Aliases for ETFA Gene
External Ids for ETFA Gene
ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ETFA Gene
ETFA (Electron-Transfer-Flavoprotein, Alpha Polypeptide) is a Protein Coding gene. Diseases associated with ETFA include multiple acyl-coa dehydrogenation deficiency, severe neonatal type and multiple acyl-coa dehydrogenation deficiency, mild type. Among its related pathways are Metabolism and Apoptosis and survival Caspase cascade. GO annotations related to this gene include electron carrier activity and flavin adenine dinucleotide binding.
UniProtKB/Swiss-Prot for ETFA Gene
The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase)