
  • 91.68 (a)
ETS2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ETS2 35
  • 88.12 (n)
  • 91.19 (a)
ETS2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ets2 35
  • 85.94 (n)
  • 91.86 (a)
Ets2 16
Ets2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ETS2 35
  • 99.34 (n)
  • 99.51 (a)
ETS2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ets2 35
  • 86.71 (n)
  • 91.9 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ETS2 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves ETS2 35
  • 76.33 (n)
  • 79.53 (a)
ETS2 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ETS2 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ets2 35
  • 70.17 (n)
  • 69.53 (a)
Str.3274 35
African clawed frog
(Xenopus laevis)
Amphibia ets2a-A 35
zebrafish
(Danio rerio)
Actinopterygii ets2 35
  • 64.56 (n)
  • 62.15 (a)
ets2 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pnt 37
  • 84 (a)
pnt 36
  • 27 (a)
OneToMany
Species with no ortholog for ETS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ETS2 Gene

ENSEMBL:
Gene Tree for ETS2 (if available)
TreeFam:
Gene Tree for ETS2 (if available)

Paralogs for ETS2 Gene

Paralogs for ETS2 Gene

(2) SIMAP similar genes for ETS2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ETS2 Gene

genes like me logo Genes that share paralogs with ETS2: view

Variants for ETS2 Gene

Sequence variations from dbSNP and Humsavar for ETS2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1209952 -- 38,803,903(+) TCTAA(C/T)ATATT upstream-variant-2KB
rs1209953 -- 38,808,459(+) GACTA(A/T)TATTT intron-variant
rs1209954 -- 38,809,842(+) ATCCC(A/G)TTGTG intron-variant
rs1209955 -- 38,812,610(+) ACCCT(A/G)TCTGT intron-variant
rs374575 -- 38,821,990(+) TCTGC(C/T)GACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ETS2 Gene

Variant ID Type Subtype PubMed ID
nsv3518 CNV Insertion 18451855

Variation tolerance for ETS2 Gene

Residual Variation Intolerance Score: 39.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 28.99% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ETS2 Gene

Disorders for ETS2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ETS2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
choriocarcinoma
  • choriocarcinoma, no icd-o subtype
down syndrome
  • complete trisomy 21 syndrome
frey syndrome
  • baillarger syndrome
star syndrome
  • syndactyly, telecanthus, anogenital and renal malformations
chromosomal disease
  • chromosomal disorders
- elite association - COSMIC cancer census association via MalaCards
Search ETS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ETS2

Genetic Association Database (GAD)
ETS2
Human Genome Epidemiology (HuGE) Navigator
ETS2
Tumor Gene Database (TGDB):
ETS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ETS2
genes like me logo Genes that share disorders with ETS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ETS2 Gene

Publications for ETS2 Gene

  1. Molecular organization and differential polyadenylation sites of the human ETS2 gene. (PMID: 2250910) Watson D.K. … Papas T.S. (Oncogene 1990) 3 4 23 67
  2. An ets2-driven transcriptional program in tumor-associated macrophages promotes tumor metastasis. (PMID: 20145133) Zabuawala T. … Ostrowski M.C. (Cancer Res. 2010) 3 23
  3. Effect of different biomaterials on the expression pattern of the transcription factor Ets2 in bone-like constructs. (PMID: 19318269) Sutter W. … Turhani D. (J Craniomaxillofac Surg 2009) 3 23
  4. The role of the proto-oncogene ETS2 in acute megakaryocytic leukemia biology and therapy. (PMID: 18094719) Ge Y. … Taub J.W. (Leukemia 2008) 3 23
  5. Feedback regulation of DUSP6 transcription responding to MAPK1 via ETS2 in human cells. (PMID: 18848526) Furukawa T. … Horii A. (Biochem. Biophys. Res. Commun. 2008) 3 23

Products for ETS2 Gene

  • Addgene plasmids for ETS2

Sources for ETS2 Gene

Content