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Aliases for ETS1 Gene

Aliases for ETS1 Gene

  • ETS Proto-Oncogene 1, Transcription Factor 2 3
  • V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1 2 3 5
  • Avian Erythroblastosis Virus E26 (V-Ets) Oncogene Homolog-1 2 3
  • EWSR2 3 4
  • P54 3 4
  • V-Ets Avian Erythroblastosis Virus E2 Oncogene Homolog 1 3
  • Ets Protein 2
  • C-Ets-1 3
  • ETS-1 3

External Ids for ETS1 Gene

Previous HGNC Symbols for ETS1 Gene

  • EWSR2

Previous GeneCards Identifiers for ETS1 Gene

  • GC11M130331
  • GC11M129841
  • GC11M128362
  • GC11M127869
  • GC11M127866
  • GC11M127833
  • GC11M124277
  • GC11M128328

Summaries for ETS1 Gene

Entrez Gene Summary for ETS1 Gene

  • This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

GeneCards Summary for ETS1 Gene

ETS1 (ETS Proto-Oncogene 1, Transcription Factor) is a Protein Coding gene. Diseases associated with ETS1 include Jacobsen Syndrome and Estrogen-Receptor Negative Breast Cancer. Among its related pathways are HTLV-I infection and Dorso-ventral axis formation. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is ETS2.

UniProtKB/Swiss-Prot for ETS1 Gene

  • Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.

Gene Wiki entry for ETS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ETS1 Gene

Genomics for ETS1 Gene

Regulatory Elements for ETS1 Gene

Enhancers for ETS1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ETS1 on UCSC Golden Path with GeneCards custom track

Promoters for ETS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ETS1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ETS1 gene promoter:

Genomic Location for ETS1 Gene

Chromosome:
11
Start:
128,458,761 bp from pter
End:
128,587,584 bp from pter
Size:
128,824 bases
Orientation:
Minus strand

Genomic View for ETS1 Gene

Genes around ETS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ETS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ETS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETS1 Gene

Proteins for ETS1 Gene

  • Protein details for ETS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14921-ETS1_HUMAN
    Recommended name:
    Protein C-ets-1
    Protein Accession:
    P14921
    Secondary Accessions:
    • A9UL17
    • F5GYX9
    • Q14278
    • Q16080
    • Q6N087
    • Q96AC5

    Protein attributes for ETS1 Gene

    Size:
    441 amino acids
    Molecular mass:
    50408 Da
    Quaternary structure:
    • Binds DNA as a homodimer; homodimerization is required for transcription activation. Interacts with MAF and MAFB. Interacts with PAX5; the interaction alters DNA-binding properties (By similarity). Interacts with DAXX. Interacts with UBE2I. Interacts with SP100; the interaction is direct and modulates ETS1 transcriptional activity.

    Three dimensional structures from OCA and Proteopedia for ETS1 Gene

    Alternative splice isoforms for ETS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ETS1 Gene

Proteomics data for ETS1 Gene at MOPED

Post-translational modifications for ETS1 Gene

  • Sumoylated on Lys-15 and Lys-227, preferentially with SUMO2; which inhibits transcriptional activity.
  • Ubiquitinated; which induces proteasomal degradation.
  • Ubiquitination at Lys 2, Lys 8, Lys 50, Lys 58, and Lys 245
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ETS1 Gene

Domains & Families for ETS1 Gene

Gene Families for ETS1 Gene

Graphical View of Domain Structure for InterPro Entry

P14921

UniProtKB/Swiss-Prot:

ETS1_HUMAN :
  • Contains 1 ETS DNA-binding domain.
  • Belongs to the ETS family.
Domain:
  • Contains 1 ETS DNA-binding domain.
  • Contains 1 PNT (pointed) domain.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ETS1: view

Function for ETS1 Gene

Molecular function for ETS1 Gene

GENATLAS Biochemistry:
avian erythroblastosis virus E26 (v-ets) oncogene homolog 1
UniProtKB/Swiss-Prot Function:
Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.
UniProtKB/Swiss-Prot Induction:
Up-regulated by retinoic acid, VEGF, TNF-alpha/TNFA, lipopolysaccharide and in response to hypoxia (at protein level).

Gene Ontology (GO) - Molecular Function for ETS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008134 transcription factor binding NAS 10698492
GO:0035035 histone acetyltransferase binding IEA --
GO:0042802 identical protein binding IPI 25609649
genes like me logo Genes that share ontologies with ETS1: view
genes like me logo Genes that share phenotypes with ETS1: view

Animal Models for ETS1 Gene

MGI Knock Outs for ETS1:

Animal Model Products

miRNA for ETS1 Gene

miRTarBase miRNAs that target ETS1

Transcription Factor Targets for ETS1 Gene

Selected GeneGlobe predicted Target genes for ETS1
Targeted motifs for ETS1 Gene
HOMER Transcription Factor Regulatory Elements motif ETS1
  • Consensus sequence: ACAGGAAGTG Submotif: canonical Cell Type: Jurkat GEO ID: GSE17954

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for ETS1 Gene

Localization for ETS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ETS1 Gene

Cytoplasm. Nucleus. Note=Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27. {ECO:0000269 PubMed:19377509}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ETS1 Gene COMPARTMENTS Subcellular localization image for ETS1 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
cytoskeleton 1
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for ETS1 Gene

Pathways & Interactions for ETS1 Gene

genes like me logo Genes that share pathways with ETS1: view

SIGNOR curated interactions for ETS1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ETS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IDA 7753825
GO:0006955 immune response TAS 2187191
GO:0007565 female pregnancy IEA --
genes like me logo Genes that share ontologies with ETS1: view

Drugs & Compounds for ETS1 Gene

(23) Drugs for ETS1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(16) Additional Compounds for ETS1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ETS1: view

Transcripts for ETS1 Gene

Unigene Clusters for ETS1 Gene

V-ets erythroblastosis virus E26 oncogene homolog 1 (avian):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ETS1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: -
SP2: - - -
SP3:

Relevant External Links for ETS1 Gene

GeneLoc Exon Structure for
ETS1
ECgene alternative splicing isoforms for
ETS1

Expression for ETS1 Gene

mRNA expression in normal human tissues for ETS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ETS1 Gene

This gene is overexpressed in Liver (37.8), Blymphocyte (13.6), and CD8 Tcells (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ETS1 Gene



SOURCE GeneReport for Unigene cluster for ETS1 Gene Hs.369438

mRNA Expression by UniProt/SwissProt for ETS1 Gene

P14921-ETS1_HUMAN
Tissue specificity: Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney.
genes like me logo Genes that share expression patterns with ETS1: view

Protein tissue co-expression partners for ETS1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for ETS1 Gene

Orthologs for ETS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ETS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ETS1 35
  • 91.99 (n)
  • 98.41 (a)
ETS1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ETS1 35
  • 95.09 (n)
  • 99.09 (a)
ETS1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ets1 35
  • 92.35 (n)
  • 97.27 (a)
Ets1 16
Ets1 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ets1 35
  • 92.52 (n)
  • 98.87 (a)
oppossum
(Monodelphis domestica)
Mammalia ETS1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ETS1 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ETS1 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves ETS1 35
  • 84.66 (n)
  • 95.92 (a)
ETS1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ETS1 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100170599 35
  • 77.7 (n)
  • 89.27 (a)
Str.1672 35
African clawed frog
(Xenopus laevis)
Amphibia ets1a-A-prov 35
zebrafish
(Danio rerio)
Actinopterygii ets1 35
  • 74.06 (n)
  • 80.31 (a)
idibd1116 35
ETS1 36
  • 37 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pnt 37
  • 57 (a)
pnt 36
  • 26 (a)
OneToMany
Species with no ortholog for ETS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ETS1 Gene

ENSEMBL:
Gene Tree for ETS1 (if available)
TreeFam:
Gene Tree for ETS1 (if available)

Paralogs for ETS1 Gene

Paralogs for ETS1 Gene

(4) SIMAP similar genes for ETS1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ETS1 Gene

genes like me logo Genes that share paralogs with ETS1: view

Variants for ETS1 Gene

Sequence variations from dbSNP and Humsavar for ETS1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1122832 -- 128,485,964(-) AAATA(A/G)TATCT intron-variant
rs2105777 -- 128,556,267(-) GCTGG(G/T)AATGA intron-variant
rs2230004 -- 128,463,608(-) CAGCT(A/G)TGGCA reference, synonymous-codon
rs2230005 -- 128,490,550(-) CACTA(C/T)TAACT intron-variant, reference, synonymous-codon
rs7115613 -- 128,501,546(+) tagcc(A/G)tcatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ETS1 Gene

Variant ID Type Subtype PubMed ID
nsv442246 CNV CNV 18776908
esv274885 CNV Gain+Loss 21479260
nsv898448 CNV Loss 21882294
esv25513 CNV Loss 19812545
esv2745237 CNV Deletion 23290073
esv275584 CNV Loss 21479260
esv269752 CNV Insertion 20981092
nsv517012 CNV Loss 19592680
esv275204 CNV Gain+Loss 21479260
esv1757388 CNV Insertion 17803354
esv8500 OTHER Inversion 19470904
esv2745238 CNV Deletion 23290073
esv2745239 CNV Deletion 23290073
esv1237588 CNV Deletion 17803354

Variation tolerance for ETS1 Gene

Residual Variation Intolerance Score: 26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ETS1 Gene

Human Gene Mutation Database (HGMD)
ETS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ETS1 Gene

Disorders for ETS1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ETS1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
jacobsen syndrome
  • johanson-blizzard syndrome
estrogen-receptor negative breast cancer
chromosome 3q29 microdeletion syndrome
  • 3q subtelomere deletion syndrome
hypoxia
ewing sarcoma
  • neuroepithelioma
- elite association - COSMIC cancer census association via MalaCards
Search ETS1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ETS1

Genetic Association Database (GAD)
ETS1
Human Genome Epidemiology (HuGE) Navigator
ETS1
Tumor Gene Database (TGDB):
ETS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ETS1
genes like me logo Genes that share disorders with ETS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ETS1 Gene

Publications for ETS1 Gene

  1. Quantitative and qualitative variation of ETS-1 transcripts in hematologic malignancies. (PMID: 8231246) Collyn d'Hooghe M. … Kerckaert J.P. (Leukemia 1993) 3 4 23 67
  2. Highly cooperative recruitment of Ets-1 and release of autoinhibition by Pax5. (PMID: 19616560) Fitzsimmons D. … Hagman J. (J. Mol. Biol. 2009) 3 23
  3. DNA-dependent protein kinase is a novel interaction partner for Ets-1 isoforms. (PMID: 19836356) Choul-li S. … Aumercier M. (Biochem. Biophys. Res. Commun. 2009) 3 23
  4. DNA specificity determinants associate with distinct transcription factor functions. (PMID: 20019798) Hollenhorst P.C. … Graves B.J. (PLoS Genet. 2009) 3 23
  5. [Relationship between Ets-1 expression and angiogenesis, clinicopathological features and survival of patients with gastric carcinoma]. (PMID: 20021863) Ren T.W. … Zhao Y. (Zhonghua Zhong Liu Za Zhi 2009) 3 23

Products for ETS1 Gene

Sources for ETS1 Gene

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